Hub : Genes

TNFRSF6B

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Head and Neck Squamous Cell Carcinoma	0.0280	0.0160	0.00056	0.015	0.025	0.018	NA	0.014	0.0079	0.00071	0.0038	NA	0.0093
2	TCGA	Lung Adenocarcinoma	0.0227	0.0155	0.00410	0.012	0.013	0.015	NA	0.008	0.0140	0.00910	0.0069	NA	0.0350
3	TCGA	Ovarian Serous Cystadenocarcinoma	0.0470	0.0340	0.00980	0.017	0.032	0.024	NA	0.014	0.0230	0.00280	0.0087	NA	0.0380

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Irritable Bowel Disease (IBD)	27.8	66.3	76.4	-7.2	-8.7	-8.4
Crohns Disease (2012)	24.3	39.2	44.4	-6.2	-6.7	-5.9
Lung FVC	21.6	109.8	132.2	8.6	11.1	11.5
Crohns Disease (2017)	20.6	45.3	53.6	-5.7	-7.1	-7.3
Prostate Cancer	18.2	25.6	27.3	-4.9	-5.2	-5.0
Ulcerative Colitis	18.0	26.2	31.9	-5.1	-5.6	-4.6
Ulcerative Colitis (UC)	16.7	31.3	37.2	-5.0	-6.1	-5.6
Wheeze or whistling in the chest in last year	16.4	29.3	35.8	-5.2	-6.0	-5.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	15.2	32.2	43.8	4.3	5.8	6.6
Allergy or Eczema	14.5	38.0	45.0	-6.7	-6.6	-5.1
Allergy	14.5	33.3	39.9	6.3	6.2	4.7
Current tobacco smoking	13.7	22.3	27.5	-4.0	-4.9	-5.2
Forced vital capacity (FVC)	12.9	49.7	57.3	6.0	7.6	7.5
Smoking status: Current	11.8	18.7	22.7	-3.7	-4.4	-4.8
Respiratory disease	11.2	24.9	31.3	-5.0	-5.6	-4.2
Hayfever, allergic rhinitis or eczema	10.9	23.7	29.5	-5.4	-5.1	-3.9
Pain all over the body in last month	10.7	11.5	14.7	-2.8	-3.5	-3.8
Number of self-reported non-cancer illnesses	10.0	17.3	21.1	-4.0	-4.6	-3.9
Forced vital capacity (FVC), Best measure	9.9	36.2	44.8	4.9	6.3	6.7
Forced expiratory volume in 1-second (FEV1)	9.3	31.4	36.5	4.6	6.0	6.0
Leg fat percentage (left)	9.2	33.3	39.6	-4.8	-6.1	-6.3
Asthma	8.9	17.5	21.2	-4.6	-4.6	-3.2
Medication: Omeprazole (e.g. Zanprol)	8.6	10.5	13.4	-2.6	-3.3	-3.7
Forced expiratory volume in 1-second (FEV1), Best measure	8.1	25.8	32.4	4.0	5.3	5.7
Asthma (self-reported)	8.0	15.8	19.0	-4.3	-4.4	-3.1
Diastolic blood pressure, automated reading	8.0	24.9	30.8	-5.6	-5.5	-3.7
Leg fat percentage (right)	7.9	28.7	34.9	-4.4	-5.7	-5.9
Body fat percentage	7.1	28.1	40.4	-3.8	-5.4	-6.4
Whole body fat mass	6.7	28.1	34.5	-4.2	-5.7	-5.9
Long-standing illness, disability or infirmity	6.6	10.0	12.7	-2.7	-3.6	-3.2
Smoking Status	6.5	15.5	16.5	-3.7	-4.0	-4.1
Type 2 Diabetes (T2D) (2018)	6.5	12.2	17.1	-2.7	-3.5	-4.1
Leg fat mass (left)	6.5	25.4	30.0	-4.1	-5.4	-5.5
Trunk fat percentage	6.3	25.3	38.3	-3.4	-5.1	-6.2
Leg fat mass (right)	6.1	23.5	27.5	-4.0	-5.2	-5.2
Chronic bronchitis/emphysema (father)	6.0	7.0	9.5	-1.8	-2.8	-3.1
Trunk fat mass	6.0	25.6	34.7	-3.7	-5.3	-5.9
Medication: Blood pressure	5.9	11.3	19.0	-4.4	-3.6	-1.3
Waist circumference	5.8	21.3	26.2	-3.9	-5.1	-4.7
Frequency of unenthusiasm / disinterest in last 2 weeks	5.7	7.6	9.4	-2.7	-3.1	-2.5
Systolic blood pressure, automated reading	5.6	16.2	25.4	-5.0	-4.3	-2.3
Hip circumference	5.6	24.1	30.5	-4.7	-5.5	-4.5
Qualifications: College or University degree	5.5	17.2	18.2	3.9	4.3	4.3
Blood Platelet Count	5.0	58.0	64.8	-7.6	-8.1	-7.2
Medication: Omeprazole	4.9	5.8	8.1	-1.9	-2.4	-2.8
Arm fat mass (right)	4.6	19.0	22.8	-3.5	-4.7	-4.8
Emphysema/chronic bronchitis	4.6	5.1	7.0	-1.5	-2.5	-2.6
Mouth/teeth dental problems: Dentures	4.5	7.6	9.1	-2.9	-3.0	-2.3
Pain experienced in last month	4.5	7.5	9.2	2.1	2.9	3.0
Pack years adult smoking proportion	4.4	6.7	8.2	-2.1	-2.7	-2.9
Medication: Ventolin 100micrograms inhaler	4.4	5.6	7.1	-1.7	-2.6	-2.7
Qualifications: NVQ or HND or HNC or equivalent	4.3	5.2	6.8	-2.6	-2.5	-1.6
Illness, injury, bereavement, stress in last 2 years	4.3	5.3	5.5	2.2	2.3	2.4
Arm fat mass (left)	4.3	17.7	21.3	-3.4	-4.5	-4.6
Mouth/teeth dental problems: Mouth ulcers	4.2	6.6	7.5	2.2	2.7	2.7
Pack years of smoking	4.2	6.2	7.9	-2.0	-2.6	-2.8
Arm fat percentage (right)	4.1	16.1	24.3	-2.8	-4.0	-4.9
Diabetes diagnosed by doctor	4.1	6.7	8.4	-2.1	-2.7	-2.9
Other serious medical condition/disability diagnosed by doctor	4.0	5.2	7.3	-2.7	-2.5	-1.5
Number of incorrect matches in round	4.0	6.7	8.5	2.1	2.7	2.9
Type 2 Diabetes (T2D) (2012)	3.9	4.5	5.9	-1.6	-2.2	-2.4
Arm fat percentage (left)	3.9	15.4	23.3	-2.7	-4.0	-4.8
Medication for cholesterol	3.9	6.0	10.0	3.2	2.7	0.8
Taking other prescription medications	3.8	5.9	7.0	-2.5	-2.7	-2.1
Diabetes (self-reported)	3.8	5.8	7.9	-1.8	-2.5	-2.8
Frequency of tiredness / lethargy in last 2 weeks	3.8	6.1	7.7	-1.9	-2.7	-2.8
Severe depression (siblings)	3.6	4.0	4.6	-2.0	-2.1	-1.9
Maternal smoking around birth	3.6	5.2	6.5	-2.3	-2.6	-2.0
Medication: Ramipril	3.5	4.5	4.9	-2.1	-2.2	-2.0
Weight	3.5	17.3	21.7	-3.6	-4.7	-4.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.5	4.2	7.1	-2.7	-2.1	-1.0
Illnesses of siblings: Diabetes	3.5	4.3	6.9	-2.6	-2.1	-1.4
Number of treatments/medications taken	3.4	6.1	7.6	-2.8	-2.8	-1.7
Medication for pain relief, constipation, heartburn	3.4	5.9	7.7	2.8	2.5	1.9
HDL Cholesterol	3.2	5.4	6.8	1.9	2.4	2.6
LDL Cholesterol	3.2	5.0	6.1	2.2	2.5	2.1
Blood White Count	3.2	23.8	25.8	-4.5	-5.1	-5.0
Cardiovascular Disease	3.2	10.5	12.9	-3.6	-3.6	-2.4
Seen doctor (GP) for nerves, anxiety, tension or depression	3.2	4.9	6.3	-2.5	-2.4	-1.7
Chronic bronchitis/emphysema (mother)	3.2	3.8	5.2	-1.6	-2.3	-1.9
Blood Red Count	3.1	30.2	37.2	-6.1	-5.9	-4.3
Frequency of tenseness / restlessness in last 2 weeks	3.1	4.8	6.2	-2.0	-2.5	-2.0
Hair/balding pattern: Pattern 2	3.1	3.9	5.1	-1.7	-1.9	-2.3
Commuting to job workplace: Cycle	3.0	3.6	4.5	1.6	2.0	2.1
Depression (Nagel 2018)	2.9	4.4	5.6	-2.0	-2.4	-1.9
Systolic Blood Pressure	2.9	14.3	25.1	-5.0	-4.0	-1.4
Body mass index (BMI)	2.9	12.3	15.2	-3.2	-3.9	-3.4
Had menopause	2.9	3.6	4.5	-2.1	-2.1	-1.4
Financial difficulties in last 2 years	2.9	3.9	5.0	-2.1	-2.2	-1.5
Age at first live birth	2.9	5.2	5.9	2.0	2.4	2.4
Pulse rate, automated reading	2.8	9.1	12.5	-2.4	-3.0	-3.5
Vascular/heart problems diagnosed by doctor	2.8	7.7	14.3	3.8	2.8	0.7
Diabetes (father)	2.7	3.3	4.4	-2.1	-1.8	-1.5
High blood pressure	2.7	7.5	14.0	-3.7	-2.8	-0.6
BMI	2.6	15.3	19.1	-4.1	-4.4	-3.2
Medication: Co-codamol	2.6	3.0	3.4	-1.8	-1.8	-1.6
Overall health rating	2.6	5.6	8.7	-1.4	-2.5	-2.9
Hypertension (Self-reported)	2.6	7.4	14.3	-3.8	-2.8	-0.4
Arm fat-free mass (left)	2.6	13.3	18.0	-4.1	-4.2	-2.4
Primary Biliary Cirrhosis	2.5	3.6	4.9	-1.4	-2.0	-2.2
Qualifications: CSEs or equivalent	2.5	3.3	4.4	-2.1	-1.9	-1.4
Medication: Aspirin	2.5	3.3	3.4	-1.7	-1.8	-1.9
Arm predicted mass (left)	2.5	12.6	17.0	-3.9	-4.1	-2.3
Schizophrenia (2018)	2.4	4.9	6.7	2.6	2.4	1.6
Hayfever/allergic rhinitis (self-reported)	2.4	3.2	4.2	-1.2	-2.0	-2.0
Illnesses of mother	2.4	2.9	3.5	1.8	1.9	1.4
Ovarian Cancer	2.2	2.9	3.7	-1.5	-1.7	-1.9
Arm predicted mass (right)	2.2	11.5	15.8	-3.9	-4.0	-1.8
Alcohol drinker status: Previous	2.2	2.5	3.9	-1.1	-1.6	-2.0
Bipolar Disorder or Schizophrenia	2.1	5.2	6.9	2.6	2.5	1.7
Rheumatoid Arthritis	2.1	2.9	4.6	-2.2	-1.9	-0.7
Medication: Metformin	2.1	2.9	5.9	-0.7	-1.5	-2.4
Arm fat-free mass (right)	2.1	10.9	15.0	-3.9	-3.9	-1.7
Average weekly beer plus cider intake	2.1	3.0	4.4	-1.1	-1.8	-2.1
Supplements: Glucosamine	2.0	2.6	3.2	-1.8	-1.7	-1.3
Diverticular disease/diverticulitis (self-reported)	2.0	2.4	4.0	2.0	1.6	0.7
Pulse wave reflection index	2.0	2.5	6.2	0.3	1.1	2.5
Medication: Aspirin	1.9	2.5	2.7	-1.5	-1.6	-1.7
Migraine (self-reported)	1.8	2.2	4.3	-2.1	-1.5	-0.4
Lung cancer (father)	1.7	2.0	2.9	-1.7	-1.4	-1.1
Medication: Gliclazide	1.7	2.0	2.5	-1.2	-1.4	-1.6
Guilty feelings	1.7	2.5	3.9	1.1	1.5	2.0
Financial situation satisfaction	1.7	2.1	2.7	1.1	1.6	1.5
Triglycerides	1.6	2.6	5.5	-0.7	-1.3	-2.4
Medication for hormone replacement therapy	1.6	1.8	4.5	-0.0	0.9	2.1
Miserableness	1.6	2.7	4.0	-1.2	-1.7	-2.0
Basal metabolic rate	1.6	8.8	12.2	-3.1	-3.5	-2.2
Myopia	1.6	2.4	4.1	2.0	1.7	0.3
Verbal and Numeric Reasoning (VNR)	1.5	3.5	4.0	-1.6	-2.0	-2.0
Frequency of depressed mood in last 2 weeks	1.5	2.1	2.5	-1.2	-1.5	-1.6
Reason for reducing amount of alcohol drunk: Health precaution	1.5	1.8	3.5	0.5	1.3	1.9
Medication: Bendroflumethiazide	1.5	2.3	3.3	-1.8	-1.6	-1.0
Schizophrenia (2014)	1.4	3.0	4.3	2.1	1.9	1.1
Number of live births	1.4	1.9	2.7	-0.9	-1.6	-1.5
Eye problems/disorders: Cataract	1.4	1.6	3.0	1.7	1.2	0.7
Hearing aid user	1.4	1.6	2.0	-0.9	-1.4	-1.4
Unable to work because of sickness or disability	1.4	1.9	4.3	-0.1	-1.1	-2.1
Heel T-Score	1.3	10.1	22.2	0.9	2.7	4.7
Height	1.3	24.3	28.5	-4.1	-5.3	-5.3
Average weekly spirits intake	1.3	1.6	1.7	-1.3	-1.3	-1.1
Medication: Atenolol	1.3	1.7	2.5	-1.6	-1.4	-0.8
Medication: Lansoprazole	1.3	1.5	2.4	-0.8	-1.2	-1.6
Medication: Seretide 50 evohaler	1.3	1.5	2.0	-1.4	-1.4	-0.6
Breast cancer (self-reported)	1.3	1.6	2.0	1.0	1.3	1.4
Ever had prostate specific antigen (PSA) test	1.3	1.4	1.8	0.8	1.4	1.3
Alzheimer’s Disease (in mother)	1.2	1.4	2.9	1.7	1.1	-0.0
Impedance of leg (left)	1.2	5.9	13.2	-1.0	-1.9	-3.6
Knee pain experienced in last month	1.2	1.9	2.7	-1.0	-1.4	-1.6
Mood swings	1.2	2.2	3.4	-0.9	-1.6	-1.8
Ever taken oral contraceptive pill	1.2	1.3	2.1	-1.4	-1.1	-0.7
Irritability	1.2	2.1	3.1	-1.8	-1.5	-0.9
Alzheimer’s Disease (including proxy)	1.1	1.6	3.4	1.8	1.2	-0.1
Reaction Time	1.1	2.0	2.7	-1.2	-1.4	-1.6
High blood pressure (mother)	1.1	1.6	2.5	-1.6	-1.5	-0.5
Worry too long after embarrassment	1.1	1.9	4.8	0.1	0.9	2.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	3.2	-0.1	-0.8	-1.8
Loneliness, isolation	1.1	1.5	2.9	-0.6	-1.2	-1.7
Serious illness, injury or assault to yourself	1.0	1.3	2.5	-0.7	-0.9	-1.6
Heart attack	1.0	1.2	2.6	0.3	1.0	1.6
Alcohol intake versus 10 years previously	1.0	1.5	2.8	-1.7	-1.3	-0.0
Depression (self-reported)	1.0	1.2	2.5	1.6	1.1	0.2
Impedance of arm (left)	1.0	4.5	8.6	2.9	1.8	-1.2
Qualifications: O levels/GCSEs or equivalent	1.0	1.5	3.3	-1.8	-1.1	-0.2
Age at last live birth	1.0	1.4	1.9	0.8	1.3	1.4
Whole body fat-free mass	1.0	5.5	8.0	-2.7	-2.8	-1.2
Whole body water mass	1.0	5.7	8.1	-2.8	-2.8	-1.2
Age at First Birth	0.9	1.3	1.5	1.1	1.2	1.1
Impedance of leg (right)	0.9	4.2	10.2	-0.5	-1.5	-3.2
Leg fat-free mass (left)	0.9	4.8	6.9	-2.1	-2.6	-1.8
Leg predicted mass (left)	0.9	4.6	6.6	-2.0	-2.6	-1.7
Impedance of arm (right)	0.9	4.2	7.7	2.8	1.6	-1.6
Trunk fat-free mass	0.9	4.9	7.3	-2.7	-2.6	-0.7
Worrier / anxious feelings	0.9	1.6	3.4	-1.8	-1.2	-0.3
Falls in the last year	0.9	1.3	1.8	-0.8	-1.2	-1.3
Trunk predicted mass	0.9	5.0	7.2	-2.7	-2.7	-0.8
Gout (self-reported)	0.9	1.2	1.4	1.2	1.0	1.1
Medication: Allopurinol	0.9	1.2	2.2	0.7	1.0	1.5
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.9	2.8	-0.9	-1.4	-1.7
Pain type(s) experienced in last month: Hip pain	0.9	1.1	2.0	-0.1	-1.1	-1.4
Number of operations (self-reported)	0.9	1.3	1.7	-1.0	-1.3	-1.2
Heart attack/myocardial infarction (self-reported)	0.9	1.2	2.6	0.3	0.9	1.6
Schizophrenia vs Biploar Disorder	0.8	1.1	2.3	-0.2	-1.0	-1.5
Worry (Nagel 2018)	0.8	1.7	4.7	-0.3	0.7	2.2
Hypothyroidism (self reported)	0.8	1.8	4.2	0.2	1.0	2.1
Lung FEV1/FVC ratio	0.8	4.1	6.0	-2.4	-2.2	-1.2
Mouth/teeth dental problems	0.8	1.3	1.7	1.2	1.3	0.9
Prospective memory result	0.8	0.9	2.2	1.5	0.7	-0.4
Shortness of breath walking on level ground	0.8	0.9	1.2	-0.8	-1.1	-1.0
Medication: Blood pressure	0.8	1.3	2.7	-1.7	-1.1	-0.1
Leg predicted mass (right)	0.8	4.3	6.2	-2.1	-2.5	-1.5
Tinnitus: Yes, now most or all of the time	0.8	0.9	2.0	-0.9	0.0	1.4
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	1.5	-0.4	-1.2	-1.2
Major Depression (MDD)	0.7	0.9	2.2	-0.6	0.3	1.5
Fasting Glucose	0.7	0.9	2.1	-0.4	0.6	1.5
Average weekly fortified wine intake	0.7	0.9	1.2	0.8	0.9	1.1
Nervous feelings	0.7	1.3	2.8	0.5	1.0	1.7
Had other major operations	0.7	0.8	0.9	-0.8	-1.0	-0.9
Heart disease (mother)	0.7	0.9	1.2	-0.9	-1.1	-0.8
Commuting to job workplace: Car/motor vehicle	0.7	0.8	1.3	-0.7	-0.8	-1.1
Leg fat-free mass (right)	0.7	4.0	5.7	-2.0	-2.4	-1.4
Illnesses of father: None of the above (group 1)	0.7	0.9	1.2	0.8	1.1	0.9
Supplements: Fish oil (including cod liver oil)	0.7	0.9	1.5	-0.6	-0.9	-1.2
Blood Eosinophil Count	0.6	5.0	9.8	-0.8	-2.1	-3.1
Waist Hip Ratio (WHR)	0.6	2.6	6.0	-0.4	-1.3	-2.4
Neuroticism	0.6	1.4	2.8	-1.7	-0.7	1.0
Relative age of first facial hair	0.6	1.3	2.8	-1.7	-1.0	-0.2
Medication: Levothyroxine sodium	0.6	1.0	2.6	0.2	0.7	1.6
Alcohol usually taken with meals	0.6	1.0	2.4	-0.2	0.8	1.5
Ever unenthusiastic/disinterested for a whole week	0.6	0.8	1.1	-1.1	-1.0	-0.3
Noisy workplace	0.6	0.8	0.9	-0.9	-0.9	-0.8
Blood clot in the leg (DVT)	0.6	0.7	1.1	-0.5	-1.1	-0.9
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	3.1	0.0	0.6	1.8
Medication: Amlodipine	0.6	0.9	1.7	-1.3	-0.5	0.8
Number of full brothers	0.6	0.8	1.1	-0.4	-1.0	-1.0
Mean time to correctly identify matches	0.6	1.2	1.3	-1.1	-1.1	-1.0
Alcohol intake frequency.	0.6	1.4	2.1	-0.8	-1.3	-1.5
Chest pain or discomfort	0.6	0.9	1.1	-0.6	-1.1	-1.0
Leg pain on walking	0.6	0.8	0.9	-0.9	-0.9	-0.8
Illnesses of father: Heart disease	0.6	0.9	1.1	0.7	1.1	1.0
Smoking status: Previous	0.6	0.9	1.9	0.1	0.8	1.4
Average weekly red wine intake	0.6	0.8	1.8	-1.4	-0.3	0.8
Ever had bowel cancer screening	0.6	0.8	1.3	-1.1	-1.0	-0.2
Mineral and other dietary supplements	0.6	0.8	1.5	0.5	0.7	1.2
Impedance of whole body	0.6	2.9	6.6	1.4	0.2	-2.6
Bipolar Disorder (2018)	0.5	0.8	0.9	1.0	1.0	0.7
Diabetes (mother)	0.5	0.6	0.6	-0.8	-0.8	-0.8
Fed-up feelings	0.5	0.9	1.1	-1.0	-1.1	-0.7
Tinnitus: Yes, but not now, but have in the past	0.5	0.6	0.6	0.7	0.8	0.8
Hearing difficulty/problems with background noise	0.5	0.8	1.4	-1.2	-0.9	-0.4
Peak expiratory flow (PEF)	0.5	1.2	1.5	0.6	1.2	1.2
Exposure to tobacco smoke outside home	0.5	0.7	1.2	-0.3	-0.9	-1.1
Health satisfaction	0.5	0.6	0.7	-0.7	-0.8	-0.8
Eye problems/disorders: None of the above	0.5	0.6	1.2	-1.1	-0.7	-0.2
High cholesterol (Self-reported)	0.5	0.8	1.8	0.8	0.0	-1.4
Age started oral contraceptive pill	0.5	0.6	1.6	0.1	0.6	1.3
Cholesterol lowering medication	0.5	0.7	1.3	-0.4	-0.7	-1.2
Alzheimer’s Disease (in father)	0.4	0.4	0.9	-0.2	-0.6	-0.9
Coronary Artery Disease (CAD)	0.4	0.4	1.1	1.0	0.4	-0.2
HbA1C	0.4	0.4	0.8	0.9	0.6	0.2
Neuroticism (2016)	0.4	0.6	1.4	-0.5	0.5	1.2
Angina	0.4	0.5	1.0	-1.0	-0.4	0.5
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	1.0	-1.0	-0.5	0.2
Standing height	0.4	4.4	5.6	-1.5	-2.4	-2.3
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	0.9	0.4	0.6	1.0
Headache pain in last month	0.4	0.6	1.0	-0.9	-1.0	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.2	0.6	0.1	-1.1
Mouth/teeth dental problems: Loose teeth	0.4	0.5	0.7	-0.5	-0.6	-0.9
Angina (self-reported)	0.4	0.6	1.2	-1.1	-0.6	0.4
Family relationship satisfaction	0.4	0.4	0.7	-0.8	-0.7	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	0.9	-0.4	-0.6	-0.9
Risk taking	0.4	0.6	1.4	1.2	0.5	-0.5
Neuroticism (Nagel 2018)	0.3	0.8	2.0	-0.6	0.0	1.4
Breast Cancer	0.3	0.6	1.2	-1.1	-0.8	-0.1
Hair Pigment	0.3	9.7	11.2	-2.9	-3.3	-3.1
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.6	-0.8	-0.5	-0.1
Relative age voice broke	0.3	0.5	0.9	-0.9	-0.4	0.6
Sitting height	0.3	2.0	2.4	1.5	1.4	1.3
Fluid intelligence score	0.3	0.6	0.9	-0.5	-0.7	-0.9
Illnesses of siblings	0.3	0.4	0.9	1.0	0.6	-0.0
Father’s age at death	0.3	0.5	0.6	0.6	0.7	0.7
Hair/balding pattern: Pattern 3	0.3	0.5	1.1	-1.1	-0.6	0.1
Qualifications: A levels/AS levels or equivalent	0.3	0.6	1.1	0.4	0.7	1.1
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	0.8	0.1	-0.5	-0.9
Tense / ‘highly strung’	0.3	0.6	0.9	-1.0	-0.8	0.3
Hair/balding pattern: Pattern 4	0.3	0.6	1.2	-1.1	-0.6	0.5
Birth weight of first child	0.3	0.5	1.3	0.1	-0.4	-1.1
Medication: Paracetamol	0.3	0.6	1.0	-1.0	-0.4	0.7
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	0.8	0.9	0.7	0.5
Birth weight	0.3	0.5	0.9	0.9	0.8	-0.2
Pulse wave peak to peak time	0.3	0.3	0.9	0.0	-0.3	-1.0
Had major operations	0.3	0.3	0.5	0.6	0.7	0.4
Qualifications: nursing, teaching	0.3	0.4	0.6	0.7	0.8	0.5
Commuting to job workplace: Walk	0.3	0.4	0.9	-0.9	-0.5	-0.0
Osteoarthritis (self-reported)	0.3	0.4	0.5	-0.7	-0.7	-0.6
Average weekly champagne plus white wine intake	0.3	0.4	1.2	-0.1	0.3	1.1
Wears glasses or contact lenses	0.3	0.3	0.4	0.3	0.6	0.7
Fractured/broken bones in last 5 years	0.3	0.3	0.5	0.7	0.4	0.5
Basal cell carcinoma (self-reported)	0.3	0.4	1.0	0.1	-0.5	-1.0
Depressed Affect (Nagel 2018)	0.2	0.5	0.9	-0.7	-0.9	-0.5
Lupus	0.2	0.3	0.6	-0.8	-0.5	-0.1
Hearing difficulty/problems: Yes	0.2	0.3	0.5	-0.7	-0.6	-0.0
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.6	-0.8	-0.3	0.4
Ever had hysterectomy (womb removed)	0.2	0.2	0.3	-0.4	-0.5	-0.3
Supplements: Zinc	0.2	0.3	0.7	-0.0	0.3	0.9
Age when periods started (menarche)	0.2	0.5	0.7	0.5	0.8	0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	0.9	-0.9	0.1	0.9
Multivitamins +/- minerals	0.2	0.3	0.3	0.3	0.5	0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	0.8	-0.9	-0.0	0.8
Medication: Simvastatin	0.2	0.3	0.9	0.2	-0.3	-1.0
Time employed in main current job	0.2	0.2	0.5	0.1	0.2	0.7
Pulse rate	0.2	0.4	0.7	-0.5	-0.5	-0.8
Happiness	0.2	0.3	0.7	-0.8	-0.2	0.3
Pulse wave Arterial Stiffness index	0.2	0.2	0.6	-0.2	0.1	0.8
Loud music exposure frequency	0.2	0.2	0.3	-0.3	-0.3	-0.6
High blood pressure (siblings)	0.2	0.2	0.6	-0.3	0.2	0.8
Comparative body size at age 10	0.2	0.5	0.8	0.9	0.0	-0.9
Comparative height size at age 10	0.2	0.9	1.7	0.8	-0.5	-1.3
Number of full sisters	0.2	0.2	0.3	-0.3	-0.5	-0.6
Osteoporosis (self-reported)	0.2	0.3	0.4	0.7	0.6	0.2
Medication: Lisinopril	0.2	0.3	0.3	-0.5	-0.6	-0.6
Illnesses of father: High blood pressure	0.2	0.3	0.7	-0.8	-0.3	-0.1
Ever depressed for a whole week	0.2	0.3	0.4	-0.5	-0.2	0.6
Mean Putamen Volume	0.1	0.1	0.1	-0.1	0.4	0.3
Chronotype (morning person)	0.1	0.3	0.5	-0.6	0.0	0.7
Tanning	0.1	0.7	1.8	-0.2	0.5	1.4
Hand grip strength (left)	0.1	0.2	0.4	-0.6	-0.4	0.2
Sensitivity / hurt feelings	0.1	0.1	0.2	0.2	0.4	0.4
Hand grip strength (right)	0.1	0.4	0.7	-0.8	-0.6	0.2
Past tobacco smoking	0.1	0.2	0.6	0.8	0.3	0.1
Neuroticism score	0.1	0.2	0.4	-0.6	-0.5	0.2
Length of working week for main job	0.1	0.1	0.2	0.1	-0.3	-0.5
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.3	-0.5	-0.1	0.3
Glaucoma (self-reported)	0.1	0.2	0.3	-0.4	0.3	0.5
Number of children fathered	0.1	0.1	0.2	-0.5	-0.2	-0.0
Medication: Ibuprofen	0.1	0.1	0.3	0.6	0.3	-0.0
Suffer from ‘nerves’	0.1	0.1	0.1	0.3	0.3	0.4
Supplements: Vitamin C	0.1	0.1	0.2	-0.2	-0.1	-0.5
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.2	-0.3	-0.4	-0.4
Friendships satisfaction	0.1	0.1	0.2	-0.5	0.0	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.2	-0.4	-0.2	-0.2
Mother’s age at death	0.1	0.1	0.3	0.5	0.4	0.1
Commuting to job workplace: Public transport	0.1	0.1	0.1	-0.0	-0.4	-0.3
Medication: Paracetamol	0.1	0.1	0.2	0.0	0.1	0.5
Medication: Atorvastatin	0.1	0.1	0.2	-0.4	-0.2	-0.3
Alcohol drinker status: Never	0.1	0.2	0.4	0.1	-0.3	-0.6
Supplements: Calcium	0.1	0.1	0.2	0.5	0.3	0.1
Heart disease (siblings)	0.1	0.1	0.2	-0.5	-0.3	-0.2
Intelligence (Savage-Jansen 2018)	0.0	0.1	0.2	0.1	-0.1	-0.4
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.0	0.0	0.1	0.1	0.3	-0.2
Vitamin and mineral supplements	0.0	0.1	0.1	0.1	-0.3	-0.2
Townsend deprivation index at recruitment	0.0	0.0	0.0	0.1	0.0	0.0
Stomach or abdominal pain in last month	0.0	0.0	0.0	0.1	0.1	0.1
Qualifications: None of the above	0.0	0.0	0.0	0.2	-0.2	-0.1
Medication: Ibuprofen (e.g. Nurofen)	0.0	0.0	0.1	-0.3	-0.0	0.1
Medication: Cholesterol lowering	0.0	0.1	0.2	-0.1	-0.1	-0.4
Exposure to tobacco smoke at home	0.0	0.0	0.1	0.3	0.0	-0.1
Breastfed as a baby	0.0	0.1	0.1	-0.4	-0.2	-0.1
Neck or shoulder pain in last month	0.0	0.1	0.1	-0.3	-0.3	-0.3
Back pain experienced in last month	0.0	0.1	0.1	0.1	-0.3	-0.3
Eye problems/disorders: Glaucoma	0.0	0.0	0.0	-0.1	0.1	0.0
Ever smoked	0.0	0.0	0.1	-0.4	0.1	0.1