Hub : Genes

TPD52L2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1350 0.0380 1.4e-05 0.071 0.068 0.075 0.081 0.073 5.3e-09 1.1e-08 1.8e-09 4.5e-10 3.6e-09
2 GTEx Artery Aorta 0.1620 0.0590 3.1e-03 0.072 NA 0.159 NA 0.153 8.9e-05 NA 4.4e-09 NA 8.3e-09
3 METSIM Adipose 0.0266 0.0139 9.0e-03 0.004 0.016 -0.001 0.016 0.002 7.9e-02 1.6e-03 4.7e-01 1.5e-03 1.2e-01
4 TCGA Head and Neck Squamous Cell Carcinoma 0.0350 0.0188 5.9e-03 0.017 0.018 0.010 NA 0.010 4.1e-03 3.8e-03 2.4e-02 NA 2.5e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 1.3 2.0 3.2 1.3 -1.4 -1.8 -1.1
Bipolar Disorder or Schizophrenia 1.6 3.8 11.0 0.6 -0.4 -3.3 -1.9
Depressed Affect (Nagel 2018) 0.6 1.2 2.0 -1.4 1.0 1.3 0.1
Depression (Nagel 2018) 0.5 0.8 2.3 0.6 -0.6 1.5 0.3
Intelligence (Savage-Jansen 2018) 0.7 2.1 4.0 1.6 -1.2 -0.6 -2.0
Neuroticism (Nagel 2018) 0.6 1.4 3.4 -1.9 0.8 -0.8 -0.9
Schizophrenia (2018) 1.3 2.6 7.0 -0.2 0.8 -2.6 -1.7
Schizophrenia vs Biploar Disorder 0.7 0.9 1.6 -1.3 0.0 1.1 -0.8
Worry (Nagel 2018) 1.3 2.8 4.9 -1.8 1.6 -2.2 -0.5
Alzheimer’s Disease (in mother) 0.8 0.9 2.8 0.3 0.8 -0.5 1.7
Alzheimer’s Disease (in father) 0.5 0.6 1.3 -0.1 -0.5 1.1 0.9
Alzheimer’s Disease (including proxy) 0.5 0.7 2.1 -0.3 0.8 -0.2 1.5
Crohns Disease (2017) 5.1 11.3 35.3 1.4 1.2 5.9 2.6
Irritable Bowel Disease (IBD) 6.3 15.1 34.5 0.6 2.6 5.9 4.3
Ulcerative Colitis (UC) 4.4 8.2 15.3 -1.0 2.6 3.1 3.9
Major Depression (MDD) 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Reaction Time 1.1 2.1 5.1 1.8 0.1 -0.0 2.3
Verbal and Numeric Reasoning (VNR) 1.4 3.3 7.3 2.7 -1.2 1.5 -1.5
Breast Cancer 0.2 0.4 0.9 0.9 -0.7 -0.0 -0.6
Ovarian Cancer 1.3 1.7 4.4 -0.7 2.1 1.3 -0.1
Prostate Cancer 3.0 4.2 10.0 -2.5 0.7 3.2 -0.1
Age at First Birth 1.0 1.5 3.1 -0.4 -1.0 -1.4 -1.7
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.5 0.8 2.4 0.3 -0.1 -0.7 1.6
Coronary Artery Disease (CAD) 0.2 0.2 0.7 0.0 0.0 0.0 0.9
Crohns Disease (2012) 3.9 6.3 19.9 0.3 1.2 4.5 1.9
Mean Putamen Volume 0.5 0.5 1.6 1.3 -0.2 -0.3 0.7
Fasting Glucose 0.9 1.0 3.0 0.3 -0.1 -1.7 -1.0
HbA1C 0.3 0.3 1.1 -0.1 0.5 -1.1 0.1
HDL Cholesterol 1.3 2.2 4.5 -2.1 0.6 -1.9 -0.5
LDL Cholesterol 1.2 1.9 5.3 0.5 -0.7 -1.2 -2.3
Lupus 1.3 1.9 7.4 -0.2 -0.3 -0.4 -2.7
Neuroticism (2016) 0.8 1.1 1.8 -0.2 -1.3 -1.3 -1.0
Primary Biliary Cirrhosis 2.6 3.8 7.5 2.2 -1.3 1.0 2.7
Rheumatoid Arthritis 2.2 3.0 10.4 -0.3 0.9 0.7 3.2
Schizophrenia (2014) 1.1 2.3 7.1 -0.4 0.8 -2.7 -1.2
Triglycerides 1.6 2.6 7.8 1.3 -0.8 2.8 -0.3
Type 2 Diabetes (T2D) (2012) 1.1 1.2 4.4 2.1 0.0 0.0 0.7
Ulcerative Colitis 5.9 8.6 17.1 0.3 2.4 3.4 4.1
Blood Eosinophil Count 0.3 2.5 6.7 1.6 -0.9 2.6 0.4
Blood Platelet Count 1.7 19.3 62.6 1.7 -2.8 7.9 -2.0
Blood Red Count 0.5 4.8 10.9 0.8 0.8 2.6 3.3
Blood White Count 0.8 5.9 10.2 2.6 -1.6 3.2 2.0
Heel T-Score 0.7 5.9 11.3 1.5 -2.0 -2.5 -3.4
BMI 1.3 7.4 12.2 1.9 -2.0 3.5 3.1
Height 0.3 5.2 19.8 -0.8 0.7 4.5 0.0
Waist Hip Ratio (WHR) 1.4 6.2 15.0 1.1 -0.5 3.9 -2.9
Systolic Blood Pressure 4.6 22.9 46.1 6.8 -6.1 1.5 -2.3
Smoking Status 1.8 4.4 11.2 -1.7 -0.3 3.3 1.9
Allergy or Eczema 1.9 5.0 17.2 1.4 -0.2 4.1 0.8
Cardiovascular Disease 5.9 19.6 46.2 6.8 -5.0 2.4 -1.0
Hypothyroidism (self reported) 0.5 1.1 3.5 1.0 0.1 0.0 -1.9
Respiratory disease 2.6 5.7 22.7 -0.3 -0.0 4.8 -0.1
Type 2 Diabetes (T2D) (2018) 3.2 6.1 17.7 2.3 -1.1 4.2 0.1
Lung FEV1/FVC ratio 0.7 3.3 6.8 0.5 -2.2 -1.3 2.6
Lung FVC 7.0 35.7 127.7 -3.3 1.9 -11.3 -0.4
Neuroticism 0.2 0.5 1.2 -1.1 -0.2 -0.9 -0.3
Chronotype (morning person) 0.0 0.1 0.3 0.0 -0.4 0.0 -0.5
Hair Pigment 0.1 2.5 4.5 -1.7 0.6 1.5 2.1
Tanning 0.0 0.5 0.9 -1.0 0.2 -0.7 -0.6
Hand grip strength (left) 0.4 1.0 2.4 0.9 -1.6 0.4 0.6
Number of treatments/medications taken 0.9 1.5 2.6 1.3 -1.6 1.3 0.2
Average weekly spirits intake 1.7 2.1 6.0 -0.3 0.2 1.5 2.5
Sensitivity / hurt feelings 1.5 2.6 6.6 0.6 -2.6 -1.1 -1.5
Frequency of depressed mood in last 2 weeks 0.7 1.0 3.3 -0.0 0.1 1.8 0.7
Hearing difficulty/problems: Yes 0.5 0.8 2.6 -1.6 -0.4 -0.2 -0.4
Relative age of first facial hair 0.3 0.7 2.2 -0.1 1.5 -0.5 -0.4
Other serious medical condition/disability diagnosed by doctor 0.8 1.1 2.1 0.4 -1.4 1.5 -0.3
Ever used hormone-replacement therapy (HRT) 0.4 0.5 1.4 -0.5 -1.2 -0.4 -0.2
Ever had hysterectomy (womb removed) 3.3 3.7 7.4 -0.8 -2.6 -0.4 -2.7
Systolic blood pressure, automated reading 4.0 11.7 19.7 3.3 -4.4 3.0 -2.6
Eye problems/disorders: Diabetes related eye disease 0.8 0.9 2.0 0.7 -1.4 1.0 -0.4
Angina 8.3 10.8 16.9 4.1 -4.1 -0.3 -3.1
Medication for hormone replacement therapy 0.9 1.0 3.4 -0.9 -0.2 -1.8 -0.2
Vitamin and mineral supplements 0.4 0.5 1.4 0.6 0.2 0.5 1.2
Supplements: Zinc 1.1 1.2 1.9 1.1 -1.3 -0.2 -1.4
Medication: Co-codamol 0.8 1.0 1.7 0.9 -0.6 1.3 -1.1
Medication: Metformin 3.8 5.4 9.3 2.8 -1.9 3.0 -0.8
Diabetes (father) 0.9 1.1 3.7 0.3 -0.7 1.9 -0.2
Diabetes (mother) 0.5 0.7 1.1 -0.9 1.1 0.8 -0.4
Severe depression (siblings) 1.5 1.7 4.4 -0.2 -1.1 2.1 1.0
Pack years adult smoking proportion 2.4 3.6 8.2 1.4 -2.0 2.9 0.7
Impedance of leg (right) 0.6 2.8 5.2 -0.9 2.3 2.3 -0.1
Leg fat-free mass (left) 0.6 3.2 4.9 1.3 -1.8 2.2 1.7
Trunk fat percentage 3.0 12.2 36.7 1.8 -0.6 6.1 2.9
Hand grip strength (right) 1.1 3.1 7.0 1.9 -2.6 -0.3 1.3
Townsend deprivation index at recruitment 0.8 1.2 2.7 0.5 -1.1 0.7 -1.6
Current tobacco smoking 4.3 7.0 18.5 -0.4 0.2 4.3 3.1
Average weekly fortified wine intake 1.3 1.5 2.2 0.7 -1.4 -1.1 -1.5
Maternal smoking around birth 1.6 2.3 5.3 0.2 -1.3 2.3 1.5
Fed-up feelings 0.4 0.7 1.3 -1.0 0.0 1.1 0.8
Frequency of unenthusiasm / disinterest in last 2 weeks 1.1 1.5 3.7 1.0 -1.1 1.9 0.3
Relative age voice broke 0.1 0.2 0.3 0.3 0.4 -0.6 -0.4
Taking other prescription medications 1.3 2.0 7.2 -0.2 -0.9 2.7 0.1
Age when periods started (menarche) 0.2 0.4 0.9 -0.6 0.9 -0.7 -0.2
Bilateral oophorectomy (both ovaries removed) 0.7 0.8 1.2 -1.0 -1.0 0.1 -1.1
Heel bone mineral density (BMD) T-score, automated (left) 0.7 1.7 4.3 1.2 -0.3 0.9 -2.1
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 0.8 0.3 0.6 -0.3 0.9
Qualifications: CSEs or equivalent 0.5 0.7 1.4 0.3 -0.9 1.2 -0.8
Serious illness, injury or assault to yourself 0.9 1.0 2.1 -0.0 0.4 1.5 -1.4
High blood pressure 6.1 17.0 33.4 5.8 -5.5 0.2 -1.9
Hayfever, allergic rhinitis or eczema 1.5 3.3 10.5 0.9 1.0 3.2 0.9
Multivitamins +/- minerals 0.6 0.7 2.1 -0.9 -0.2 -0.1 -1.4
Stomach or abdominal pain in last month 1.1 1.3 3.7 -1.0 0.0 0.8 1.9
Supplements: Glucosamine 0.9 1.2 2.7 -1.0 -0.6 0.8 1.6
Diverticular disease/diverticulitis (self-reported) 1.1 1.3 3.3 -1.4 -0.2 -1.8 0.0
Medication: Atenolol 3.9 4.9 9.7 3.0 -3.1 -0.6 -0.3
Medication: Levothyroxine sodium 0.3 0.5 1.7 0.5 -0.3 -0.1 -1.3
Sitting height 0.1 0.4 0.8 -0.3 0.2 -0.9 -0.8
Chronic bronchitis/emphysema (father) 1.6 1.9 3.5 1.2 -1.1 1.9 1.1
High blood pressure (mother) 1.6 2.3 4.1 1.6 -1.6 -0.2 -2.0
Body mass index (BMI) 1.7 7.1 12.0 1.9 -2.9 3.5 2.1
Impedance of leg (left) 0.7 3.6 8.1 -0.7 2.4 2.8 0.2
Leg predicted mass (left) 0.6 3.3 5.0 1.3 -1.8 2.2 1.7
Trunk fat mass 2.9 12.3 35.7 1.9 -1.1 6.0 2.9
Waist circumference 3.1 11.3 31.0 2.0 -2.9 5.6 1.3
Number of incorrect matches in round 0.6 1.0 1.8 -1.3 0.7 -1.4 -0.1
Past tobacco smoking 0.6 1.0 3.6 0.2 1.9 -0.0 -0.6
Alcohol usually taken with meals 0.7 1.1 2.7 0.1 1.1 -1.6 0.5
Nervous feelings 0.2 0.5 1.0 -0.5 0.5 -1.0 -0.6
Frequency of tenseness / restlessness in last 2 weeks 1.1 1.7 3.9 -1.3 1.0 2.0 0.1
Hearing difficulty/problems with background noise 0.2 0.3 0.7 -0.8 -0.2 0.4 0.4
Hair/balding pattern: Pattern 2 1.4 1.7 6.3 -0.1 -0.8 2.5 -0.1
Had menopause 0.3 0.4 1.3 -0.6 0.0 1.1 -0.3
Had other major operations 1.2 1.5 5.2 -2.3 0.8 -0.1 -0.3
Forced vital capacity (FVC) 4.0 15.3 55.3 -1.5 1.8 -7.4 -0.7
Heel bone mineral density (BMD) T-score, automated (right) 0.8 1.8 4.5 1.1 -0.6 1.0 -2.1
Ever unenthusiastic/disinterested for a whole week 0.7 0.9 2.0 0.5 -0.1 1.4 1.1
Qualifications: None of the above 0.3 0.7 2.7 -1.6 -0.1 -0.1 0.2
Financial difficulties in last 2 years 0.7 0.9 2.2 -1.0 -0.3 1.5 -0.6
Mouth/teeth dental problems 0.2 0.3 0.8 0.5 0.1 -0.9 0.3
Heart attack 3.3 4.2 6.8 2.4 -2.6 -2.0 -0.2
Allergy 2.8 6.4 23.8 0.1 -1.2 -4.9 -0.6
Pain all over the body in last month 1.6 1.7 3.6 0.5 -0.6 1.9 1.6
Diabetes (self-reported) 2.7 4.1 9.7 2.2 -1.2 3.1 -0.8
Hayfever/allergic rhinitis (self-reported) 1.3 1.7 4.4 1.0 -0.7 2.1 1.0
Medication: Ramipril 1.4 1.8 3.2 1.8 -0.9 1.2 1.3
Medication: Simvastatin 1.8 2.7 7.0 2.6 -0.8 1.7 -0.5
Fluid intelligence score 1.5 3.1 9.0 3.0 -1.2 0.5 -1.3
Illnesses of siblings 2.7 3.8 6.7 -2.6 2.1 0.1 2.0
Neuroticism score 0.1 0.3 1.1 -1.1 -0.1 0.1 0.3
Weight 1.7 8.2 19.1 1.8 -2.1 4.4 2.5
Impedance of arm (right) 0.7 3.3 10.4 -0.0 3.2 1.3 -1.2
Arm fat percentage (right) 2.2 8.5 24.0 1.9 -1.9 4.9 1.7
Trunk fat-free mass 0.4 2.2 6.2 0.9 -2.5 1.2 0.8
Hip circumference 2.1 9.3 20.2 1.5 -2.0 4.5 3.2
Time employed in main current job 2.5 2.9 6.9 -2.6 2.1 -0.2 -0.5
Alcohol intake versus 10 years previously 0.4 0.6 1.3 -1.0 0.1 -0.3 1.1
Father’s age at death 0.8 1.1 2.9 -1.7 1.1 -0.4 -0.1
Worrier / anxious feelings 0.4 0.8 2.4 -1.6 0.4 -0.5 -0.5
Frequency of tiredness / lethargy in last 2 weeks 2.1 3.3 4.8 1.9 -1.1 2.2 2.0
Falls in the last year 1.9 2.6 5.5 1.7 -1.2 2.3 -0.8
Hair/balding pattern: Pattern 3 0.4 0.5 0.9 -0.3 0.6 -1.0 0.9
Number of live births 1.4 2.0 4.8 2.2 -0.3 1.5 1.0
Forced expiratory volume in 1-second (FEV1) 3.4 11.4 43.1 -0.9 1.2 -6.6 0.3
Pulse rate 0.3 0.5 1.3 1.1 0.4 0.2 0.8
Happiness 0.9 1.1 4.0 -0.5 0.6 0.0 2.0
Noisy workplace 0.2 0.3 0.6 -0.6 -0.2 0.4 -0.8
Qualifications: A levels/AS levels or equivalent 1.1 2.4 6.3 1.7 -0.6 0.2 -2.5
Serious illness, injury or assault of a close relative in last 2 years 0.9 1.0 2.0 -0.8 0.5 1.0 -1.4
Mouth/teeth dental problems: Dentures 0.6 1.0 2.3 -0.2 -0.7 1.1 1.5
Asthma 2.5 4.9 18.9 0.0 0.2 4.3 -0.8
Medication: Ibuprofen (e.g. Nurofen) 1.4 1.8 5.2 -1.3 0.5 -0.3 2.3
Medication: Cholesterol lowering 4.3 6.7 16.8 4.1 -2.6 1.1 -1.4
Depression (self-reported) 0.2 0.3 0.5 0.5 -0.2 0.7 -0.6
Medication: Lansoprazole 0.8 0.9 1.5 0.5 -1.0 0.9 -1.2
Prospective memory result 2.7 3.4 6.5 -2.2 2.5 0.9 1.1
Lung cancer (father) 1.0 1.2 4.2 -2.0 -0.1 -0.1 -0.7
Illnesses of mother 0.8 1.0 2.3 -0.6 1.0 -0.6 1.5
Forced expiratory volume in 1-second (FEV1), Best measure 3.4 11.0 42.8 -0.8 0.7 -6.5 -0.0
Pulse wave Arterial Stiffness index 0.8 0.9 2.2 -0.0 0.4 -1.1 -1.5
Impedance of arm (left) 0.7 3.2 12.1 0.2 3.5 0.3 -0.8
Arm fat mass (right) 2.4 9.8 24.6 1.9 -2.2 5.0 2.5
Trunk predicted mass 0.4 2.3 6.0 0.9 -2.5 1.3 0.8
Standing height 0.2 2.3 6.7 0.2 1.1 2.6 1.1
Length of working week for main job 3.4 3.8 6.5 -2.0 2.6 0.8 2.0
Exposure to tobacco smoke at home 0.4 0.4 1.6 0.0 -1.3 0.2 -0.1
Breastfed as a baby 0.1 0.1 0.4 0.6 0.4 0.1 0.2
Tense / ‘highly strung’ 0.4 0.7 1.9 -1.4 0.0 -0.8 0.6
Seen doctor (GP) for nerves, anxiety, tension or depression 1.2 1.8 2.8 1.7 -1.4 1.3 0.9
Hair/balding pattern: Pattern 4 0.2 0.5 1.2 -0.9 0.1 -1.1 -0.3
Birth weight of first child 2.4 4.4 6.4 -2.5 2.3 1.0 2.3
Peak expiratory flow (PEF) 0.9 2.1 5.3 0.5 0.5 -2.3 1.6
Pulse wave reflection index 1.5 1.8 4.4 -0.9 0.2 -2.1 -1.4
Ever highly irritable/argumentative for 2 days 0.4 0.5 1.5 -0.2 -1.2 -0.4 0.6
Loud music exposure frequency 1.0 1.1 1.9 -1.0 -0.8 1.4 1.0
Qualifications: O levels/GCSEs or equivalent 2.0 3.2 7.5 2.7 -1.8 0.1 -1.5
Mouth/teeth dental problems: Bleeding gums 0.6 0.7 1.8 -0.9 -0.5 -1.3 -0.3
Blood clot in the leg (DVT) 1.6 2.1 6.6 -1.1 0.4 2.6 -0.7
Medication: Paracetamol 0.8 1.3 2.1 -0.4 -1.4 -1.3 -1.0
Headache pain in last month 0.6 1.0 2.1 0.9 -0.0 1.0 1.4
Medication for cholesterol, blood pressure or diabetes 3.6 5.9 12.0 -3.5 3.0 -1.0 1.4
Glaucoma (self-reported) 0.2 0.2 0.6 -0.1 -0.8 -0.3 0.2
Gout (self-reported) 0.2 0.3 0.6 0.8 -0.6 -0.4 0.1
Hypothyroidism/myxoedema (self-reported) 0.3 0.5 1.8 0.4 0.1 -0.3 -1.3
Medication: Amlodipine 2.2 3.0 5.5 1.6 -2.3 -1.8 -0.9
Medication: Ventolin 100micrograms inhaler 1.9 2.5 7.6 0.4 0.8 2.8 1.2
Birth weight 2.2 4.8 9.7 -3.1 2.3 -0.3 2.0
Chronic bronchitis/emphysema (mother) 3.5 4.0 14.1 1.1 -0.3 3.8 0.8
High blood pressure (siblings) 2.7 3.9 6.1 1.8 -2.5 -0.8 -2.3
Forced vital capacity (FVC), Best measure 3.3 12.0 41.6 -1.8 1.6 -6.5 -0.6
Body fat percentage 3.0 12.0 34.8 1.8 -1.2 5.9 2.9
Leg fat percentage (right) 2.7 9.7 28.1 1.4 -1.9 5.3 2.3
Arm fat-free mass (right) 0.7 3.4 5.2 0.9 -2.3 1.9 2.0
Exposure to tobacco smoke outside home 1.1 1.4 4.6 -1.0 -0.2 2.1 0.3
Comparative body size at age 10 0.2 0.5 1.2 -0.1 -0.6 -0.5 1.1
Number of full brothers 1.1 1.3 5.0 0.3 -0.3 2.2 0.4
Worry too long after embarrassment 0.7 1.2 3.4 0.7 -0.9 -1.9 -0.1
Seen a psychiatrist for nerves, anxiety, tension or depression 1.7 2.2 3.3 1.0 -1.0 1.8 1.8
Wheeze or whistling in the chest in last year 4.4 7.9 24.9 -1.3 0.1 5.0 2.3
Number of children fathered 0.1 0.1 0.2 0.3 -0.5 0.4 -0.3
Reason for reducing amount of alcohol drunk: Health precaution 0.6 0.7 1.7 -0.0 0.1 -1.3 1.0
Age at first live birth 1.8 3.2 5.2 -1.0 1.3 -2.2 -2.3
Pulse wave peak to peak time 0.8 0.9 2.0 0.1 -0.4 1.4 1.3
Health satisfaction 0.5 0.6 1.5 0.4 -1.2 0.7 0.4
Shortness of breath walking on level ground 1.8 2.1 4.3 1.3 -2.1 0.9 1.2
Qualifications: College or University degree 1.5 4.6 6.0 -1.7 2.4 -2.5 -1.9
Eye problems/disorders: None of the above 1.3 1.5 4.4 1.0 -0.3 -0.7 2.1
Mouth/teeth dental problems: Loose teeth 0.7 0.8 2.3 0.5 -0.6 1.5 -0.5
Emphysema/chronic bronchitis 1.8 2.0 6.7 -0.7 0.6 0.6 2.6
Medication for pain relief, constipation, heartburn 1.1 1.9 3.7 -0.4 1.8 -0.8 -1.9
Neck or shoulder pain in last month 0.4 0.5 0.9 -0.3 0.9 0.5 0.9
Medication: Blood pressure 2.5 4.4 10.4 2.5 -3.2 -0.3 -1.0
Angina (self-reported) 8.1 10.7 16.4 4.0 -4.0 -0.3 -3.1
Migraine (self-reported) 1.7 2.1 3.7 1.5 -1.6 -0.1 1.9
Medication: Ibuprofen 1.2 1.5 4.3 -1.2 0.4 -0.1 2.1
Medication: Allopurinol 0.5 0.7 1.4 0.7 -1.2 -0.9 -0.4
Medication: Omeprazole 1.0 1.2 2.3 -0.4 0.4 1.5 1.5
Medication: Seretide 50 evohaler 1.6 1.9 4.3 -1.0 1.3 -0.6 2.1
Mean time to correctly identify matches 1.0 1.8 5.9 1.1 -0.3 -0.2 2.4
Heart disease (mother) 0.3 0.4 1.1 0.2 -0.5 1.0 -0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.4 1.0 -0.6 -0.6 1.0 -0.1
Whole body fat mass 2.8 11.6 32.4 1.6 -1.6 5.7 3.0
Leg fat mass (right) 2.4 9.5 24.0 1.5 -2.1 4.9 2.8
Arm predicted mass (right) 0.7 3.8 5.7 0.9 -2.4 2.1 2.1
Pulse rate, automated reading 0.4 1.4 4.7 -0.7 0.2 2.2 0.7
Alcohol intake frequency. 0.0 0.1 0.3 0.0 0.4 0.2 0.5
Comparative height size at age 10 0.3 1.8 3.5 0.6 -0.2 1.9 1.8
Number of full sisters 5.8 7.1 14.4 2.6 -3.8 2.0 -1.8
Suffer from ‘nerves’ 0.5 0.8 2.2 -1.5 0.8 -0.6 0.3
Overall health rating 2.2 4.8 12.3 2.1 -1.2 3.5 0.9
Chest pain or discomfort 1.4 2.0 5.1 1.0 -1.2 2.3 -0.6
Had major operations 0.4 0.4 1.1 0.6 -1.0 -0.5 0.4
Age at last live birth 1.4 2.0 3.1 -0.5 1.8 -1.5 -1.5
Family relationship satisfaction 0.7 0.9 1.2 1.0 -1.1 0.6 1.0
Leg pain on walking 2.0 2.5 5.2 1.4 -2.3 1.6 0.6
Qualifications: NVQ or HND or HNC or equivalent 0.8 1.0 1.9 1.0 -0.9 1.4 -0.1
Commuting to job workplace: Car/motor vehicle 1.8 2.1 4.3 -2.1 0.9 1.4 1.0
Illness, injury, bereavement, stress in last 2 years 1.9 2.3 4.8 0.1 0.4 -2.1 2.2
Medication: Aspirin 4.7 6.2 12.7 3.6 -3.1 1.6 -0.1
Supplements: Vitamin C 1.1 1.3 3.9 -0.7 -0.7 -0.3 -2.0
Knee pain experienced in last month 2.4 3.7 6.7 0.8 -1.1 2.5 2.6
Hypertension (Self-reported) 5.6 15.5 30.3 5.5 -5.3 0.3 -1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.5 1.7 0.3 0.3 1.3 -0.2
Illnesses of father: Heart disease 1.3 1.7 5.2 1.1 -0.7 -0.3 -2.3
Illnesses of siblings: Diabetes 0.8 1.0 2.9 0.8 -0.1 1.7 -0.6
Smoking status: Previous 1.3 2.0 4.8 0.1 -2.2 -1.7 -0.4
Forced expiratory volume in 1-second (FEV1), predicted 1.4 2.9 7.2 1.1 1.5 1.1 2.7
Whole body fat-free mass 0.5 2.9 5.7 1.1 -2.4 1.8 1.3
Leg fat-free mass (right) 0.6 3.0 4.1 1.4 -1.8 2.0 1.7
Arm fat percentage (left) 2.0 7.9 19.9 2.2 -1.6 4.5 2.0
Average weekly red wine intake 0.7 1.0 2.1 1.3 -1.4 -0.6 -0.2
Handedness (chirality/laterality): Left-handed 0.8 1.0 3.8 -0.3 0.2 0.3 2.0
Mood swings 1.0 1.7 6.2 -0.7 -0.4 2.5 0.2
Loneliness, isolation 1.2 1.7 4.9 0.9 -0.7 2.2 0.7
Long-standing illness, disability or infirmity 2.6 4.0 13.5 1.5 -0.5 3.7 -0.0
Ever had bowel cancer screening 0.3 0.3 0.8 -0.5 0.4 -0.1 0.9
Diabetes diagnosed by doctor 4.4 7.3 16.4 2.7 -1.9 4.0 -1.4
Ever had stillbirth, spontaneous miscarriage or termination 1.0 1.1 2.5 1.3 0.1 1.6 -0.0
Friendships satisfaction 1.4 1.7 3.5 1.5 -1.9 0.5 1.0
Qualifications: nursing, teaching 0.2 0.3 0.4 -0.3 0.6 -0.6 -0.5
Commuting to job workplace: Walk 1.6 1.7 5.7 2.4 0.3 1.0 -0.3
Eye problems/disorders: Cataract 0.3 0.3 0.5 -0.7 0.5 -0.7 0.1
Mouth/teeth dental problems: Mouth ulcers 1.2 2.0 6.0 -1.0 0.7 -2.5 -0.5
Medication for cholesterol 2.5 3.8 8.4 -2.9 2.4 -0.8 0.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.6 1.8 -0.1 0.1 0.7 1.3
Back pain experienced in last month 0.6 0.9 2.1 -0.6 0.1 1.1 1.5
Mineral and other dietary supplements 0.2 0.2 0.7 0.1 -0.2 -0.8 -0.4
Breast cancer (self-reported) 1.2 1.4 2.8 -1.1 1.7 -1.3 0.5
Asthma (self-reported) 2.3 4.5 17.4 0.1 0.3 4.2 -0.7
Osteoporosis (self-reported) 0.2 0.2 0.4 -0.6 0.5 0.4 0.3
Osteoarthritis (self-reported) 1.5 2.0 4.1 0.2 -1.9 0.1 2.0
Medication: Aspirin 3.6 4.7 10.2 3.2 -2.7 1.1 -0.1
Medication: Gliclazide 4.3 4.8 9.5 2.5 -3.1 1.7 -0.7
Illnesses of father: None of the above (group 1) 1.1 1.3 3.0 -1.7 0.7 -1.1 0.9
Smoking status: Current 3.9 6.2 17.4 -1.1 0.3 4.2 2.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 6.4 13.6 44.5 -2.4 1.9 -6.7 0.3
Whole body water mass 0.5 2.8 5.5 1.0 -2.4 1.7 1.3
Leg predicted mass (right) 0.6 3.1 4.3 1.4 -1.8 2.1 1.7
Arm fat mass (left) 2.2 8.9 21.9 1.9 -2.2 4.7 2.3
Number of self-reported non-cancer illnesses 2.7 4.6 7.5 1.8 -2.7 2.7 -0.6
Average weekly champagne plus white wine intake 0.7 1.0 1.5 -1.0 1.2 -1.1 0.5
Miserableness 0.7 1.1 2.9 -0.7 -1.0 1.7 -0.4
Guilty feelings 0.6 0.9 1.9 -1.4 -0.0 -0.2 -1.3
Wears glasses or contact lenses 0.6 0.7 1.3 -0.9 -0.1 -0.7 -1.1
Ever taken oral contraceptive pill 1.4 1.5 3.6 1.5 -0.2 0.3 1.9
Hearing aid user 1.9 2.2 3.3 1.5 -1.2 1.4 1.8
Mother’s age at death 1.0 1.3 2.5 -1.3 1.6 0.6 0.7
Financial situation satisfaction 1.1 1.4 3.8 0.5 -1.1 0.7 1.9
Tinnitus: Yes, now most or all of the time 1.5 1.8 3.5 -0.1 -1.4 -1.3 -1.9
Commuting to job workplace: Public transport 0.9 1.1 2.2 1.5 -0.8 1.2 0.4
Eye problems/disorders: Glaucoma 0.2 0.2 0.5 0.3 -0.7 -0.2 -0.1
Medication: Blood pressure 5.5 10.5 20.2 4.5 -4.4 1.0 -1.1
Pain type(s) experienced in last month: Hip pain 2.9 3.6 9.7 -1.0 0.8 1.8 3.1
Supplements: Fish oil (including cod liver oil) 0.7 0.9 2.7 0.0 -0.6 1.6 -0.7
High cholesterol (Self-reported) 5.1 9.0 26.2 5.1 -2.5 1.6 -0.9
Medication: Bendroflumethiazide 4.5 6.8 13.9 3.2 -3.7 1.0 -1.6
Medication: Paracetamol 0.6 0.9 2.0 -0.5 -0.7 -1.4 -0.9
Medication: Lisinopril 3.4 4.4 8.7 3.0 -2.8 0.9 -0.6
Medication: Atorvastatin 5.3 6.6 15.0 3.9 -2.8 -0.2 -1.9
Illnesses of father: High blood pressure 1.0 1.2 2.1 1.2 -0.2 1.4 -1.1
Alcohol drinker status: Never 0.6 0.7 1.6 -0.5 0.8 -0.6 1.3
Ever smoked 0.4 0.8 2.1 -0.1 -1.4 0.0 1.0
Basal metabolic rate 0.8 4.4 7.6 1.4 -2.3 2.8 1.7
Leg fat percentage (left) 3.2 11.5 33.5 1.5 -2.0 5.8 2.5
Arm fat-free mass (left) 1.0 5.1 9.7 0.8 -2.8 3.1 1.7
Number of operations (self-reported) 0.7 1.0 2.0 0.4 -1.4 1.4 -0.3
Average weekly beer plus cider intake 1.1 1.5 3.4 -0.2 -1.1 1.3 1.8
Irritability 0.8 1.3 3.6 -1.9 0.4 1.0 -0.8
Risk taking 0.5 0.7 1.5 0.9 0.2 0.7 1.2
Ever had prostate specific antigen (PSA) test 0.7 0.8 2.2 -1.5 0.4 -1.0 -0.1
Fractured/broken bones in last 5 years 0.3 0.4 0.8 0.6 0.2 0.6 0.9
Age started oral contraceptive pill 1.0 1.2 2.3 -1.5 0.5 -0.2 -1.5
Diastolic blood pressure, automated reading 2.1 6.7 9.1 3.0 -3.0 3.0 0.1
Ever depressed for a whole week 0.2 0.2 0.4 0.5 -0.6 -0.4 0.1
Unable to work because of sickness or disability 1.4 1.8 6.6 0.8 -0.2 2.6 0.3
Commuting to job workplace: Cycle 3.2 3.9 10.0 1.3 -1.2 -3.2 -1.5
Myopia 0.7 1.1 1.8 0.8 1.3 -1.4 0.3
Vascular/heart problems diagnosed by doctor 5.6 15.2 31.7 -5.6 5.2 -0.2 1.6
Cholesterol lowering medication 3.5 5.1 13.3 3.6 -2.1 1.0 -1.3
Medication: Omeprazole (e.g. Zanprol) 1.6 1.9 4.9 -0.7 0.4 2.2 1.5
Pain experienced in last month 3.7 6.1 17.2 0.2 -0.1 -2.7 -4.1
Supplements: Calcium 0.8 0.8 2.1 -0.6 1.4 -0.0 -0.9
Basal cell carcinoma (self-reported) 0.4 0.5 1.1 0.1 1.0 0.9 -0.5
Heart attack/myocardial infarction (self-reported) 3.3 4.3 6.6 2.6 -2.4 -2.2 -0.1
Deep venous thrombosis (DVT) (self-reported) 1.8 2.3 6.6 -1.3 0.6 2.6 -0.8
Heart disease (siblings) 0.8 1.0 3.1 1.8 -0.6 0.2 0.6
Alcohol drinker status: Previous 1.1 1.3 4.4 -0.2 0.4 2.1 -0.7
Pack years of smoking 2.0 2.9 6.8 1.2 -1.7 2.6 0.5
Impedance of whole body 0.9 4.4 14.3 -0.6 3.8 1.7 -0.1
Leg fat mass (left) 2.8 10.9 27.6 1.7 -2.1 5.3 2.9
Arm predicted mass (left) 0.9 4.6 9.2 0.5 -2.4 3.0 1.7