Best TWAS P=1.08e-09 · Best GWAS P=1.45e-10 conditioned to 0.000165
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | DHX36 | 0.05 | 0.06 | blup | 357 | 0.05 | 1.3e-06 | -4.5 | -5.7 | 1.6e-08 | 0.58 | 0.94 | 0.06 | FALSE |
2 | GTEx | Ovary | ARHGEF26 | 0.14 | 0.03 | enet | 15 | 0.06 | 1.4e-02 | 5.3 | 6.1 | 1.1e-09 | -0.53 | 0.10 | 0.31 | TRUE |
3 | GTEx | Pancreas | ARHGEF26 | 0.26 | 0.26 | lasso | 5 | 0.28 | 3.2e-12 | -4.0 | 5.2 | 2.7e-07 | -0.62 | 0.98 | 0.02 | FALSE |
4 | GTEx | Spleen | DHX36 | 0.39 | 0.09 | enet | 21 | 0.34 | 2.1e-09 | -3.4 | -5.7 | 1.5e-08 | 0.58 | 0.61 | 0.32 | FALSE |
5 | GTEx | Thyroid | ARHGEF26 | 0.09 | 0.07 | enet | 17 | 0.08 | 1.9e-06 | -4.2 | 5.7 | 1.2e-08 | -0.62 | 0.20 | 0.79 | FALSE |
6 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SGEF | 0.04 | 0.04 | enet | 12 | 0.04 | 1.1e-05 | -4.4 | 5.5 | 3.8e-08 | -0.63 | 0.14 | 0.81 | FALSE |