Hub : Genes

FAM114A2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.2790 0.0420 0.0e+00 0.393 0.377 0.402 0.406 0.408 6.9e-51 2.1e-48 1.9e-52 5.4e-53 1.8e-53
2 GTEx Muscle Skeletal 0.0564 0.0220 1.6e-03 0.033 NA 0.034 NA 0.038 3.3e-04 NA 2.5e-04 NA 1.2e-04
3 METSIM Adipose 0.0389 0.0164 2.2e-03 0.012 0.019 0.021 0.017 0.016 5.0e-03 6.5e-04 3.3e-04 1.2e-03 1.3e-03
4 NTR Blood 0.0370 0.0114 2.5e-08 0.027 0.022 0.021 0.021 0.022 4.3e-09 1.1e-07 1.5e-07 1.8e-07 8.9e-08
5 ROSMAP Brain Pre-frontal Cortex 0.0523 0.0209 6.7e-04 0.057 0.023 0.038 0.026 0.049 7.2e-08 5.0e-04 1.1e-05 2.2e-04 6.3e-07
6 TCGA Glioblastoma Multiforme 0.0690 0.0500 7.4e-03 0.085 0.055 0.047 NA 0.035 1.4e-03 9.1e-03 1.5e-02 NA 3.1e-02
7 TCGA Brain Lower Grade Glioma 0.0297 0.0204 2.3e-03 0.017 0.021 -0.001 NA 0.009 4.4e-03 1.6e-03 5.4e-01 NA 3.1e-02
8 TCGA Pheochromocytoma and Paraganglioma 0.0720 0.0490 4.1e-03 0.058 0.064 0.006 NA 0.033 2.6e-03 1.5e-03 1.7e-01 NA 1.8e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bipolar Disorder (2018) 0.2 0.4 1.3 -0.4 -0.4 1.2 -0.5 -0.1 0.6 0.7 0.7
Bipolar Disorder or Schizophrenia 3.0 7.3 10.6 -2.9 -2.9 0.9 -2.9 -2.0 3.0 3.3 3.1
Depressed Affect (Nagel 2018) 1.5 3.1 6.6 -1.9 -1.6 1.7 -1.8 -2.6 1.6 1.1 1.6
Depression (Nagel 2018) 1.9 2.9 5.7 -1.8 -1.9 0.4 -1.8 -2.4 1.7 1.3 1.5
Intelligence (Savage-Jansen 2018) 0.1 0.2 0.7 -0.4 -0.6 0.8 -0.5 -0.0 0.5 -0.0 0.3
Neuroticism (Nagel 2018) 2.5 6.0 8.4 -2.6 -2.1 1.8 -2.6 -2.9 2.5 2.4 2.5
Schizophrenia (2018) 4.7 9.7 13.4 -3.4 -3.4 0.2 -3.3 -2.5 3.5 3.7 3.4
Schizophrenia vs Biploar Disorder 0.7 0.9 1.2 -1.1 -1.0 -0.9 -1.1 -0.9 1.0 1.0 0.8
Worry (Nagel 2018) 1.9 4.1 6.7 -2.1 -2.0 0.5 -2.2 -2.6 2.0 2.1 2.0
Alzheimer’s Disease (in mother) 0.4 0.5 1.0 -0.8 -1.0 0.5 -0.8 -0.9 0.7 0.5 0.4
Alzheimer’s Disease (in father) 0.4 0.4 1.1 0.5 0.5 -1.1 0.6 0.5 -0.6 -0.4 -0.6
Alzheimer’s Disease (including proxy) 0.2 0.2 0.4 -0.5 -0.6 -0.6 -0.5 -0.5 0.4 0.3 0.2
Crohns Disease (2017) 0.4 0.9 1.5 0.8 1.2 0.9 1.2 0.9 -0.9 -1.0 -0.6
Irritable Bowel Disease (IBD) 0.9 2.2 3.4 1.4 1.9 -0.4 1.7 1.1 -1.7 -1.7 -1.3
Ulcerative Colitis (UC) 1.4 2.6 3.6 1.4 1.8 -1.4 1.7 0.8 -1.9 -1.9 -1.7
Major Depression (MDD) 0.3 0.4 2.1 -0.0 0.2 1.5 0.2 -0.1 -0.2 -0.8 -0.4
Reaction Time 1.8 3.4 4.5 -2.0 -2.0 1.4 -2.0 -1.6 2.1 1.6 1.8
Verbal and Numeric Reasoning (VNR) 0.5 1.3 3.2 -1.0 -1.2 1.8 -1.2 -0.3 1.2 0.7 0.9
Breast Cancer 0.2 0.6 1.6 -0.8 -0.8 0.1 -0.6 -1.3 0.7 0.6 0.7
Ovarian Cancer 1.1 1.4 2.0 -1.3 -1.4 -0.6 -1.4 -0.9 1.3 1.2 1.0
Prostate Cancer 0.5 0.6 1.0 -0.9 -0.8 -0.6 -0.9 -0.8 0.8 1.0 0.5
Age at First Birth 4.4 6.5 8.8 3.0 2.8 -0.8 2.7 2.4 -2.9 -2.4 -2.7
Bipolar Disorder (2011) 1.8 1.7 3.6 -0.9 -1.1 1.9 -1.1 -0.1 1.4 1.6 1.5
Body Mass Index (BMI) (2010) 1.5 2.0 3.6 1.5 1.5 1.1 1.5 1.9 -1.4 -1.2 -1.1
Coronary Artery Disease (CAD) 0.1 0.2 0.8 0.5 0.1 -0.5 0.1 0.9 -0.1 0.1 -0.0
Crohns Disease (2012) 0.2 0.3 1.9 0.1 0.1 1.4 0.1 0.8 0.1 -0.1 0.3
Mean Putamen Volume 0.1 0.2 0.7 -0.3 -0.1 0.8 -0.2 -0.6 0.1 0.2 0.2
Fasting Glucose 1.1 1.4 5.3 -1.2 -0.7 0.6 -1.2 -2.3 0.9 0.4 0.7
HbA1C 2.2 2.4 3.4 1.6 1.1 -0.8 1.8 1.4 -1.8 -1.7 -1.8
HDL Cholesterol 4.9 8.2 11.6 -3.0 -3.0 0.3 -3.2 -2.4 3.1 3.4 3.1
LDL Cholesterol 2.8 4.5 6.1 2.2 2.5 1.0 2.3 1.8 -2.4 -2.2 -2.2
Lupus 1.9 2.9 4.3 -1.6 -1.6 2.0 -1.6 -1.1 1.7 1.7 2.1
Neuroticism (2016) 4.5 6.4 11.6 -2.9 -2.4 0.5 -2.5 -3.4 2.6 2.4 2.6
Primary Biliary Cirrhosis 0.6 0.9 1.3 1.1 1.1 -0.0 1.1 1.1 -1.0 -0.8 -0.9
Rheumatoid Arthritis 0.4 0.5 1.8 0.6 0.5 -1.4 0.6 0.7 -0.5 -0.7 -0.6
Schizophrenia (2014) 4.1 9.1 13.7 -3.2 -3.3 0.4 -3.3 -1.9 3.4 3.7 3.4
Triglycerides 0.3 0.5 0.8 0.6 0.9 -0.2 0.6 0.6 -0.8 -0.7 -0.9
Type 2 Diabetes (T2D) (2012) 2.1 2.4 3.1 1.8 1.8 -1.7 1.4 1.2 -1.6 -1.4 -1.6
Ulcerative Colitis 1.6 2.3 2.7 1.6 1.6 -1.2 1.6 1.6 -1.6 -1.5 -1.5
Blood Eosinophil Count 0.0 0.1 0.4 0.2 0.1 -0.3 0.2 0.6 -0.1 -0.1 -0.3
Blood Platelet Count 0.5 6.1 7.5 -2.7 -2.6 1.7 -2.7 -2.5 2.7 2.2 2.4
Blood Red Count 0.2 1.7 2.7 1.2 1.0 -1.6 1.2 1.3 -1.3 -1.3 -1.4
Blood White Count 0.2 1.4 2.0 1.2 1.1 -0.3 1.2 1.3 -1.1 -1.4 -1.3
Heel T-Score 1.6 12.8 17.5 4.2 3.8 -1.1 4.1 4.0 -3.9 -3.2 -3.5
BMI 7.0 40.7 47.6 6.8 6.4 -4.9 6.7 6.9 -6.5 -6.0 -6.6
Height 0.2 4.6 10.0 2.4 2.0 -0.2 2.2 3.2 -2.1 -2.1 -2.0
Waist Hip Ratio (WHR) 0.7 3.3 6.0 -2.2 -2.0 -1.8 -1.9 -2.5 1.6 0.8 1.2
Systolic Blood Pressure 0.5 2.3 4.5 -1.4 -1.0 0.3 -1.3 -1.7 1.5 2.1 2.0
Smoking Status 0.1 0.2 0.7 -0.6 -0.2 -0.4 -0.3 -0.9 0.2 0.1 0.2
Allergy or Eczema 0.2 0.4 2.5 -0.1 -0.2 -1.6 -0.1 -0.5 -0.2 -0.5 -0.5
Cardiovascular Disease 0.7 2.4 4.7 1.1 1.4 -2.2 1.4 0.4 -1.4 -1.9 -1.8
Hypothyroidism (self reported) 0.1 0.2 1.5 -0.0 0.1 -1.2 0.0 -0.4 -0.2 -0.4 -0.4
Respiratory disease 0.5 1.1 2.1 -1.2 -1.0 -0.5 -1.0 -1.5 1.1 1.2 0.9
Type 2 Diabetes (T2D) (2018) 2.8 5.3 6.6 2.4 2.6 -0.1 2.5 2.3 -2.4 -2.5 -2.6
Lung FEV1/FVC ratio 0.5 2.8 3.6 1.9 1.7 0.6 1.6 1.8 -1.7 -1.8 -1.8
Lung FVC 2.4 12.2 16.7 -3.4 -3.3 2.8 -3.6 -2.7 3.8 4.0 4.1
Neuroticism 4.9 11.8 13.6 -3.6 -3.3 2.5 -3.7 -3.5 3.7 3.5 3.6
Chronotype (morning person) 0.2 0.4 1.4 -0.4 -0.6 -1.2 -0.6 -0.3 0.5 0.6 0.5
Hair Pigment 0.1 3.3 4.4 2.1 1.8 -0.1 1.8 2.0 -2.1 -1.9 -1.9
Tanning 0.1 1.0 1.8 -1.1 -1.0 0.0 -1.0 -1.3 1.0 1.0 0.8
Hand grip strength (left) 0.5 1.4 5.3 1.5 1.2 -0.1 1.1 2.3 -0.8 0.3 -0.2
Number of treatments/medications taken 2.6 4.6 7.7 1.7 2.5 -1.9 2.1 0.3 -2.2 -2.8 -2.6
Average weekly spirits intake 3.1 3.8 6.0 1.8 2.1 -0.7 2.1 1.5 -2.2 -2.5 -2.2
Sensitivity / hurt feelings 1.1 2.0 3.6 -1.3 -1.5 -0.3 -1.6 -0.8 1.6 1.9 1.5
Frequency of depressed mood in last 2 weeks 1.7 2.4 5.7 -1.8 -1.6 -0.5 -1.5 -2.4 1.5 1.4 1.3
Hearing difficulty/problems: Yes 1.8 2.7 3.5 1.7 1.8 -0.4 1.7 1.7 -1.8 -1.8 -1.9
Relative age of first facial hair 2.4 5.0 6.4 -2.5 -2.4 0.6 -2.5 -2.2 2.5 2.1 2.4
Other serious medical condition/disability diagnosed by doctor 0.4 0.5 1.6 -0.8 -0.7 -0.7 -0.7 -1.2 0.7 0.5 0.4
Ever used hormone-replacement therapy (HRT) 0.4 0.5 1.8 0.9 0.6 0.9 0.5 1.3 -0.4 -0.2 -0.3
Ever had hysterectomy (womb removed) 4.6 5.2 8.3 2.6 2.1 -2.9 2.1 2.8 -2.1 -1.4 -1.9
Systolic blood pressure, automated reading 0.0 0.1 0.6 0.2 0.5 0.8 0.2 0.0 -0.2 -0.1 0.1
Eye problems/disorders: Diabetes related eye disease 0.1 0.1 0.2 -0.4 -0.3 0.3 -0.3 -0.4 0.4 -0.1 -0.1
Angina 0.4 0.6 1.0 0.8 0.4 -0.6 0.5 0.9 -0.7 -1.0 -0.9
Medication for hormone replacement therapy 0.4 0.5 2.2 -0.7 -0.6 -0.2 -0.6 -1.5 0.4 0.3 0.4
Vitamin and mineral supplements 0.9 1.2 5.5 0.9 0.8 -2.4 0.9 1.0 -0.6 0.1 -0.3
Supplements: Zinc 0.4 0.5 3.5 -0.0 -0.0 1.9 -0.1 0.1 0.1 0.3 0.3
Medication: Co-codamol 0.1 0.1 0.5 -0.3 -0.1 -0.7 -0.1 -0.3 0.1 0.1 -0.0
Medication: Metformin 0.2 0.3 0.8 0.6 0.5 0.6 0.4 0.9 -0.4 -0.5 -0.5
Diabetes (father) 0.4 0.5 1.2 0.7 0.7 -0.6 0.7 0.3 -0.7 -1.1 -0.8
Diabetes (mother) 1.4 1.8 3.9 1.4 1.3 0.1 1.1 2.0 -1.1 -1.5 -1.4
Severe depression (siblings) 2.0 2.2 3.4 -1.5 -1.3 0.3 -1.6 -1.4 1.7 1.9 1.8
Pack years adult smoking proportion 3.1 4.8 7.1 1.8 2.1 -2.3 2.1 1.1 -2.3 -2.6 -2.7
Impedance of leg (right) 1.9 9.2 22.8 -3.5 -2.9 1.8 -3.1 -4.8 2.6 1.9 2.5
Leg fat-free mass (left) 3.0 16.0 31.2 4.4 3.9 -2.8 4.1 5.6 -3.7 -3.2 -3.6
Trunk fat percentage 4.8 19.2 22.0 4.5 4.3 -3.7 4.4 4.4 -4.4 -4.5 -4.7
Hand grip strength (right) 0.7 1.9 5.3 1.8 1.7 -0.1 1.6 2.3 -1.1 -0.2 -0.4
Townsend deprivation index at recruitment 0.3 0.5 1.1 -1.0 -0.5 0.3 -0.7 -1.0 0.6 0.3 0.5
Current tobacco smoking 0.2 0.3 0.8 0.2 0.4 -0.9 0.4 -0.2 -0.6 -0.7 -0.7
Average weekly fortified wine intake 0.1 0.2 1.3 -0.0 -0.1 -1.1 -0.1 -0.1 0.1 0.1 0.0
Maternal smoking around birth 0.4 0.6 1.9 0.5 0.6 0.0 0.6 0.0 -0.9 -1.4 -1.1
Fed-up feelings 1.6 2.8 4.0 -1.7 -1.5 0.4 -1.8 -1.7 1.9 2.0 1.9
Frequency of unenthusiasm / disinterest in last 2 weeks 0.9 1.2 2.5 -1.3 -1.1 0.6 -1.1 -1.6 1.1 0.6 0.8
Relative age voice broke 0.2 0.3 2.0 0.0 0.1 -1.4 0.1 -0.2 -0.3 -0.6 -0.4
Taking other prescription medications 1.4 2.1 6.0 1.1 1.3 -2.5 1.3 0.3 -1.3 -1.4 -1.5
Age when periods started (menarche) 2.9 6.9 8.8 -2.9 -2.8 1.2 -3.0 -2.9 2.8 2.5 2.6
Bilateral oophorectomy (both ovaries removed) 2.1 2.4 3.6 1.6 1.7 -1.9 1.9 1.3 -1.6 -1.1 -1.2
Heel bone mineral density (BMD) T-score, automated (left) 1.1 2.5 3.6 1.6 1.9 -0.4 1.8 1.1 -1.8 -1.7 -1.7
Tinnitus: Yes, but not now, but have in the past 0.2 0.2 1.1 -0.4 -0.1 0.6 -0.2 -1.1 0.1 -0.3 0.1
Qualifications: CSEs or equivalent 0.8 1.1 2.0 -1.2 -0.9 0.1 -1.2 -1.4 1.0 0.9 1.0
Serious illness, injury or assault to yourself 0.1 0.2 0.9 -0.3 -0.3 -0.1 -0.3 -1.0 0.0 -0.1 -0.2
High blood pressure 1.6 4.5 7.8 1.9 2.3 -1.6 2.3 0.7 -2.3 -2.8 -2.5
Hayfever, allergic rhinitis or eczema 0.1 0.3 1.7 -0.2 -0.3 -1.3 -0.3 -0.6 -0.1 -0.3 -0.4
Multivitamins +/- minerals 0.1 0.1 1.1 -0.1 -0.0 1.0 -0.1 -0.1 0.1 -0.1 0.0
Stomach or abdominal pain in last month 1.8 2.3 3.1 1.8 1.5 -0.2 1.6 1.6 -1.6 -1.6 -1.6
Supplements: Glucosamine 1.0 1.3 3.7 -0.7 -1.1 1.9 -1.1 0.2 1.0 1.2 1.1
Diverticular disease/diverticulitis (self-reported) 0.8 0.9 1.3 1.1 1.1 -1.2 0.9 1.2 -0.9 -0.4 -0.9
Medication: Atenolol 2.5 3.2 5.1 1.5 1.8 -1.7 1.9 0.7 -1.9 -2.3 -2.1
Medication: Levothyroxine sodium 0.4 0.6 2.1 -0.7 -0.6 -1.2 -0.5 -1.5 0.4 0.2 0.2
Sitting height 0.2 1.4 4.2 1.2 1.0 -0.3 1.1 2.0 -1.0 -1.1 -0.9
Chronic bronchitis/emphysema (father) 0.2 0.3 0.5 -0.5 -0.4 0.7 -0.5 -0.1 0.6 0.7 0.5
High blood pressure (mother) 1.7 2.4 3.6 1.4 1.7 -1.3 1.7 0.5 -1.7 -1.9 -1.7
Body mass index (BMI) 5.1 21.8 29.4 5.0 4.6 -3.7 4.8 5.4 -4.6 -4.3 -4.7
Impedance of leg (left) 1.4 6.7 17.3 -3.0 -2.6 1.1 -2.8 -4.2 2.2 1.6 2.0
Leg predicted mass (left) 3.0 15.8 31.0 4.3 3.9 -2.8 4.1 5.6 -3.6 -3.2 -3.5
Trunk fat mass 5.8 24.8 29.8 5.2 4.9 -3.9 5.1 5.5 -5.0 -4.9 -5.2
Waist circumference 3.4 12.3 16.4 3.6 3.3 -3.5 3.5 4.0 -3.3 -3.3 -3.5
Number of incorrect matches in round 0.4 0.6 4.2 -0.2 0.1 -2.1 0.1 -0.9 -0.1 0.1 -0.3
Past tobacco smoking 0.0 0.0 0.1 0.2 0.1 -0.3 0.1 0.2 0.0 0.2 0.0
Alcohol usually taken with meals 0.9 1.5 3.4 -0.5 -0.8 1.7 -0.7 -0.2 1.1 1.8 1.7
Nervous feelings 1.6 2.9 7.1 -1.8 -1.4 1.4 -1.7 -2.7 1.5 1.3 1.5
Frequency of tenseness / restlessness in last 2 weeks 3.4 5.3 7.2 -2.7 -2.3 0.6 -2.5 -2.7 2.5 2.1 2.3
Hearing difficulty/problems with background noise 0.1 0.1 0.6 -0.2 -0.2 0.8 -0.2 0.1 0.1 -0.0 -0.1
Hair/balding pattern: Pattern 2 6.3 8.0 12.2 -2.7 -3.1 0.9 -3.1 -1.7 3.2 3.5 3.3
Had menopause 1.5 1.8 2.4 1.5 1.4 0.7 1.4 1.4 -1.4 -1.6 -1.3
Had other major operations 1.4 1.7 2.5 1.6 1.5 -0.1 1.5 1.6 -1.3 -0.8 -1.1
Forced vital capacity (FVC) 0.6 2.5 4.7 -1.2 -1.4 1.3 -1.5 -0.0 1.8 2.2 2.1
Heel bone mineral density (BMD) T-score, automated (right) 2.2 5.1 7.4 2.3 2.7 -0.0 2.6 1.5 -2.5 -2.5 -2.4
Ever unenthusiastic/disinterested for a whole week 5.7 7.0 10.7 2.5 2.8 -1.5 3.1 1.5 -2.9 -3.3 -2.9
Qualifications: None of the above 0.5 1.0 2.5 -1.3 -0.8 0.5 -1.0 -1.6 0.9 0.7 0.9
Financial difficulties in last 2 years 1.1 1.4 1.9 -1.2 -1.3 0.7 -1.4 -1.1 1.3 1.2 1.1
Mouth/teeth dental problems 3.7 5.6 7.1 2.5 2.6 -1.4 2.7 2.2 -2.6 -2.4 -2.3
Heart attack 0.3 0.4 1.7 0.6 0.4 0.9 0.4 1.3 -0.3 0.2 -0.2
Allergy 0.2 0.4 1.0 0.6 0.8 1.0 0.8 0.4 -0.7 -0.5 -0.3
Pain all over the body in last month 1.1 1.1 2.2 0.9 1.5 -1.2 1.1 0.4 -1.1 -0.8 -1.2
Diabetes (self-reported) 2.3 3.6 5.4 1.9 2.1 -0.1 1.9 1.7 -2.0 -2.3 -2.2
Hayfever/allergic rhinitis (self-reported) 0.8 1.0 4.0 -1.0 -0.8 -0.8 -0.7 -2.0 0.6 0.8 0.7
Medication: Ramipril 0.3 0.4 1.2 0.6 0.5 -1.1 0.5 0.8 -0.3 0.1 -0.3
Medication: Simvastatin 2.1 3.0 4.1 1.7 2.0 -1.6 1.8 1.4 -1.8 -1.8 -1.8
Fluid intelligence score 0.2 0.5 1.8 -0.4 -0.6 1.4 -0.6 0.4 0.7 0.4 0.6
Illnesses of siblings 0.5 0.7 1.6 -0.8 -0.7 0.3 -0.8 -1.3 0.7 0.8 0.8
Neuroticism score 3.7 7.6 10.4 -3.0 -2.7 1.3 -3.0 -3.2 2.9 2.7 2.8
Weight 4.8 23.8 36.8 5.2 4.8 -3.8 5.1 6.1 -4.7 -4.4 -4.7
Impedance of arm (right) 1.6 7.3 15.3 -3.1 -2.7 1.5 -2.8 -3.9 2.5 2.1 2.3
Arm fat percentage (right) 5.5 21.6 24.7 4.8 4.6 -3.7 4.8 4.8 -4.7 -4.6 -5.0
Trunk fat-free mass 2.0 11.6 25.0 3.8 3.3 -1.8 3.6 5.0 -3.2 -2.8 -3.0
Hip circumference 3.8 16.3 25.0 4.4 4.2 -2.8 4.2 5.0 -3.9 -3.5 -3.9
Time employed in main current job 0.2 0.2 0.4 0.5 0.6 -0.4 0.4 0.1 -0.5 -0.5 -0.6
Alcohol intake versus 10 years previously 0.7 1.1 2.3 -1.5 -1.2 0.0 -1.2 -1.5 1.0 0.4 0.6
Father’s age at death 0.2 0.3 1.4 0.4 0.1 -0.6 0.1 1.2 -0.0 0.3 0.2
Worrier / anxious feelings 2.2 4.2 8.3 -2.1 -1.6 -1.1 -2.0 -2.9 1.9 2.3 2.1
Frequency of tiredness / lethargy in last 2 weeks 3.0 4.9 6.7 -2.6 -2.4 1.0 -2.5 -2.6 2.4 1.9 1.8
Falls in the last year 0.8 1.1 2.2 0.8 1.0 -0.5 1.0 -0.5 -1.3 -1.5 -1.4
Hair/balding pattern: Pattern 3 3.7 5.5 7.5 2.4 2.7 -0.2 2.6 1.7 -2.7 -2.7 -2.5
Number of live births 0.8 1.1 7.5 -0.5 -0.3 2.7 -0.6 -0.2 0.5 0.1 0.4
Forced expiratory volume in 1-second (FEV1) 0.4 1.2 2.4 -0.6 -0.8 1.1 -0.9 0.6 1.2 1.5 1.5
Pulse rate 0.2 0.3 1.0 -0.2 -0.4 0.4 -0.3 0.6 0.6 1.0 0.7
Happiness 0.1 0.1 0.5 -0.0 0.0 0.3 0.1 -0.7 -0.2 -0.4 -0.2
Noisy workplace 0.2 0.3 0.8 -0.1 0.0 -0.9 0.0 -0.7 -0.3 -0.8 -0.6
Qualifications: A levels/AS levels or equivalent 0.4 0.8 2.2 -0.2 -1.0 1.5 -0.8 0.6 1.0 1.0 0.7
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.1 0.3 0.0 -0.2 0.6 -0.3 0.4 0.2 0.0 0.2
Mouth/teeth dental problems: Dentures 0.6 1.0 3.2 -1.3 -1.2 -0.1 -1.0 -1.8 0.7 0.3 0.4
Asthma 0.8 1.5 2.4 -1.2 -1.3 -0.3 -1.2 -1.1 1.4 1.5 1.2
Medication: Ibuprofen (e.g. Nurofen) 1.0 1.3 2.4 1.3 1.5 0.5 1.3 0.9 -1.2 -1.0 -1.1
Medication: Cholesterol lowering 0.7 1.1 1.8 1.1 1.0 -0.2 0.9 1.1 -1.1 -1.4 -1.3
Depression (self-reported) 0.8 0.9 1.6 -0.8 -0.9 -1.0 -0.9 -0.6 1.1 1.3 1.0
Medication: Lansoprazole 0.5 0.5 1.1 0.5 0.7 -0.9 0.5 -0.0 -0.8 -1.1 -0.9
Prospective memory result 0.1 0.2 0.9 0.0 0.2 -1.0 0.1 0.6 0.0 0.1 -0.1
Lung cancer (father) 2.0 2.3 3.8 1.5 1.6 0.1 1.5 1.0 -1.7 -1.9 -1.9
Illnesses of mother 0.2 0.2 0.4 -0.2 -0.5 -0.2 -0.4 0.4 0.4 0.7 0.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.6 1.1 -0.3 -0.4 1.0 -0.6 0.6 0.8 1.0 0.9
Pulse wave Arterial Stiffness index 0.3 0.3 0.8 0.5 0.6 0.9 0.5 0.4 -0.4 -0.5 -0.6
Impedance of arm (left) 0.9 4.1 10.6 -2.3 -1.9 1.2 -2.0 -3.3 1.8 1.4 1.6
Arm fat mass (right) 6.0 24.7 33.1 5.3 4.9 -3.9 5.1 5.8 -4.9 -4.7 -5.1
Trunk predicted mass 1.9 11.0 24.1 3.7 3.2 -1.7 3.5 4.9 -3.1 -2.7 -2.9
Standing height 0.1 1.0 4.1 1.1 0.8 -0.4 1.0 2.0 -0.7 -0.6 -0.5
Length of working week for main job 1.7 1.9 3.7 -1.7 -1.4 0.1 -1.4 -1.9 1.4 1.2 1.2
Exposure to tobacco smoke at home 1.5 1.6 4.2 -1.3 -1.2 -2.0 -1.0 -1.6 0.9 0.9 0.8
Breastfed as a baby 0.0 0.1 0.2 0.2 0.1 0.3 0.1 0.3 0.0 0.4 0.1
Tense / ‘highly strung’ 4.0 6.7 8.6 -2.8 -2.9 0.8 -2.9 -2.3 2.9 2.7 2.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.4 0.7 4.6 0.0 0.2 -2.2 0.2 -0.8 -0.2 0.2 -0.2
Hair/balding pattern: Pattern 4 2.0 5.0 6.7 2.3 2.4 -0.6 2.4 1.9 -2.5 -2.5 -2.6
Birth weight of first child 0.1 0.3 0.7 0.7 0.4 -0.2 0.4 0.8 -0.4 -0.4 -0.4
Peak expiratory flow (PEF) 0.2 0.4 2.0 0.7 0.4 -0.3 0.4 1.4 -0.3 0.3 0.0
Pulse wave reflection index 1.6 2.0 3.5 1.2 1.4 -1.0 1.4 0.2 -1.6 -1.8 -1.9
Ever highly irritable/argumentative for 2 days 3.3 3.9 4.8 2.1 2.0 -1.5 2.1 1.6 -2.1 -2.2 -2.2
Loud music exposure frequency 0.2 0.2 0.7 -0.6 -0.6 -0.3 -0.6 -0.8 0.4 -0.1 0.2
Qualifications: O levels/GCSEs or equivalent 0.7 1.1 1.7 1.3 0.7 -1.0 0.9 1.2 -0.9 -1.1 -1.3
Mouth/teeth dental problems: Bleeding gums 3.2 4.1 5.3 -2.1 -2.2 0.3 -2.2 -1.9 2.2 2.3 2.2
Blood clot in the leg (DVT) 0.7 0.9 1.6 -0.8 -0.8 1.2 -1.0 -0.3 1.1 0.7 1.1
Medication: Paracetamol 0.1 0.2 0.4 0.1 0.7 0.2 0.3 -0.6 -0.2 -0.4 -0.3
Headache pain in last month 0.5 0.8 1.5 0.8 1.2 -0.5 1.2 0.2 -1.0 -0.9 -1.0
Medication for cholesterol, blood pressure or diabetes 0.8 1.4 2.5 -1.2 -1.2 0.2 -1.1 -0.9 1.2 1.6 1.5
Glaucoma (self-reported) 0.4 0.5 1.1 0.6 0.6 -0.1 0.6 0.5 -0.8 -1.0 -1.1
Gout (self-reported) 2.8 3.8 9.2 2.3 2.0 -0.0 2.1 3.0 -1.9 -1.2 -1.7
Hypothyroidism/myxoedema (self-reported) 0.2 0.3 1.1 -0.4 -0.3 -1.0 -0.3 -1.1 0.3 0.1 0.1
Medication: Amlodipine 2.3 3.2 6.5 1.6 1.8 -2.5 1.8 0.8 -1.9 -1.6 -1.8
Medication: Ventolin 100micrograms inhaler 3.3 4.2 6.2 -2.3 -2.1 1.6 -2.1 -2.5 2.0 1.7 1.8
Birth weight 0.9 1.9 9.1 -0.7 -0.8 3.0 -0.9 0.3 1.1 1.0 1.4
Chronic bronchitis/emphysema (mother) 2.4 2.7 5.1 -2.0 -1.6 1.1 -1.8 -2.2 1.6 1.2 1.4
High blood pressure (siblings) 0.1 0.1 0.2 -0.1 -0.2 -0.3 -0.1 0.4 0.3 0.3 0.3
Forced vital capacity (FVC), Best measure 0.5 1.9 3.6 -1.1 -1.2 1.1 -1.4 0.1 1.6 1.9 1.8
Body fat percentage 5.6 22.2 25.7 4.9 4.7 -3.9 4.8 4.7 -4.8 -4.8 -5.1
Leg fat percentage (right) 4.3 15.6 19.3 4.0 3.9 -2.9 4.1 3.6 -4.1 -4.3 -4.4
Arm fat-free mass (right) 2.8 14.2 28.5 4.2 3.7 -2.7 3.9 5.3 -3.5 -3.0 -3.4
Exposure to tobacco smoke outside home 1.4 1.9 4.5 -1.6 -1.3 0.3 -1.4 -2.1 1.3 1.0 1.1
Comparative body size at age 10 5.9 16.3 21.9 4.6 4.2 -2.9 4.4 4.7 -4.1 -3.3 -3.9
Number of full brothers 1.2 1.5 2.8 -1.5 -1.1 1.5 -1.2 -1.7 1.1 0.4 0.7
Worry too long after embarrassment 0.1 0.1 0.4 -0.2 0.1 0.1 -0.1 -0.6 0.3 0.6 0.5
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.6 2.5 -0.6 -0.3 -1.6 -0.2 -1.4 0.1 -0.0 -0.1
Wheeze or whistling in the chest in last year 0.3 0.5 1.1 -0.8 -0.9 0.5 -0.8 -1.0 0.6 0.3 0.1
Number of children fathered 0.7 0.8 1.3 -0.8 -1.0 -0.6 -0.8 -0.3 1.0 1.1 1.1
Reason for reducing amount of alcohol drunk: Health precaution 1.6 1.8 2.7 -1.3 -1.5 0.4 -1.3 -1.5 1.3 1.6 1.4
Age at first live birth 1.8 3.2 3.8 1.9 1.8 -0.9 1.9 1.9 -1.9 -1.8 -1.9
Pulse wave peak to peak time 0.3 0.3 0.7 -0.5 -0.7 -0.9 -0.5 -0.3 0.5 0.5 0.6
Health satisfaction 0.2 0.3 1.8 0.4 0.4 -1.4 0.4 -0.0 -0.3 -0.1 -0.4
Shortness of breath walking on level ground 0.1 0.2 0.9 0.4 0.1 -0.1 0.2 0.9 -0.2 -0.0 -0.4
Qualifications: College or University degree 0.3 1.1 6.5 0.2 -0.2 2.5 0.1 1.1 0.3 0.4 0.7
Eye problems/disorders: None of the above 0.2 0.2 1.9 0.1 -0.0 -1.4 0.1 -0.1 -0.2 0.1 -0.0
Mouth/teeth dental problems: Loose teeth 2.0 2.4 9.4 -0.9 -1.3 3.1 -1.1 0.0 1.4 1.5 1.4
Emphysema/chronic bronchitis 0.4 0.5 0.8 -0.6 -0.5 0.8 -0.8 -0.1 0.8 0.9 0.7
Medication for pain relief, constipation, heartburn 2.0 3.4 6.2 -1.7 -2.0 1.0 -1.8 -0.6 2.0 2.5 2.3
Neck or shoulder pain in last month 0.1 0.1 0.5 -0.1 0.2 0.5 0.1 -0.7 -0.1 -0.4 -0.4
Medication: Blood pressure 1.2 2.1 3.0 1.5 1.7 0.1 1.6 1.1 -1.5 -1.7 -1.5
Angina (self-reported) 0.8 1.0 1.7 1.1 0.7 -0.6 0.8 1.1 -1.0 -1.3 -1.2
Migraine (self-reported) 0.1 0.1 0.4 -0.1 0.2 0.1 0.3 -0.6 -0.3 -0.4 -0.4
Medication: Ibuprofen 1.6 2.0 3.4 1.4 1.9 0.8 1.6 1.0 -1.4 -1.6 -1.3
Medication: Allopurinol 2.6 3.5 6.6 2.1 2.0 0.8 2.1 2.6 -1.9 -1.5 -1.6
Medication: Omeprazole 0.0 0.1 0.2 -0.0 -0.0 0.5 -0.0 -0.3 -0.0 -0.2 -0.2
Medication: Seretide 50 evohaler 0.3 0.4 0.9 0.6 0.3 -0.9 0.6 0.7 -0.5 -0.5 -0.6
Mean time to correctly identify matches 0.9 1.7 2.5 -1.4 -1.4 1.6 -1.4 -1.0 1.5 0.9 1.2
Heart disease (mother) 1.4 1.7 3.6 1.3 1.1 1.9 1.1 1.5 -1.0 -1.0 -1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.3 2.5 0.1 0.3 -1.6 0.1 -0.2 -0.2 0.1 -0.2
Whole body fat mass 6.2 25.8 31.7 5.3 5.0 -3.9 5.2 5.6 -5.1 -5.0 -5.3
Leg fat mass (right) 5.8 22.3 27.2 5.0 4.7 -3.6 4.9 5.2 -4.7 -4.6 -4.9
Arm predicted mass (right) 3.0 15.3 30.7 4.3 3.8 -2.7 4.0 5.5 -3.6 -3.2 -3.5
Pulse rate, automated reading 0.2 0.7 2.6 0.8 0.7 0.2 0.6 1.6 -0.6 -0.6 -0.7
Alcohol intake frequency. 0.2 0.4 1.2 -0.1 0.6 -0.4 0.4 -1.1 -0.3 -0.7 -0.5
Comparative height size at age 10 1.7 9.5 12.9 3.5 3.3 -0.6 3.5 3.6 -3.2 -2.9 -2.9
Number of full sisters 7.7 9.3 11.3 -3.4 -2.6 3.1 -3.1 -3.3 3.2 2.7 3.1
Suffer from ‘nerves’ 0.4 0.6 1.4 -0.9 -0.6 -0.2 -0.8 -1.2 0.7 0.5 0.6
Overall health rating 0.3 0.5 1.7 -0.7 -0.4 -1.3 -0.4 -1.3 0.4 0.2 0.1
Chest pain or discomfort 0.2 0.3 1.0 -0.5 -0.5 -1.0 -0.5 -0.4 0.5 0.4 0.2
Had major operations 0.2 0.2 0.6 -0.1 0.3 0.2 0.3 -0.7 -0.3 -0.7 -0.4
Age at last live birth 1.3 1.9 5.9 1.7 1.2 0.1 1.3 2.4 -1.2 -0.6 -1.2
Family relationship satisfaction 0.4 0.5 1.1 -0.8 -0.8 1.1 -0.7 -0.8 0.6 0.0 0.4
Leg pain on walking 0.0 0.0 0.1 -0.1 -0.2 -0.3 -0.0 -0.2 -0.1 -0.2 -0.3
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.4 1.2 0.7 0.4 -1.1 0.5 0.6 -0.5 -0.4 -0.8
Commuting to job workplace: Car/motor vehicle 0.7 0.8 2.3 1.1 0.8 -0.2 0.9 1.5 -0.7 -0.4 -0.7
Illness, injury, bereavement, stress in last 2 years 0.1 0.2 0.4 0.4 0.6 -0.4 0.6 0.2 -0.4 -0.2 -0.3
Medication: Aspirin 4.5 6.0 7.2 2.6 2.2 -1.8 2.4 2.7 -2.4 -2.6 -2.6
Supplements: Vitamin C 0.8 0.9 2.1 -1.1 -1.1 0.2 -1.1 -1.4 0.9 0.5 0.6
Knee pain experienced in last month 0.1 0.1 0.3 -0.3 -0.6 -0.1 -0.4 -0.1 0.3 0.2 0.0
Hypertension (Self-reported) 0.7 1.9 3.4 1.2 1.6 -1.0 1.5 0.3 -1.5 -1.8 -1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.9 1.0 3.4 -1.2 -0.9 -0.2 -1.0 -1.9 0.8 0.3 0.7
Illnesses of father: Heart disease 2.6 3.6 5.1 2.0 2.3 -0.5 2.2 1.8 -2.0 -2.0 -1.9
Illnesses of siblings: Diabetes 0.3 0.4 0.6 0.7 0.6 -0.7 0.8 0.4 -0.7 -0.6 -0.6
Smoking status: Previous 0.1 0.2 0.4 0.3 0.3 -0.4 0.4 0.5 -0.4 -0.6 -0.4
Forced expiratory volume in 1-second (FEV1), predicted 0.0 0.1 0.2 0.3 0.4 0.2 0.3 0.3 -0.3 -0.1 -0.2
Whole body fat-free mass 2.4 13.8 29.1 4.1 3.6 -2.3 3.9 5.4 -3.4 -3.0 -3.3
Leg fat-free mass (right) 2.8 15.0 31.1 4.2 3.7 -2.9 4.0 5.6 -3.5 -3.0 -3.4
Arm fat percentage (left) 6.2 24.9 28.3 5.2 5.0 -3.9 5.2 5.1 -5.1 -5.0 -5.3
Average weekly red wine intake 0.2 0.3 1.2 0.1 -0.4 -0.1 -0.3 0.6 0.5 1.1 0.8
Handedness (chirality/laterality): Left-handed 1.1 1.4 3.8 1.0 1.1 2.0 0.9 0.9 -1.0 -1.3 -0.9
Mood swings 0.5 0.9 3.8 -0.9 -0.3 2.0 -0.5 -1.3 0.5 0.2 0.7
Loneliness, isolation 2.2 3.1 3.9 -1.8 -1.8 1.2 -1.8 -2.0 1.9 1.5 1.9
Long-standing illness, disability or infirmity 0.9 1.4 2.7 0.6 1.1 -0.9 1.1 -0.8 -1.2 -1.6 -1.6
Ever had bowel cancer screening 0.7 0.8 1.1 1.1 0.9 0.8 0.9 1.0 -0.8 -0.7 -0.6
Diabetes diagnosed by doctor 2.7 4.4 5.8 2.1 2.3 -0.8 2.1 2.0 -2.2 -2.3 -2.4
Ever had stillbirth, spontaneous miscarriage or termination 1.7 1.9 2.9 1.2 1.6 0.7 1.4 0.5 -1.7 -1.7 -1.6
Friendships satisfaction 5.7 7.1 10.9 -2.8 -3.0 1.6 -2.8 -3.3 2.6 2.3 2.5
Qualifications: nursing, teaching 1.1 1.7 3.6 1.6 1.1 -0.2 1.2 1.9 -1.2 -1.3 -1.3
Commuting to job workplace: Walk 2.0 2.2 5.5 -1.6 -1.5 1.1 -1.4 -2.3 1.1 1.0 1.2
Eye problems/disorders: Cataract 0.1 0.2 0.2 0.4 0.4 -0.5 0.5 0.4 -0.3 -0.3 -0.3
Mouth/teeth dental problems: Mouth ulcers 0.3 0.5 0.6 -0.5 -0.6 0.7 -0.7 -0.5 0.8 0.7 0.7
Medication for cholesterol 0.9 1.4 8.9 0.1 -0.4 3.0 -0.4 0.7 0.5 0.9 0.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.0 1.1 2.2 -1.2 -1.1 0.4 -1.2 -1.5 1.1 0.7 0.9
Back pain experienced in last month 0.7 1.0 2.5 -1.1 -0.7 1.2 -0.9 -1.6 0.8 0.5 0.6
Mineral and other dietary supplements 0.6 0.8 6.2 0.1 0.2 -2.5 0.3 0.2 -0.0 0.1 -0.1
Breast cancer (self-reported) 0.1 0.1 0.4 -0.1 0.2 0.1 0.0 -0.6 0.1 0.5 0.2
Asthma (self-reported) 0.7 1.5 2.2 -1.2 -1.3 -0.4 -1.2 -1.2 1.4 1.5 1.2
Osteoporosis (self-reported) 0.5 0.6 1.2 -0.2 -0.7 0.9 -0.7 0.6 0.9 1.1 1.0
Osteoarthritis (self-reported) 0.1 0.1 0.5 -0.4 -0.2 -0.3 -0.3 -0.7 0.3 0.2 0.1
Medication: Aspirin 4.3 5.6 7.4 2.6 2.2 -2.0 2.3 2.7 -2.3 -2.3 -2.4
Medication: Gliclazide 0.4 0.5 0.7 0.7 0.8 -0.8 0.8 0.5 -0.6 -0.6 -0.5
Illnesses of father: None of the above (group 1) 0.9 1.1 1.4 -1.1 -1.2 0.9 -1.2 -0.8 1.1 1.1 1.1
Smoking status: Current 0.1 0.1 0.3 -0.0 0.2 -0.3 0.2 -0.5 -0.4 -0.6 -0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.3 0.9 0.1 -0.1 0.7 -0.4 0.9 0.5 0.9 0.5
Whole body water mass 2.4 13.7 29.4 4.1 3.6 -2.4 3.8 5.4 -3.4 -2.9 -3.3
Leg predicted mass (right) 2.8 15.1 31.5 4.2 3.7 -2.9 4.0 5.6 -3.5 -3.0 -3.4
Arm fat mass (left) 6.0 24.6 32.7 5.2 4.9 -3.8 5.1 5.7 -4.9 -4.7 -5.1
Number of self-reported non-cancer illnesses 3.2 5.5 10.5 1.8 2.2 -3.2 2.1 0.1 -2.3 -2.8 -2.8
Average weekly champagne plus white wine intake 0.8 1.1 2.4 -1.0 -0.9 0.5 -1.0 -0.7 1.2 1.5 1.4
Miserableness 0.6 1.1 3.4 -1.1 -0.8 -0.6 -1.0 -1.8 0.9 0.9 0.8
Guilty feelings 5.7 8.5 12.3 -2.9 -3.0 1.4 -3.0 -1.9 3.4 3.5 3.5
Wears glasses or contact lenses 0.0 0.0 0.1 0.1 0.3 0.2 0.2 -0.3 -0.1 -0.0 0.2
Ever taken oral contraceptive pill 0.3 0.4 0.7 0.6 0.8 0.6 0.7 0.0 -0.8 -0.5 -0.4
Hearing aid user 0.4 0.4 0.9 -0.8 -0.7 0.6 -0.6 -1.0 0.5 -0.1 0.3
Mother’s age at death 0.5 0.7 1.0 0.9 0.8 0.4 1.0 0.9 -0.8 -0.7 -0.7
Financial situation satisfaction 0.4 0.4 3.5 0.1 0.0 -1.9 0.2 -0.2 -0.1 -0.0 -0.1
Tinnitus: Yes, now most or all of the time 0.8 0.9 2.5 0.9 1.0 -1.6 0.9 0.6 -0.9 -0.7 -0.8
Commuting to job workplace: Public transport 0.3 0.4 0.9 -0.7 -0.4 -0.9 -0.5 -0.8 0.6 0.4 0.6
Eye problems/disorders: Glaucoma 0.4 0.5 1.7 -0.7 -0.7 1.3 -0.7 -0.3 0.7 0.4 0.4
Medication: Blood pressure 0.6 1.2 7.7 -0.1 0.3 -2.8 0.4 -0.9 -0.4 -0.6 -0.6
Pain type(s) experienced in last month: Hip pain 0.4 0.5 1.0 0.0 0.5 0.9 0.5 -1.0 -0.5 -0.9 -0.6
Supplements: Fish oil (including cod liver oil) 0.4 0.5 3.7 0.1 0.1 1.9 0.1 -0.2 -0.2 -0.3 -0.0
High cholesterol (Self-reported) 0.7 1.2 2.7 0.9 1.0 -1.6 0.9 0.7 -1.0 -1.2 -1.2
Medication: Bendroflumethiazide 0.2 0.3 1.8 0.1 0.4 -1.3 0.3 0.0 -0.3 -0.6 -0.5
Medication: Paracetamol 0.1 0.1 0.5 0.0 0.6 0.7 0.2 -0.5 0.0 -0.0 0.0
Medication: Lisinopril 0.6 0.7 2.2 0.4 0.8 -0.1 0.7 -0.6 -0.9 -1.5 -1.2
Medication: Atorvastatin 0.3 0.4 0.7 -0.5 -0.7 0.1 -0.6 0.2 0.8 0.8 0.7
Illnesses of father: High blood pressure 2.0 2.5 8.2 0.8 1.1 -2.9 1.2 -0.8 -1.5 -1.7 -1.6
Alcohol drinker status: Never 0.2 0.2 1.2 -0.3 -0.1 -1.1 -0.2 -0.3 0.3 0.5 0.1
Ever smoked 0.1 0.1 0.4 -0.3 -0.2 -0.6 -0.3 -0.4 0.2 0.3 0.2
Basal metabolic rate 3.1 17.4 33.6 4.6 4.0 -3.0 4.3 5.8 -3.9 -3.4 -3.8
Leg fat percentage (left) 5.1 18.4 22.3 4.4 4.2 -3.4 4.4 4.1 -4.4 -4.5 -4.7
Arm fat-free mass (left) 2.4 12.0 25.8 3.8 3.3 -2.4 3.5 5.1 -3.2 -2.7 -3.0
Number of operations (self-reported) 0.6 0.9 1.6 0.9 1.2 0.4 1.1 0.3 -1.1 -1.1 -1.1
Average weekly beer plus cider intake 0.9 1.3 2.0 -1.4 -1.3 0.1 -1.4 -1.0 1.3 0.9 1.2
Irritability 1.8 3.1 8.2 -1.5 -1.1 2.9 -1.3 -1.6 1.6 1.6 1.8
Risk taking 2.2 3.3 4.6 2.0 1.7 0.3 2.0 1.8 -2.0 -1.9 -2.1
Ever had prostate specific antigen (PSA) test 0.3 0.4 1.1 0.2 0.5 -0.2 0.4 -1.1 -0.5 -0.7 -0.7
Fractured/broken bones in last 5 years 0.3 0.3 0.8 0.4 0.2 -0.7 0.4 0.1 -0.6 -0.9 -0.8
Age started oral contraceptive pill 1.2 1.5 2.1 1.4 1.1 0.3 1.2 1.3 -1.2 -1.5 -1.2
Diastolic blood pressure, automated reading 0.8 2.4 3.8 1.6 2.0 -1.0 1.9 0.7 -1.9 -1.6 -1.5
Ever depressed for a whole week 7.1 8.8 11.6 3.1 3.4 -1.1 3.4 1.9 -3.4 -3.3 -3.3
Unable to work because of sickness or disability 0.1 0.1 0.6 -0.2 0.1 0.8 -0.1 -0.6 0.0 -0.3 -0.1
Commuting to job workplace: Cycle 1.3 1.5 4.2 -0.9 -1.1 -0.9 -1.0 -0.2 1.3 2.1 1.5
Myopia 0.1 0.1 0.6 -0.1 -0.1 0.2 -0.1 -0.0 0.3 0.8 0.5
Vascular/heart problems diagnosed by doctor 1.7 4.5 7.3 -1.9 -2.3 1.7 -2.2 -0.9 2.3 2.7 2.5
Cholesterol lowering medication 1.4 2.0 3.7 0.9 1.4 -1.9 1.3 0.4 -1.3 -1.8 -1.6
Medication: Omeprazole (e.g. Zanprol) 0.4 0.5 1.2 0.4 0.6 0.0 0.6 -0.3 -0.7 -1.1 -1.0
Pain experienced in last month 1.0 1.6 3.3 -0.9 -1.4 -1.0 -1.3 -0.0 1.3 1.8 1.6
Supplements: Calcium 0.2 0.2 0.5 -0.3 -0.5 -0.2 -0.4 -0.3 0.4 0.7 0.3
Basal cell carcinoma (self-reported) 0.1 0.1 0.5 -0.3 -0.6 0.7 -0.3 -0.3 0.2 -0.0 0.0
Heart attack/myocardial infarction (self-reported) 0.3 0.4 1.7 0.6 0.4 0.9 0.4 1.3 -0.3 0.1 -0.2
Deep venous thrombosis (DVT) (self-reported) 0.8 1.0 2.0 -0.9 -0.9 1.4 -1.1 -0.5 1.2 0.8 1.2
Heart disease (siblings) 0.5 0.6 1.1 0.8 0.8 0.5 0.8 1.1 -0.7 -0.8 -0.7
Alcohol drinker status: Previous 0.6 0.6 2.7 -1.0 -0.5 -0.2 -0.6 -1.6 0.7 0.4 0.4
Pack years of smoking 3.0 4.4 6.6 1.8 2.1 -2.2 2.0 1.0 -2.2 -2.5 -2.6
Impedance of whole body 1.4 7.0 17.5 -3.0 -2.6 1.2 -2.8 -4.2 2.4 1.8 2.2
Leg fat mass (left) 6.2 24.3 29.7 5.2 4.9 -3.9 5.1 5.5 -4.9 -4.8 -5.1
Arm predicted mass (left) 2.5 12.5 26.4 3.9 3.4 -2.5 3.6 5.1 -3.2 -2.8 -3.1