Best TWAS P=1.35e-09 · Best GWAS P=4.46e-09 conditioned to 0.317
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | ZDHHC4 | 0.29 | 0.09 | enet | 19 | 0.13 | 7.5e-08 | 4.2 | -6.1 | 1.4e-09 | -0.27 | 0.85 | 0.10 | TRUE |
| 2 | GTEx | Breast Mammary Tissue (Female) | PMS2CL | 0.20 | -0.01 | lasso | 4 | -0.01 | 6.7e-01 | 5.1 | -5.2 | 1.9e-07 | -0.09 | 0.03 | 0.15 | FALSE |
| 3 | GTEx | Nerve Tibial | ZNF12 | 0.16 | 0.10 | enet | 7 | 0.15 | 5.3e-11 | 4.8 | -5.3 | 1.2e-07 | 0.01 | 0.47 | 0.52 | FALSE |
| 4 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | PMS2CL | 0.14 | 0.10 | lasso | 2 | 0.07 | 1.5e-03 | 5.1 | -5.2 | 1.7e-07 | -0.06 | 0.00 | 0.87 | TRUE |
| 5 | The Cancer Genome Atlas | Thyroid Carcinoma | DAGLB | 0.06 | 0.02 | blup | 71 | 0.03 | 7.4e-04 | 4.0 | -5.2 | 2.1e-07 | -0.61 | 0.04 | 0.26 | TRUE |
| 6 | The Cancer Genome Atlas | Thyroid Carcinoma | PMS2CL | 0.08 | 0.12 | lasso | 5 | 0.11 | 1.0e-10 | 5.1 | -5.1 | 3.0e-07 | -0.05 | 0.00 | 1.00 | FALSE |