Best TWAS P=1.12e-20 · Best GWAS P=1.7e-22 conditioned to 0.0226
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 4 | GTEx | Skin Sun Exposed Lower leg | MLLT10 | 0.06 | 0.02 | lasso | 4 | 0.03 | 8.0e-04 | 9.09 | -9.3 | 1.1e-20 | -0.94 | 0.01 | 0.99 | TRUE |
| 2 | CommonMind | Brain Pre-frontal Cortex | NEBL | 0.07 | 0.01 | blup | 662 | 0.03 | 9.7e-05 | -5.07 | -6.4 | 1.7e-10 | -0.03 | 0.76 | 0.01 | TRUE |
| 6 | GTEx | Spleen | MLLT10 | 0.16 | 0.02 | lasso | 7 | 0.02 | 1.0e-01 | 7.52 | -8.6 | 9.3e-18 | -0.92 | 0.02 | 0.66 | FALSE |
| 5 | GTEx | Skin Sun Exposed Lower leg | CASC10 | 0.08 | 0.02 | lasso | 5 | 0.01 | 6.1e-02 | 7.52 | 8.5 | 2.0e-17 | 0.90 | 0.10 | 0.79 | FALSE |
| 3 | GTEx | Artery Tibial | CASC10 | 0.05 | 0.06 | lasso | 4 | 0.02 | 1.3e-02 | 3.90 | 6.1 | 1.1e-09 | 0.52 | 0.29 | 0.40 | FALSE |
| 1 | CommonMind | Brain Pre-frontal Cortex | LOC100499489 | 0.06 | 0.00 | bslmm | 297 | 0.02 | 1.2e-03 | 0.89 | -5.4 | 8.5e-08 | -0.49 | 0.02 | 0.75 | FALSE |