Hub : Genes

NEBL

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.072	0.0260	0.00061	0.009	0.031	0.012	0.030	0.014	2.5e-02	9.7e-05	1.2e-02	1.4e-04	7.6e-03
2	GTEx	Whole Blood	0.199	0.0700	0.00069	0.120	NA	0.141	NA	0.124	3.7e-11	NA	6.4e-13	NA	1.6e-11
3	METSIM	Adipose	0.114	0.0369	0.00023	0.087	0.036	0.068	0.078	0.073	5.3e-13	3.8e-06	1.8e-10	9.4e-12	5.2e-11
4	NTR	Blood	0.159	0.0254	0.00000	0.101	0.065	0.101	0.096	0.106	9.5e-31	3.0e-20	8.2e-31	3.0e-29	2.4e-32
5	YFS	Blood	0.525	0.0368	0.00000	0.231	0.321	0.350	0.381	0.334	3.3e-74	3.0e-108	2.6e-120	7.4e-134	1.6e-113
6	TCGA	Thyroid Carcinoma	0.093	0.0410	0.00630	0.012	0.005	0.000	NA	0.004	2.2e-02	9.5e-02	2.9e-01	NA	1.1e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.3	0.5	1.3	-0.2	-1.1	-0.9	-0.9	-0.4	0.2
Bipolar Disorder or Schizophrenia	1.0	2.4	5.0	1.2	-1.8	-1.7	-2.2	-1.1	-0.5
Depressed Affect (Nagel 2018)	0.4	0.9	3.4	-1.9	-0.8	-1.0	-0.7	0.1	0.2
Depression (Nagel 2018)	0.8	1.2	3.4	-1.5	0.4	0.7	0.4	1.9	-0.9
Intelligence (Savage-Jansen 2018)	0.6	1.8	9.0	3.0	1.1	0.5	0.1	0.4	0.1
Neuroticism (Nagel 2018)	0.1	0.3	1.5	-0.6	-0.0	-0.0	0.0	1.2	-0.4
Schizophrenia (2018)	1.1	2.4	4.7	1.7	-1.5	-1.5	-2.2	-1.1	-0.9
Schizophrenia vs Biploar Disorder	0.3	0.4	1.1	0.4	-0.6	-0.6	-1.0	-0.6	0.1
Worry (Nagel 2018)	0.4	0.8	2.1	0.3	0.7	1.2	0.7	1.5	-0.3
Alzheimer’s Disease (in mother)	1.1	1.2	3.2	1.4	1.8	0.7	1.1	0.6	-0.6
Alzheimer’s Disease (in father)	0.6	0.7	1.8	-1.2	-0.6	0.3	-0.5	-0.2	-1.3
Alzheimer’s Disease (including proxy)	0.4	0.6	2.0	0.3	1.1	0.6	0.5	0.2	-1.4
Crohns Disease (2017)	1.3	2.9	6.7	-0.5	-1.8	-2.1	-1.6	-2.6	-0.6
Irritable Bowel Disease (IBD)	2.1	5.1	8.7	-0.7	-2.8	-2.8	-2.3	-3.0	-0.3
Ulcerative Colitis (UC)	1.2	2.3	4.8	-1.3	-2.2	-1.6	-1.5	-1.6	0.5
Major Depression (MDD)	0.7	0.9	3.3	-1.8	0.2	0.2	0.4	-0.3	-1.3
Reaction Time	1.5	2.9	5.1	-1.9	1.7	1.4	1.8	2.3	-0.9
Verbal and Numeric Reasoning (VNR)	0.6	1.4	7.3	2.7	1.0	0.4	0.1	0.3	0.0
Breast Cancer	0.9	2.1	4.5	-0.9	1.5	1.7	2.1	1.1	-0.9
Ovarian Cancer	1.0	1.4	2.6	0.9	1.0	1.6	1.2	1.3	-0.7
Prostate Cancer	0.5	0.7	3.2	-1.8	-0.4	-0.2	-0.4	-0.1	0.8
Age at First Birth	1.1	1.7	5.9	2.4	1.1	1.3	1.1	0.2	0.1
Bipolar Disorder (2011)	2.2	2.1	3.8	-0.2	-2.0	-1.4	-1.6	-1.8	0.9
Body Mass Index (BMI) (2010)	0.8	1.1	4.9	-2.2	0.1	0.7	0.2	1.0	-0.3
Coronary Artery Disease (CAD)	0.7	0.8	2.2	-1.5	0.5	0.8	0.5	-0.1	-1.2
Crohns Disease (2012)	0.6	1.0	2.0	-0.4	-1.2	-1.3	-0.7	-1.4	-0.2
Mean Putamen Volume	0.6	0.6	1.8	-0.5	-0.8	-1.3	-0.8	-0.3	0.6
Fasting Glucose	2.5	2.9	4.8	-1.4	1.6	1.7	1.7	2.2	1.6
HbA1C	0.7	0.7	1.6	0.7	0.7	0.7	1.0	1.3	-0.6
HDL Cholesterol	0.4	0.7	3.3	1.8	-0.2	-0.2	-0.2	-0.6	-0.8
LDL Cholesterol	0.2	0.4	1.0	-1.0	0.5	0.3	0.6	0.3	-0.6
Lupus	0.1	0.1	0.5	0.2	0.4	-0.1	-0.0	0.3	-0.7
Neuroticism (2016)	0.5	0.7	1.1	-0.8	1.1	0.4	0.8	1.0	0.6
Primary Biliary Cirrhosis	1.1	1.5	2.6	0.9	-1.6	-1.4	-1.5	-1.1	0.7
Rheumatoid Arthritis	0.3	0.4	1.1	1.0	0.0	0.6	0.5	0.8	-0.4
Schizophrenia (2014)	0.6	1.2	2.3	1.4	-1.3	-1.1	-1.5	-0.3	0.3
Triglycerides	1.1	1.8	5.1	-2.3	1.4	0.9	1.3	1.0	-0.5
Type 2 Diabetes (T2D) (2012)	1.2	1.4	3.5	-1.9	0.7	1.1	1.0	1.5	0.5
Ulcerative Colitis	1.0	1.4	2.8	-1.6	-1.7	-1.0	-1.0	-1.1	0.3
Blood Eosinophil Count	0.1	0.7	2.2	-1.0	0.7	0.2	0.5	0.3	-1.5
Blood Platelet Count	0.1	1.2	1.8	0.4	-1.2	-1.3	-1.2	-1.3	-0.9
Blood Red Count	0.3	2.5	4.5	0.2	-2.1	-1.8	-2.0	-1.8	-0.5
Blood White Count	0.2	1.5	5.1	-2.2	0.4	0.6	0.3	1.9	-0.1
Heel T-Score	0.3	2.1	6.0	0.9	1.3	2.4	1.6	0.9	-0.9
BMI	1.7	10.1	40.1	-6.3	-2.5	-2.9	-1.5	-1.9	0.2
Height	0.0	0.4	1.4	-0.2	0.5	0.6	0.4	0.6	1.2
Waist Hip Ratio (WHR)	0.1	0.6	2.3	0.2	0.9	0.7	1.5	0.5	-0.1
Systolic Blood Pressure	0.6	2.8	11.2	3.3	0.6	-0.1	-0.3	-0.9	-2.0
Smoking Status	1.5	3.6	7.0	0.2	-2.4	-2.3	-2.6	-1.9	-0.1
Allergy or Eczema	0.2	0.6	2.6	1.6	0.1	0.1	0.0	0.1	0.9
Cardiovascular Disease	0.4	1.2	3.5	-1.9	-0.6	-0.9	-0.7	-0.8	-1.1
Hypothyroidism (self reported)	0.2	0.5	1.3	0.6	-0.2	0.9	0.6	1.1	0.5
Respiratory disease	0.3	0.8	1.5	-0.3	1.1	0.8	1.2	1.0	-0.4
Type 2 Diabetes (T2D) (2018)	1.6	2.9	4.0	-1.9	1.8	1.4	2.0	1.3	-1.8
Lung FEV1/FVC ratio	1.0	5.1	9.2	-1.7	-3.0	-2.2	-2.4	-2.8	-0.1
Lung FVC	0.5	2.7	15.0	3.9	-0.7	0.6	-0.5	-0.5	0.2
Neuroticism	0.1	0.3	0.8	-0.7	0.3	0.3	0.4	0.9	-0.1
Chronotype (morning person)	1.9	4.4	19.6	-4.4	0.7	1.0	0.8	1.2	1.8
Hair Pigment	0.1	2.0	8.2	-2.9	0.3	0.4	0.4	1.0	-1.6
Tanning	0.1	1.6	5.7	-2.4	1.0	0.5	1.1	0.3	-1.3
Hand grip strength (left)	0.3	0.7	2.0	1.4	0.3	0.9	0.4	0.7	0.8
Number of treatments/medications taken	1.2	2.1	12.2	-3.5	-0.5	-0.3	0.1	0.1	-0.3
Average weekly spirits intake	1.1	1.4	3.3	0.0	-0.6	-1.6	-1.4	-1.8	-0.2
Sensitivity / hurt feelings	1.2	2.0	3.2	-1.3	-1.7	-1.7	-1.8	-1.2	-0.4
Frequency of depressed mood in last 2 weeks	1.3	1.8	2.9	-1.7	1.1	1.1	0.9	1.4	-1.7
Hearing difficulty/problems: Yes	0.5	0.7	1.4	1.2	0.7	0.6	1.1	0.7	-0.6
Relative age of first facial hair	0.1	0.2	0.6	0.8	0.0	-0.7	-0.4	0.0	-0.1
Other serious medical condition/disability diagnosed by doctor	0.3	0.3	1.1	-1.0	-0.0	-0.4	-0.7	-0.2	-0.5
Ever used hormone-replacement therapy (HRT)	0.3	0.3	0.6	-0.3	0.7	0.4	0.3	0.7	-0.8
Ever had hysterectomy (womb removed)	2.2	2.5	4.1	-2.0	-1.8	-2.0	-1.4	-1.2	0.6
Systolic blood pressure, automated reading	0.3	0.9	4.2	0.7	0.6	-0.5	-0.1	-0.1	-2.0
Eye problems/disorders: Diabetes related eye disease	0.8	0.8	2.6	-1.5	-0.0	-0.3	-0.2	-0.3	-1.6
Angina	1.3	1.7	3.3	-0.9	1.8	1.5	1.4	1.3	0.5
Medication for hormone replacement therapy	0.1	0.1	0.3	-0.5	-0.1	-0.5	0.1	-0.1	-0.6
Vitamin and mineral supplements	0.6	0.8	3.1	0.9	0.5	0.5	0.4	0.4	-1.8
Supplements: Zinc	1.0	1.1	2.0	-0.7	1.4	1.1	1.4	1.0	0.2
Medication: Co-codamol	0.7	0.8	2.9	-1.7	0.9	0.0	0.6	0.3	-0.8
Medication: Metformin	1.2	1.7	3.3	-1.4	1.1	1.3	1.3	0.8	-1.8
Diabetes (father)	0.3	0.4	1.3	-1.1	0.3	0.4	-0.0	0.6	-0.5
Diabetes (mother)	0.4	0.5	1.9	0.8	-0.2	-0.1	-0.5	0.1	-1.4
Severe depression (siblings)	0.2	0.3	0.9	0.3	-0.2	-0.2	-0.3	-0.7	0.9
Pack years adult smoking proportion	0.7	1.1	3.2	-0.9	-0.7	-0.9	-0.6	-0.9	-1.8
Impedance of leg (right)	0.6	2.7	11.7	3.4	0.9	1.1	0.7	1.2	0.8
Leg fat-free mass (left)	0.6	3.3	16.4	-4.0	-0.6	-1.3	-0.4	-1.1	0.2
Trunk fat percentage	1.9	7.5	25.2	-5.0	-2.5	-2.8	-1.8	-1.4	-0.7
Hand grip strength (right)	0.2	0.6	3.3	1.8	-0.2	0.2	-0.1	0.0	-0.1
Townsend deprivation index at recruitment	1.1	1.6	5.4	-1.9	-0.2	-0.4	-0.1	-0.2	2.3
Current tobacco smoking	0.2	0.2	0.6	0.7	-0.2	0.2	-0.5	-0.1	-0.8
Average weekly fortified wine intake	1.0	1.2	2.7	-0.9	-0.8	-1.6	-1.1	-1.3	0.1
Maternal smoking around birth	1.1	1.6	6.0	-0.8	1.2	0.4	0.9	0.4	-2.5
Fed-up feelings	0.5	0.8	2.1	-0.5	-1.1	-1.5	-1.2	-0.3	0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.9	-0.7	-0.3	-1.0	-0.6	0.5	-0.4
Relative age voice broke	1.5	2.3	4.8	-0.4	2.2	1.7	1.6	1.7	0.4
Taking other prescription medications	1.6	2.4	11.0	-3.3	0.1	0.2	0.5	0.5	-1.7
Age when periods started (menarche)	0.6	1.4	5.0	2.2	0.7	0.4	0.0	0.0	1.7
Bilateral oophorectomy (both ovaries removed)	1.9	2.2	8.9	-3.0	-0.5	-0.8	-0.2	-0.8	-1.7
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.6	1.4	-0.2	-1.2	0.9	1.0	-0.2	0.1
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.5	0.2	0.0	0.6	0.7	0.5	-0.6
Qualifications: CSEs or equivalent	0.3	0.4	1.5	0.2	0.4	0.5	0.5	0.0	-1.2
Serious illness, injury or assault to yourself	1.2	1.5	2.7	0.1	-1.7	-1.3	-1.5	-1.5	-0.3
High blood pressure	1.0	2.9	5.2	-2.1	-1.2	-2.3	-1.7	-1.6	-0.6
Hayfever, allergic rhinitis or eczema	0.3	0.7	2.5	1.6	-0.5	-0.2	-0.4	-0.1	1.2
Multivitamins +/- minerals	0.8	1.0	4.8	-0.4	-0.5	-0.5	-0.6	-0.4	2.2
Stomach or abdominal pain in last month	0.4	0.5	1.5	-0.6	0.8	0.0	0.5	1.2	-0.5
Supplements: Glucosamine	0.3	0.5	2.4	-0.3	0.0	0.2	-0.0	-0.4	1.5
Diverticular disease/diverticulitis (self-reported)	2.5	2.9	7.1	0.6	0.9	2.7	1.9	2.0	-1.3
Medication: Atenolol	0.2	0.3	0.7	0.1	0.5	0.7	0.0	0.3	0.8
Medication: Levothyroxine sodium	0.2	0.3	1.0	0.3	-1.0	-0.3	-0.6	-0.6	-0.2
Sitting height	0.1	1.0	3.8	1.9	0.5	-0.0	0.3	-0.0	1.4
Chronic bronchitis/emphysema (father)	1.7	2.0	3.7	-0.1	-1.9	-1.4	-0.9	-1.5	-1.8
High blood pressure (mother)	0.2	0.3	0.6	0.7	0.8	-0.2	0.4	-0.1	-0.6
Body mass index (BMI)	2.3	9.8	40.8	-6.4	-2.3	-2.6	-1.6	-1.7	0.0
Impedance of leg (left)	0.4	2.0	10.5	3.2	0.2	0.6	0.2	1.0	0.1
Leg predicted mass (left)	0.6	3.3	15.8	-4.0	-0.6	-1.3	-0.4	-1.1	0.1
Trunk fat mass	1.9	8.1	30.6	-5.5	-2.3	-2.8	-1.6	-1.5	-0.4
Waist circumference	1.9	6.9	31.2	-5.6	-1.7	-2.2	-0.8	-1.5	-0.1
Number of incorrect matches in round	0.7	1.1	2.1	0.3	-0.9	-1.2	-1.0	-1.1	1.4
Past tobacco smoking	2.8	5.1	9.2	-0.7	2.5	3.0	3.0	2.3	0.7
Alcohol usually taken with meals	0.3	0.4	2.1	0.3	0.2	0.1	0.2	0.6	1.5
Nervous feelings	0.2	0.3	0.7	0.3	0.7	0.6	0.5	0.8	-0.1
Frequency of tenseness / restlessness in last 2 weeks	1.6	2.5	4.4	-1.8	1.4	1.5	1.4	2.1	-1.1
Hearing difficulty/problems with background noise	0.6	1.0	3.0	1.7	0.6	0.4	0.7	1.3	-0.2
Hair/balding pattern: Pattern 2	0.4	0.5	0.9	-0.8	-0.3	-0.9	-0.5	-0.8	-0.6
Had menopause	0.5	0.7	1.6	-1.1	0.7	0.6	0.6	1.3	-0.1
Had other major operations	2.3	2.8	4.8	-2.0	-1.7	-2.2	-1.3	-1.5	1.1
Forced vital capacity (FVC)	0.3	1.3	6.2	2.5	-0.2	0.6	-0.5	-0.4	0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	1.4	0.1	-1.2	0.6	0.5	-0.3	-0.2
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	4.2	-2.0	0.0	0.2	0.6	0.7	-0.2
Qualifications: None of the above	1.6	3.3	18.1	-4.3	-0.6	-0.4	0.4	0.4	0.9
Financial difficulties in last 2 years	0.8	1.1	2.3	-0.3	-1.5	-1.3	-1.2	-1.1	0.4
Mouth/teeth dental problems	1.0	1.6	5.1	-2.2	-1.1	-0.6	-1.0	-1.2	-0.8
Heart attack	0.8	1.0	1.6	-1.1	0.9	1.3	0.8	1.2	0.5
Allergy	0.1	0.3	0.7	-0.1	0.7	0.3	0.3	0.3	-0.9
Pain all over the body in last month	2.7	2.9	5.3	0.6	-2.3	-1.7	-1.8	-2.0	1.0
Diabetes (self-reported)	1.4	2.2	5.2	-2.3	1.1	0.9	1.6	0.8	-1.6
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	1.3	1.2	0.0	-0.1	0.2	-0.2	-0.1
Medication: Ramipril	0.2	0.3	0.9	-1.0	-0.1	0.3	0.1	0.4	-0.6
Medication: Simvastatin	1.4	2.1	3.7	-1.2	1.6	1.5	1.5	1.9	-0.8
Fluid intelligence score	0.8	1.6	6.5	2.6	1.6	0.5	0.4	0.6	0.3
Illnesses of siblings	0.0	0.1	0.2	0.4	-0.2	-0.1	-0.3	-0.2	0.1
Neuroticism score	0.1	0.3	0.8	-0.4	0.4	0.4	0.6	0.9	0.2
Weight	1.5	7.5	33.2	-5.8	-1.7	-2.3	-1.2	-1.4	0.3
Impedance of arm (right)	1.5	7.0	21.0	4.6	2.6	2.4	2.0	1.9	-0.9
Arm fat percentage (right)	1.6	6.4	26.7	-5.2	-1.8	-2.3	-1.1	-1.2	-0.9
Trunk fat-free mass	0.4	2.5	11.7	-3.4	-0.2	-0.9	-0.1	-0.8	1.3
Hip circumference	2.1	9.2	35.8	-6.0	-2.4	-2.7	-1.7	-1.8	0.6
Time employed in main current job	1.5	1.7	4.2	0.2	2.0	1.2	1.4	1.3	-1.0
Alcohol intake versus 10 years previously	1.4	2.1	3.2	-1.8	-1.7	-1.7	-0.8	-1.5	0.9
Father’s age at death	0.8	1.0	2.2	-0.3	1.5	1.2	0.9	1.3	0.2
Worrier / anxious feelings	1.1	2.2	3.8	-0.9	1.6	2.0	1.7	1.7	-0.3
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	3.7	-1.9	0.4	-0.3	0.1	0.6	-0.8
Falls in the last year	1.3	1.8	2.5	-0.3	1.3	1.6	1.6	1.5	-1.3
Hair/balding pattern: Pattern 3	1.0	1.5	8.7	3.0	0.0	0.2	-0.0	-0.1	-0.2
Number of live births	0.8	1.1	3.7	-1.9	1.0	0.3	0.7	0.3	-1.1
Forced expiratory volume in 1-second (FEV1)	0.4	1.4	6.0	2.4	-0.8	0.3	-0.9	-1.0	0.3
Pulse rate	0.4	0.6	3.4	-1.9	-0.2	0.5	-0.1	0.3	-0.0
Happiness	2.7	3.2	12.5	0.8	1.4	1.0	1.2	1.3	-3.5
Noisy workplace	0.5	0.6	1.4	-0.4	0.5	1.2	0.7	1.0	0.5
Qualifications: A levels/AS levels or equivalent	1.2	2.7	7.8	2.8	-1.0	-0.7	-1.2	-2.0	-1.4
Serious illness, injury or assault of a close relative in last 2 years	1.6	1.8	2.7	-0.2	-1.4	-1.6	-1.3	-1.6	1.4
Mouth/teeth dental problems: Dentures	0.3	0.4	0.7	-0.5	0.8	-0.1	0.8	0.6	0.9
Asthma	0.2	0.4	1.2	-1.1	-0.6	-0.3	-0.4	-0.2	-0.7
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	2.0	0.1	0.3	-0.1	-0.1	0.2	1.4
Medication: Cholesterol lowering	0.8	1.3	2.1	-1.4	0.9	1.1	1.2	1.1	-0.9
Depression (self-reported)	1.9	2.3	7.0	-2.7	1.1	0.8	1.3	1.0	-1.5
Medication: Lansoprazole	1.0	1.1	2.3	-1.1	-1.5	-1.0	-0.4	-1.1	-1.1
Prospective memory result	0.5	0.6	1.1	-0.8	0.4	0.8	0.7	0.9	-1.1
Lung cancer (father)	0.3	0.3	1.1	1.0	0.1	0.1	0.1	0.1	-0.8
Illnesses of mother	0.3	0.4	2.5	1.6	-0.1	0.2	0.0	0.1	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.6	2.5	0.9	-1.4	-0.5	-1.4	-1.6	1.4
Pulse wave Arterial Stiffness index	1.5	1.8	3.1	-0.5	1.6	1.2	1.2	1.3	-1.8
Impedance of arm (left)	1.0	4.9	16.0	4.0	1.9	1.8	1.4	1.6	-1.4
Arm fat mass (right)	1.9	7.9	32.4	-5.7	-2.0	-2.6	-1.4	-1.6	-0.1
Trunk predicted mass	0.4	2.4	11.4	-3.4	-0.3	-1.0	-0.2	-0.8	1.2
Standing height	0.0	0.3	0.8	0.5	0.8	0.2	0.5	0.1	0.9
Length of working week for main job	0.2	0.2	0.5	0.6	-0.0	0.3	0.2	0.7	0.4
Exposure to tobacco smoke at home	1.1	1.2	4.8	-1.3	-0.1	-0.4	-0.4	-0.5	2.2
Breastfed as a baby	1.9	2.4	3.4	-1.7	-1.7	-1.5	-1.3	-1.0	1.8
Tense / ‘highly strung’	1.1	1.8	3.2	0.4	1.4	1.8	1.6	1.7	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	3.8	-1.9	-0.3	-1.0	-0.3	-0.5	0.2
Hair/balding pattern: Pattern 4	1.1	2.7	11.1	-3.3	-1.4	-0.9	-1.1	-0.8	0.6
Birth weight of first child	0.2	0.3	0.8	0.1	-0.6	-0.5	-0.1	-0.9	-0.8
Peak expiratory flow (PEF)	0.2	0.4	0.8	0.9	-0.5	0.4	-0.3	-0.6	-0.8
Pulse wave reflection index	0.1	0.1	0.1	0.4	-0.0	-0.3	-0.2	-0.4	-0.2
Ever highly irritable/argumentative for 2 days	0.3	0.4	1.7	-0.5	0.0	0.1	0.1	0.5	-1.3
Loud music exposure frequency	2.3	2.5	3.4	-0.2	-1.8	-1.8	-1.7	-1.6	1.8
Qualifications: O levels/GCSEs or equivalent	0.7	1.2	3.2	1.8	-0.3	-0.7	-0.9	-1.3	-0.9
Mouth/teeth dental problems: Bleeding gums	1.9	2.4	7.7	2.8	1.4	1.1	0.9	1.2	-1.1
Blood clot in the leg (DVT)	0.3	0.3	1.0	-1.0	-0.9	-0.5	0.1	-0.1	-0.1
Medication: Paracetamol	0.8	1.3	2.6	-1.6	-1.0	-0.8	-0.7	-1.4	1.2
Headache pain in last month	0.3	0.5	1.4	-0.4	-1.2	-0.9	-0.6	-0.4	0.6
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	3.7	1.2	-0.5	-0.4	-0.5	-0.2	1.9
Glaucoma (self-reported)	0.7	0.8	1.6	0.2	-1.3	-0.5	-0.7	-1.1	-1.0
Gout (self-reported)	1.0	1.3	5.8	-1.1	0.2	0.4	0.7	0.6	-2.4
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.5	0.7	-0.4	0.4	0.1	0.7	0.3
Medication: Amlodipine	0.1	0.2	0.6	-0.4	0.5	0.1	0.0	-0.2	-0.8
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.7	-1.3	-0.5	-0.1	0.5	0.2	-0.7
Birth weight	0.8	1.7	3.1	1.8	1.4	1.4	1.5	1.0	0.4
Chronic bronchitis/emphysema (mother)	3.7	4.3	7.0	-2.2	-2.6	-1.7	-2.2	-1.7	1.7
High blood pressure (siblings)	0.1	0.2	0.3	-0.0	-0.2	-0.5	-0.4	-0.6	-0.4
Forced vital capacity (FVC), Best measure	0.3	1.0	2.9	1.3	-0.5	0.3	-0.7	-0.7	1.7
Body fat percentage	2.2	8.8	29.8	-5.5	-2.7	-3.1	-1.9	-1.6	-0.7
Leg fat percentage (right)	2.2	8.1	34.2	-5.8	-2.3	-2.6	-1.4	-1.1	0.1
Arm fat-free mass (right)	1.0	5.3	18.2	-4.3	-1.7	-2.2	-1.4	-1.6	1.2
Exposure to tobacco smoke outside home	1.1	1.4	2.4	-0.8	1.3	1.5	1.4	1.3	0.2
Comparative body size at age 10	0.5	1.3	6.1	-2.5	-0.4	-0.9	-0.4	-0.7	-0.6
Number of full brothers	0.8	1.1	2.3	0.2	1.0	1.5	1.4	1.0	-0.2
Worry too long after embarrassment	0.3	0.5	1.2	0.6	0.8	0.4	0.8	1.1	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.9	-1.4	0.2	0.5	0.3	0.4	-0.3
Wheeze or whistling in the chest in last year	0.7	1.2	4.2	-2.0	-0.1	0.5	0.7	0.7	-1.5
Number of children fathered	0.2	0.2	0.5	-0.6	-0.1	-0.1	-0.1	-0.4	0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.1	2.3	1.2	-0.4	-1.0	-1.1	-0.2	1.5
Age at first live birth	0.5	0.8	2.9	1.7	-0.4	-0.2	-0.3	-1.0	0.9
Pulse wave peak to peak time	1.4	1.6	2.9	0.7	-1.5	-1.1	-1.2	-1.2	1.7
Health satisfaction	0.8	1.1	3.8	-1.6	0.3	-0.2	0.0	0.2	-1.9
Shortness of breath walking on level ground	3.5	4.1	11.5	-0.7	-1.8	-2.1	-1.8	-1.4	-3.4
Qualifications: College or University degree	1.1	3.5	15.7	4.0	0.9	1.8	0.8	0.2	0.9
Eye problems/disorders: None of the above	0.5	0.6	2.3	0.9	0.5	0.1	0.2	0.2	1.5
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.5	0.1	-0.1	-0.7	-0.6	-0.1	0.4
Emphysema/chronic bronchitis	0.9	1.1	2.4	1.5	-1.1	-1.0	-0.6	-1.1	0.2
Medication for pain relief, constipation, heartburn	0.5	0.8	1.8	1.4	0.8	1.1	0.8	0.6	-0.4
Neck or shoulder pain in last month	0.8	1.2	2.6	-1.6	-0.7	0.5	-0.1	1.2	-1.6
Medication: Blood pressure	0.3	0.5	1.2	-0.7	0.5	0.8	0.7	0.2	-1.1
Angina (self-reported)	1.4	1.8	3.0	-0.8	1.7	1.6	1.5	1.3	0.6
Migraine (self-reported)	0.3	0.4	1.5	-0.6	-0.3	0.0	0.5	0.2	-1.2
Medication: Ibuprofen	0.6	0.8	4.4	0.2	-0.2	-0.4	-0.2	-0.1	2.1
Medication: Allopurinol	1.4	1.9	7.8	-1.6	-0.9	-0.4	-0.1	-0.1	-2.8
Medication: Omeprazole	0.8	0.9	3.4	-1.9	0.7	0.2	0.6	1.1	0.3
Medication: Seretide 50 evohaler	0.6	0.6	1.7	-0.3	0.6	1.0	0.3	0.7	-1.3
Mean time to correctly identify matches	1.0	1.9	4.2	-1.6	1.3	0.8	1.3	2.1	-0.9
Heart disease (mother)	2.9	3.6	5.8	-1.8	-1.8	-2.1	-2.4	-2.1	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.3	0.5	-0.2	-0.2	-0.4	-0.2	-0.0
Whole body fat mass	2.2	9.2	33.6	-5.8	-2.5	-3.1	-1.8	-1.7	-0.1
Leg fat mass (right)	2.3	9.0	36.6	-6.1	-2.2	-2.8	-1.5	-1.5	0.1
Arm predicted mass (right)	1.1	5.5	20.3	-4.5	-1.6	-2.1	-1.3	-1.6	1.1
Pulse rate, automated reading	0.4	1.3	6.4	-2.5	-0.5	0.2	0.3	0.3	0.9
Alcohol intake frequency.	0.6	1.3	5.7	-2.4	0.5	0.2	0.9	0.8	-0.8
Comparative height size at age 10	0.2	1.2	4.8	-2.2	0.3	0.4	0.9	0.5	0.9
Number of full sisters	0.4	0.5	1.2	-1.1	-0.6	-1.0	-0.4	-0.6	0.2
Suffer from ‘nerves’	0.7	1.1	1.8	0.3	1.4	1.2	1.4	1.1	0.3
Overall health rating	1.2	2.7	13.3	-3.7	-0.7	-0.3	-0.0	0.3	-1.4
Chest pain or discomfort	1.2	1.7	5.2	-1.8	0.4	0.7	0.9	0.6	-2.3
Had major operations	0.5	0.5	1.4	-0.6	-0.6	-0.8	-0.5	-0.5	-1.2
Age at last live birth	1.0	1.4	2.0	1.4	-1.0	-0.8	-1.4	-1.2	1.3
Family relationship satisfaction	2.5	3.1	10.3	0.1	1.3	1.5	1.1	1.7	-3.2
Leg pain on walking	0.8	1.0	2.0	-1.4	1.1	0.8	1.2	0.9	0.2
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.5	1.6	0.0	0.7	0.8	0.5	1.3	-0.4
Commuting to job workplace: Car/motor vehicle	1.6	1.8	3.5	-0.4	1.9	0.8	1.5	1.1	-1.8
Illness, injury, bereavement, stress in last 2 years	1.6	1.9	3.5	-0.2	1.4	1.8	1.4	1.9	-1.0
Medication: Aspirin	1.8	2.3	3.3	-1.7	-1.4	-1.8	-1.8	-1.0	-1.3
Supplements: Vitamin C	0.5	0.6	1.9	-1.0	-0.0	0.3	0.4	0.4	1.4
Knee pain experienced in last month	1.6	2.5	7.6	-2.8	0.8	0.9	1.2	1.2	-1.7
Hypertension (Self-reported)	0.8	2.2	4.4	-2.1	-1.0	-1.9	-1.4	-1.4	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	0.6	-0.2	0.4	0.6	0.7	0.8	0.6
Illnesses of father: Heart disease	0.7	1.0	1.6	-0.6	0.4	1.3	0.9	1.2	-1.3
Illnesses of siblings: Diabetes	1.0	1.2	6.2	-2.5	0.2	0.4	0.3	0.9	-0.2
Smoking status: Previous	2.5	3.8	6.9	0.3	-2.2	-2.6	-2.6	-2.0	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.3	0.9	-0.9	0.2	-0.2	0.2	0.3	0.9
Whole body fat-free mass	0.6	3.3	15.2	-3.9	-0.7	-1.4	-0.5	-1.1	0.9
Leg fat-free mass (right)	0.7	3.6	15.4	-3.9	-1.0	-1.6	-0.8	-1.4	-0.1
Arm fat percentage (left)	1.8	7.2	29.7	-5.4	-1.9	-2.4	-1.2	-1.3	-1.1
Average weekly red wine intake	0.7	1.0	3.0	-0.5	0.9	1.2	0.6	1.7	-0.7
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.6	0.4	0.2	-0.4	-0.4	-0.8	-0.5
Mood swings	0.1	0.2	0.5	0.2	0.3	0.3	0.3	0.7	0.7
Loneliness, isolation	2.3	3.1	8.2	-2.9	1.4	1.1	1.8	2.0	-0.5
Long-standing illness, disability or infirmity	1.6	2.5	6.4	-2.5	0.6	0.6	0.8	1.1	-2.5
Ever had bowel cancer screening	0.4	0.5	1.9	0.8	-0.0	-0.5	-0.0	0.2	-1.4
Diabetes diagnosed by doctor	1.5	2.5	4.9	-2.2	1.2	0.9	1.4	1.1	-2.2
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.6	1.4	-0.7	0.8	0.8	1.2	0.1	-0.4
Friendships satisfaction	0.7	0.9	2.8	1.6	-0.2	0.3	-0.4	0.1	-1.7
Qualifications: nursing, teaching	1.0	1.5	5.3	2.3	-0.6	-0.9	-0.9	-1.1	0.5
Commuting to job workplace: Walk	0.8	0.9	4.8	-0.3	-0.5	-0.0	0.4	0.1	2.2
Eye problems/disorders: Cataract	1.0	1.1	1.6	-1.0	-1.2	-1.2	-1.1	-1.2	-0.0
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	1.3	0.5	-0.3	0.7	0.6	1.1	0.2
Medication for cholesterol	1.8	2.7	5.5	2.2	1.5	2.3	1.3	1.5	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.0	-1.0	0.8	0.7	0.8	0.6	0.1
Back pain experienced in last month	2.5	3.7	5.2	-2.3	1.3	1.9	1.8	2.1	-2.0
Mineral and other dietary supplements	0.0	0.1	0.2	0.0	0.2	0.1	0.1	0.2	-0.5
Breast cancer (self-reported)	0.5	0.6	1.8	1.2	0.3	-0.1	-0.1	0.3	1.3
Asthma (self-reported)	0.1	0.3	0.7	-0.8	-0.6	-0.0	-0.2	-0.0	-0.8
Osteoporosis (self-reported)	0.5	0.6	1.6	-0.1	0.1	1.3	1.1	0.7	0.0
Osteoarthritis (self-reported)	1.0	1.3	5.3	-2.3	-0.4	-0.9	-0.5	-1.1	-0.6
Medication: Aspirin	1.1	1.5	3.3	-1.8	-1.1	-1.1	-1.3	-0.5	-1.1
Medication: Gliclazide	2.3	2.6	4.9	0.6	1.7	1.6	2.0	0.8	-2.2
Illnesses of father: None of the above (group 1)	0.3	0.4	1.4	0.6	0.8	0.1	0.4	0.0	1.2
Smoking status: Current	0.3	0.5	1.1	0.5	-0.7	-0.5	-1.0	-0.6	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.1	4.5	13.1	0.9	-1.9	-1.7	-1.9	-1.7	3.6
Whole body water mass	0.6	3.3	15.5	-3.9	-0.7	-1.3	-0.4	-1.1	0.9
Leg predicted mass (right)	0.7	3.8	15.8	-4.0	-1.1	-1.6	-0.9	-1.5	-0.1
Arm fat mass (left)	2.0	8.1	34.5	-5.9	-1.9	-2.5	-1.3	-1.5	-0.5
Number of self-reported non-cancer illnesses	1.0	1.7	4.4	-2.1	-1.0	-1.0	-0.6	-0.8	-1.7
Average weekly champagne plus white wine intake	0.9	1.2	3.4	1.8	-1.0	-1.0	-0.8	-0.5	1.0
Miserableness	0.4	0.7	1.4	-0.8	-0.9	-1.2	-0.9	-0.6	-0.0
Guilty feelings	0.1	0.2	0.7	-0.5	0.8	-0.0	0.4	0.4	-0.0
Wears glasses or contact lenses	1.6	1.8	3.0	-1.7	-1.6	-1.6	-1.3	-1.0	-0.3
Ever taken oral contraceptive pill	0.6	0.6	2.0	0.6	-0.7	-0.5	-1.4	-0.7	0.2
Hearing aid user	0.6	0.7	1.4	0.6	1.1	0.5	0.9	0.5	1.2
Mother’s age at death	0.4	0.5	1.0	-0.7	-0.9	-0.5	-1.0	-0.5	0.7
Financial situation satisfaction	0.5	0.6	1.7	-1.3	-0.4	-0.4	-0.6	-0.8	-0.6
Tinnitus: Yes, now most or all of the time	0.8	0.9	4.6	2.1	0.6	0.4	0.2	0.5	0.1
Commuting to job workplace: Public transport	1.3	1.6	1.9	1.4	-1.2	-1.2	-1.2	-1.3	1.4
Eye problems/disorders: Glaucoma	0.5	0.5	2.0	-1.4	-0.6	0.3	0.3	-0.5	-0.7
Medication: Blood pressure	1.7	3.3	7.1	-2.7	-1.6	-2.0	-1.6	-1.8	0.7
Pain type(s) experienced in last month: Hip pain	0.6	0.8	3.2	-1.8	-0.8	-0.2	-0.4	-0.4	-0.8
Supplements: Fish oil (including cod liver oil)	0.1	0.2	0.4	-0.1	-0.6	-0.0	-0.4	0.4	0.6
High cholesterol (Self-reported)	1.4	2.5	5.7	-2.4	0.9	1.0	0.9	1.2	-2.3
Medication: Bendroflumethiazide	0.4	0.6	3.1	-1.8	-0.1	-0.1	0.0	-0.2	0.4
Medication: Paracetamol	1.4	2.1	2.9	-1.6	-1.5	-1.1	-1.1	-1.6	1.7
Medication: Lisinopril	0.4	0.5	1.0	-0.4	-0.5	-0.7	-0.6	-0.8	1.0
Medication: Atorvastatin	1.5	1.9	4.9	-2.2	1.0	1.3	1.4	1.2	-0.0
Illnesses of father: High blood pressure	0.4	0.5	1.0	0.9	-0.3	-0.1	-0.8	-0.7	1.0
Alcohol drinker status: Never	2.2	2.6	5.5	-0.1	2.3	1.8	2.0	1.6	-0.6
Ever smoked	2.5	4.4	7.0	1.7	-2.0	-2.5	-2.6	-2.2	-1.0
Basal metabolic rate	0.8	4.3	20.4	-4.5	-0.9	-1.6	-0.6	-1.2	0.7
Leg fat percentage (left)	2.7	9.9	39.2	-6.3	-2.7	-2.8	-1.8	-1.3	-0.3
Arm fat-free mass (left)	1.2	5.9	21.8	-4.7	-1.7	-2.2	-1.4	-1.5	1.4
Number of operations (self-reported)	1.1	1.7	3.8	-1.4	-1.0	-1.4	-0.8	-0.8	-2.0
Average weekly beer plus cider intake	1.5	2.2	8.0	2.8	0.1	0.4	0.4	0.0	-2.3
Irritability	0.5	0.9	4.0	2.0	-0.1	-0.0	-0.2	0.2	-1.0
Risk taking	0.4	0.6	3.4	1.9	0.3	0.4	0.2	0.2	-0.1
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.7	-0.8	-0.3	0.2	-0.2	0.7	0.7
Fractured/broken bones in last 5 years	0.5	0.6	2.5	-0.6	-0.8	0.5	0.1	0.1	1.6
Age started oral contraceptive pill	0.8	1.0	4.1	-0.6	0.8	-0.6	-0.5	0.4	2.0
Diastolic blood pressure, automated reading	0.7	2.2	4.8	-2.2	-1.0	-2.0	-1.1	-1.3	-0.4
Ever depressed for a whole week	0.9	1.1	5.7	-2.4	-0.6	-0.4	-0.2	-0.2	-0.6
Unable to work because of sickness or disability	0.4	0.6	1.4	-0.1	-0.5	1.2	0.6	1.0	0.6
Commuting to job workplace: Cycle	2.3	2.8	5.1	1.5	-2.2	-1.7	-1.9	-1.6	-0.2
Myopia	1.3	1.9	9.5	3.1	0.5	0.5	0.1	0.0	-1.2
Vascular/heart problems diagnosed by doctor	1.3	3.6	6.6	2.6	1.6	2.4	1.9	1.7	0.7
Cholesterol lowering medication	1.1	1.6	7.4	-2.7	0.6	0.4	0.4	0.8	-0.8
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	2.9	-1.7	0.3	0.1	0.1	0.7	0.1
Pain experienced in last month	0.7	1.1	4.8	2.2	0.0	-0.6	-0.5	-0.9	0.7
Supplements: Calcium	0.8	0.9	2.0	-0.6	-1.0	-1.4	-1.1	-1.0	0.3
Basal cell carcinoma (self-reported)	2.3	2.7	4.3	-2.1	-1.3	-2.0	-2.0	-1.4	-0.4
Heart attack/myocardial infarction (self-reported)	1.0	1.2	1.9	-1.2	0.9	1.4	0.9	1.4	0.8
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.6	-1.3	-0.7	-0.4	0.2	0.0	0.4
Heart disease (siblings)	0.2	0.3	0.7	-0.9	0.0	0.0	0.0	0.8	-0.4
Alcohol drinker status: Previous	0.7	0.8	2.1	-1.0	-0.8	-0.5	-0.8	-0.2	-1.4
Pack years of smoking	0.6	0.9	3.9	-0.9	-0.3	-0.7	-0.2	-0.6	-2.0
Impedance of whole body	0.7	3.3	16.4	4.0	0.8	1.0	0.6	1.1	-0.6
Leg fat mass (left)	2.6	10.0	40.7	-6.4	-2.4	-2.9	-1.6	-1.5	-0.1
Arm predicted mass (left)	1.1	5.7	19.6	-4.4	-1.7	-2.2	-1.4	-1.6	1.5