Hub : Genes

NEBL

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.072 0.0260 0.00061 0.009 0.031 0.012 0.030 0.014 2.5e-02 9.7e-05 1.2e-02 1.4e-04 7.6e-03
2 GTEx Whole Blood 0.199 0.0700 0.00069 0.120 NA 0.141 NA 0.124 3.7e-11 NA 6.4e-13 NA 1.6e-11
3 METSIM Adipose 0.114 0.0369 0.00023 0.087 0.036 0.068 0.078 0.073 5.3e-13 3.8e-06 1.8e-10 9.4e-12 5.2e-11
4 NTR Blood 0.159 0.0254 0.00000 0.101 0.065 0.101 0.096 0.106 9.5e-31 3.0e-20 8.2e-31 3.0e-29 2.4e-32
5 YFS Blood 0.525 0.0368 0.00000 0.231 0.321 0.350 0.381 0.334 3.3e-74 3.0e-108 2.6e-120 7.4e-134 1.6e-113
6 TCGA Thyroid Carcinoma 0.093 0.0410 0.00630 0.012 0.005 0.000 NA 0.004 2.2e-02 9.5e-02 2.9e-01 NA 1.1e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 0.3 0.5 1.3 -0.2 -1.1 -0.9 -0.9 -0.4 0.2
Bipolar Disorder or Schizophrenia 1.0 2.4 5.0 1.2 -1.8 -1.7 -2.2 -1.1 -0.5
Depressed Affect (Nagel 2018) 0.4 0.9 3.4 -1.9 -0.8 -1.0 -0.7 0.1 0.2
Depression (Nagel 2018) 0.8 1.2 3.4 -1.5 0.4 0.7 0.4 1.9 -0.9
Intelligence (Savage-Jansen 2018) 0.6 1.8 9.0 3.0 1.1 0.5 0.1 0.4 0.1
Neuroticism (Nagel 2018) 0.1 0.3 1.5 -0.6 -0.0 -0.0 0.0 1.2 -0.4
Schizophrenia (2018) 1.1 2.4 4.7 1.7 -1.5 -1.5 -2.2 -1.1 -0.9
Schizophrenia vs Biploar Disorder 0.3 0.4 1.1 0.4 -0.6 -0.6 -1.0 -0.6 0.1
Worry (Nagel 2018) 0.4 0.8 2.1 0.3 0.7 1.2 0.7 1.5 -0.3
Alzheimer’s Disease (in mother) 1.1 1.2 3.2 1.4 1.8 0.7 1.1 0.6 -0.6
Alzheimer’s Disease (in father) 0.6 0.7 1.8 -1.2 -0.6 0.3 -0.5 -0.2 -1.3
Alzheimer’s Disease (including proxy) 0.4 0.6 2.0 0.3 1.1 0.6 0.5 0.2 -1.4
Crohns Disease (2017) 1.3 2.9 6.7 -0.5 -1.8 -2.1 -1.6 -2.6 -0.6
Irritable Bowel Disease (IBD) 2.1 5.1 8.7 -0.7 -2.8 -2.8 -2.3 -3.0 -0.3
Ulcerative Colitis (UC) 1.2 2.3 4.8 -1.3 -2.2 -1.6 -1.5 -1.6 0.5
Major Depression (MDD) 0.7 0.9 3.3 -1.8 0.2 0.2 0.4 -0.3 -1.3
Reaction Time 1.5 2.9 5.1 -1.9 1.7 1.4 1.8 2.3 -0.9
Verbal and Numeric Reasoning (VNR) 0.6 1.4 7.3 2.7 1.0 0.4 0.1 0.3 0.0
Breast Cancer 0.9 2.1 4.5 -0.9 1.5 1.7 2.1 1.1 -0.9
Ovarian Cancer 1.0 1.4 2.6 0.9 1.0 1.6 1.2 1.3 -0.7
Prostate Cancer 0.5 0.7 3.2 -1.8 -0.4 -0.2 -0.4 -0.1 0.8
Age at First Birth 1.1 1.7 5.9 2.4 1.1 1.3 1.1 0.2 0.1
Bipolar Disorder (2011) 2.2 2.1 3.8 -0.2 -2.0 -1.4 -1.6 -1.8 0.9
Body Mass Index (BMI) (2010) 0.8 1.1 4.9 -2.2 0.1 0.7 0.2 1.0 -0.3
Coronary Artery Disease (CAD) 0.7 0.8 2.2 -1.5 0.5 0.8 0.5 -0.1 -1.2
Crohns Disease (2012) 0.6 1.0 2.0 -0.4 -1.2 -1.3 -0.7 -1.4 -0.2
Mean Putamen Volume 0.6 0.6 1.8 -0.5 -0.8 -1.3 -0.8 -0.3 0.6
Fasting Glucose 2.5 2.9 4.8 -1.4 1.6 1.7 1.7 2.2 1.6
HbA1C 0.7 0.7 1.6 0.7 0.7 0.7 1.0 1.3 -0.6
HDL Cholesterol 0.4 0.7 3.3 1.8 -0.2 -0.2 -0.2 -0.6 -0.8
LDL Cholesterol 0.2 0.4 1.0 -1.0 0.5 0.3 0.6 0.3 -0.6
Lupus 0.1 0.1 0.5 0.2 0.4 -0.1 -0.0 0.3 -0.7
Neuroticism (2016) 0.5 0.7 1.1 -0.8 1.1 0.4 0.8 1.0 0.6
Primary Biliary Cirrhosis 1.1 1.5 2.6 0.9 -1.6 -1.4 -1.5 -1.1 0.7
Rheumatoid Arthritis 0.3 0.4 1.1 1.0 0.0 0.6 0.5 0.8 -0.4
Schizophrenia (2014) 0.6 1.2 2.3 1.4 -1.3 -1.1 -1.5 -0.3 0.3
Triglycerides 1.1 1.8 5.1 -2.3 1.4 0.9 1.3 1.0 -0.5
Type 2 Diabetes (T2D) (2012) 1.2 1.4 3.5 -1.9 0.7 1.1 1.0 1.5 0.5
Ulcerative Colitis 1.0 1.4 2.8 -1.6 -1.7 -1.0 -1.0 -1.1 0.3
Blood Eosinophil Count 0.1 0.7 2.2 -1.0 0.7 0.2 0.5 0.3 -1.5
Blood Platelet Count 0.1 1.2 1.8 0.4 -1.2 -1.3 -1.2 -1.3 -0.9
Blood Red Count 0.3 2.5 4.5 0.2 -2.1 -1.8 -2.0 -1.8 -0.5
Blood White Count 0.2 1.5 5.1 -2.2 0.4 0.6 0.3 1.9 -0.1
Heel T-Score 0.3 2.1 6.0 0.9 1.3 2.4 1.6 0.9 -0.9
BMI 1.7 10.1 40.1 -6.3 -2.5 -2.9 -1.5 -1.9 0.2
Height 0.0 0.4 1.4 -0.2 0.5 0.6 0.4 0.6 1.2
Waist Hip Ratio (WHR) 0.1 0.6 2.3 0.2 0.9 0.7 1.5 0.5 -0.1
Systolic Blood Pressure 0.6 2.8 11.2 3.3 0.6 -0.1 -0.3 -0.9 -2.0
Smoking Status 1.5 3.6 7.0 0.2 -2.4 -2.3 -2.6 -1.9 -0.1
Allergy or Eczema 0.2 0.6 2.6 1.6 0.1 0.1 0.0 0.1 0.9
Cardiovascular Disease 0.4 1.2 3.5 -1.9 -0.6 -0.9 -0.7 -0.8 -1.1
Hypothyroidism (self reported) 0.2 0.5 1.3 0.6 -0.2 0.9 0.6 1.1 0.5
Respiratory disease 0.3 0.8 1.5 -0.3 1.1 0.8 1.2 1.0 -0.4
Type 2 Diabetes (T2D) (2018) 1.6 2.9 4.0 -1.9 1.8 1.4 2.0 1.3 -1.8
Lung FEV1/FVC ratio 1.0 5.1 9.2 -1.7 -3.0 -2.2 -2.4 -2.8 -0.1
Lung FVC 0.5 2.7 15.0 3.9 -0.7 0.6 -0.5 -0.5 0.2
Neuroticism 0.1 0.3 0.8 -0.7 0.3 0.3 0.4 0.9 -0.1
Chronotype (morning person) 1.9 4.4 19.6 -4.4 0.7 1.0 0.8 1.2 1.8
Hair Pigment 0.1 2.0 8.2 -2.9 0.3 0.4 0.4 1.0 -1.6
Tanning 0.1 1.6 5.7 -2.4 1.0 0.5 1.1 0.3 -1.3
Hand grip strength (left) 0.3 0.7 2.0 1.4 0.3 0.9 0.4 0.7 0.8
Number of treatments/medications taken 1.2 2.1 12.2 -3.5 -0.5 -0.3 0.1 0.1 -0.3
Average weekly spirits intake 1.1 1.4 3.3 0.0 -0.6 -1.6 -1.4 -1.8 -0.2
Sensitivity / hurt feelings 1.2 2.0 3.2 -1.3 -1.7 -1.7 -1.8 -1.2 -0.4
Frequency of depressed mood in last 2 weeks 1.3 1.8 2.9 -1.7 1.1 1.1 0.9 1.4 -1.7
Hearing difficulty/problems: Yes 0.5 0.7 1.4 1.2 0.7 0.6 1.1 0.7 -0.6
Relative age of first facial hair 0.1 0.2 0.6 0.8 0.0 -0.7 -0.4 0.0 -0.1
Other serious medical condition/disability diagnosed by doctor 0.3 0.3 1.1 -1.0 -0.0 -0.4 -0.7 -0.2 -0.5
Ever used hormone-replacement therapy (HRT) 0.3 0.3 0.6 -0.3 0.7 0.4 0.3 0.7 -0.8
Ever had hysterectomy (womb removed) 2.2 2.5 4.1 -2.0 -1.8 -2.0 -1.4 -1.2 0.6
Systolic blood pressure, automated reading 0.3 0.9 4.2 0.7 0.6 -0.5 -0.1 -0.1 -2.0
Eye problems/disorders: Diabetes related eye disease 0.8 0.8 2.6 -1.5 -0.0 -0.3 -0.2 -0.3 -1.6
Angina 1.3 1.7 3.3 -0.9 1.8 1.5 1.4 1.3 0.5
Medication for hormone replacement therapy 0.1 0.1 0.3 -0.5 -0.1 -0.5 0.1 -0.1 -0.6
Vitamin and mineral supplements 0.6 0.8 3.1 0.9 0.5 0.5 0.4 0.4 -1.8
Supplements: Zinc 1.0 1.1 2.0 -0.7 1.4 1.1 1.4 1.0 0.2
Medication: Co-codamol 0.7 0.8 2.9 -1.7 0.9 0.0 0.6 0.3 -0.8
Medication: Metformin 1.2 1.7 3.3 -1.4 1.1 1.3 1.3 0.8 -1.8
Diabetes (father) 0.3 0.4 1.3 -1.1 0.3 0.4 -0.0 0.6 -0.5
Diabetes (mother) 0.4 0.5 1.9 0.8 -0.2 -0.1 -0.5 0.1 -1.4
Severe depression (siblings) 0.2 0.3 0.9 0.3 -0.2 -0.2 -0.3 -0.7 0.9
Pack years adult smoking proportion 0.7 1.1 3.2 -0.9 -0.7 -0.9 -0.6 -0.9 -1.8
Impedance of leg (right) 0.6 2.7 11.7 3.4 0.9 1.1 0.7 1.2 0.8
Leg fat-free mass (left) 0.6 3.3 16.4 -4.0 -0.6 -1.3 -0.4 -1.1 0.2
Trunk fat percentage 1.9 7.5 25.2 -5.0 -2.5 -2.8 -1.8 -1.4 -0.7
Hand grip strength (right) 0.2 0.6 3.3 1.8 -0.2 0.2 -0.1 0.0 -0.1
Townsend deprivation index at recruitment 1.1 1.6 5.4 -1.9 -0.2 -0.4 -0.1 -0.2 2.3
Current tobacco smoking 0.2 0.2 0.6 0.7 -0.2 0.2 -0.5 -0.1 -0.8
Average weekly fortified wine intake 1.0 1.2 2.7 -0.9 -0.8 -1.6 -1.1 -1.3 0.1
Maternal smoking around birth 1.1 1.6 6.0 -0.8 1.2 0.4 0.9 0.4 -2.5
Fed-up feelings 0.5 0.8 2.1 -0.5 -1.1 -1.5 -1.2 -0.3 0.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.4 0.9 -0.7 -0.3 -1.0 -0.6 0.5 -0.4
Relative age voice broke 1.5 2.3 4.8 -0.4 2.2 1.7 1.6 1.7 0.4
Taking other prescription medications 1.6 2.4 11.0 -3.3 0.1 0.2 0.5 0.5 -1.7
Age when periods started (menarche) 0.6 1.4 5.0 2.2 0.7 0.4 0.0 0.0 1.7
Bilateral oophorectomy (both ovaries removed) 1.9 2.2 8.9 -3.0 -0.5 -0.8 -0.2 -0.8 -1.7
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.6 1.4 -0.2 -1.2 0.9 1.0 -0.2 0.1
Tinnitus: Yes, but not now, but have in the past 0.2 0.2 0.5 0.2 0.0 0.6 0.7 0.5 -0.6
Qualifications: CSEs or equivalent 0.3 0.4 1.5 0.2 0.4 0.5 0.5 0.0 -1.2
Serious illness, injury or assault to yourself 1.2 1.5 2.7 0.1 -1.7 -1.3 -1.5 -1.5 -0.3
High blood pressure 1.0 2.9 5.2 -2.1 -1.2 -2.3 -1.7 -1.6 -0.6
Hayfever, allergic rhinitis or eczema 0.3 0.7 2.5 1.6 -0.5 -0.2 -0.4 -0.1 1.2
Multivitamins +/- minerals 0.8 1.0 4.8 -0.4 -0.5 -0.5 -0.6 -0.4 2.2
Stomach or abdominal pain in last month 0.4 0.5 1.5 -0.6 0.8 0.0 0.5 1.2 -0.5
Supplements: Glucosamine 0.3 0.5 2.4 -0.3 0.0 0.2 -0.0 -0.4 1.5
Diverticular disease/diverticulitis (self-reported) 2.5 2.9 7.1 0.6 0.9 2.7 1.9 2.0 -1.3
Medication: Atenolol 0.2 0.3 0.7 0.1 0.5 0.7 0.0 0.3 0.8
Medication: Levothyroxine sodium 0.2 0.3 1.0 0.3 -1.0 -0.3 -0.6 -0.6 -0.2
Sitting height 0.1 1.0 3.8 1.9 0.5 -0.0 0.3 -0.0 1.4
Chronic bronchitis/emphysema (father) 1.7 2.0 3.7 -0.1 -1.9 -1.4 -0.9 -1.5 -1.8
High blood pressure (mother) 0.2 0.3 0.6 0.7 0.8 -0.2 0.4 -0.1 -0.6
Body mass index (BMI) 2.3 9.8 40.8 -6.4 -2.3 -2.6 -1.6 -1.7 0.0
Impedance of leg (left) 0.4 2.0 10.5 3.2 0.2 0.6 0.2 1.0 0.1
Leg predicted mass (left) 0.6 3.3 15.8 -4.0 -0.6 -1.3 -0.4 -1.1 0.1
Trunk fat mass 1.9 8.1 30.6 -5.5 -2.3 -2.8 -1.6 -1.5 -0.4
Waist circumference 1.9 6.9 31.2 -5.6 -1.7 -2.2 -0.8 -1.5 -0.1
Number of incorrect matches in round 0.7 1.1 2.1 0.3 -0.9 -1.2 -1.0 -1.1 1.4
Past tobacco smoking 2.8 5.1 9.2 -0.7 2.5 3.0 3.0 2.3 0.7
Alcohol usually taken with meals 0.3 0.4 2.1 0.3 0.2 0.1 0.2 0.6 1.5
Nervous feelings 0.2 0.3 0.7 0.3 0.7 0.6 0.5 0.8 -0.1
Frequency of tenseness / restlessness in last 2 weeks 1.6 2.5 4.4 -1.8 1.4 1.5 1.4 2.1 -1.1
Hearing difficulty/problems with background noise 0.6 1.0 3.0 1.7 0.6 0.4 0.7 1.3 -0.2
Hair/balding pattern: Pattern 2 0.4 0.5 0.9 -0.8 -0.3 -0.9 -0.5 -0.8 -0.6
Had menopause 0.5 0.7 1.6 -1.1 0.7 0.6 0.6 1.3 -0.1
Had other major operations 2.3 2.8 4.8 -2.0 -1.7 -2.2 -1.3 -1.5 1.1
Forced vital capacity (FVC) 0.3 1.3 6.2 2.5 -0.2 0.6 -0.5 -0.4 0.9
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.4 1.4 0.1 -1.2 0.6 0.5 -0.3 -0.2
Ever unenthusiastic/disinterested for a whole week 0.7 0.9 4.2 -2.0 0.0 0.2 0.6 0.7 -0.2
Qualifications: None of the above 1.6 3.3 18.1 -4.3 -0.6 -0.4 0.4 0.4 0.9
Financial difficulties in last 2 years 0.8 1.1 2.3 -0.3 -1.5 -1.3 -1.2 -1.1 0.4
Mouth/teeth dental problems 1.0 1.6 5.1 -2.2 -1.1 -0.6 -1.0 -1.2 -0.8
Heart attack 0.8 1.0 1.6 -1.1 0.9 1.3 0.8 1.2 0.5
Allergy 0.1 0.3 0.7 -0.1 0.7 0.3 0.3 0.3 -0.9
Pain all over the body in last month 2.7 2.9 5.3 0.6 -2.3 -1.7 -1.8 -2.0 1.0
Diabetes (self-reported) 1.4 2.2 5.2 -2.3 1.1 0.9 1.6 0.8 -1.6
Hayfever/allergic rhinitis (self-reported) 0.2 0.2 1.3 1.2 0.0 -0.1 0.2 -0.2 -0.1
Medication: Ramipril 0.2 0.3 0.9 -1.0 -0.1 0.3 0.1 0.4 -0.6
Medication: Simvastatin 1.4 2.1 3.7 -1.2 1.6 1.5 1.5 1.9 -0.8
Fluid intelligence score 0.8 1.6 6.5 2.6 1.6 0.5 0.4 0.6 0.3
Illnesses of siblings 0.0 0.1 0.2 0.4 -0.2 -0.1 -0.3 -0.2 0.1
Neuroticism score 0.1 0.3 0.8 -0.4 0.4 0.4 0.6 0.9 0.2
Weight 1.5 7.5 33.2 -5.8 -1.7 -2.3 -1.2 -1.4 0.3
Impedance of arm (right) 1.5 7.0 21.0 4.6 2.6 2.4 2.0 1.9 -0.9
Arm fat percentage (right) 1.6 6.4 26.7 -5.2 -1.8 -2.3 -1.1 -1.2 -0.9
Trunk fat-free mass 0.4 2.5 11.7 -3.4 -0.2 -0.9 -0.1 -0.8 1.3
Hip circumference 2.1 9.2 35.8 -6.0 -2.4 -2.7 -1.7 -1.8 0.6
Time employed in main current job 1.5 1.7 4.2 0.2 2.0 1.2 1.4 1.3 -1.0
Alcohol intake versus 10 years previously 1.4 2.1 3.2 -1.8 -1.7 -1.7 -0.8 -1.5 0.9
Father’s age at death 0.8 1.0 2.2 -0.3 1.5 1.2 0.9 1.3 0.2
Worrier / anxious feelings 1.1 2.2 3.8 -0.9 1.6 2.0 1.7 1.7 -0.3
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.8 3.7 -1.9 0.4 -0.3 0.1 0.6 -0.8
Falls in the last year 1.3 1.8 2.5 -0.3 1.3 1.6 1.6 1.5 -1.3
Hair/balding pattern: Pattern 3 1.0 1.5 8.7 3.0 0.0 0.2 -0.0 -0.1 -0.2
Number of live births 0.8 1.1 3.7 -1.9 1.0 0.3 0.7 0.3 -1.1
Forced expiratory volume in 1-second (FEV1) 0.4 1.4 6.0 2.4 -0.8 0.3 -0.9 -1.0 0.3
Pulse rate 0.4 0.6 3.4 -1.9 -0.2 0.5 -0.1 0.3 -0.0
Happiness 2.7 3.2 12.5 0.8 1.4 1.0 1.2 1.3 -3.5
Noisy workplace 0.5 0.6 1.4 -0.4 0.5 1.2 0.7 1.0 0.5
Qualifications: A levels/AS levels or equivalent 1.2 2.7 7.8 2.8 -1.0 -0.7 -1.2 -2.0 -1.4
Serious illness, injury or assault of a close relative in last 2 years 1.6 1.8 2.7 -0.2 -1.4 -1.6 -1.3 -1.6 1.4
Mouth/teeth dental problems: Dentures 0.3 0.4 0.7 -0.5 0.8 -0.1 0.8 0.6 0.9
Asthma 0.2 0.4 1.2 -1.1 -0.6 -0.3 -0.4 -0.2 -0.7
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.4 2.0 0.1 0.3 -0.1 -0.1 0.2 1.4
Medication: Cholesterol lowering 0.8 1.3 2.1 -1.4 0.9 1.1 1.2 1.1 -0.9
Depression (self-reported) 1.9 2.3 7.0 -2.7 1.1 0.8 1.3 1.0 -1.5
Medication: Lansoprazole 1.0 1.1 2.3 -1.1 -1.5 -1.0 -0.4 -1.1 -1.1
Prospective memory result 0.5 0.6 1.1 -0.8 0.4 0.8 0.7 0.9 -1.1
Lung cancer (father) 0.3 0.3 1.1 1.0 0.1 0.1 0.1 0.1 -0.8
Illnesses of mother 0.3 0.4 2.5 1.6 -0.1 0.2 0.0 0.1 -0.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.5 1.6 2.5 0.9 -1.4 -0.5 -1.4 -1.6 1.4
Pulse wave Arterial Stiffness index 1.5 1.8 3.1 -0.5 1.6 1.2 1.2 1.3 -1.8
Impedance of arm (left) 1.0 4.9 16.0 4.0 1.9 1.8 1.4 1.6 -1.4
Arm fat mass (right) 1.9 7.9 32.4 -5.7 -2.0 -2.6 -1.4 -1.6 -0.1
Trunk predicted mass 0.4 2.4 11.4 -3.4 -0.3 -1.0 -0.2 -0.8 1.2
Standing height 0.0 0.3 0.8 0.5 0.8 0.2 0.5 0.1 0.9
Length of working week for main job 0.2 0.2 0.5 0.6 -0.0 0.3 0.2 0.7 0.4
Exposure to tobacco smoke at home 1.1 1.2 4.8 -1.3 -0.1 -0.4 -0.4 -0.5 2.2
Breastfed as a baby 1.9 2.4 3.4 -1.7 -1.7 -1.5 -1.3 -1.0 1.8
Tense / ‘highly strung’ 1.1 1.8 3.2 0.4 1.4 1.8 1.6 1.7 -0.3
Seen doctor (GP) for nerves, anxiety, tension or depression 0.6 0.9 3.8 -1.9 -0.3 -1.0 -0.3 -0.5 0.2
Hair/balding pattern: Pattern 4 1.1 2.7 11.1 -3.3 -1.4 -0.9 -1.1 -0.8 0.6
Birth weight of first child 0.2 0.3 0.8 0.1 -0.6 -0.5 -0.1 -0.9 -0.8
Peak expiratory flow (PEF) 0.2 0.4 0.8 0.9 -0.5 0.4 -0.3 -0.6 -0.8
Pulse wave reflection index 0.1 0.1 0.1 0.4 -0.0 -0.3 -0.2 -0.4 -0.2
Ever highly irritable/argumentative for 2 days 0.3 0.4 1.7 -0.5 0.0 0.1 0.1 0.5 -1.3
Loud music exposure frequency 2.3 2.5 3.4 -0.2 -1.8 -1.8 -1.7 -1.6 1.8
Qualifications: O levels/GCSEs or equivalent 0.7 1.2 3.2 1.8 -0.3 -0.7 -0.9 -1.3 -0.9
Mouth/teeth dental problems: Bleeding gums 1.9 2.4 7.7 2.8 1.4 1.1 0.9 1.2 -1.1
Blood clot in the leg (DVT) 0.3 0.3 1.0 -1.0 -0.9 -0.5 0.1 -0.1 -0.1
Medication: Paracetamol 0.8 1.3 2.6 -1.6 -1.0 -0.8 -0.7 -1.4 1.2
Headache pain in last month 0.3 0.5 1.4 -0.4 -1.2 -0.9 -0.6 -0.4 0.6
Medication for cholesterol, blood pressure or diabetes 0.6 1.0 3.7 1.2 -0.5 -0.4 -0.5 -0.2 1.9
Glaucoma (self-reported) 0.7 0.8 1.6 0.2 -1.3 -0.5 -0.7 -1.1 -1.0
Gout (self-reported) 1.0 1.3 5.8 -1.1 0.2 0.4 0.7 0.6 -2.4
Hypothyroidism/myxoedema (self-reported) 0.1 0.2 0.5 0.7 -0.4 0.4 0.1 0.7 0.3
Medication: Amlodipine 0.1 0.2 0.6 -0.4 0.5 0.1 0.0 -0.2 -0.8
Medication: Ventolin 100micrograms inhaler 0.4 0.5 1.7 -1.3 -0.5 -0.1 0.5 0.2 -0.7
Birth weight 0.8 1.7 3.1 1.8 1.4 1.4 1.5 1.0 0.4
Chronic bronchitis/emphysema (mother) 3.7 4.3 7.0 -2.2 -2.6 -1.7 -2.2 -1.7 1.7
High blood pressure (siblings) 0.1 0.2 0.3 -0.0 -0.2 -0.5 -0.4 -0.6 -0.4
Forced vital capacity (FVC), Best measure 0.3 1.0 2.9 1.3 -0.5 0.3 -0.7 -0.7 1.7
Body fat percentage 2.2 8.8 29.8 -5.5 -2.7 -3.1 -1.9 -1.6 -0.7
Leg fat percentage (right) 2.2 8.1 34.2 -5.8 -2.3 -2.6 -1.4 -1.1 0.1
Arm fat-free mass (right) 1.0 5.3 18.2 -4.3 -1.7 -2.2 -1.4 -1.6 1.2
Exposure to tobacco smoke outside home 1.1 1.4 2.4 -0.8 1.3 1.5 1.4 1.3 0.2
Comparative body size at age 10 0.5 1.3 6.1 -2.5 -0.4 -0.9 -0.4 -0.7 -0.6
Number of full brothers 0.8 1.1 2.3 0.2 1.0 1.5 1.4 1.0 -0.2
Worry too long after embarrassment 0.3 0.5 1.2 0.6 0.8 0.4 0.8 1.1 -0.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.4 1.9 -1.4 0.2 0.5 0.3 0.4 -0.3
Wheeze or whistling in the chest in last year 0.7 1.2 4.2 -2.0 -0.1 0.5 0.7 0.7 -1.5
Number of children fathered 0.2 0.2 0.5 -0.6 -0.1 -0.1 -0.1 -0.4 0.7
Reason for reducing amount of alcohol drunk: Health precaution 0.9 1.1 2.3 1.2 -0.4 -1.0 -1.1 -0.2 1.5
Age at first live birth 0.5 0.8 2.9 1.7 -0.4 -0.2 -0.3 -1.0 0.9
Pulse wave peak to peak time 1.4 1.6 2.9 0.7 -1.5 -1.1 -1.2 -1.2 1.7
Health satisfaction 0.8 1.1 3.8 -1.6 0.3 -0.2 0.0 0.2 -1.9
Shortness of breath walking on level ground 3.5 4.1 11.5 -0.7 -1.8 -2.1 -1.8 -1.4 -3.4
Qualifications: College or University degree 1.1 3.5 15.7 4.0 0.9 1.8 0.8 0.2 0.9
Eye problems/disorders: None of the above 0.5 0.6 2.3 0.9 0.5 0.1 0.2 0.2 1.5
Mouth/teeth dental problems: Loose teeth 0.2 0.2 0.5 0.1 -0.1 -0.7 -0.6 -0.1 0.4
Emphysema/chronic bronchitis 0.9 1.1 2.4 1.5 -1.1 -1.0 -0.6 -1.1 0.2
Medication for pain relief, constipation, heartburn 0.5 0.8 1.8 1.4 0.8 1.1 0.8 0.6 -0.4
Neck or shoulder pain in last month 0.8 1.2 2.6 -1.6 -0.7 0.5 -0.1 1.2 -1.6
Medication: Blood pressure 0.3 0.5 1.2 -0.7 0.5 0.8 0.7 0.2 -1.1
Angina (self-reported) 1.4 1.8 3.0 -0.8 1.7 1.6 1.5 1.3 0.6
Migraine (self-reported) 0.3 0.4 1.5 -0.6 -0.3 0.0 0.5 0.2 -1.2
Medication: Ibuprofen 0.6 0.8 4.4 0.2 -0.2 -0.4 -0.2 -0.1 2.1
Medication: Allopurinol 1.4 1.9 7.8 -1.6 -0.9 -0.4 -0.1 -0.1 -2.8
Medication: Omeprazole 0.8 0.9 3.4 -1.9 0.7 0.2 0.6 1.1 0.3
Medication: Seretide 50 evohaler 0.6 0.6 1.7 -0.3 0.6 1.0 0.3 0.7 -1.3
Mean time to correctly identify matches 1.0 1.9 4.2 -1.6 1.3 0.8 1.3 2.1 -0.9
Heart disease (mother) 2.9 3.6 5.8 -1.8 -1.8 -2.1 -2.4 -2.1 -0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.1 0.1 0.3 0.5 -0.2 -0.2 -0.4 -0.2 -0.0
Whole body fat mass 2.2 9.2 33.6 -5.8 -2.5 -3.1 -1.8 -1.7 -0.1
Leg fat mass (right) 2.3 9.0 36.6 -6.1 -2.2 -2.8 -1.5 -1.5 0.1
Arm predicted mass (right) 1.1 5.5 20.3 -4.5 -1.6 -2.1 -1.3 -1.6 1.1
Pulse rate, automated reading 0.4 1.3 6.4 -2.5 -0.5 0.2 0.3 0.3 0.9
Alcohol intake frequency. 0.6 1.3 5.7 -2.4 0.5 0.2 0.9 0.8 -0.8
Comparative height size at age 10 0.2 1.2 4.8 -2.2 0.3 0.4 0.9 0.5 0.9
Number of full sisters 0.4 0.5 1.2 -1.1 -0.6 -1.0 -0.4 -0.6 0.2
Suffer from ‘nerves’ 0.7 1.1 1.8 0.3 1.4 1.2 1.4 1.1 0.3
Overall health rating 1.2 2.7 13.3 -3.7 -0.7 -0.3 -0.0 0.3 -1.4
Chest pain or discomfort 1.2 1.7 5.2 -1.8 0.4 0.7 0.9 0.6 -2.3
Had major operations 0.5 0.5 1.4 -0.6 -0.6 -0.8 -0.5 -0.5 -1.2
Age at last live birth 1.0 1.4 2.0 1.4 -1.0 -0.8 -1.4 -1.2 1.3
Family relationship satisfaction 2.5 3.1 10.3 0.1 1.3 1.5 1.1 1.7 -3.2
Leg pain on walking 0.8 1.0 2.0 -1.4 1.1 0.8 1.2 0.9 0.2
Qualifications: NVQ or HND or HNC or equivalent 0.5 0.5 1.6 0.0 0.7 0.8 0.5 1.3 -0.4
Commuting to job workplace: Car/motor vehicle 1.6 1.8 3.5 -0.4 1.9 0.8 1.5 1.1 -1.8
Illness, injury, bereavement, stress in last 2 years 1.6 1.9 3.5 -0.2 1.4 1.8 1.4 1.9 -1.0
Medication: Aspirin 1.8 2.3 3.3 -1.7 -1.4 -1.8 -1.8 -1.0 -1.3
Supplements: Vitamin C 0.5 0.6 1.9 -1.0 -0.0 0.3 0.4 0.4 1.4
Knee pain experienced in last month 1.6 2.5 7.6 -2.8 0.8 0.9 1.2 1.2 -1.7
Hypertension (Self-reported) 0.8 2.2 4.4 -2.1 -1.0 -1.9 -1.4 -1.4 -0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.3 0.6 -0.2 0.4 0.6 0.7 0.8 0.6
Illnesses of father: Heart disease 0.7 1.0 1.6 -0.6 0.4 1.3 0.9 1.2 -1.3
Illnesses of siblings: Diabetes 1.0 1.2 6.2 -2.5 0.2 0.4 0.3 0.9 -0.2
Smoking status: Previous 2.5 3.8 6.9 0.3 -2.2 -2.6 -2.6 -2.0 0.1
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.3 0.9 -0.9 0.2 -0.2 0.2 0.3 0.9
Whole body fat-free mass 0.6 3.3 15.2 -3.9 -0.7 -1.4 -0.5 -1.1 0.9
Leg fat-free mass (right) 0.7 3.6 15.4 -3.9 -1.0 -1.6 -0.8 -1.4 -0.1
Arm fat percentage (left) 1.8 7.2 29.7 -5.4 -1.9 -2.4 -1.2 -1.3 -1.1
Average weekly red wine intake 0.7 1.0 3.0 -0.5 0.9 1.2 0.6 1.7 -0.7
Handedness (chirality/laterality): Left-handed 0.2 0.2 0.6 0.4 0.2 -0.4 -0.4 -0.8 -0.5
Mood swings 0.1 0.2 0.5 0.2 0.3 0.3 0.3 0.7 0.7
Loneliness, isolation 2.3 3.1 8.2 -2.9 1.4 1.1 1.8 2.0 -0.5
Long-standing illness, disability or infirmity 1.6 2.5 6.4 -2.5 0.6 0.6 0.8 1.1 -2.5
Ever had bowel cancer screening 0.4 0.5 1.9 0.8 -0.0 -0.5 -0.0 0.2 -1.4
Diabetes diagnosed by doctor 1.5 2.5 4.9 -2.2 1.2 0.9 1.4 1.1 -2.2
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.6 1.4 -0.7 0.8 0.8 1.2 0.1 -0.4
Friendships satisfaction 0.7 0.9 2.8 1.6 -0.2 0.3 -0.4 0.1 -1.7
Qualifications: nursing, teaching 1.0 1.5 5.3 2.3 -0.6 -0.9 -0.9 -1.1 0.5
Commuting to job workplace: Walk 0.8 0.9 4.8 -0.3 -0.5 -0.0 0.4 0.1 2.2
Eye problems/disorders: Cataract 1.0 1.1 1.6 -1.0 -1.2 -1.2 -1.1 -1.2 -0.0
Mouth/teeth dental problems: Mouth ulcers 0.3 0.4 1.3 0.5 -0.3 0.7 0.6 1.1 0.2
Medication for cholesterol 1.8 2.7 5.5 2.2 1.5 2.3 1.3 1.5 0.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.5 1.0 -1.0 0.8 0.7 0.8 0.6 0.1
Back pain experienced in last month 2.5 3.7 5.2 -2.3 1.3 1.9 1.8 2.1 -2.0
Mineral and other dietary supplements 0.0 0.1 0.2 0.0 0.2 0.1 0.1 0.2 -0.5
Breast cancer (self-reported) 0.5 0.6 1.8 1.2 0.3 -0.1 -0.1 0.3 1.3
Asthma (self-reported) 0.1 0.3 0.7 -0.8 -0.6 -0.0 -0.2 -0.0 -0.8
Osteoporosis (self-reported) 0.5 0.6 1.6 -0.1 0.1 1.3 1.1 0.7 0.0
Osteoarthritis (self-reported) 1.0 1.3 5.3 -2.3 -0.4 -0.9 -0.5 -1.1 -0.6
Medication: Aspirin 1.1 1.5 3.3 -1.8 -1.1 -1.1 -1.3 -0.5 -1.1
Medication: Gliclazide 2.3 2.6 4.9 0.6 1.7 1.6 2.0 0.8 -2.2
Illnesses of father: None of the above (group 1) 0.3 0.4 1.4 0.6 0.8 0.1 0.4 0.0 1.2
Smoking status: Current 0.3 0.5 1.1 0.5 -0.7 -0.5 -1.0 -0.6 -0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.1 4.5 13.1 0.9 -1.9 -1.7 -1.9 -1.7 3.6
Whole body water mass 0.6 3.3 15.5 -3.9 -0.7 -1.3 -0.4 -1.1 0.9
Leg predicted mass (right) 0.7 3.8 15.8 -4.0 -1.1 -1.6 -0.9 -1.5 -0.1
Arm fat mass (left) 2.0 8.1 34.5 -5.9 -1.9 -2.5 -1.3 -1.5 -0.5
Number of self-reported non-cancer illnesses 1.0 1.7 4.4 -2.1 -1.0 -1.0 -0.6 -0.8 -1.7
Average weekly champagne plus white wine intake 0.9 1.2 3.4 1.8 -1.0 -1.0 -0.8 -0.5 1.0
Miserableness 0.4 0.7 1.4 -0.8 -0.9 -1.2 -0.9 -0.6 -0.0
Guilty feelings 0.1 0.2 0.7 -0.5 0.8 -0.0 0.4 0.4 -0.0
Wears glasses or contact lenses 1.6 1.8 3.0 -1.7 -1.6 -1.6 -1.3 -1.0 -0.3
Ever taken oral contraceptive pill 0.6 0.6 2.0 0.6 -0.7 -0.5 -1.4 -0.7 0.2
Hearing aid user 0.6 0.7 1.4 0.6 1.1 0.5 0.9 0.5 1.2
Mother’s age at death 0.4 0.5 1.0 -0.7 -0.9 -0.5 -1.0 -0.5 0.7
Financial situation satisfaction 0.5 0.6 1.7 -1.3 -0.4 -0.4 -0.6 -0.8 -0.6
Tinnitus: Yes, now most or all of the time 0.8 0.9 4.6 2.1 0.6 0.4 0.2 0.5 0.1
Commuting to job workplace: Public transport 1.3 1.6 1.9 1.4 -1.2 -1.2 -1.2 -1.3 1.4
Eye problems/disorders: Glaucoma 0.5 0.5 2.0 -1.4 -0.6 0.3 0.3 -0.5 -0.7
Medication: Blood pressure 1.7 3.3 7.1 -2.7 -1.6 -2.0 -1.6 -1.8 0.7
Pain type(s) experienced in last month: Hip pain 0.6 0.8 3.2 -1.8 -0.8 -0.2 -0.4 -0.4 -0.8
Supplements: Fish oil (including cod liver oil) 0.1 0.2 0.4 -0.1 -0.6 -0.0 -0.4 0.4 0.6
High cholesterol (Self-reported) 1.4 2.5 5.7 -2.4 0.9 1.0 0.9 1.2 -2.3
Medication: Bendroflumethiazide 0.4 0.6 3.1 -1.8 -0.1 -0.1 0.0 -0.2 0.4
Medication: Paracetamol 1.4 2.1 2.9 -1.6 -1.5 -1.1 -1.1 -1.6 1.7
Medication: Lisinopril 0.4 0.5 1.0 -0.4 -0.5 -0.7 -0.6 -0.8 1.0
Medication: Atorvastatin 1.5 1.9 4.9 -2.2 1.0 1.3 1.4 1.2 -0.0
Illnesses of father: High blood pressure 0.4 0.5 1.0 0.9 -0.3 -0.1 -0.8 -0.7 1.0
Alcohol drinker status: Never 2.2 2.6 5.5 -0.1 2.3 1.8 2.0 1.6 -0.6
Ever smoked 2.5 4.4 7.0 1.7 -2.0 -2.5 -2.6 -2.2 -1.0
Basal metabolic rate 0.8 4.3 20.4 -4.5 -0.9 -1.6 -0.6 -1.2 0.7
Leg fat percentage (left) 2.7 9.9 39.2 -6.3 -2.7 -2.8 -1.8 -1.3 -0.3
Arm fat-free mass (left) 1.2 5.9 21.8 -4.7 -1.7 -2.2 -1.4 -1.5 1.4
Number of operations (self-reported) 1.1 1.7 3.8 -1.4 -1.0 -1.4 -0.8 -0.8 -2.0
Average weekly beer plus cider intake 1.5 2.2 8.0 2.8 0.1 0.4 0.4 0.0 -2.3
Irritability 0.5 0.9 4.0 2.0 -0.1 -0.0 -0.2 0.2 -1.0
Risk taking 0.4 0.6 3.4 1.9 0.3 0.4 0.2 0.2 -0.1
Ever had prostate specific antigen (PSA) test 0.3 0.3 0.7 -0.8 -0.3 0.2 -0.2 0.7 0.7
Fractured/broken bones in last 5 years 0.5 0.6 2.5 -0.6 -0.8 0.5 0.1 0.1 1.6
Age started oral contraceptive pill 0.8 1.0 4.1 -0.6 0.8 -0.6 -0.5 0.4 2.0
Diastolic blood pressure, automated reading 0.7 2.2 4.8 -2.2 -1.0 -2.0 -1.1 -1.3 -0.4
Ever depressed for a whole week 0.9 1.1 5.7 -2.4 -0.6 -0.4 -0.2 -0.2 -0.6
Unable to work because of sickness or disability 0.4 0.6 1.4 -0.1 -0.5 1.2 0.6 1.0 0.6
Commuting to job workplace: Cycle 2.3 2.8 5.1 1.5 -2.2 -1.7 -1.9 -1.6 -0.2
Myopia 1.3 1.9 9.5 3.1 0.5 0.5 0.1 0.0 -1.2
Vascular/heart problems diagnosed by doctor 1.3 3.6 6.6 2.6 1.6 2.4 1.9 1.7 0.7
Cholesterol lowering medication 1.1 1.6 7.4 -2.7 0.6 0.4 0.4 0.8 -0.8
Medication: Omeprazole (e.g. Zanprol) 0.5 0.6 2.9 -1.7 0.3 0.1 0.1 0.7 0.1
Pain experienced in last month 0.7 1.1 4.8 2.2 0.0 -0.6 -0.5 -0.9 0.7
Supplements: Calcium 0.8 0.9 2.0 -0.6 -1.0 -1.4 -1.1 -1.0 0.3
Basal cell carcinoma (self-reported) 2.3 2.7 4.3 -2.1 -1.3 -2.0 -2.0 -1.4 -0.4
Heart attack/myocardial infarction (self-reported) 1.0 1.2 1.9 -1.2 0.9 1.4 0.9 1.4 0.8
Deep venous thrombosis (DVT) (self-reported) 0.3 0.4 1.6 -1.3 -0.7 -0.4 0.2 0.0 0.4
Heart disease (siblings) 0.2 0.3 0.7 -0.9 0.0 0.0 0.0 0.8 -0.4
Alcohol drinker status: Previous 0.7 0.8 2.1 -1.0 -0.8 -0.5 -0.8 -0.2 -1.4
Pack years of smoking 0.6 0.9 3.9 -0.9 -0.3 -0.7 -0.2 -0.6 -2.0
Impedance of whole body 0.7 3.3 16.4 4.0 0.8 1.0 0.6 1.1 -0.6
Leg fat mass (left) 2.6 10.0 40.7 -6.4 -2.4 -2.9 -1.6 -1.5 -0.1
Arm predicted mass (left) 1.1 5.7 19.6 -4.4 -1.7 -2.2 -1.4 -1.6 1.5