TWAS hub - MLLT10

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Skin Sun Exposed Lower leg	0.0630	0.027	0.00046	0.017	NA	0.027	NA	0.034	0.0140	NA	0.0023	NA	0.00079
2	GTEx	Spleen	0.1600	0.073	0.00630	0.024	NA	-0.007	NA	0.019	0.0790	NA	0.5400	NA	0.10000
3	YFS	Blood	0.0247	0.010	0.00072	0.005	0.005	0.000	0.007	0.004	0.0068	0.0075	0.2100	0.0021	0.01700

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Ovarian Cancer	19.4	25.6	34.4	5.9	5.7	3.2
Leg fat percentage (right)	17.6	63.7	92.1	-9.6	-8.9	-4.4
Leg fat percentage (left)	17.1	61.8	89.1	-9.4	-8.7	-4.6
Breast Cancer	16.6	40.0	50.8	7.1	6.5	5.1
Leg fat mass (right)	16.3	63.0	89.3	-9.5	-8.8	-4.7
Waist circumference	15.7	57.3	83.7	-9.2	-8.2	-4.5
Leg fat mass (left)	15.6	60.8	86.9	-9.3	-8.6	-4.7
Number of operations (self-reported)	13.1	19.5	26.0	-5.0	-5.1	-2.7
Body mass index (BMI)	13.0	55.6	80.5	-9.0	-8.3	-4.2
Body fat percentage	12.9	51.0	73.3	-8.6	-7.9	-4.2
BMI	12.5	72.6	104.0	-10.2	-9.3	-5.2
Whole body fat mass	12.0	50.2	73.6	-8.6	-7.8	-4.0
Bilateral oophorectomy (both ovaries removed)	11.6	13.4	19.4	-4.4	-4.1	-2.1
Number of treatments/medications taken	11.3	20.3	29.5	-5.4	-4.8	-3.0
Arm fat mass (left)	10.9	44.6	66.6	-8.2	-7.4	-3.6
Hip circumference	10.8	46.6	68.6	-8.3	-7.4	-4.0
Medication: Paracetamol	10.8	17.9	24.2	-4.9	-4.6	-3.0
Arm fat percentage (left)	10.8	43.3	63.9	-8.0	-7.2	-3.7
Ever had hysterectomy (womb removed)	10.6	11.9	19.3	-4.4	-3.9	-1.0
Trunk fat percentage	10.6	42.6	62.8	-7.9	-7.2	-3.7
Trunk fat mass	10.4	44.6	66.7	-8.2	-7.4	-3.5
Arm fat mass (right)	10.4	42.9	63.3	-8.0	-7.3	-3.5
Arm fat percentage (right)	10.2	40.1	59.1	-7.7	-7.0	-3.4
Medication: Paracetamol	9.9	15.3	21.2	-4.6	-4.3	-2.5
Smoking status: Previous	9.2	13.8	16.2	-4.0	-4.0	-3.0
Medication for pain relief, constipation, heartburn	8.9	15.2	15.5	3.9	3.9	3.9
Past tobacco smoking	8.5	15.7	19.1	4.4	4.4	3.0
Breast cancer (self-reported)	8.4	10.0	15.3	-3.9	-3.6	-1.4
Smoking Status	8.2	19.6	28.0	-5.3	-5.0	-2.4
Maternal smoking around birth	8.1	11.7	18.8	-4.3	-4.0	-0.3
Ever had bowel cancer screening	8.0	9.3	14.7	-3.8	-3.3	-1.6
Alcohol intake versus 10 years previously	7.5	11.2	13.9	-2.9	-3.3	-3.7
Weight	7.2	35.3	54.7	-7.4	-6.6	-2.8
Lung FEV1/FVC ratio	7.0	35.4	41.3	-5.4	-6.0	-6.4
Chronic bronchitis/emphysema (mother)	6.6	7.7	9.8	-3.1	-3.1	-2.0
Number of self-reported non-cancer illnesses	6.6	11.4	18.8	-4.3	-3.5	-1.7
Had other major operations	6.3	7.7	10.1	-3.2	-2.9	-2.1
Shortness of breath walking on level ground	6.2	7.3	11.0	-3.3	-2.6	-2.0
Emphysema/chronic bronchitis	6.1	6.8	11.6	-3.4	-2.8	-1.0
Pain experienced in last month	6.0	10.0	14.2	3.8	3.4	2.1
Vascular/heart problems diagnosed by doctor	5.9	16.1	26.0	5.1	4.2	2.1
Diastolic blood pressure, automated reading	5.8	17.9	30.8	-5.5	-4.3	-2.0
Worry (Nagel 2018)	5.7	12.0	16.5	3.5	4.1	2.7
Forced vital capacity (FVC), Best measure	5.7	20.8	28.1	5.3	5.2	2.7
Number of full sisters	5.7	7.0	9.4	-3.1	-2.9	-1.7
Taking other prescription medications	5.6	8.6	13.9	-3.7	-3.1	-1.6
Worrier / anxious feelings	5.4	10.2	13.6	2.9	3.7	3.0
Bipolar Disorder (2011)	5.2	5.0	8.8	3.0	2.5	0.3
Lung FVC	5.2	26.5	36.5	5.9	6.0	2.9
Hand grip strength (right)	5.2	14.0	19.1	4.4	4.0	2.7
Overall health rating	5.2	11.1	19.7	-4.4	-3.2	-1.9
Had major operations	5.1	6.0	8.1	-2.8	-2.8	-1.5
Hand grip strength (left)	4.9	12.9	15.6	3.9	4.0	2.9
Asthma	4.9	9.7	16.6	-4.1	-3.5	-0.8
Suffer from ‘nerves’	4.9	7.6	10.7	1.9	2.9	3.3
Average weekly red wine intake	4.9	7.2	10.4	3.2	2.8	1.8
Peak expiratory flow (PEF)	4.8	11.1	15.3	-3.9	-3.7	-2.1
Medication: Omeprazole	4.8	5.8	8.0	-2.8	-2.2	-2.1
Commuting to job workplace: Walk	4.8	5.1	6.1	2.1	2.5	2.2
Medication for cholesterol	4.7	7.1	8.8	3.0	2.4	2.6
Mother’s age at death	4.6	5.8	6.9	2.0	2.6	2.5
High blood pressure	4.5	12.5	20.4	-4.5	-3.6	-1.9
Hypertension (Self-reported)	4.5	12.5	20.3	-4.5	-3.6	-2.1
Worry too long after embarrassment	4.4	7.3	10.6	2.8	3.3	1.9
Supplements: Fish oil (including cod liver oil)	4.3	5.6	8.5	2.7	2.9	0.8
Forced vital capacity (FVC)	4.2	16.3	20.9	4.6	4.5	2.9
Impedance of arm (right)	4.2	19.7	24.4	4.9	4.8	3.4
Commuting to job workplace: Cycle	4.1	4.9	7.2	2.7	2.4	1.4
Deep venous thrombosis (DVT) (self-reported)	4.1	5.3	7.5	-2.7	-2.4	-1.7
Medication: Gliclazide	3.8	4.3	8.1	0.8	2.0	2.9
Medication: Ibuprofen (e.g. Nurofen)	3.7	4.7	7.2	-1.8	-1.9	-2.7
Ever had stillbirth, spontaneous miscarriage or termination	3.7	3.9	6.6	2.6	2.0	1.0
Asthma (self-reported)	3.7	7.4	13.0	-3.6	-3.0	-0.4
Ever smoked	3.7	6.4	8.1	-2.6	-2.8	-2.1
Impedance of arm (left)	3.6	16.8	21.4	4.6	4.6	2.8
Qualifications: College or University degree	3.6	11.4	18.9	4.4	3.5	1.7
Arm predicted mass (right)	3.6	18.4	26.9	-5.2	-4.8	-2.4
Pain type(s) experienced in last month: Hip pain	3.6	4.5	6.7	-2.6	-2.2	-1.4
Age at First Birth	3.5	5.1	5.3	2.3	2.3	2.2
Medication: Bendroflumethiazide	3.5	5.4	6.6	-2.6	-2.5	-1.8
Neuroticism	3.4	8.2	10.9	2.4	3.3	2.8
Qualifications: CSEs or equivalent	3.4	4.6	8.1	-2.8	-2.3	-0.6
Age at first live birth	3.4	6.1	8.7	2.9	2.8	1.3
Health satisfaction	3.4	4.4	7.0	-2.6	-2.2	-1.2
Arm fat-free mass (left)	3.4	17.0	24.5	-5.0	-4.7	-2.0
Medication: Omeprazole (e.g. Zanprol)	3.3	4.1	4.9	-2.1	-1.7	-2.2
Angina	3.2	4.2	5.0	-2.1	-1.8	-2.2
Qualifications: A levels/AS levels or equivalent	3.2	7.1	13.4	3.7	2.8	-0.0
Arm fat-free mass (right)	3.2	16.6	24.0	-4.9	-4.5	-2.3
Arm predicted mass (left)	3.2	16.5	23.6	-4.9	-4.6	-2.1
Neuroticism (Nagel 2018)	3.1	7.3	9.1	2.3	3.0	2.7
Cardiovascular Disease	3.1	10.3	16.6	-4.1	-3.3	-1.7
Neuroticism score	3.1	6.5	9.6	2.1	3.1	2.3
Tense / ‘highly strung’	3.1	5.2	8.7	2.4	2.9	1.1
Angina (self-reported)	3.1	4.1	5.2	-2.0	-1.7	-2.3
Serious illness, injury or assault to yourself	3.0	3.7	6.1	-2.0	-2.5	-0.9
Medication: Ventolin 100micrograms inhaler	3.0	3.8	6.7	-2.6	-2.2	0.2
Medication: Blood pressure	3.0	5.2	8.7	-2.9	-2.5	-0.8
Irritability	3.0	5.1	7.6	2.5	2.8	1.2
Medication for cholesterol, blood pressure or diabetes	2.9	4.8	6.9	2.6	2.6	0.9
Commuting to job workplace: Car/motor vehicle	2.9	3.3	4.7	-2.2	-2.1	-0.8
Osteoarthritis (self-reported)	2.9	3.8	5.9	-2.3	-2.4	-0.3
Exposure to tobacco smoke at home	2.8	3.2	5.0	-1.8	-2.2	-1.1
Pulse wave peak to peak time	2.8	3.3	7.5	2.7	1.6	0.3
Had menopause	2.7	3.4	4.1	1.5	2.0	2.0
Illnesses of mother	2.7	3.4	5.3	2.3	2.1	0.7
Medication: Blood pressure	2.7	5.2	8.0	-2.8	-2.3	-1.5
Illnesses of father: High blood pressure	2.7	3.4	5.9	-2.4	-1.9	-0.8
Alcohol usually taken with meals	2.6	4.2	7.2	2.7	2.2	0.8
Birth weight of first child	2.6	4.8	7.6	-2.8	-2.5	-0.8
Headache pain in last month	2.6	4.5	5.0	-2.0	-2.2	-2.1
Body Mass Index (BMI) (2010)	2.5	3.5	5.1	-2.3	-2.2	-0.6
Happiness	2.5	3.1	4.9	0.9	1.9	2.2
Basal metabolic rate	2.5	13.7	21.6	-4.6	-4.2	-1.5
Systolic blood pressure, automated reading	2.4	6.9	11.9	-3.5	-2.7	-1.2
Leg fat-free mass (left)	2.4	12.7	20.1	-4.5	-4.1	-1.1
Stomach or abdominal pain in last month	2.4	3.0	3.7	-1.9	-1.7	-1.6
Nervous feelings	2.4	4.6	6.5	1.7	2.5	2.1
Pulse wave Arterial Stiffness index	2.4	2.8	6.4	-2.5	-1.4	0.1
Medication: Ibuprofen	2.4	2.9	3.7	-1.5	-1.6	-1.9
Back pain experienced in last month	2.4	3.5	6.7	-2.6	-1.9	-0.1
Average weekly spirits intake	2.3	2.8	4.1	-1.7	-2.0	-1.2
Leg predicted mass (left)	2.3	12.0	18.9	-4.3	-4.0	-1.0
Blood clot in the leg (DVT)	2.3	3.0	4.8	-2.2	-1.7	-1.1
Number of children fathered	2.3	2.7	4.4	-1.1	-1.6	-2.1
Fractured/broken bones in last 5 years	2.3	2.9	4.0	-1.8	-2.0	-1.2
Respiratory disease	2.2	4.9	9.8	-3.1	-2.2	0.0
Frequency of depressed mood in last 2 weeks	2.2	3.0	5.5	0.7	1.7	2.4
Medication: Co-codamol	2.2	2.5	3.7	-1.9	-1.7	-1.0
Glaucoma (self-reported)	2.2	2.6	5.1	-1.2	-1.1	-2.3
Handedness (chirality/laterality): Left-handed	2.2	2.7	3.9	-2.0	-1.5	-1.3
Neck or shoulder pain in last month	2.1	2.9	5.6	-2.4	-1.6	-0.8
Age at last live birth	2.1	3.1	4.4	2.1	2.0	0.8
Qualifications: NVQ or HND or HNC or equivalent	2.1	2.5	4.2	-2.0	-1.1	-1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.1	2.5	6.0	-2.4	-1.2	-0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.1	4.4	6.5	2.6	2.5	0.4
Family relationship satisfaction	2.0	2.5	4.8	1.0	1.3	2.2
Long-standing illness, disability or infirmity	2.0	3.1	6.0	-2.4	-1.8	0.1
Chronotype (morning person)	1.9	4.4	6.3	1.5	2.5	2.2
Wheeze or whistling in the chest in last year	1.9	3.4	6.4	-2.5	-2.0	0.3
Heart disease (mother)	1.9	2.3	3.2	-1.6	-1.8	-1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.9	2.3	2.9	-1.4	-1.7	-1.4
Average weekly beer plus cider intake	1.9	2.8	3.3	1.5	1.8	1.7
Schizophrenia vs Biploar Disorder	1.8	2.4	2.9	-1.6	-1.7	-1.3
Sitting height	1.8	12.8	16.8	4.1	3.7	2.8
Illness, injury, bereavement, stress in last 2 years	1.8	2.2	2.6	1.6	1.6	1.2
Impedance of whole body	1.8	9.0	13.9	3.7	3.4	1.2
Bipolar Disorder (2018)	1.7	2.8	4.6	2.1	1.7	0.9
Neuroticism (2016)	1.7	2.5	3.2	1.3	1.8	1.6
Diverticular disease/diverticulitis (self-reported)	1.7	2.0	5.4	0.3	0.8	2.3
Medication: Simvastatin	1.7	2.4	4.2	-2.0	-1.7	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	1.7	5.5	8.4	2.9	2.8	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	1.7	2.5	3.9	-2.0	-1.8	-0.7
Leg fat-free mass (right)	1.7	8.9	14.0	-3.7	-3.4	-1.1
Waist Hip Ratio (WHR)	1.6	7.0	11.2	-3.3	-2.7	-1.6
Systolic Blood Pressure	1.6	8.1	14.1	-3.8	-3.0	-1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.6	1.9	2.7	-1.6	-1.5	-0.9
Illnesses of siblings: Diabetes	1.6	2.0	3.2	-1.8	-1.6	0.2
Leg predicted mass (right)	1.6	8.8	13.8	-3.7	-3.4	-1.1
Myopia	1.6	2.4	3.3	1.4	1.4	1.8
Depression (Nagel 2018)	1.5	2.3	3.2	1.2	1.4	1.8
Primary Biliary Cirrhosis	1.5	2.1	4.9	-0.3	-1.1	-2.2
Hair/balding pattern: Pattern 2	1.5	1.9	5.0	-0.3	0.7	2.2
Leg pain on walking	1.5	1.9	3.1	-1.7	-1.3	-0.9
Eye problems/disorders: Cataract	1.5	1.7	2.0	-1.3	-1.4	-1.2
Mineral and other dietary supplements	1.5	2.0	3.1	-1.8	-1.6	-0.4
Whole body water mass	1.5	8.6	13.6	-3.7	-3.3	-1.0
Hearing aid user	1.5	1.7	2.7	-1.6	-1.5	-0.2
Frequency of tenseness / restlessness in last 2 weeks	1.4	2.1	3.3	0.7	1.6	1.8
Financial difficulties in last 2 years	1.4	1.9	3.0	-1.4	-1.7	-0.8
Medication: Amlodipine	1.4	1.9	3.6	-1.4	-1.9	-0.5
Eye problems/disorders: None of the above	1.4	1.6	3.9	0.8	0.5	2.0
Medication: Seretide 50 evohaler	1.4	1.6	2.7	-1.6	-1.4	0.0
Knee pain experienced in last month	1.4	2.2	3.3	-1.8	-1.8	-0.3
Whole body fat-free mass	1.4	8.2	13.2	-3.6	-3.3	-0.9
Mood swings	1.4	2.4	4.0	0.8	1.6	2.0
Qualifications: nursing, teaching	1.4	2.1	3.8	1.9	1.4	0.7
Average weekly champagne plus white wine intake	1.4	1.9	2.3	1.5	1.3	-1.4
Medication: Lisinopril	1.4	1.8	2.8	-1.5	-0.6	-1.7
Reaction Time	1.3	2.4	3.6	1.8	1.9	0.5
HDL Cholesterol	1.3	2.2	3.3	1.4	1.8	1.2
Rheumatoid Arthritis	1.3	1.8	2.5	1.6	1.3	1.1
Medication: Atenolol	1.3	1.6	1.8	-1.4	-1.3	-1.2
Length of working week for main job	1.3	1.4	3.7	-0.7	-0.3	1.9
Mean time to correctly identify matches	1.3	2.4	3.8	1.9	1.8	0.4
Intelligence (Savage-Jansen 2018)	1.2	3.6	4.6	2.2	1.9	1.6
HbA1C	1.2	1.3	3.0	1.7	0.9	0.2
Medication for hormone replacement therapy	1.2	1.3	2.6	-1.6	-1.1	-0.5
Townsend deprivation index at recruitment	1.2	1.7	2.9	-0.9	-1.2	-1.7
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	2.6	0.9	1.6	0.7
Loud music exposure frequency	1.2	1.3	3.7	-0.1	-0.4	-1.9
Osteoporosis (self-reported)	1.2	1.4	3.1	-1.0	-0.4	1.8
Medication: Atorvastatin	1.2	1.5	2.7	-1.6	-1.4	-0.3
Alcohol drinker status: Never	1.2	1.5	3.7	-0.7	0.5	1.9
Bipolar Disorder or Schizophrenia	1.1	2.6	5.6	2.4	1.5	0.3
Number of incorrect matches in round	1.1	1.7	3.4	1.9	1.2	-0.5
Heel bone mineral density (BMD) T-score, automated (right)	1.1	2.4	3.0	1.7	1.4	1.6
Guilty feelings	1.1	1.7	3.3	0.8	1.0	1.8
Alzheimer’s Disease (in father)	1.0	1.0	1.8	-1.3	-1.1	-0.4
Irritable Bowel Disease (IBD)	1.0	2.4	4.3	-2.1	-1.6	-0.4
Hypothyroidism (self reported)	1.0	2.2	4.1	0.5	1.5	2.0
Diabetes (father)	1.0	1.3	1.9	0.9	1.4	1.1
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.4	2.7	1.6	1.4	1.6
High blood pressure (mother)	1.0	1.4	2.2	-1.4	-1.5	0.1
Illnesses of siblings	1.0	1.4	2.2	1.5	1.3	0.4
Birth weight	1.0	2.2	3.3	1.8	1.8	0.2
Exposure to tobacco smoke outside home	1.0	1.3	2.9	-0.8	-0.6	-1.7
Medication: Aspirin	1.0	1.3	1.6	-0.9	-1.2	-1.3
Eye problems/disorders: Glaucoma	1.0	1.2	2.0	-1.0	-0.8	-1.4
Unable to work because of sickness or disability	1.0	1.3	2.6	-1.1	-0.3	-1.6
Cholesterol lowering medication	1.0	1.5	2.5	-1.6	-1.1	-0.9
Crohns Disease (2012)	0.9	1.4	3.1	-1.8	-1.1	0.0
Blood Platelet Count	0.9	10.7	11.4	-3.1	-3.4	-3.3
Blood White Count	0.9	7.0	8.7	-3.0	-2.7	-2.2
Current tobacco smoking	0.9	1.4	2.2	-1.4	-1.5	-0.2
Falls in the last year	0.9	1.2	2.3	-0.1	1.2	1.5
Hair/balding pattern: Pattern 3	0.9	1.3	3.5	0.0	-0.6	-1.9
Forced expiratory volume in 1-second (FEV1)	0.9	3.1	4.9	2.2	2.1	0.5
Pulse rate	0.9	1.5	2.0	-1.1	-1.2	-1.4
Mouth/teeth dental problems: Dentures	0.9	1.5	2.5	1.4	1.6	0.3
Alcohol intake frequency.	0.9	2.0	3.3	-1.8	-1.7	-0.0
Coronary Artery Disease (CAD)	0.8	0.9	1.6	-0.9	-0.7	1.2
Severe depression (siblings)	0.8	0.9	1.1	-0.8	-1.0	1.0
Pack years adult smoking proportion	0.8	1.3	1.8	-0.9	-1.4	-1.1
Average weekly fortified wine intake	0.8	1.0	2.6	-0.4	-0.4	-1.6
Impedance of leg (left)	0.8	3.8	5.8	2.4	2.4	-0.1
Allergy	0.8	1.7	3.3	1.8	1.3	0.3
Trunk fat-free mass	0.8	4.4	7.4	-2.7	-2.4	-0.4
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.4	3.2	-1.8	-0.9	0.3
Medication: Cholesterol lowering	0.8	1.2	2.2	-1.2	-1.5	0.1
Trunk predicted mass	0.8	4.4	7.3	-2.7	-2.4	-0.4
Hypothyroidism/myxoedema (self-reported)	0.8	1.5	2.6	0.5	1.6	1.3
Migraine (self-reported)	0.8	1.0	1.3	-1.1	-0.8	1.1
Comparative height size at age 10	0.8	4.1	8.2	1.4	1.5	2.9
Smoking status: Current	0.8	1.2	1.9	-1.2	-1.4	-0.6
Basal cell carcinoma (self-reported)	0.8	1.0	1.6	-0.4	-1.0	-1.3
Pack years of smoking	0.8	1.1	1.7	-0.8	-1.3	-1.0
Ever used hormone-replacement therapy (HRT)	0.7	0.9	1.6	-1.3	-1.0	-0.0
Multivitamins +/- minerals	0.7	0.9	1.1	1.0	0.9	-0.8
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	2.2	0.4	0.4	1.5
Medication: Lansoprazole	0.7	0.8	1.1	-0.8	-0.8	-1.0
Standing height	0.7	6.9	7.3	2.5	2.6	2.7
Mouth/teeth dental problems: Bleeding gums	0.7	0.8	1.0	-0.9	-0.9	-1.0
Medication: Allopurinol	0.7	0.9	1.3	-1.1	-1.0	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	2.4	0.8	1.6	0.3
Other serious medical condition/disability diagnosed by doctor	0.6	0.7	2.0	-1.4	-0.4	0.1
Relative age voice broke	0.6	0.9	2.0	-1.4	-0.5	0.7
Qualifications: None of the above	0.6	1.3	1.9	-1.4	-1.4	-0.4
Noisy workplace	0.6	0.7	1.2	-1.1	-0.9	0.5
Pulse rate, automated reading	0.6	1.9	3.7	-1.9	-1.3	-0.6
Medication: Aspirin	0.6	0.7	1.5	-0.4	-0.7	-1.2
Heart attack/myocardial infarction (self-reported)	0.6	0.7	1.5	-0.8	-1.2	-0.4
Alzheimer’s Disease (in mother)	0.5	0.6	1.0	-1.0	-0.8	-0.4
Crohns Disease (2017)	0.5	1.0	2.2	-1.5	-0.9	0.3
LDL Cholesterol	0.5	0.8	1.5	1.2	0.9	0.4
Ulcerative Colitis	0.5	0.7	1.1	-1.0	-0.8	-0.5
Heel T-Score	0.5	3.7	4.7	2.2	2.1	1.4
Supplements: Zinc	0.5	0.6	1.4	0.4	1.2	0.4
Impedance of leg (right)	0.5	2.2	3.6	1.9	1.7	0.2
Hayfever, allergic rhinitis or eczema	0.5	1.0	1.3	0.9	1.1	1.0
Pain all over the body in last month	0.5	0.5	0.9	-0.9	-0.8	-0.4
Depression (self-reported)	0.5	0.6	1.0	0.1	1.0	0.9
Breastfed as a baby	0.5	0.6	1.7	-0.3	-0.3	-1.3
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.5	-0.6	0.2	1.2
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	1.4	0.9	1.2	1.1
Friendships satisfaction	0.5	0.6	1.0	0.9	1.0	0.4
Ulcerative Colitis (UC)	0.4	0.8	1.1	-1.1	-0.9	-0.5
Major Depression (MDD)	0.4	0.5	0.9	-0.6	-0.9	-0.5
Prostate Cancer	0.4	0.6	1.0	1.0	0.3	-0.8
Schizophrenia (2014)	0.4	0.9	1.9	0.8	0.3	-1.4
Blood Red Count	0.4	3.6	4.8	-1.6	-1.9	-2.2
Hearing difficulty/problems: Yes	0.4	0.7	1.3	-0.3	-0.8	-1.1
Relative age of first facial hair	0.4	0.8	0.8	-0.8	-0.9	-0.9
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.3	0.1	0.1	-1.1
Diabetes (mother)	0.4	0.5	0.8	-0.7	-0.3	0.9
Heart attack	0.4	0.5	1.2	-0.6	-1.1	-0.2
Time employed in main current job	0.4	0.4	1.0	0.4	0.3	1.0
Prospective memory result	0.4	0.4	0.7	0.5	0.8	0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.4	0.5	-0.7	-0.4	-0.7
Loneliness, isolation	0.4	0.6	0.9	-0.4	0.9	1.0
Miserableness	0.4	0.8	1.8	-0.7	0.2	1.3
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.2	-0.5	0.1	1.1
Alcohol drinker status: Previous	0.4	0.5	0.9	-0.3	-0.9	-0.7
Schizophrenia (2018)	0.3	0.7	1.7	1.3	0.5	-0.4
Verbal and Numeric Reasoning (VNR)	0.3	0.7	0.8	0.8	0.9	0.8
Lupus	0.3	0.4	0.8	-0.2	-0.5	-0.9
Vitamin and mineral supplements	0.3	0.4	0.8	-0.9	-0.7	0.2
Medication: Metformin	0.3	0.4	1.0	-0.3	0.5	1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.5	0.7	0.7	0.5
Supplements: Glucosamine	0.3	0.4	1.1	1.1	0.3	0.1
Mouth/teeth dental problems	0.3	0.4	0.6	-0.7	-0.8	0.1
Fluid intelligence score	0.3	0.6	1.1	1.0	0.8	-0.1
Father’s age at death	0.3	0.4	0.7	0.6	0.2	0.8
Qualifications: O levels/GCSEs or equivalent	0.3	0.6	1.0	-0.6	-0.5	-1.0
Number of full brothers	0.3	0.4	0.7	-0.7	-0.2	0.8
Financial situation satisfaction	0.3	0.3	0.7	0.8	0.5	0.3
Ever depressed for a whole week	0.3	0.4	1.0	-1.0	-0.3	-0.3
Mean Putamen Volume	0.2	0.3	0.6	0.4	0.3	-0.8
Triglycerides	0.2	0.3	0.4	-0.5	-0.4	0.6
Height	0.2	4.0	5.2	1.7	2.0	2.3
Allergy or Eczema	0.2	0.4	0.7	0.7	0.9	0.2
Type 2 Diabetes (T2D) (2018)	0.2	0.4	0.6	-0.2	0.7	0.8
Fed-up feelings	0.2	0.4	0.7	-0.7	0.0	0.8
Age when periods started (menarche)	0.2	0.5	0.9	-1.0	-0.6	-0.4
Hearing difficulty/problems with background noise	0.2	0.3	0.4	-0.6	-0.5	-0.6
Medication: Ramipril	0.2	0.3	0.6	-0.8	-0.4	-0.2
Number of live births	0.2	0.3	0.6	-0.8	-0.5	0.3
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.3	-0.4	-0.2	0.6
Lung cancer (father)	0.2	0.3	0.6	0.8	0.2	0.3
Comparative body size at age 10	0.2	0.5	1.4	-0.1	0.1	1.2
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.7	0.0	0.0	-0.9
Illnesses of father: Heart disease	0.2	0.2	0.4	-0.7	-0.4	0.2
Illnesses of father: None of the above (group 1)	0.2	0.3	0.6	0.8	0.2	-0.5
Wears glasses or contact lenses	0.2	0.2	0.5	-0.4	-0.7	-0.3
Ever taken oral contraceptive pill	0.2	0.3	0.8	0.0	-0.3	-0.9
Commuting to job workplace: Public transport	0.2	0.2	0.3	0.3	0.5	0.5
Age started oral contraceptive pill	0.2	0.2	0.4	0.3	0.7	-0.4
Supplements: Calcium	0.2	0.2	0.4	0.6	0.4	-0.3
Depressed Affect (Nagel 2018)	0.1	0.3	0.7	-0.2	0.3	0.8
Alzheimer’s Disease (including proxy)	0.1	0.2	0.3	-0.5	-0.3	-0.4
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.1	0.2	0.3	0.3
Hair Pigment	0.1	3.3	4.0	-1.7	-2.0	-1.7
Tanning	0.1	0.7	1.7	0.6	1.3	0.3
Sensitivity / hurt feelings	0.1	0.2	0.5	-0.7	-0.3	0.0
Hayfever/allergic rhinitis (self-reported)	0.1	0.2	0.3	0.0	0.4	0.6
Pulse wave reflection index	0.1	0.2	0.2	-0.4	-0.3	0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.4	-0.6	0.1	0.1
Diabetes diagnosed by doctor	0.1	0.1	0.2	-0.2	0.4	0.4
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.2	-0.4	-0.0	-0.3
Risk taking	0.1	0.1	0.3	0.1	-0.3	-0.6
Fasting Glucose	0.0	0.0	0.1	0.1	0.3	-0.1
Blood Eosinophil Count	0.0	0.1	0.1	0.3	-0.3	0.2
Medication: Levothyroxine sodium	0.0	0.0	0.0	-0.2	0.2	0.1
Chronic bronchitis/emphysema (father)	0.0	0.0	0.1	-0.3	-0.2	0.0
Diabetes (self-reported)	0.0	0.1	0.2	-0.1	0.5	0.1
Hair/balding pattern: Pattern 4	0.0	0.1	0.1	-0.3	-0.1	0.3
Gout (self-reported)	0.0	0.1	0.1	0.2	0.4	-0.1
High blood pressure (siblings)	0.0	0.1	0.1	-0.2	-0.2	0.3
Chest pain or discomfort	0.0	0.1	0.1	0.0	0.4	0.1
Supplements: Vitamin C	0.0	0.0	0.0	0.0	0.0	-0.2
High cholesterol (Self-reported)	0.0	0.0	0.1	-0.2	-0.1	-0.0
Heart disease (siblings)	0.0	0.0	0.0	0.1	-0.0	0.1

Hub : Genes

MLLT10

Models

Trait associations