TWAS hub - CASC10

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.0473	0.0244	0.00490	0.058	NA	0.013	NA	0.018	2.4e-05	NA	0.030	NA	0.013
2	GTEx	Skin Sun Exposed Lower leg	0.0760	0.0330	0.00026	0.018	NA	0.006	NA	0.008	1.1e-02	NA	0.092	NA	0.061

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Number of operations (self-reported)	20.3	30.2	33.6	5.8	5.2
Ovarian Cancer	20.0	26.5	33.1	-4.5	-5.8
Leg fat percentage (right)	16.1	58.5	80.5	6.0	9.0
Leg fat percentage (left)	15.3	55.2	75.5	5.9	8.7
Leg fat mass (right)	14.7	57.0	75.5	6.2	8.7
Waist circumference	14.2	51.9	71.1	5.7	8.4
Leg fat mass (left)	14.0	54.7	72.2	6.1	8.5
Ever had hysterectomy (womb removed)	12.8	14.5	19.8	3.0	4.5
Bilateral oophorectomy (both ovaries removed)	11.3	13.1	15.0	3.4	3.9
Breast cancer (self-reported)	11.3	13.5	14.3	3.8	3.6
Had major operations	11.2	13.1	15.8	4.0	3.2
Hip circumference	11.1	48.0	55.4	6.4	7.4
Whole body fat mass	10.9	45.6	59.5	5.6	7.7
Body mass index (BMI)	10.7	45.6	65.1	5.1	8.1
Body fat percentage	10.7	42.3	58.8	5.1	7.7
BMI	10.1	58.5	85.0	5.7	9.2
Smoking status: Previous	10.1	15.1	17.9	3.5	4.2
Trunk fat mass	9.5	40.7	53.4	5.3	7.3
Maternal smoking around birth	9.1	13.2	21.2	2.3	4.6
Arm fat mass (left)	9.1	37.3	51.0	4.9	7.1
Past tobacco smoking	8.8	16.1	20.5	-3.4	-4.5
Arm fat mass (right)	8.8	36.3	49.1	4.9	7.0
Trunk fat percentage	8.6	34.3	48.6	4.5	7.0
Smoking Status	8.5	20.3	30.2	3.2	5.5
Breast Cancer	8.4	20.3	34.8	-2.4	-5.9
Arm fat percentage (left)	8.3	33.1	48.8	4.2	7.0
Medication: Paracetamol	8.0	13.3	20.7	2.4	4.5
Ever had bowel cancer screening	7.8	9.1	11.6	2.6	3.4
Weight	7.7	37.6	42.9	5.7	6.6
Arm fat percentage (right)	7.5	29.6	44.3	3.9	6.7
Number of treatments/medications taken	7.4	13.4	21.0	2.4	4.6
Medication: Paracetamol	7.4	11.4	19.4	1.8	4.4
Bipolar Disorder (2011)	6.8	6.6	6.6	-2.6	-2.6
Had other major operations	6.4	7.8	11.9	1.9	3.5
Medication: Omeprazole	6.1	7.3	9.1	3.0	2.3
Emphysema/chronic bronchitis	5.7	6.4	9.1	1.9	3.0
Lung FVC	5.4	27.6	35.6	-4.4	-6.0
Shortness of breath walking on level ground	5.4	6.4	9.2	1.9	3.0
Medication for pain relief, constipation, heartburn	5.4	9.2	12.8	-2.4	-3.6
Arm predicted mass (right)	5.3	27.0	27.1	5.2	5.2
Number of full sisters	5.1	6.2	11.5	1.0	3.4
Average weekly red wine intake	5.1	7.5	12.5	-1.6	-3.5
Handedness (chirality/laterality): Left-handed	5.1	6.1	8.9	3.0	1.8
Arm fat-free mass (left)	5.1	26.1	28.6	5.3	4.9
Number of self-reported non-cancer illnesses	5.0	8.7	11.8	2.4	3.4
Chronic bronchitis/emphysema (mother)	4.9	5.8	9.4	1.5	3.1
Forced vital capacity (FVC), Best measure	4.9	18.0	30.2	-2.4	-5.5
Arm fat-free mass (right)	4.9	25.1	26.4	5.1	4.9
Arm predicted mass (left)	4.8	24.5	26.8	5.2	4.7
Medication: Omeprazole (e.g. Zanprol)	4.7	5.8	8.5	2.9	1.7
Pain experienced in last month	4.6	7.7	9.4	-2.4	-3.1
Impedance of arm (right)	4.4	20.4	26.4	-3.8	-5.1
Worry (Nagel 2018)	4.3	9.1	16.2	-1.4	-4.0
Asthma	4.3	8.6	13.4	1.9	3.7
Medication: Bendroflumethiazide	4.3	6.5	7.6	2.3	2.8
Ever smoked	4.3	7.5	8.4	2.6	2.9
Taking other prescription medications	4.2	6.4	8.0	2.2	2.8
Alcohol intake versus 10 years previously	4.2	6.3	10.8	1.4	3.3
Impedance of arm (left)	4.1	18.9	24.1	-3.7	-4.9
Worry too long after embarrassment	4.0	6.6	11.3	-1.4	-3.4
Diastolic blood pressure, automated reading	3.9	11.9	18.8	2.3	4.3
Forced vital capacity (FVC)	3.8	14.5	21.7	-2.7	-4.7
Peak expiratory flow (PEF)	3.8	8.9	15.3	1.6	3.9
Back pain experienced in last month	3.8	5.5	6.3	2.5	2.2
Supplements: Fish oil (including cod liver oil)	3.8	5.0	9.0	-1.0	-3.0
Hearing aid user	3.7	4.2	4.2	2.1	2.0
Basal metabolic rate	3.6	19.9	22.4	4.7	4.2
Reaction Time	3.5	6.7	10.6	-3.3	-1.7
Hand grip strength (right)	3.5	9.5	15.0	-2.0	-3.9
Serious illness, injury or assault to yourself	3.5	4.3	4.8	2.0	2.2
Hand grip strength (left)	3.4	8.8	15.1	-1.6	-3.9
Medication: Co-codamol	3.4	3.9	5.3	2.3	1.6
Qualifications: College or University degree	3.4	10.6	17.4	-2.0	-4.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.4	7.3	7.7	-2.6	-2.8
Vascular/heart problems diagnosed by doctor	3.4	9.2	14.6	-1.9	-3.8
Leg fat-free mass (left)	3.3	17.3	18.8	4.3	4.0
Illnesses of mother	3.3	4.1	4.7	-1.9	-2.2
Asthma (self-reported)	3.3	6.6	10.2	1.7	3.2
Deep venous thrombosis (DVT) (self-reported)	3.3	4.3	7.4	1.1	2.7
Worrier / anxious feelings	3.2	6.1	11.4	-0.9	-3.4
Qualifications: O levels/GCSEs or equivalent	3.2	5.1	8.6	2.9	1.3
Pulse wave peak to peak time	3.2	3.8	5.6	-1.4	-2.4
Medication: Ventolin 100micrograms inhaler	3.1	4.0	8.0	0.2	2.8
Commuting to job workplace: Car/motor vehicle	3.1	3.5	7.0	-0.3	2.6
Respiratory disease	3.0	6.7	7.1	2.5	2.7
Leg predicted mass (left)	3.0	16.0	17.5	4.2	3.8
Tense / ‘highly strung’	3.0	5.0	7.6	-1.6	-2.7
Health satisfaction	3.0	3.8	4.5	1.8	2.1
Overall health rating	3.0	6.5	11.3	1.3	3.4
Pulse wave Arterial Stiffness index	2.9	3.4	4.8	1.4	2.2
Birth weight of first child	2.9	5.3	6.1	2.5	2.1
Age at first live birth	2.9	5.2	8.6	-1.3	-2.9
Medication: Blood pressure	2.9	5.6	8.7	1.6	3.0
Depression (Nagel 2018)	2.8	4.2	6.6	-2.6	-1.4
Mean time to correctly identify matches	2.8	5.4	8.0	-2.8	-1.7
Osteoarthritis (self-reported)	2.8	3.6	4.4	1.6	2.1
Medication for cholesterol	2.7	4.2	6.7	-1.3	-2.6
Whole body water mass	2.7	15.5	19.4	4.4	3.4
Irritability	2.7	4.6	7.9	-1.1	-2.8
Ulcerative Colitis (UC)	2.6	4.8	7.8	2.8	1.4
Qualifications: CSEs or equivalent	2.6	3.5	6.9	-0.3	2.6
Alcohol usually taken with meals	2.6	4.2	6.9	-1.2	-2.6
Heel bone mineral density (BMD) T-score, automated (right)	2.6	5.9	7.5	-2.7	-2.1
Age at last live birth	2.6	3.8	4.2	-1.8	-2.0
Whole body fat-free mass	2.6	15.1	18.9	4.3	3.4
Commuting to job workplace: Walk	2.6	2.8	5.5	-0.5	-2.3
Pain type(s) experienced in last month: Hip pain	2.6	3.3	4.3	1.5	2.1
Lung FEV1/FVC ratio	2.5	12.7	22.8	1.6	4.8
Chronotype (morning person)	2.5	5.7	7.5	-2.0	-2.7
Myopia	2.5	3.6	4.4	-2.1	-1.7
High blood pressure	2.4	6.7	11.5	1.4	3.4
Nervous feelings	2.4	4.5	6.2	-1.7	-2.5
Forced expiratory volume in 1-second (FEV1), Best measure	2.4	7.6	11.5	-1.9	-3.4
Leg pain on walking	2.4	3.0	3.0	1.7	1.7
Hypertension (Self-reported)	2.4	6.7	12.0	1.2	3.5
Commuting to job workplace: Cycle	2.4	2.9	5.0	-0.9	-2.2
Neuroticism score	2.3	4.8	8.6	-1.0	-2.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.3	2.8	4.3	1.1	2.1
Impedance of whole body	2.3	11.5	12.9	-3.2	-3.6
Schizophrenia vs Biploar Disorder	2.2	2.9	4.7	1.1	2.2
Age at First Birth	2.2	3.3	5.2	-1.2	-2.3
Ulcerative Colitis	2.2	3.2	3.7	1.9	1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.2	2.6	4.1	2.0	1.1
Neuroticism (Nagel 2018)	2.1	5.0	9.2	-0.9	-3.0
Blood clot in the leg (DVT)	2.1	2.7	4.8	0.8	2.2
Medication for cholesterol, blood pressure or diabetes	2.1	3.4	5.7	-1.1	-2.4
Migraine (self-reported)	2.1	2.6	3.8	1.9	1.2
Leg fat-free mass (right)	2.1	11.3	13.0	3.6	3.1
Leg predicted mass (right)	2.1	11.4	13.2	3.6	3.1
Neuroticism	2.0	4.8	8.9	-0.8	-3.0
Stomach or abdominal pain in last month	2.0	2.5	4.9	0.3	2.2
Trunk fat-free mass	2.0	11.4	15.9	4.0	2.6
Happiness	2.0	2.5	4.7	-0.5	-2.2
Trunk predicted mass	2.0	11.4	16.0	4.0	2.6
Body Mass Index (BMI) (2010)	1.9	2.6	3.7	1.2	1.9
Hearing difficulty/problems: Yes	1.9	2.9	5.1	2.3	0.8
Heel bone mineral density (BMD) T-score, automated (left)	1.9	4.4	5.8	-2.4	-1.7
Qualifications: A levels/AS levels or equivalent	1.9	4.2	7.6	-0.9	-2.7
Medication: Gliclazide	1.9	2.2	3.0	-1.7	-1.2
Alzheimer’s Disease (in mother)	1.8	2.2	2.3	1.5	1.4
Ever used hormone-replacement therapy (HRT)	1.8	2.3	3.0	1.7	1.3
Systolic blood pressure, automated reading	1.8	5.2	9.7	0.9	3.1
Relative age voice broke	1.8	2.7	3.4	1.9	1.4
Knee pain experienced in last month	1.8	2.8	3.5	1.5	1.9
Frequency of unenthusiasm / disinterest in last 2 weeks	1.7	2.2	4.4	-2.1	-0.1
Chronic bronchitis/emphysema (father)	1.7	2.0	3.9	2.0	0.3
Forced expiratory volume in 1-second (FEV1)	1.7	5.9	7.1	-2.2	-2.7
Lung cancer (father)	1.7	2.0	3.0	-1.7	-1.0
Headache pain in last month	1.7	2.9	3.7	1.5	1.9
Neck or shoulder pain in last month	1.7	2.4	4.5	0.5	2.1
Illnesses of father: High blood pressure	1.7	2.1	3.9	0.5	2.0
Number of incorrect matches in round	1.6	2.7	4.1	-1.1	-2.0
Medication: Lisinopril	1.6	2.1	3.2	1.8	1.0
Neuroticism (2016)	1.5	2.1	3.2	-1.0	-1.8
Systolic Blood Pressure	1.5	7.3	14.5	-0.2	3.8
Hearing difficulty/problems with background noise	1.5	2.3	4.0	2.0	0.8
Had menopause	1.5	1.8	3.5	-0.4	-1.9
Medication: Blood pressure	1.5	2.7	5.0	0.7	2.2
Suffer from ‘nerves’	1.5	2.4	4.7	-0.4	-2.2
Tinnitus: Yes, now most or all of the time	1.5	1.7	3.4	1.8	0.1
Risk taking	1.5	2.1	4.2	2.0	-0.3
Ever had prostate specific antigen (PSA) test	1.5	1.8	3.1	1.8	0.6
Irritable Bowel Disease (IBD)	1.4	3.3	3.6	1.8	1.9
Exposure to tobacco smoke at home	1.4	1.5	3.0	0.3	1.7
Fractured/broken bones in last 5 years	1.4	1.8	3.1	0.7	1.8
Bipolar Disorder (2018)	1.3	2.1	4.2	-0.2	-2.0
Waist Hip Ratio (WHR)	1.3	5.8	11.6	0.2	3.4
Cardiovascular Disease	1.3	4.4	8.8	-0.1	3.0
Medication: Simvastatin	1.3	1.9	3.5	0.6	1.9
Number of children fathered	1.3	1.5	2.1	1.0	1.4
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	3.2	-0.2	-1.8
Illnesses of siblings: Diabetes	1.3	1.6	2.5	0.8	1.6
Long-standing illness, disability or infirmity	1.3	2.1	3.5	0.8	1.9
Friendships satisfaction	1.3	1.6	2.1	1.5	-1.0
Qualifications: nursing, teaching	1.3	2.0	3.4	0.8	-1.8
Mother’s age at death	1.3	1.7	3.3	0.2	-1.8
Alzheimer’s Disease (in father)	1.2	1.4	2.5	-0.4	1.6
High blood pressure (mother)	1.2	1.6	2.0	1.1	1.4
Noisy workplace	1.2	1.5	1.5	1.2	1.2
Bipolar Disorder or Schizophrenia	1.1	2.6	3.9	-1.1	-2.0
Medication for hormone replacement therapy	1.1	1.2	1.8	0.8	1.4
Age when periods started (menarche)	1.1	2.7	5.3	2.3	0.1
Sitting height	1.1	7.6	14.9	-0.6	-3.9
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.7	2.2	1.1	1.5
Age started oral contraceptive pill	1.1	1.3	2.6	1.6	-0.2
Mean Putamen Volume	1.0	1.2	2.2	1.5	-0.4
Type 2 Diabetes (T2D) (2012)	1.0	1.2	2.4	1.5	-0.2
Heel T-Score	1.0	8.1	10.4	-3.2	-2.4
Pack years adult smoking proportion	1.0	1.6	2.0	1.4	1.0
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.2	2.0	0.7	1.4
Glaucoma (self-reported)	1.0	1.2	2.3	0.0	1.5
Birth weight	1.0	2.2	4.3	0.1	-2.1
Wheeze or whistling in the chest in last year	1.0	1.7	3.4	-0.0	1.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	2.5	0.0	1.6
Family relationship satisfaction	1.0	1.3	2.5	0.3	-1.6
Coronary Artery Disease (CAD)	0.9	1.1	1.9	0.4	1.4
LDL Cholesterol	0.9	1.5	1.5	-1.2	-1.2
Average weekly spirits intake	0.9	1.1	2.0	0.4	1.4
Frequency of depressed mood in last 2 weeks	0.9	1.3	1.5	-1.2	-1.1
Current tobacco smoking	0.9	1.5	2.7	0.4	1.6
Tinnitus: Yes, but not now, but have in the past	0.9	0.9	1.7	-0.3	-1.3
Mineral and other dietary supplements	0.9	1.2	2.2	0.5	1.5
Average weekly champagne plus white wine intake	0.9	1.2	2.5	-0.0	-1.6
Pack years of smoking	0.9	1.3	1.8	1.4	0.9
Supplements: Zinc	0.8	0.8	1.5	-0.4	-1.2
Impedance of leg (left)	0.8	3.7	4.0	-1.8	-2.0
Hayfever/allergic rhinitis (self-reported)	0.8	1.0	1.9	-1.4	-0.4
Illnesses of siblings	0.8	1.2	1.3	-1.0	-1.1
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.4	2.1	0.8	1.4
Loud music exposure frequency	0.8	0.8	1.5	1.2	0.4
Gout (self-reported)	0.8	1.0	1.9	-0.4	-1.4
Angina (self-reported)	0.8	1.0	1.5	0.7	1.2
Medication: Ibuprofen	0.8	1.0	2.0	0.1	1.4
Medication: Seretide 50 evohaler	0.8	0.9	1.4	-0.7	1.2
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	1.4	1.2	0.8
Medication: Aspirin	0.8	1.1	1.3	0.9	1.1
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.8	1.5	-0.4	-1.2
Intelligence (Savage-Jansen 2018)	0.7	2.0	3.7	-0.6	-1.9
HbA1C	0.7	0.8	1.4	-0.3	-1.2
Blood White Count	0.7	5.3	10.2	-0.6	3.2
Angina	0.7	1.0	1.6	0.6	1.2
Financial difficulties in last 2 years	0.7	0.9	1.9	0.1	1.4
Allergy	0.7	1.7	2.8	-0.8	-1.7
Number of live births	0.7	1.0	1.7	0.5	1.3
Eye problems/disorders: None of the above	0.7	0.8	1.6	1.3	-0.2
Financial situation satisfaction	0.7	0.9	1.5	-1.2	-0.6
Heart attack/myocardial infarction (self-reported)	0.7	0.9	1.5	1.2	0.5
Schizophrenia (2018)	0.6	1.2	1.6	-1.3	-0.9
Fasting Glucose	0.6	0.7	1.0	1.0	-0.6
HDL Cholesterol	0.6	0.9	1.1	-1.0	-0.9
Diabetes (father)	0.6	0.7	1.0	-0.7	-1.0
Townsend deprivation index at recruitment	0.6	0.8	1.6	0.3	1.3
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	1.9	0.1	-1.4
Qualifications: None of the above	0.6	1.3	2.5	0.5	1.6
Heart attack	0.6	0.7	1.4	1.2	0.3
Pulse wave reflection index	0.6	0.8	1.4	1.2	0.3
Medication: Amlodipine	0.6	0.9	1.6	-0.4	1.2
Exposure to tobacco smoke outside home	0.6	0.8	0.9	0.9	0.8
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	1.6	-0.5	-1.3
Smoking status: Current	0.6	1.0	1.9	0.2	1.4
Guilty feelings	0.6	0.9	1.4	-0.6	-1.2
Ever depressed for a whole week	0.6	0.7	1.0	1.0	0.6
Alcohol drinker status: Previous	0.6	0.7	0.9	0.9	0.7
Crohns Disease (2012)	0.5	0.8	1.5	-0.0	1.2
Primary Biliary Cirrhosis	0.5	0.7	1.1	1.0	0.6
Blood Platelet Count	0.5	5.9	9.9	1.4	3.1
Height	0.5	9.0	15.4	3.9	-1.6
Medication: Atenolol	0.5	0.7	1.2	-1.1	0.4
Prospective memory result	0.5	0.7	0.7	0.8	-0.8
Pulse rate, automated reading	0.5	1.6	1.8	1.2	1.3
Eye problems/disorders: Cataract	0.5	0.6	1.1	-0.2	1.1
Eye problems/disorders: Glaucoma	0.5	0.6	1.1	0.0	1.1
Alzheimer’s Disease (including proxy)	0.4	0.5	0.8	0.5	0.9
Rheumatoid Arthritis	0.4	0.5	0.9	0.4	-0.9
Hypothyroidism (self reported)	0.4	0.9	1.6	-0.4	-1.3
Hayfever, allergic rhinitis or eczema	0.4	0.8	1.3	-0.7	-1.1
Multivitamins +/- minerals	0.4	0.5	0.6	-0.6	-0.8
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.0	-1.0	-0.2
Medication: Ramipril	0.4	0.6	1.1	-1.0	0.3
Time employed in main current job	0.4	0.5	0.9	1.0	-0.1
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	0.7	-0.8	0.4
Medication: Cholesterol lowering	0.4	0.6	1.1	0.4	1.0
Medication: Lansoprazole	0.4	0.4	0.7	-0.5	0.8
Standing height	0.4	4.0	5.5	1.6	-2.4
Ever highly irritable/argumentative for 2 days	0.4	0.5	0.6	0.8	0.7
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	0.9	0.5	0.9
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	1.3	-0.3	-1.1
Alcohol intake frequency.	0.4	0.9	1.8	0.2	1.3
Mood swings	0.4	0.7	0.8	0.8	-0.9
Medication: Aspirin	0.4	0.5	0.5	0.7	0.6
Medication: Atorvastatin	0.4	0.5	1.1	0.2	1.0
Alcohol drinker status: Never	0.4	0.5	0.6	-0.8	-0.6
Cholesterol lowering medication	0.4	0.6	1.1	-0.5	1.0
Heart disease (siblings)	0.4	0.5	0.8	-0.9	-0.5
Verbal and Numeric Reasoning (VNR)	0.3	0.8	1.3	-0.5	-1.1
Relative age of first facial hair	0.3	0.7	1.2	0.4	1.1
Impedance of leg (right)	0.3	1.5	1.8	-1.1	-1.3
Hair/balding pattern: Pattern 2	0.3	0.3	0.7	-0.8	-0.1
Falls in the last year	0.3	0.3	0.6	0.2	-0.8
Depression (self-reported)	0.3	0.3	0.4	-0.4	-0.7
High blood pressure (siblings)	0.3	0.4	0.8	0.9	0.1
Heart disease (mother)	0.3	0.4	0.7	0.2	0.8
Comparative height size at age 10	0.3	1.4	1.7	1.3	-1.0
Supplements: Vitamin C	0.3	0.3	0.7	0.8	0.1
Wears glasses or contact lenses	0.3	0.3	0.4	0.5	0.6
Ever taken oral contraceptive pill	0.3	0.3	0.6	0.8	-0.1
Commuting to job workplace: Public transport	0.3	0.3	0.6	-0.1	-0.8
High cholesterol (Self-reported)	0.3	0.6	1.1	-1.1	-0.2
Average weekly beer plus cider intake	0.3	0.4	0.6	0.5	-0.8
Unable to work because of sickness or disability	0.3	0.4	0.7	-0.0	0.9
Crohns Disease (2017)	0.2	0.4	0.6	-0.5	0.8
Major Depression (MDD)	0.2	0.2	0.5	-0.7	0.1
Type 2 Diabetes (T2D) (2018)	0.2	0.4	0.7	0.8	-0.4
Tanning	0.2	2.7	5.2	-2.3	-0.5
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.4	0.6	0.3
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.4	-0.3	-0.6
Severe depression (siblings)	0.2	0.3	0.5	-0.2	0.7
Fed-up feelings	0.2	0.3	0.5	0.7	0.3
Supplements: Glucosamine	0.2	0.2	0.3	0.5	-0.4
Fluid intelligence score	0.2	0.4	0.6	-0.8	-0.5
Father’s age at death	0.2	0.3	0.5	0.7	-0.0
Pulse rate	0.2	0.4	0.6	0.4	0.8
Medication: Allopurinol	0.2	0.3	0.4	0.3	0.7
Chest pain or discomfort	0.2	0.3	0.5	0.7	0.0
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.3	0.5	0.7	-0.4
Osteoporosis (self-reported)	0.2	0.3	0.5	-0.2	0.7
Supplements: Calcium	0.2	0.2	0.4	0.3	-0.6
Basal cell carcinoma (self-reported)	0.2	0.2	0.3	-0.5	0.3
Depressed Affect (Nagel 2018)	0.1	0.2	0.4	0.6	-0.0
Prostate Cancer	0.1	0.1	0.2	-0.5	0.3
Lupus	0.1	0.2	0.3	-0.4	0.5
Schizophrenia (2014)	0.1	0.2	0.3	-0.3	-0.6
Blood Red Count	0.1	1.2	2.1	0.6	1.5
Allergy or Eczema	0.1	0.3	0.5	-0.3	-0.7
Hair Pigment	0.1	2.3	2.7	1.4	1.6
Sensitivity / hurt feelings	0.1	0.2	0.4	0.2	0.6
Vitamin and mineral supplements	0.1	0.1	0.1	-0.2	0.3
Diabetes (mother)	0.1	0.2	0.3	0.6	0.2
Average weekly fortified wine intake	0.1	0.1	0.1	-0.3	0.3
Ever unenthusiastic/disinterested for a whole week	0.1	0.2	0.2	-0.3	-0.5
Pain all over the body in last month	0.1	0.1	0.2	-0.3	0.4
Diabetes (self-reported)	0.1	0.2	0.3	0.6	-0.1
Hair/balding pattern: Pattern 3	0.1	0.1	0.1	0.3	0.3
Mouth/teeth dental problems: Dentures	0.1	0.2	0.2	0.5	-0.4
Length of working week for main job	0.1	0.1	0.2	-0.3	0.4
Breastfed as a baby	0.1	0.1	0.2	-0.4	0.2
Hair/balding pattern: Pattern 4	0.1	0.3	0.5	0.7	0.3
Comparative body size at age 10	0.1	0.4	0.7	-0.3	0.8
Number of full brothers	0.1	0.2	0.3	-0.2	0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.3	-0.6	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.1	0.2	0.3
Loneliness, isolation	0.1	0.1	0.1	-0.3	-0.3
Diabetes diagnosed by doctor	0.1	0.1	0.2	0.4	-0.2
Illnesses of father: None of the above (group 1)	0.1	0.1	0.2	-0.2	-0.4
Miserableness	0.1	0.2	0.2	0.5	0.4
Triglycerides	0.0	0.0	0.1	0.1	0.3
Blood Eosinophil Count	0.0	0.2	0.4	-0.0	0.6
Medication: Metformin	0.0	0.0	0.0	0.2	-0.2
Medication: Levothyroxine sodium	0.0	0.1	0.1	0.0	-0.3
Mouth/teeth dental problems	0.0	0.0	0.1	-0.3	0.1
Mouth/teeth dental problems: Loose teeth	0.0	0.0	0.0	-0.0	0.1
Illnesses of father: Heart disease	0.0	0.0	0.0	0.0	0.0

Hub : Genes

CASC10

Models

Trait associations