[Hub]/) : Traits : Leg fat-free mass (left) :

chr6:41,005,502-42,715,323

Best TWAS P=1.95e-27 · Best GWAS P=1.62e-27 conditioned to 5.39e-06

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex MED20 0.15 0.11 blup 471 0.13 3.1e-15 -7.63 7.2 4.8e-13 0.61 1.00 0.00 FALSE
2 GTEx Adipose Subcutaneous MED20 0.08 0.07 enet 9 0.05 4.7e-05 8.28 8.2 1.8e-16 0.61 0.96 0.01 FALSE
3 GTEx Adipose Subcutaneous FRS3 0.15 0.04 enet 22 0.04 5.9e-04 9.02 7.0 2.6e-12 0.57 0.20 0.56 FALSE
4 GTEx Artery Tibial MED20 0.14 0.11 lasso 2 0.09 9.7e-08 8.38 8.4 5.4e-17 0.60 0.99 0.01 FALSE
5 GTEx Cells EBV-transformed lymphocytes MED20 0.25 0.01 lasso 5 0.07 3.0e-03 -7.49 6.5 7.2e-11 0.53 0.15 0.12 FALSE
6 GTEx Cells Transformed fibroblasts MED20 0.11 0.05 lasso 4 0.08 9.4e-07 -9.54 9.9 4.9e-23 0.46 0.86 0.09 FALSE
7 GTEx Cells Transformed fibroblasts USP49 0.13 0.02 lasso 4 0.02 2.4e-02 -9.05 -8.4 5.9e-17 -0.37 0.29 0.03 FALSE
8 GTEx Colon Transverse MED20 0.17 0.01 enet 10 0.06 6.0e-04 8.37 9.6 5.2e-22 0.69 0.17 0.62 FALSE
9 GTEx Esophagus Mucosa MED20 0.09 0.07 enet 10 0.02 2.7e-02 -7.63 8.0 1.5e-15 0.59 0.76 0.13 FALSE
10 GTEx Esophagus Muscularis MED20 0.15 0.05 lasso 7 0.04 1.0e-03 -7.64 8.1 6.2e-16 0.62 0.45 0.50 FALSE
11 GTEx Heart Atrial Appendage MED20 0.14 0.12 enet 11 0.09 5.9e-05 8.09 7.9 3.9e-15 0.58 0.84 0.09 FALSE
12 GTEx Heart Left Ventricle PRICKLE4 0.11 0.05 lasso 4 0.03 9.8e-03 7.39 -7.7 1.7e-14 -0.59 0.26 0.06 FALSE
13 GTEx Heart Left Ventricle MED20 0.22 0.19 enet 8 0.12 5.8e-07 8.37 8.5 1.8e-17 0.61 1.00 0.00 FALSE
14 GTEx Lung BYSL 0.08 0.03 lasso 4 0.02 4.9e-03 9.25 -9.2 2.6e-20 -0.80 0.27 0.56 FALSE
15 GTEx Lung PRICKLE4 0.12 0.05 lasso 3 0.06 2.2e-05 7.39 -5.3 9.6e-08 -0.54 0.60 0.07 FALSE
16 GTEx Lung MED20 0.10 0.01 lasso 4 0.00 2.7e-01 -0.86 6.5 8.2e-11 0.52 0.06 0.32 FALSE
17 GTEx Lung USP49 0.09 0.08 lasso 2 0.05 6.2e-05 -9.05 -8.5 1.6e-17 -0.33 0.84 0.01 FALSE
18 GTEx Muscle Skeletal MED20 0.16 0.15 lasso 4 0.16 6.7e-16 7.39 7.7 1.7e-14 0.60 1.00 0.00 FALSE
19 GTEx Nerve Tibial MED20 0.13 0.11 enet 8 0.10 1.5e-07 8.09 8.1 7.4e-16 0.58 1.00 0.00 FALSE
20 GTEx Spleen MED20 0.44 0.13 enet 23 0.07 6.4e-03 8.38 7.1 1.4e-12 0.57 0.11 0.51 FALSE
21 GTEx Testis MED20 0.13 0.03 lasso 6 0.00 2.0e-01 -9.03 9.3 9.0e-21 0.46 0.16 0.17 FALSE
22 GTEx Thyroid MED20 0.05 0.05 lasso 2 0.02 8.1e-03 8.44 8.6 8.6e-18 0.61 0.50 0.36 FALSE
23 GTEx Thyroid FRS3 0.20 0.16 lasso 4 0.16 5.2e-12 9.02 8.4 5.1e-17 0.67 0.98 0.02 FALSE
24 METSIM Adipose BYSL 0.05 0.00 blup 476 0.02 2.3e-04 7.39 -5.3 1.3e-07 -0.46 0.18 0.06 FALSE
25 METSIM Adipose MED20 0.13 0.11 enet 27 0.11 2.3e-16 8.21 8.6 7.7e-18 0.61 1.00 0.00 FALSE
26 ROSMAP Brain Pre-frontal Cortex PGC 0.13 0.06 blup 520 0.06 3.2e-08 9.02 -7.8 9.2e-15 -0.58 0.97 0.03 FALSE
27 ROSMAP Brain Pre-frontal Cortex MED20 0.10 0.10 enet 21 0.09 6.0e-12 8.44 8.1 4.1e-16 0.61 1.00 0.00 FALSE
28 YFS Blood BYSL 0.07 0.06 lasso 7 0.09 2.8e-28 8.38 -5.2 1.5e-07 -0.55 1.00 0.00 FALSE
29 YFS Blood CCND3 0.02 0.01 enet 13 0.02 2.3e-06 7.93 -8.3 9.9e-17 -0.55 0.72 0.22 FALSE
30 YFS Blood MED20 0.04 0.03 lasso 5 0.03 3.6e-11 7.39 7.0 3.4e-12 0.61 1.00 0.00 FALSE
31 The Cancer Genome Atlas Breast Invasive Carcinoma CCND3 0.04 0.00 blup 99 0.01 1.8e-03 -8.98 8.2 1.6e-16 0.45 0.02 0.10 FALSE
32 The Cancer Genome Atlas Colon Adenocarcinoma MED20 0.05 0.00 blup 50 0.04 2.8e-03 7.39 10.9 1.9e-27 0.70 0.06 0.27 TRUE
33 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma MED20 0.04 0.03 lasso 3 0.04 7.3e-05 -9.54 9.6 5.5e-22 0.45 0.57 0.02 FALSE
34 The Cancer Genome Atlas Brain Lower Grade Glioma MED20 0.09 0.08 enet 12 0.09 5.5e-10 8.38 9.4 7.5e-21 0.62 1.00 0.00 FALSE
35 The Cancer Genome Atlas Liver Hepatocellular Carcinoma MED20 0.09 0.07 lasso 5 0.07 3.4e-04 -9.03 10.1 4.9e-24 0.51 0.17 0.55 FALSE
36 The Cancer Genome Atlas Lung Squamous Cell Carcinoma PRICKLE4 0.03 0.01 blup 43 0.02 1.6e-03 0.16 -5.6 2.4e-08 -0.58 0.23 0.42 FALSE
37 The Cancer Genome Atlas Prostate Adenocarcinoma MED20 0.04 0.06 enet 6 0.05 2.6e-06 7.39 8.7 3.0e-18 0.58 0.91 0.02 FALSE
38 The Cancer Genome Atlas Stomach Adenocarcinoma MED20 0.03 0.05 lasso 2 0.04 1.2e-03 -9.54 9.7 2.8e-22 0.44 0.11 0.06 FALSE
39 The Cancer Genome Atlas Thyroid Carcinoma BYSL 0.05 0.06 enet 7 0.06 4.3e-06 8.44 -8.1 4.6e-16 -0.56 0.82 0.09 FALSE
40 The Cancer Genome Atlas Thyroid Carcinoma PRICKLE4 0.04 0.03 lasso 3 0.04 1.1e-04 6.23 -5.9 2.9e-09 -0.60 0.38 0.20 FALSE