TWAS
hub
About
Usage
Models
Genes
Traits
[Hub]/) :
Traits
:
Leg fat-free mass (left)
:
←
→
chr6:141,924,760-143,855,272
Best TWAS P=1.08e-18 · Best GWAS P=1.68e-20 conditioned to 1
142M
142.5M
143M
143.5M
0
5
10
15
20
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Adipose Subcutaneous
GPR126
0.06
0.04
lasso
4
0.04
0.00061
-8.8
8.8
1.1e-18
-0.98
0.02
0.96
TRUE
4
The Cancer Genome Atlas
Uterine Corpus Endometrial Carcinoma
NMBR
0.09
0.01
blup
46
0.04
0.03380
3.7
-5.5
5.1e-08
0.11
0.02
0.64
TRUE
2
METSIM
Adipose
GPR126
0.05
0.01
blup
429
0.02
0.00019
-5.1
6.4
1.4e-10
-0.74
0.10
0.90
FALSE
3
NTR
Blood
HIVEP2
0.02
0.01
blup
424
0.01
0.00262
-3.4
-5.5
4.7e-08
0.41
0.34
0.05
FALSE