Hub : Genes

GPR126

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.0580	0.0250	0.00300	0.037	NA	0.028	NA	0.036	0.00051	NA	0.0023	NA	0.00061
2	GTEx	Colon Transverse	0.1270	0.0530	0.00510	-0.006	NA	-0.006	NA	-0.002	0.77000	NA	1.0000	NA	0.42000
3	METSIM	Adipose	0.0469	0.0163	0.00003	0.009	0.023	0.013	0.019	0.012	0.01300	0.00019	0.0039	0.00071	0.00470
4	TCGA	Bladder Urothelial Carcinoma	0.0590	0.0300	0.00440	-0.003	0.010	0.002	NA	-0.002	0.86000	0.04600	0.1900	NA	0.56000

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	1.3	2.1	4.0	-1.5	2.0	-1.4	-0.6
Bipolar Disorder or Schizophrenia	1.1	2.6	4.5	-2.1	1.8	-1.5	-0.6
Depressed Affect (Nagel 2018)	2.9	6.0	15.6	-1.7	1.7	-4.0	-1.7
Depression (Nagel 2018)	0.3	0.5	1.3	0.0	-0.6	-1.1	-0.4
Intelligence (Savage-Jansen 2018)	0.0	0.1	0.2	0.4	-0.5	-0.1	-0.1
Neuroticism (Nagel 2018)	1.1	2.7	6.2	-0.3	2.5	-1.5	-1.5
Schizophrenia (2018)	0.4	0.9	2.3	-1.5	0.7	-0.8	-0.0
Schizophrenia vs Biploar Disorder	1.3	1.7	4.2	0.5	-2.0	1.0	-1.1
Worry (Nagel 2018)	1.4	2.9	11.0	-0.4	3.3	0.6	-0.3
Alzheimer’s Disease (in mother)	2.3	2.7	5.3	-1.3	2.3	-1.6	-1.2
Alzheimer’s Disease (in father)	1.0	1.1	2.3	-0.6	1.5	-0.3	1.2
Alzheimer’s Disease (including proxy)	1.7	2.4	6.7	-1.3	2.6	-1.2	-0.2
Crohns Disease (2017)	0.7	1.5	2.3	-1.5	0.6	-1.5	1.2
Irritable Bowel Disease (IBD)	0.5	1.3	3.0	-1.7	0.4	-1.4	-0.1
Ulcerative Colitis (UC)	0.5	0.9	1.5	-1.2	0.1	-0.7	-1.2
Major Depression (MDD)	1.7	2.1	6.1	-1.1	1.0	-2.5	0.2
Reaction Time	0.1	0.2	0.5	-0.1	0.3	0.7	0.3
Verbal and Numeric Reasoning (VNR)	0.1	0.1	0.3	-0.3	0.5	-0.4	0.2
Breast Cancer	0.1	0.3	0.7	0.0	0.3	-0.7	-0.8
Ovarian Cancer	1.0	1.3	3.6	1.2	-0.0	1.9	-0.2
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.6	0.8	1.8	0.8	-1.4	0.2	-0.9
Bipolar Disorder (2011)	3.7	3.5	10.1	-1.5	3.2	-1.0	0.9
Body Mass Index (BMI) (2010)	1.3	1.8	4.3	-1.2	2.1	-1.2	0.1
Coronary Artery Disease (CAD)	0.1	0.1	0.3	-0.6	-0.1	0.0	0.2
Crohns Disease (2012)	0.7	1.2	2.1	-0.9	-1.0	-0.8	1.4
Mean Putamen Volume	2.0	2.2	5.6	1.0	-2.4	1.4	-0.6
Fasting Glucose	1.3	1.5	3.6	-0.3	0.2	-1.5	-1.9
HbA1C	0.3	0.4	1.1	0.3	-0.5	0.2	-1.1
HDL Cholesterol	0.3	0.6	1.1	-0.6	-1.1	-0.1	0.8
LDL Cholesterol	0.1	0.2	0.4	-0.0	0.0	-0.6	0.7
Lupus	0.1	0.2	0.4	0.5	0.3	-0.7	-0.2
Neuroticism (2016)	1.1	1.5	3.6	-0.6	1.9	-1.4	-0.3
Primary Biliary Cirrhosis	1.2	1.8	4.7	2.2	-0.2	1.2	-0.9
Rheumatoid Arthritis	0.1	0.2	0.7	0.1	-0.0	-0.1	0.8
Schizophrenia (2014)	0.9	2.1	4.5	-2.1	1.2	-1.5	0.6
Triglycerides	0.1	0.2	0.3	0.0	0.6	-0.5	-0.2
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.6	0.7	-0.3	0.3	0.1
Ulcerative Colitis	0.2	0.3	0.9	-0.6	-0.9	0.2	-0.2
Blood Eosinophil Count	0.1	0.6	1.5	1.2	0.7	-0.2	-0.7
Blood Platelet Count	0.1	0.8	1.8	0.5	-0.9	-0.4	1.3
Blood Red Count	0.9	8.6	18.6	4.3	-2.2	3.2	-0.7
Blood White Count	0.5	3.7	7.8	2.8	-2.1	0.4	-1.5
Heel T-Score	1.7	13.7	31.6	-5.6	1.9	-4.3	1.0
BMI	1.5	8.7	18.3	-4.3	0.2	-4.0	0.6
Height	24.0	462.8	986.0	31.4	-10.7	25.9	-8.9
Waist Hip Ratio (WHR)	0.9	4.1	10.1	-2.0	1.5	-3.2	0.2
Systolic Blood Pressure	2.1	10.5	17.4	4.2	-2.5	3.5	-2.6
Smoking Status	1.5	3.6	8.0	-1.4	2.0	-2.8	-0.6
Allergy or Eczema	0.8	2.0	6.2	-0.5	2.5	-1.0	-0.8
Cardiovascular Disease	0.4	1.2	3.1	1.0	0.1	0.9	-1.8
Hypothyroidism (self reported)	0.3	0.6	1.7	-0.6	-0.5	-0.1	1.3
Respiratory disease	0.2	0.5	1.3	0.7	1.2	-0.1	-0.1
Type 2 Diabetes (T2D) (2018)	1.3	2.4	7.5	2.7	0.1	-0.5	-1.3
Lung FEV1/FVC ratio	79.3	402.0	979.7	-31.3	6.0	-21.5	11.4
Lung FVC	1.3	6.5	17.4	2.7	4.2	-0.8	-0.7
Neuroticism	1.8	4.4	9.1	-0.9	3.0	-2.1	-1.8
Chronotype (morning person)	0.1	0.3	0.7	-0.8	0.1	-0.6	0.3
Hair Pigment	0.0	0.3	0.6	-0.2	0.7	-0.2	0.8
Tanning	0.3	3.3	8.1	-2.2	0.2	-2.8	0.3
Hand grip strength (left)	0.1	0.4	0.9	0.4	0.7	-1.0	0.1
Number of treatments/medications taken	0.2	0.4	0.9	1.0	-0.3	0.6	0.2
Average weekly spirits intake	0.4	0.5	0.9	0.7	0.7	-1.0	0.4
Sensitivity / hurt feelings	1.3	2.3	4.2	-0.3	2.0	-1.2	-1.8
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.2	-0.1	-1.1	-0.6	-0.4
Hearing difficulty/problems: Yes	0.5	0.8	1.8	-0.3	-1.4	-0.9	0.7
Relative age of first facial hair	2.3	4.7	12.0	-3.5	0.4	-2.5	0.5
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.9	-0.2	-0.2	-0.7	0.9
Ever used hormone-replacement therapy (HRT)	0.3	0.3	0.7	-0.6	0.4	-0.9	0.4
Ever had hysterectomy (womb removed)	1.0	1.2	2.0	-1.4	0.3	-1.1	1.1
Systolic blood pressure, automated reading	0.5	1.3	4.8	0.5	-2.2	0.0	0.5
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	1.7	1.3	-0.4	0.2	-0.2
Angina	1.4	1.8	3.6	1.9	-0.7	1.3	-1.2
Medication for hormone replacement therapy	3.1	3.4	11.0	1.2	-3.3	1.1	0.3
Vitamin and mineral supplements	0.3	0.3	0.7	-0.2	-0.8	-0.3	-0.8
Supplements: Zinc	2.9	3.2	4.5	-1.7	1.0	-2.1	2.1
Medication: Co-codamol	0.6	0.7	1.3	-0.8	0.6	-0.8	1.1
Medication: Metformin	1.0	1.4	2.8	1.7	0.7	-0.9	-1.2
Diabetes (father)	0.6	0.8	2.9	0.4	-0.1	0.3	-1.7
Diabetes (mother)	1.3	1.6	4.4	2.1	-0.6	0.1	-1.3
Severe depression (siblings)	0.3	0.3	0.5	0.6	0.5	-0.7	0.2
Pack years adult smoking proportion	0.2	0.2	0.5	-0.3	0.0	-0.7	0.6
Impedance of leg (right)	2.2	10.8	17.6	3.9	-2.6	4.2	-1.8
Leg fat-free mass (left)	6.3	33.2	78.0	8.8	-2.5	6.4	-2.7
Trunk fat percentage	2.7	11.0	15.4	3.9	-3.7	3.7	-1.1
Hand grip strength (right)	0.2	0.6	1.3	1.2	0.4	-0.4	-0.9
Townsend deprivation index at recruitment	7.5	10.5	21.8	-3.5	2.3	-4.7	1.5
Current tobacco smoking	0.9	1.5	4.1	-0.5	0.5	-2.0	-1.2
Average weekly fortified wine intake	1.8	2.1	5.5	0.3	-0.6	1.6	2.4
Maternal smoking around birth	0.5	0.8	1.3	-0.0	1.0	-0.9	1.2
Fed-up feelings	1.8	3.2	6.7	-0.1	1.4	-2.6	-2.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	1.8	-0.5	-0.9	-1.4	-0.4
Relative age voice broke	1.3	2.0	3.7	-1.9	1.0	-1.5	1.0
Taking other prescription medications	0.5	0.8	2.0	0.2	1.0	-1.4	-0.3
Age when periods started (menarche)	0.6	1.5	3.7	-1.9	0.2	-1.3	0.8
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	2.3	-1.5	-0.0	-0.4	0.4
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.2	5.0	-2.2	1.1	-1.5	-0.6
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.6	0.1	0.5	-0.5	-0.8
Qualifications: CSEs or equivalent	0.7	0.9	3.0	0.6	0.0	-0.5	-1.7
Serious illness, injury or assault to yourself	0.2	0.2	0.5	0.4	-0.7	-0.3	0.2
High blood pressure	0.8	2.3	3.3	1.4	-1.4	1.8	-1.3
Hayfever, allergic rhinitis or eczema	0.6	1.3	3.0	0.3	1.5	0.1	-1.7
Multivitamins +/- minerals	0.0	0.1	0.2	0.4	0.1	-0.0	-0.2
Stomach or abdominal pain in last month	4.3	5.3	7.4	-2.7	0.0	-2.6	2.7
Supplements: Glucosamine	2.3	3.0	7.2	2.7	0.3	2.0	0.7
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	3.4	-1.2	-0.3	-1.9	-0.1
Medication: Atenolol	0.1	0.2	0.4	0.2	-0.2	0.6	-0.4
Medication: Levothyroxine sodium	0.3	0.5	1.1	-0.3	-1.1	0.8	0.2
Sitting height	46.6	330.9	712.9	26.7	-8.2	21.1	-9.9
Chronic bronchitis/emphysema (father)	1.5	1.7	3.6	1.3	1.9	-1.0	-0.9
High blood pressure (mother)	0.7	1.0	2.4	0.3	1.0	-0.7	-1.6
Body mass index (BMI)	0.9	3.7	7.9	-2.5	0.5	-2.8	0.6
Impedance of leg (left)	2.8	13.8	23.6	4.4	-2.9	4.9	-2.0
Leg predicted mass (left)	6.1	32.4	75.6	8.7	-2.5	6.3	-2.8
Trunk fat mass	4.7	20.3	38.2	6.2	-3.8	4.9	-2.1
Waist circumference	0.9	3.5	8.0	2.8	-1.2	1.3	-1.7
Number of incorrect matches in round	0.3	0.6	1.1	-0.9	-0.3	0.5	1.1
Past tobacco smoking	1.7	3.1	7.2	0.9	-2.1	2.7	-0.0
Alcohol usually taken with meals	1.2	1.9	3.8	0.8	-1.9	1.6	0.8
Nervous feelings	0.8	1.4	3.9	0.1	2.0	1.3	-0.3
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	2.0	-0.3	1.4	-0.3	-0.1
Hearing difficulty/problems with background noise	0.6	1.0	1.8	-1.4	-0.7	-0.9	0.8
Hair/balding pattern: Pattern 2	0.1	0.1	0.2	0.5	0.1	0.2	0.3
Had menopause	1.2	1.6	3.4	-1.5	0.5	-0.6	1.9
Had other major operations	0.1	0.1	0.3	0.1	-0.2	-0.5	0.3
Forced vital capacity (FVC)	13.2	50.8	127.7	11.3	-1.4	7.0	-4.9
Heel bone mineral density (BMD) T-score, automated (right)	1.3	2.9	7.5	-2.7	1.2	-1.4	1.0
Ever unenthusiastic/disinterested for a whole week	1.5	1.8	2.9	-1.7	1.3	-1.5	-0.7
Qualifications: None of the above	2.7	5.8	8.6	-2.8	2.2	-1.3	2.9
Financial difficulties in last 2 years	1.5	2.0	5.3	0.1	0.7	-1.4	-2.3
Mouth/teeth dental problems	1.6	2.4	4.0	1.3	-1.0	2.0	1.7
Heart attack	0.6	0.8	2.0	0.7	0.4	0.6	-1.4
Allergy	0.7	1.6	2.8	-0.9	-1.5	-0.5	1.7
Pain all over the body in last month	0.5	0.5	1.4	-0.4	0.7	-1.2	-0.2
Diabetes (self-reported)	1.5	2.4	6.9	2.6	-0.5	0.5	-1.4
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.5	-0.0	-0.6	0.7	0.2
Medication: Ramipril	2.4	3.1	6.3	1.4	-2.5	2.0	-0.2
Medication: Simvastatin	1.7	2.5	6.3	1.4	-2.5	1.3	-0.3
Fluid intelligence score	0.4	0.9	2.4	1.6	0.2	0.8	-0.6
Illnesses of siblings	0.3	0.4	1.0	0.6	-0.0	1.0	-0.3
Neuroticism score	2.3	4.8	12.5	-0.5	3.5	-1.7	-1.9
Weight	5.4	26.6	59.3	7.7	-2.9	5.5	-2.8
Impedance of arm (right)	3.3	15.5	28.3	4.8	-3.3	5.3	-0.5
Arm fat percentage (right)	0.2	0.6	2.2	-0.1	-1.5	-0.1	0.4
Trunk fat-free mass	7.8	44.6	104.0	10.2	-2.2	7.3	-3.9
Hip circumference	7.0	30.3	59.1	7.7	-3.5	6.0	-3.8
Time employed in main current job	1.0	1.2	1.9	0.9	0.8	1.1	-1.4
Alcohol intake versus 10 years previously	0.9	1.4	1.8	-1.2	0.9	-1.2	1.3
Father’s age at death	0.7	0.9	2.6	1.0	-0.2	1.6	-0.0
Worrier / anxious feelings	1.5	2.8	9.8	0.9	3.1	0.4	-0.5
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	3.0	-0.5	0.0	-1.7	-0.0
Falls in the last year	0.7	1.0	3.3	0.2	1.8	-0.6	-0.5
Hair/balding pattern: Pattern 3	1.7	2.6	4.2	-1.3	2.0	-2.0	-0.7
Number of live births	0.8	1.1	3.0	-1.0	0.7	-1.7	0.1
Forced expiratory volume in 1-second (FEV1)	0.4	1.2	2.7	1.6	0.4	0.5	-1.3
Pulse rate	1.4	2.4	8.9	-0.8	-3.0	-0.4	0.1
Happiness	0.9	1.1	1.8	1.3	-0.8	0.4	-1.3
Noisy workplace	2.5	3.1	6.9	-2.6	0.7	-2.2	0.5
Qualifications: A levels/AS levels or equivalent	0.3	0.6	1.5	0.9	-0.4	1.2	0.1
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.5	1.0	-0.7	-1.0	-0.7	0.5
Mouth/teeth dental problems: Dentures	2.4	4.1	7.4	-2.7	0.3	-2.7	-1.3
Asthma	0.9	1.7	3.1	1.6	0.5	1.8	-0.9
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	2.3	0.2	1.5	-0.6	-0.9
Medication: Cholesterol lowering	2.5	3.9	7.6	2.5	-2.8	1.4	-0.3
Depression (self-reported)	1.3	1.6	4.3	-0.9	1.1	-2.1	0.3
Medication: Lansoprazole	0.1	0.1	0.3	-0.3	0.3	-0.3	-0.5
Prospective memory result	0.2	0.3	0.5	-0.5	0.0	0.7	0.7
Lung cancer (father)	0.4	0.5	1.8	-0.3	1.3	-0.1	-0.0
Illnesses of mother	0.6	0.8	1.4	-0.6	-1.0	1.2	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	1.1	1.1	0.8	0.3	-1.0
Pulse wave Arterial Stiffness index	0.2	0.2	0.3	-0.5	0.6	-0.4	-0.2
Impedance of arm (left)	3.8	17.7	35.5	4.7	-3.5	6.0	-0.6
Arm fat mass (right)	1.1	4.7	8.9	3.0	-2.0	2.2	-0.9
Trunk predicted mass	8.0	45.9	106.1	10.3	-2.4	7.5	-4.0
Standing height	24.3	241.1	501.8	22.4	-8.0	18.5	-7.5
Length of working week for main job	0.3	0.3	1.2	-1.1	-0.4	0.1	-0.1
Exposure to tobacco smoke at home	0.6	0.7	1.6	-0.7	0.0	-1.3	0.8
Breastfed as a baby	0.8	1.0	2.3	-0.8	1.0	-0.3	1.5
Tense / ‘highly strung’	1.3	2.2	6.5	-0.0	2.6	-0.2	-1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	2.4	3.7	6.7	-1.9	2.0	-2.6	-0.9
Hair/balding pattern: Pattern 4	0.4	1.0	1.8	1.1	0.4	0.9	1.4
Birth weight of first child	2.1	3.8	7.9	2.8	-1.3	2.2	-1.0
Peak expiratory flow (PEF)	1.6	3.8	8.8	-3.0	0.8	-2.4	0.4
Pulse wave reflection index	2.8	3.4	8.5	-1.8	2.9	-1.4	0.2
Ever highly irritable/argumentative for 2 days	1.8	2.2	3.8	-1.9	0.9	-1.6	1.2
Loud music exposure frequency	2.2	2.4	5.2	-0.9	0.6	-1.8	-2.3
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	0.9	1.0	-0.7	-0.0	-0.9
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	2.7	-0.0	-1.6	-0.6	-0.7
Blood clot in the leg (DVT)	1.1	1.4	2.0	-1.2	1.4	-1.3	0.4
Medication: Paracetamol	1.5	2.5	3.9	-1.6	1.8	-2.0	-0.5
Headache pain in last month	0.5	0.8	2.3	-0.6	1.5	-0.4	0.6
Medication for cholesterol, blood pressure or diabetes	1.9	3.1	7.4	-1.6	2.7	-1.6	-0.2
Glaucoma (self-reported)	1.2	1.5	5.7	-0.2	-2.4	0.1	-0.3
Gout (self-reported)	0.3	0.4	0.8	0.8	0.9	0.2	-0.1
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	1.3	-0.7	-0.6	-0.2	1.1
Medication: Amlodipine	2.8	4.0	5.6	1.6	-2.4	2.4	-1.4
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.2	0.4	0.0	0.5	-1.1
Birth weight	9.6	20.7	39.2	6.3	-2.4	5.6	-2.5
Chronic bronchitis/emphysema (mother)	0.7	0.8	2.9	0.6	1.7	-0.1	0.2
High blood pressure (siblings)	0.2	0.3	0.6	0.2	-0.7	0.8	-0.1
Forced vital capacity (FVC), Best measure	11.1	40.5	99.8	10.0	-0.9	6.3	-4.7
Body fat percentage	1.0	4.0	7.6	2.2	-2.8	1.8	-0.7
Leg fat percentage (right)	0.3	1.1	2.4	-1.1	-0.9	-1.6	0.0
Arm fat-free mass (right)	6.6	34.0	76.4	8.7	-2.2	6.4	-3.8
Exposure to tobacco smoke outside home	0.5	0.7	2.2	-0.3	1.5	-0.3	0.5
Comparative body size at age 10	2.7	7.4	11.2	-3.3	2.9	-2.1	2.3
Number of full brothers	2.3	3.0	4.0	-1.7	1.8	-2.0	1.3
Worry too long after embarrassment	3.2	5.3	12.4	3.5	0.2	2.6	-1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	4.7	6.1	10.0	-3.2	2.0	-3.0	1.3
Wheeze or whistling in the chest in last year	0.2	0.3	0.6	0.7	-0.2	-0.2	0.8
Number of children fathered	2.6	2.9	7.0	-1.5	-1.4	-2.6	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	2.0	2.3	3.2	-1.6	1.2	-1.4	-1.8
Age at first live birth	2.4	4.2	6.2	2.5	-1.7	2.4	-1.5
Pulse wave peak to peak time	1.9	2.2	5.0	2.2	-1.0	1.6	-0.3
Health satisfaction	0.8	1.0	2.3	-0.2	-1.2	-0.6	1.5
Shortness of breath walking on level ground	1.0	1.2	4.3	0.6	0.3	-0.1	-2.1
Qualifications: College or University degree	0.1	0.3	1.2	-0.4	-0.2	1.1	0.2
Eye problems/disorders: None of the above	0.9	1.1	2.2	0.2	1.3	0.4	-1.5
Mouth/teeth dental problems: Loose teeth	0.7	0.9	3.1	-0.5	-0.2	-1.8	-0.1
Emphysema/chronic bronchitis	0.6	0.7	1.4	1.1	-0.3	1.2	-0.1
Medication for pain relief, constipation, heartburn	0.8	1.3	3.3	0.3	-1.8	1.3	0.5
Neck or shoulder pain in last month	0.1	0.1	0.2	-0.1	0.4	-0.3	-0.1
Medication: Blood pressure	1.3	2.3	4.3	1.3	-1.6	2.1	0.7
Angina (self-reported)	1.2	1.6	3.1	1.8	-0.6	1.1	-1.3
Migraine (self-reported)	0.4	0.5	1.3	-0.5	-0.2	-1.2	-0.4
Medication: Ibuprofen	0.5	0.6	2.4	-0.2	1.5	-0.3	-0.3
Medication: Allopurinol	0.1	0.1	0.3	0.3	0.5	0.0	-0.0
Medication: Omeprazole	2.6	3.1	4.4	-2.1	0.6	-2.0	1.9
Medication: Seretide 50 evohaler	0.4	0.4	0.8	0.8	0.4	-0.1	-0.9
Mean time to correctly identify matches	0.2	0.4	0.8	-0.4	-0.9	0.5	0.8
Heart disease (mother)	0.1	0.1	0.3	-0.1	-0.6	-0.3	0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.1	3.7	6.6	-2.4	1.6	-2.6	0.2
Whole body fat mass	3.0	12.7	24.2	4.9	-3.1	3.8	-1.6
Leg fat mass (right)	0.8	2.9	6.0	2.5	-1.8	1.3	-0.9
Arm predicted mass (right)	6.6	33.9	75.5	8.7	-2.3	6.4	-3.6
Pulse rate, automated reading	0.8	2.7	7.7	-1.4	-2.8	-0.8	0.6
Alcohol intake frequency.	0.6	1.4	3.5	-1.2	1.9	-0.7	0.1
Comparative height size at age 10	20.9	115.3	240.2	15.5	-6.6	12.2	-5.3
Number of full sisters	1.1	1.3	2.5	-1.2	1.1	-1.6	0.0
Suffer from ‘nerves’	0.8	1.3	3.4	-0.9	1.9	0.7	-0.6
Overall health rating	0.3	0.6	2.1	-0.1	0.4	-1.5	0.1
Chest pain or discomfort	0.2	0.2	0.8	0.3	-0.9	0.1	-0.3
Had major operations	3.6	4.2	8.2	-2.4	1.3	-2.9	1.2
Age at last live birth	4.4	6.5	10.7	3.0	-1.2	3.3	-2.1
Family relationship satisfaction	0.3	0.4	0.5	0.7	0.4	0.6	-0.7
Leg pain on walking	1.6	2.0	4.8	-1.6	0.4	-2.2	-0.7
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.5	3.4	0.1	-0.0	-1.8	-1.6
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.7	-0.2	-1.3	-0.3	0.2
Illness, injury, bereavement, stress in last 2 years	0.8	0.9	2.2	0.3	0.7	1.5	0.9
Medication: Aspirin	2.4	3.2	7.8	2.8	-1.1	0.8	-1.8
Supplements: Vitamin C	0.5	0.6	1.8	0.0	1.4	-0.0	0.8
Knee pain experienced in last month	0.4	0.6	1.0	0.0	1.0	-0.8	-0.9
Hypertension (Self-reported)	0.8	2.1	3.2	1.6	-1.2	1.8	-1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.1	3.3	-0.5	0.3	-1.8	0.9
Illnesses of father: Heart disease	0.1	0.2	0.4	-0.6	-0.1	-0.3	0.3
Illnesses of siblings: Diabetes	0.9	1.0	3.3	-0.8	0.5	-1.8	-0.1
Smoking status: Previous	0.9	1.3	3.7	-0.5	0.9	-1.9	0.7
Forced expiratory volume in 1-second (FEV1), predicted	17.2	35.8	70.4	8.4	-2.5	6.7	-4.7
Whole body fat-free mass	7.4	42.1	98.4	9.9	-2.5	7.2	-3.5
Leg fat-free mass (right)	6.6	35.2	80.8	9.0	-2.6	6.7	-2.9
Arm fat percentage (left)	0.1	0.6	2.1	-0.1	-1.4	0.1	0.4
Average weekly red wine intake	0.4	0.6	1.6	0.0	0.6	-1.3	0.8
Handedness (chirality/laterality): Left-handed	0.9	1.1	2.2	0.1	-1.3	1.5	0.7
Mood swings	5.2	9.4	20.8	-2.8	2.5	-4.6	-1.7
Loneliness, isolation	2.7	3.7	8.2	-1.4	2.1	-2.9	0.3
Long-standing illness, disability or infirmity	0.4	0.6	1.8	1.4	0.1	0.5	-0.4
Ever had bowel cancer screening	3.9	4.5	11.0	-3.3	-0.1	-2.5	1.0
Diabetes diagnosed by doctor	1.0	1.7	5.5	2.4	-0.6	-0.1	-1.0
Ever had stillbirth, spontaneous miscarriage or termination	2.7	2.9	5.1	2.1	-2.3	1.1	-1.0
Friendships satisfaction	0.0	0.0	0.1	-0.3	-0.0	-0.0	-0.2
Qualifications: nursing, teaching	2.5	3.8	5.0	2.1	-1.6	1.8	-2.2
Commuting to job workplace: Walk	0.1	0.1	0.2	-0.3	-0.5	-0.2	-0.4
Eye problems/disorders: Cataract	0.6	0.6	1.0	0.8	-1.0	0.8	0.5
Mouth/teeth dental problems: Mouth ulcers	1.1	1.7	3.6	-0.9	1.9	-1.4	-0.8
Medication for cholesterol	0.6	0.9	1.8	-0.6	1.0	-1.3	0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	0.9	-0.4	0.9	-0.9	0.1
Back pain experienced in last month	1.5	2.2	4.5	2.1	0.8	0.6	-1.8
Mineral and other dietary supplements	0.7	1.0	1.5	-1.1	1.2	-0.5	-1.0
Breast cancer (self-reported)	0.7	0.8	1.3	0.3	1.1	0.8	1.1
Asthma (self-reported)	1.0	2.0	3.7	1.9	0.3	1.9	-0.7
Osteoporosis (self-reported)	0.3	0.3	0.6	0.6	-0.1	0.8	-0.6
Osteoarthritis (self-reported)	0.3	0.4	1.0	-0.4	0.1	-1.0	0.6
Medication: Aspirin	1.8	2.3	6.6	2.6	-0.9	0.6	-1.3
Medication: Gliclazide	1.3	1.5	2.5	0.3	1.6	-1.4	-1.2
Illnesses of father: None of the above (group 1)	0.1	0.2	0.4	0.3	0.1	0.6	-0.3
Smoking status: Current	1.2	1.9	4.4	-0.8	1.0	-2.1	-1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.8	8.1	19.5	-4.4	1.4	-3.0	1.4
Whole body water mass	7.2	41.2	96.2	9.8	-2.4	7.0	-3.6
Leg predicted mass (right)	6.6	35.1	80.5	9.0	-2.5	6.7	-2.8
Arm fat mass (left)	1.2	4.9	9.2	3.0	-1.9	2.3	-1.0
Number of self-reported non-cancer illnesses	0.4	0.7	1.4	-0.2	0.7	-1.2	1.0
Average weekly champagne plus white wine intake	2.2	3.0	4.5	1.6	-1.9	2.1	-1.1
Miserableness	1.7	2.9	4.2	-0.5	1.7	-2.0	-2.0
Guilty feelings	1.0	1.6	3.9	0.9	2.0	0.6	-1.0
Wears glasses or contact lenses	1.7	1.9	4.2	-1.0	2.0	-0.6	1.4
Ever taken oral contraceptive pill	0.8	0.9	2.2	0.5	1.5	-1.0	-0.2
Hearing aid user	0.6	0.7	1.9	0.5	0.8	0.4	1.4
Mother’s age at death	1.8	2.3	3.6	1.7	-1.2	1.9	1.1
Financial situation satisfaction	0.7	0.8	2.5	0.5	-0.1	-0.7	-1.6
Tinnitus: Yes, now most or all of the time	0.7	0.8	1.0	-1.0	-0.7	0.9	1.0
Commuting to job workplace: Public transport	0.5	0.6	0.7	0.7	0.9	0.8	-0.8
Eye problems/disorders: Glaucoma	1.7	2.0	3.9	-2.0	-0.9	-1.5	1.1
Medication: Blood pressure	0.4	0.7	1.5	0.7	-0.6	0.7	-1.2
Pain type(s) experienced in last month: Hip pain	0.0	0.0	0.1	-0.0	0.0	-0.3	0.2
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.4	0.1	-1.2	-0.1	0.5
High cholesterol (Self-reported)	0.3	0.5	1.3	-0.7	-1.1	-0.0	-0.2
Medication: Bendroflumethiazide	0.5	0.8	1.9	-0.9	-1.4	-0.7	0.1
Medication: Paracetamol	1.1	1.8	2.7	-1.4	1.7	-1.4	-0.5
Medication: Lisinopril	0.4	0.5	1.6	0.4	-1.3	-0.2	-0.0
Medication: Atorvastatin	0.4	0.5	1.0	0.2	0.3	0.8	-1.0
Illnesses of father: High blood pressure	0.0	0.1	0.1	-0.1	0.3	-0.1	-0.3
Alcohol drinker status: Never	2.3	2.8	4.8	-2.2	1.6	-1.9	0.3
Ever smoked	1.9	3.4	6.8	-1.3	2.3	-2.6	0.2
Basal metabolic rate	7.5	41.8	96.6	9.8	-2.7	7.1	-3.6
Leg fat percentage (left)	0.2	0.9	1.4	-0.9	-1.1	-1.2	-0.2
Arm fat-free mass (left)	7.1	35.9	81.4	9.0	-2.4	6.5	-3.8
Number of operations (self-reported)	3.1	4.6	9.3	-2.4	0.7	-3.1	1.8
Average weekly beer plus cider intake	1.7	2.4	7.6	-0.2	2.8	-1.3	-0.6
Irritability	2.5	4.2	9.7	-1.6	1.7	-3.1	-1.1
Risk taking	0.9	1.4	3.6	-1.9	0.3	-0.9	1.0
Ever had prostate specific antigen (PSA) test	0.4	0.4	0.5	-0.7	0.7	-0.5	0.7
Fractured/broken bones in last 5 years	0.6	0.8	2.2	0.3	1.5	-0.7	-0.7
Age started oral contraceptive pill	0.2	0.2	0.4	-0.5	0.4	-0.2	0.6
Diastolic blood pressure, automated reading	0.4	1.3	3.7	1.0	-1.9	0.5	-0.4
Ever depressed for a whole week	1.4	1.8	3.6	-1.6	-0.5	-0.9	1.9
Unable to work because of sickness or disability	0.5	0.6	1.0	-0.9	0.3	-0.8	1.0
Commuting to job workplace: Cycle	0.1	0.2	0.2	-0.4	0.5	-0.4	0.2
Myopia	0.5	0.7	1.4	1.2	-0.9	0.4	0.7
Vascular/heart problems diagnosed by doctor	1.3	3.4	4.5	-2.0	1.3	-2.1	1.9
Cholesterol lowering medication	0.2	0.3	0.5	-0.7	0.4	-0.2	-0.7
Medication: Omeprazole (e.g. Zanprol)	4.0	4.9	8.4	-2.8	0.4	-1.7	2.9
Pain experienced in last month	0.4	0.6	1.5	-0.3	-1.2	0.6	0.8
Supplements: Calcium	1.1	1.2	2.8	0.7	1.7	-0.9	-0.9
Basal cell carcinoma (self-reported)	0.6	0.7	2.1	0.7	-1.4	0.3	-0.5
Heart attack/myocardial infarction (self-reported)	0.5	0.7	1.8	0.6	0.6	0.5	-1.3
Deep venous thrombosis (DVT) (self-reported)	1.1	1.4	1.8	-1.2	1.3	-1.3	0.8
Heart disease (siblings)	0.3	0.4	1.1	-0.2	0.6	-1.1	-0.5
Alcohol drinker status: Previous	1.8	2.1	4.7	-1.0	2.2	-1.5	-0.5
Pack years of smoking	0.2	0.3	0.5	-0.3	-0.5	-0.6	0.7
Impedance of whole body	3.9	19.9	37.8	5.1	-3.6	6.2	-1.5
Leg fat mass (left)	0.9	3.6	6.8	2.6	-2.0	1.6	-1.1
Arm predicted mass (left)	6.8	34.4	79.9	8.9	-2.3	6.2	-3.8