Hub : Genes

GPR126

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Subcutaneous 0.0580 0.0250 0.00300 0.037 NA 0.028 NA 0.036 0.00051 NA 0.0023 NA 0.00061
2 GTEx Colon Transverse 0.1270 0.0530 0.00510 -0.006 NA -0.006 NA -0.002 0.77000 NA 1.0000 NA 0.42000
3 METSIM Adipose 0.0469 0.0163 0.00003 0.009 0.023 0.013 0.019 0.012 0.01300 0.00019 0.0039 0.00071 0.00470
4 TCGA Bladder Urothelial Carcinoma 0.0590 0.0300 0.00440 -0.003 0.010 0.002 NA -0.002 0.86000 0.04600 0.1900 NA 0.56000

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 1.3 2.1 4.0 -1.5 2.0 -1.4 -0.6
Bipolar Disorder or Schizophrenia 1.1 2.6 4.5 -2.1 1.8 -1.5 -0.6
Depressed Affect (Nagel 2018) 2.9 6.0 15.6 -1.7 1.7 -4.0 -1.7
Depression (Nagel 2018) 0.3 0.5 1.3 0.0 -0.6 -1.1 -0.4
Intelligence (Savage-Jansen 2018) 0.0 0.1 0.2 0.4 -0.5 -0.1 -0.1
Neuroticism (Nagel 2018) 1.1 2.7 6.2 -0.3 2.5 -1.5 -1.5
Schizophrenia (2018) 0.4 0.9 2.3 -1.5 0.7 -0.8 -0.0
Schizophrenia vs Biploar Disorder 1.3 1.7 4.2 0.5 -2.0 1.0 -1.1
Worry (Nagel 2018) 1.4 2.9 11.0 -0.4 3.3 0.6 -0.3
Alzheimer’s Disease (in mother) 2.3 2.7 5.3 -1.3 2.3 -1.6 -1.2
Alzheimer’s Disease (in father) 1.0 1.1 2.3 -0.6 1.5 -0.3 1.2
Alzheimer’s Disease (including proxy) 1.7 2.4 6.7 -1.3 2.6 -1.2 -0.2
Crohns Disease (2017) 0.7 1.5 2.3 -1.5 0.6 -1.5 1.2
Irritable Bowel Disease (IBD) 0.5 1.3 3.0 -1.7 0.4 -1.4 -0.1
Ulcerative Colitis (UC) 0.5 0.9 1.5 -1.2 0.1 -0.7 -1.2
Major Depression (MDD) 1.7 2.1 6.1 -1.1 1.0 -2.5 0.2
Reaction Time 0.1 0.2 0.5 -0.1 0.3 0.7 0.3
Verbal and Numeric Reasoning (VNR) 0.1 0.1 0.3 -0.3 0.5 -0.4 0.2
Breast Cancer 0.1 0.3 0.7 0.0 0.3 -0.7 -0.8
Ovarian Cancer 1.0 1.3 3.6 1.2 -0.0 1.9 -0.2
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 0.6 0.8 1.8 0.8 -1.4 0.2 -0.9
Bipolar Disorder (2011) 3.7 3.5 10.1 -1.5 3.2 -1.0 0.9
Body Mass Index (BMI) (2010) 1.3 1.8 4.3 -1.2 2.1 -1.2 0.1
Coronary Artery Disease (CAD) 0.1 0.1 0.3 -0.6 -0.1 0.0 0.2
Crohns Disease (2012) 0.7 1.2 2.1 -0.9 -1.0 -0.8 1.4
Mean Putamen Volume 2.0 2.2 5.6 1.0 -2.4 1.4 -0.6
Fasting Glucose 1.3 1.5 3.6 -0.3 0.2 -1.5 -1.9
HbA1C 0.3 0.4 1.1 0.3 -0.5 0.2 -1.1
HDL Cholesterol 0.3 0.6 1.1 -0.6 -1.1 -0.1 0.8
LDL Cholesterol 0.1 0.2 0.4 -0.0 0.0 -0.6 0.7
Lupus 0.1 0.2 0.4 0.5 0.3 -0.7 -0.2
Neuroticism (2016) 1.1 1.5 3.6 -0.6 1.9 -1.4 -0.3
Primary Biliary Cirrhosis 1.2 1.8 4.7 2.2 -0.2 1.2 -0.9
Rheumatoid Arthritis 0.1 0.2 0.7 0.1 -0.0 -0.1 0.8
Schizophrenia (2014) 0.9 2.1 4.5 -2.1 1.2 -1.5 0.6
Triglycerides 0.1 0.2 0.3 0.0 0.6 -0.5 -0.2
Type 2 Diabetes (T2D) (2012) 0.2 0.2 0.6 0.7 -0.3 0.3 0.1
Ulcerative Colitis 0.2 0.3 0.9 -0.6 -0.9 0.2 -0.2
Blood Eosinophil Count 0.1 0.6 1.5 1.2 0.7 -0.2 -0.7
Blood Platelet Count 0.1 0.8 1.8 0.5 -0.9 -0.4 1.3
Blood Red Count 0.9 8.6 18.6 4.3 -2.2 3.2 -0.7
Blood White Count 0.5 3.7 7.8 2.8 -2.1 0.4 -1.5
Heel T-Score 1.7 13.7 31.6 -5.6 1.9 -4.3 1.0
BMI 1.5 8.7 18.3 -4.3 0.2 -4.0 0.6
Height 24.0 462.8 986.0 31.4 -10.7 25.9 -8.9
Waist Hip Ratio (WHR) 0.9 4.1 10.1 -2.0 1.5 -3.2 0.2
Systolic Blood Pressure 2.1 10.5 17.4 4.2 -2.5 3.5 -2.6
Smoking Status 1.5 3.6 8.0 -1.4 2.0 -2.8 -0.6
Allergy or Eczema 0.8 2.0 6.2 -0.5 2.5 -1.0 -0.8
Cardiovascular Disease 0.4 1.2 3.1 1.0 0.1 0.9 -1.8
Hypothyroidism (self reported) 0.3 0.6 1.7 -0.6 -0.5 -0.1 1.3
Respiratory disease 0.2 0.5 1.3 0.7 1.2 -0.1 -0.1
Type 2 Diabetes (T2D) (2018) 1.3 2.4 7.5 2.7 0.1 -0.5 -1.3
Lung FEV1/FVC ratio 79.3 402.0 979.7 -31.3 6.0 -21.5 11.4
Lung FVC 1.3 6.5 17.4 2.7 4.2 -0.8 -0.7
Neuroticism 1.8 4.4 9.1 -0.9 3.0 -2.1 -1.8
Chronotype (morning person) 0.1 0.3 0.7 -0.8 0.1 -0.6 0.3
Hair Pigment 0.0 0.3 0.6 -0.2 0.7 -0.2 0.8
Tanning 0.3 3.3 8.1 -2.2 0.2 -2.8 0.3
Hand grip strength (left) 0.1 0.4 0.9 0.4 0.7 -1.0 0.1
Number of treatments/medications taken 0.2 0.4 0.9 1.0 -0.3 0.6 0.2
Average weekly spirits intake 0.4 0.5 0.9 0.7 0.7 -1.0 0.4
Sensitivity / hurt feelings 1.3 2.3 4.2 -0.3 2.0 -1.2 -1.8
Frequency of depressed mood in last 2 weeks 0.3 0.4 1.2 -0.1 -1.1 -0.6 -0.4
Hearing difficulty/problems: Yes 0.5 0.8 1.8 -0.3 -1.4 -0.9 0.7
Relative age of first facial hair 2.3 4.7 12.0 -3.5 0.4 -2.5 0.5
Other serious medical condition/disability diagnosed by doctor 0.3 0.4 0.9 -0.2 -0.2 -0.7 0.9
Ever used hormone-replacement therapy (HRT) 0.3 0.3 0.7 -0.6 0.4 -0.9 0.4
Ever had hysterectomy (womb removed) 1.0 1.2 2.0 -1.4 0.3 -1.1 1.1
Systolic blood pressure, automated reading 0.5 1.3 4.8 0.5 -2.2 0.0 0.5
Eye problems/disorders: Diabetes related eye disease 0.4 0.5 1.7 1.3 -0.4 0.2 -0.2
Angina 1.4 1.8 3.6 1.9 -0.7 1.3 -1.2
Medication for hormone replacement therapy 3.1 3.4 11.0 1.2 -3.3 1.1 0.3
Vitamin and mineral supplements 0.3 0.3 0.7 -0.2 -0.8 -0.3 -0.8
Supplements: Zinc 2.9 3.2 4.5 -1.7 1.0 -2.1 2.1
Medication: Co-codamol 0.6 0.7 1.3 -0.8 0.6 -0.8 1.1
Medication: Metformin 1.0 1.4 2.8 1.7 0.7 -0.9 -1.2
Diabetes (father) 0.6 0.8 2.9 0.4 -0.1 0.3 -1.7
Diabetes (mother) 1.3 1.6 4.4 2.1 -0.6 0.1 -1.3
Severe depression (siblings) 0.3 0.3 0.5 0.6 0.5 -0.7 0.2
Pack years adult smoking proportion 0.2 0.2 0.5 -0.3 0.0 -0.7 0.6
Impedance of leg (right) 2.2 10.8 17.6 3.9 -2.6 4.2 -1.8
Leg fat-free mass (left) 6.3 33.2 78.0 8.8 -2.5 6.4 -2.7
Trunk fat percentage 2.7 11.0 15.4 3.9 -3.7 3.7 -1.1
Hand grip strength (right) 0.2 0.6 1.3 1.2 0.4 -0.4 -0.9
Townsend deprivation index at recruitment 7.5 10.5 21.8 -3.5 2.3 -4.7 1.5
Current tobacco smoking 0.9 1.5 4.1 -0.5 0.5 -2.0 -1.2
Average weekly fortified wine intake 1.8 2.1 5.5 0.3 -0.6 1.6 2.4
Maternal smoking around birth 0.5 0.8 1.3 -0.0 1.0 -0.9 1.2
Fed-up feelings 1.8 3.2 6.7 -0.1 1.4 -2.6 -2.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.6 0.8 1.8 -0.5 -0.9 -1.4 -0.4
Relative age voice broke 1.3 2.0 3.7 -1.9 1.0 -1.5 1.0
Taking other prescription medications 0.5 0.8 2.0 0.2 1.0 -1.4 -0.3
Age when periods started (menarche) 0.6 1.5 3.7 -1.9 0.2 -1.3 0.8
Bilateral oophorectomy (both ovaries removed) 0.6 0.7 2.3 -1.5 -0.0 -0.4 0.4
Heel bone mineral density (BMD) T-score, automated (left) 1.0 2.2 5.0 -2.2 1.1 -1.5 -0.6
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 0.6 0.1 0.5 -0.5 -0.8
Qualifications: CSEs or equivalent 0.7 0.9 3.0 0.6 0.0 -0.5 -1.7
Serious illness, injury or assault to yourself 0.2 0.2 0.5 0.4 -0.7 -0.3 0.2
High blood pressure 0.8 2.3 3.3 1.4 -1.4 1.8 -1.3
Hayfever, allergic rhinitis or eczema 0.6 1.3 3.0 0.3 1.5 0.1 -1.7
Multivitamins +/- minerals 0.0 0.1 0.2 0.4 0.1 -0.0 -0.2
Stomach or abdominal pain in last month 4.3 5.3 7.4 -2.7 0.0 -2.6 2.7
Supplements: Glucosamine 2.3 3.0 7.2 2.7 0.3 2.0 0.7
Diverticular disease/diverticulitis (self-reported) 1.1 1.3 3.4 -1.2 -0.3 -1.9 -0.1
Medication: Atenolol 0.1 0.2 0.4 0.2 -0.2 0.6 -0.4
Medication: Levothyroxine sodium 0.3 0.5 1.1 -0.3 -1.1 0.8 0.2
Sitting height 46.6 330.9 712.9 26.7 -8.2 21.1 -9.9
Chronic bronchitis/emphysema (father) 1.5 1.7 3.6 1.3 1.9 -1.0 -0.9
High blood pressure (mother) 0.7 1.0 2.4 0.3 1.0 -0.7 -1.6
Body mass index (BMI) 0.9 3.7 7.9 -2.5 0.5 -2.8 0.6
Impedance of leg (left) 2.8 13.8 23.6 4.4 -2.9 4.9 -2.0
Leg predicted mass (left) 6.1 32.4 75.6 8.7 -2.5 6.3 -2.8
Trunk fat mass 4.7 20.3 38.2 6.2 -3.8 4.9 -2.1
Waist circumference 0.9 3.5 8.0 2.8 -1.2 1.3 -1.7
Number of incorrect matches in round 0.3 0.6 1.1 -0.9 -0.3 0.5 1.1
Past tobacco smoking 1.7 3.1 7.2 0.9 -2.1 2.7 -0.0
Alcohol usually taken with meals 1.2 1.9 3.8 0.8 -1.9 1.6 0.8
Nervous feelings 0.8 1.4 3.9 0.1 2.0 1.3 -0.3
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.5 2.0 -0.3 1.4 -0.3 -0.1
Hearing difficulty/problems with background noise 0.6 1.0 1.8 -1.4 -0.7 -0.9 0.8
Hair/balding pattern: Pattern 2 0.1 0.1 0.2 0.5 0.1 0.2 0.3
Had menopause 1.2 1.6 3.4 -1.5 0.5 -0.6 1.9
Had other major operations 0.1 0.1 0.3 0.1 -0.2 -0.5 0.3
Forced vital capacity (FVC) 13.2 50.8 127.7 11.3 -1.4 7.0 -4.9
Heel bone mineral density (BMD) T-score, automated (right) 1.3 2.9 7.5 -2.7 1.2 -1.4 1.0
Ever unenthusiastic/disinterested for a whole week 1.5 1.8 2.9 -1.7 1.3 -1.5 -0.7
Qualifications: None of the above 2.7 5.8 8.6 -2.8 2.2 -1.3 2.9
Financial difficulties in last 2 years 1.5 2.0 5.3 0.1 0.7 -1.4 -2.3
Mouth/teeth dental problems 1.6 2.4 4.0 1.3 -1.0 2.0 1.7
Heart attack 0.6 0.8 2.0 0.7 0.4 0.6 -1.4
Allergy 0.7 1.6 2.8 -0.9 -1.5 -0.5 1.7
Pain all over the body in last month 0.5 0.5 1.4 -0.4 0.7 -1.2 -0.2
Diabetes (self-reported) 1.5 2.4 6.9 2.6 -0.5 0.5 -1.4
Hayfever/allergic rhinitis (self-reported) 0.2 0.2 0.5 -0.0 -0.6 0.7 0.2
Medication: Ramipril 2.4 3.1 6.3 1.4 -2.5 2.0 -0.2
Medication: Simvastatin 1.7 2.5 6.3 1.4 -2.5 1.3 -0.3
Fluid intelligence score 0.4 0.9 2.4 1.6 0.2 0.8 -0.6
Illnesses of siblings 0.3 0.4 1.0 0.6 -0.0 1.0 -0.3
Neuroticism score 2.3 4.8 12.5 -0.5 3.5 -1.7 -1.9
Weight 5.4 26.6 59.3 7.7 -2.9 5.5 -2.8
Impedance of arm (right) 3.3 15.5 28.3 4.8 -3.3 5.3 -0.5
Arm fat percentage (right) 0.2 0.6 2.2 -0.1 -1.5 -0.1 0.4
Trunk fat-free mass 7.8 44.6 104.0 10.2 -2.2 7.3 -3.9
Hip circumference 7.0 30.3 59.1 7.7 -3.5 6.0 -3.8
Time employed in main current job 1.0 1.2 1.9 0.9 0.8 1.1 -1.4
Alcohol intake versus 10 years previously 0.9 1.4 1.8 -1.2 0.9 -1.2 1.3
Father’s age at death 0.7 0.9 2.6 1.0 -0.2 1.6 -0.0
Worrier / anxious feelings 1.5 2.8 9.8 0.9 3.1 0.4 -0.5
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.8 3.0 -0.5 0.0 -1.7 -0.0
Falls in the last year 0.7 1.0 3.3 0.2 1.8 -0.6 -0.5
Hair/balding pattern: Pattern 3 1.7 2.6 4.2 -1.3 2.0 -2.0 -0.7
Number of live births 0.8 1.1 3.0 -1.0 0.7 -1.7 0.1
Forced expiratory volume in 1-second (FEV1) 0.4 1.2 2.7 1.6 0.4 0.5 -1.3
Pulse rate 1.4 2.4 8.9 -0.8 -3.0 -0.4 0.1
Happiness 0.9 1.1 1.8 1.3 -0.8 0.4 -1.3
Noisy workplace 2.5 3.1 6.9 -2.6 0.7 -2.2 0.5
Qualifications: A levels/AS levels or equivalent 0.3 0.6 1.5 0.9 -0.4 1.2 0.1
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.5 1.0 -0.7 -1.0 -0.7 0.5
Mouth/teeth dental problems: Dentures 2.4 4.1 7.4 -2.7 0.3 -2.7 -1.3
Asthma 0.9 1.7 3.1 1.6 0.5 1.8 -0.9
Medication: Ibuprofen (e.g. Nurofen) 0.7 0.9 2.3 0.2 1.5 -0.6 -0.9
Medication: Cholesterol lowering 2.5 3.9 7.6 2.5 -2.8 1.4 -0.3
Depression (self-reported) 1.3 1.6 4.3 -0.9 1.1 -2.1 0.3
Medication: Lansoprazole 0.1 0.1 0.3 -0.3 0.3 -0.3 -0.5
Prospective memory result 0.2 0.3 0.5 -0.5 0.0 0.7 0.7
Lung cancer (father) 0.4 0.5 1.8 -0.3 1.3 -0.1 -0.0
Illnesses of mother 0.6 0.8 1.4 -0.6 -1.0 1.2 0.7
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.7 1.1 1.1 0.8 0.3 -1.0
Pulse wave Arterial Stiffness index 0.2 0.2 0.3 -0.5 0.6 -0.4 -0.2
Impedance of arm (left) 3.8 17.7 35.5 4.7 -3.5 6.0 -0.6
Arm fat mass (right) 1.1 4.7 8.9 3.0 -2.0 2.2 -0.9
Trunk predicted mass 8.0 45.9 106.1 10.3 -2.4 7.5 -4.0
Standing height 24.3 241.1 501.8 22.4 -8.0 18.5 -7.5
Length of working week for main job 0.3 0.3 1.2 -1.1 -0.4 0.1 -0.1
Exposure to tobacco smoke at home 0.6 0.7 1.6 -0.7 0.0 -1.3 0.8
Breastfed as a baby 0.8 1.0 2.3 -0.8 1.0 -0.3 1.5
Tense / ‘highly strung’ 1.3 2.2 6.5 -0.0 2.6 -0.2 -1.5
Seen doctor (GP) for nerves, anxiety, tension or depression 2.4 3.7 6.7 -1.9 2.0 -2.6 -0.9
Hair/balding pattern: Pattern 4 0.4 1.0 1.8 1.1 0.4 0.9 1.4
Birth weight of first child 2.1 3.8 7.9 2.8 -1.3 2.2 -1.0
Peak expiratory flow (PEF) 1.6 3.8 8.8 -3.0 0.8 -2.4 0.4
Pulse wave reflection index 2.8 3.4 8.5 -1.8 2.9 -1.4 0.2
Ever highly irritable/argumentative for 2 days 1.8 2.2 3.8 -1.9 0.9 -1.6 1.2
Loud music exposure frequency 2.2 2.4 5.2 -0.9 0.6 -1.8 -2.3
Qualifications: O levels/GCSEs or equivalent 0.3 0.5 0.9 1.0 -0.7 -0.0 -0.9
Mouth/teeth dental problems: Bleeding gums 0.7 0.9 2.7 -0.0 -1.6 -0.6 -0.7
Blood clot in the leg (DVT) 1.1 1.4 2.0 -1.2 1.4 -1.3 0.4
Medication: Paracetamol 1.5 2.5 3.9 -1.6 1.8 -2.0 -0.5
Headache pain in last month 0.5 0.8 2.3 -0.6 1.5 -0.4 0.6
Medication for cholesterol, blood pressure or diabetes 1.9 3.1 7.4 -1.6 2.7 -1.6 -0.2
Glaucoma (self-reported) 1.2 1.5 5.7 -0.2 -2.4 0.1 -0.3
Gout (self-reported) 0.3 0.4 0.8 0.8 0.9 0.2 -0.1
Hypothyroidism/myxoedema (self-reported) 0.3 0.5 1.3 -0.7 -0.6 -0.2 1.1
Medication: Amlodipine 2.8 4.0 5.6 1.6 -2.4 2.4 -1.4
Medication: Ventolin 100micrograms inhaler 0.3 0.4 1.2 0.4 0.0 0.5 -1.1
Birth weight 9.6 20.7 39.2 6.3 -2.4 5.6 -2.5
Chronic bronchitis/emphysema (mother) 0.7 0.8 2.9 0.6 1.7 -0.1 0.2
High blood pressure (siblings) 0.2 0.3 0.6 0.2 -0.7 0.8 -0.1
Forced vital capacity (FVC), Best measure 11.1 40.5 99.8 10.0 -0.9 6.3 -4.7
Body fat percentage 1.0 4.0 7.6 2.2 -2.8 1.8 -0.7
Leg fat percentage (right) 0.3 1.1 2.4 -1.1 -0.9 -1.6 0.0
Arm fat-free mass (right) 6.6 34.0 76.4 8.7 -2.2 6.4 -3.8
Exposure to tobacco smoke outside home 0.5 0.7 2.2 -0.3 1.5 -0.3 0.5
Comparative body size at age 10 2.7 7.4 11.2 -3.3 2.9 -2.1 2.3
Number of full brothers 2.3 3.0 4.0 -1.7 1.8 -2.0 1.3
Worry too long after embarrassment 3.2 5.3 12.4 3.5 0.2 2.6 -1.4
Seen a psychiatrist for nerves, anxiety, tension or depression 4.7 6.1 10.0 -3.2 2.0 -3.0 1.3
Wheeze or whistling in the chest in last year 0.2 0.3 0.6 0.7 -0.2 -0.2 0.8
Number of children fathered 2.6 2.9 7.0 -1.5 -1.4 -2.6 -0.7
Reason for reducing amount of alcohol drunk: Health precaution 2.0 2.3 3.2 -1.6 1.2 -1.4 -1.8
Age at first live birth 2.4 4.2 6.2 2.5 -1.7 2.4 -1.5
Pulse wave peak to peak time 1.9 2.2 5.0 2.2 -1.0 1.6 -0.3
Health satisfaction 0.8 1.0 2.3 -0.2 -1.2 -0.6 1.5
Shortness of breath walking on level ground 1.0 1.2 4.3 0.6 0.3 -0.1 -2.1
Qualifications: College or University degree 0.1 0.3 1.2 -0.4 -0.2 1.1 0.2
Eye problems/disorders: None of the above 0.9 1.1 2.2 0.2 1.3 0.4 -1.5
Mouth/teeth dental problems: Loose teeth 0.7 0.9 3.1 -0.5 -0.2 -1.8 -0.1
Emphysema/chronic bronchitis 0.6 0.7 1.4 1.1 -0.3 1.2 -0.1
Medication for pain relief, constipation, heartburn 0.8 1.3 3.3 0.3 -1.8 1.3 0.5
Neck or shoulder pain in last month 0.1 0.1 0.2 -0.1 0.4 -0.3 -0.1
Medication: Blood pressure 1.3 2.3 4.3 1.3 -1.6 2.1 0.7
Angina (self-reported) 1.2 1.6 3.1 1.8 -0.6 1.1 -1.3
Migraine (self-reported) 0.4 0.5 1.3 -0.5 -0.2 -1.2 -0.4
Medication: Ibuprofen 0.5 0.6 2.4 -0.2 1.5 -0.3 -0.3
Medication: Allopurinol 0.1 0.1 0.3 0.3 0.5 0.0 -0.0
Medication: Omeprazole 2.6 3.1 4.4 -2.1 0.6 -2.0 1.9
Medication: Seretide 50 evohaler 0.4 0.4 0.8 0.8 0.4 -0.1 -0.9
Mean time to correctly identify matches 0.2 0.4 0.8 -0.4 -0.9 0.5 0.8
Heart disease (mother) 0.1 0.1 0.3 -0.1 -0.6 -0.3 0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 3.1 3.7 6.6 -2.4 1.6 -2.6 0.2
Whole body fat mass 3.0 12.7 24.2 4.9 -3.1 3.8 -1.6
Leg fat mass (right) 0.8 2.9 6.0 2.5 -1.8 1.3 -0.9
Arm predicted mass (right) 6.6 33.9 75.5 8.7 -2.3 6.4 -3.6
Pulse rate, automated reading 0.8 2.7 7.7 -1.4 -2.8 -0.8 0.6
Alcohol intake frequency. 0.6 1.4 3.5 -1.2 1.9 -0.7 0.1
Comparative height size at age 10 20.9 115.3 240.2 15.5 -6.6 12.2 -5.3
Number of full sisters 1.1 1.3 2.5 -1.2 1.1 -1.6 0.0
Suffer from ‘nerves’ 0.8 1.3 3.4 -0.9 1.9 0.7 -0.6
Overall health rating 0.3 0.6 2.1 -0.1 0.4 -1.5 0.1
Chest pain or discomfort 0.2 0.2 0.8 0.3 -0.9 0.1 -0.3
Had major operations 3.6 4.2 8.2 -2.4 1.3 -2.9 1.2
Age at last live birth 4.4 6.5 10.7 3.0 -1.2 3.3 -2.1
Family relationship satisfaction 0.3 0.4 0.5 0.7 0.4 0.6 -0.7
Leg pain on walking 1.6 2.0 4.8 -1.6 0.4 -2.2 -0.7
Qualifications: NVQ or HND or HNC or equivalent 1.2 1.5 3.4 0.1 -0.0 -1.8 -1.6
Commuting to job workplace: Car/motor vehicle 0.4 0.5 1.7 -0.2 -1.3 -0.3 0.2
Illness, injury, bereavement, stress in last 2 years 0.8 0.9 2.2 0.3 0.7 1.5 0.9
Medication: Aspirin 2.4 3.2 7.8 2.8 -1.1 0.8 -1.8
Supplements: Vitamin C 0.5 0.6 1.8 0.0 1.4 -0.0 0.8
Knee pain experienced in last month 0.4 0.6 1.0 0.0 1.0 -0.8 -0.9
Hypertension (Self-reported) 0.8 2.1 3.2 1.6 -1.2 1.8 -1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.9 1.1 3.3 -0.5 0.3 -1.8 0.9
Illnesses of father: Heart disease 0.1 0.2 0.4 -0.6 -0.1 -0.3 0.3
Illnesses of siblings: Diabetes 0.9 1.0 3.3 -0.8 0.5 -1.8 -0.1
Smoking status: Previous 0.9 1.3 3.7 -0.5 0.9 -1.9 0.7
Forced expiratory volume in 1-second (FEV1), predicted 17.2 35.8 70.4 8.4 -2.5 6.7 -4.7
Whole body fat-free mass 7.4 42.1 98.4 9.9 -2.5 7.2 -3.5
Leg fat-free mass (right) 6.6 35.2 80.8 9.0 -2.6 6.7 -2.9
Arm fat percentage (left) 0.1 0.6 2.1 -0.1 -1.4 0.1 0.4
Average weekly red wine intake 0.4 0.6 1.6 0.0 0.6 -1.3 0.8
Handedness (chirality/laterality): Left-handed 0.9 1.1 2.2 0.1 -1.3 1.5 0.7
Mood swings 5.2 9.4 20.8 -2.8 2.5 -4.6 -1.7
Loneliness, isolation 2.7 3.7 8.2 -1.4 2.1 -2.9 0.3
Long-standing illness, disability or infirmity 0.4 0.6 1.8 1.4 0.1 0.5 -0.4
Ever had bowel cancer screening 3.9 4.5 11.0 -3.3 -0.1 -2.5 1.0
Diabetes diagnosed by doctor 1.0 1.7 5.5 2.4 -0.6 -0.1 -1.0
Ever had stillbirth, spontaneous miscarriage or termination 2.7 2.9 5.1 2.1 -2.3 1.1 -1.0
Friendships satisfaction 0.0 0.0 0.1 -0.3 -0.0 -0.0 -0.2
Qualifications: nursing, teaching 2.5 3.8 5.0 2.1 -1.6 1.8 -2.2
Commuting to job workplace: Walk 0.1 0.1 0.2 -0.3 -0.5 -0.2 -0.4
Eye problems/disorders: Cataract 0.6 0.6 1.0 0.8 -1.0 0.8 0.5
Mouth/teeth dental problems: Mouth ulcers 1.1 1.7 3.6 -0.9 1.9 -1.4 -0.8
Medication for cholesterol 0.6 0.9 1.8 -0.6 1.0 -1.3 0.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.4 0.9 -0.4 0.9 -0.9 0.1
Back pain experienced in last month 1.5 2.2 4.5 2.1 0.8 0.6 -1.8
Mineral and other dietary supplements 0.7 1.0 1.5 -1.1 1.2 -0.5 -1.0
Breast cancer (self-reported) 0.7 0.8 1.3 0.3 1.1 0.8 1.1
Asthma (self-reported) 1.0 2.0 3.7 1.9 0.3 1.9 -0.7
Osteoporosis (self-reported) 0.3 0.3 0.6 0.6 -0.1 0.8 -0.6
Osteoarthritis (self-reported) 0.3 0.4 1.0 -0.4 0.1 -1.0 0.6
Medication: Aspirin 1.8 2.3 6.6 2.6 -0.9 0.6 -1.3
Medication: Gliclazide 1.3 1.5 2.5 0.3 1.6 -1.4 -1.2
Illnesses of father: None of the above (group 1) 0.1 0.2 0.4 0.3 0.1 0.6 -0.3
Smoking status: Current 1.2 1.9 4.4 -0.8 1.0 -2.1 -1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 3.8 8.1 19.5 -4.4 1.4 -3.0 1.4
Whole body water mass 7.2 41.2 96.2 9.8 -2.4 7.0 -3.6
Leg predicted mass (right) 6.6 35.1 80.5 9.0 -2.5 6.7 -2.8
Arm fat mass (left) 1.2 4.9 9.2 3.0 -1.9 2.3 -1.0
Number of self-reported non-cancer illnesses 0.4 0.7 1.4 -0.2 0.7 -1.2 1.0
Average weekly champagne plus white wine intake 2.2 3.0 4.5 1.6 -1.9 2.1 -1.1
Miserableness 1.7 2.9 4.2 -0.5 1.7 -2.0 -2.0
Guilty feelings 1.0 1.6 3.9 0.9 2.0 0.6 -1.0
Wears glasses or contact lenses 1.7 1.9 4.2 -1.0 2.0 -0.6 1.4
Ever taken oral contraceptive pill 0.8 0.9 2.2 0.5 1.5 -1.0 -0.2
Hearing aid user 0.6 0.7 1.9 0.5 0.8 0.4 1.4
Mother’s age at death 1.8 2.3 3.6 1.7 -1.2 1.9 1.1
Financial situation satisfaction 0.7 0.8 2.5 0.5 -0.1 -0.7 -1.6
Tinnitus: Yes, now most or all of the time 0.7 0.8 1.0 -1.0 -0.7 0.9 1.0
Commuting to job workplace: Public transport 0.5 0.6 0.7 0.7 0.9 0.8 -0.8
Eye problems/disorders: Glaucoma 1.7 2.0 3.9 -2.0 -0.9 -1.5 1.1
Medication: Blood pressure 0.4 0.7 1.5 0.7 -0.6 0.7 -1.2
Pain type(s) experienced in last month: Hip pain 0.0 0.0 0.1 -0.0 0.0 -0.3 0.2
Supplements: Fish oil (including cod liver oil) 0.3 0.4 1.4 0.1 -1.2 -0.1 0.5
High cholesterol (Self-reported) 0.3 0.5 1.3 -0.7 -1.1 -0.0 -0.2
Medication: Bendroflumethiazide 0.5 0.8 1.9 -0.9 -1.4 -0.7 0.1
Medication: Paracetamol 1.1 1.8 2.7 -1.4 1.7 -1.4 -0.5
Medication: Lisinopril 0.4 0.5 1.6 0.4 -1.3 -0.2 -0.0
Medication: Atorvastatin 0.4 0.5 1.0 0.2 0.3 0.8 -1.0
Illnesses of father: High blood pressure 0.0 0.1 0.1 -0.1 0.3 -0.1 -0.3
Alcohol drinker status: Never 2.3 2.8 4.8 -2.2 1.6 -1.9 0.3
Ever smoked 1.9 3.4 6.8 -1.3 2.3 -2.6 0.2
Basal metabolic rate 7.5 41.8 96.6 9.8 -2.7 7.1 -3.6
Leg fat percentage (left) 0.2 0.9 1.4 -0.9 -1.1 -1.2 -0.2
Arm fat-free mass (left) 7.1 35.9 81.4 9.0 -2.4 6.5 -3.8
Number of operations (self-reported) 3.1 4.6 9.3 -2.4 0.7 -3.1 1.8
Average weekly beer plus cider intake 1.7 2.4 7.6 -0.2 2.8 -1.3 -0.6
Irritability 2.5 4.2 9.7 -1.6 1.7 -3.1 -1.1
Risk taking 0.9 1.4 3.6 -1.9 0.3 -0.9 1.0
Ever had prostate specific antigen (PSA) test 0.4 0.4 0.5 -0.7 0.7 -0.5 0.7
Fractured/broken bones in last 5 years 0.6 0.8 2.2 0.3 1.5 -0.7 -0.7
Age started oral contraceptive pill 0.2 0.2 0.4 -0.5 0.4 -0.2 0.6
Diastolic blood pressure, automated reading 0.4 1.3 3.7 1.0 -1.9 0.5 -0.4
Ever depressed for a whole week 1.4 1.8 3.6 -1.6 -0.5 -0.9 1.9
Unable to work because of sickness or disability 0.5 0.6 1.0 -0.9 0.3 -0.8 1.0
Commuting to job workplace: Cycle 0.1 0.2 0.2 -0.4 0.5 -0.4 0.2
Myopia 0.5 0.7 1.4 1.2 -0.9 0.4 0.7
Vascular/heart problems diagnosed by doctor 1.3 3.4 4.5 -2.0 1.3 -2.1 1.9
Cholesterol lowering medication 0.2 0.3 0.5 -0.7 0.4 -0.2 -0.7
Medication: Omeprazole (e.g. Zanprol) 4.0 4.9 8.4 -2.8 0.4 -1.7 2.9
Pain experienced in last month 0.4 0.6 1.5 -0.3 -1.2 0.6 0.8
Supplements: Calcium 1.1 1.2 2.8 0.7 1.7 -0.9 -0.9
Basal cell carcinoma (self-reported) 0.6 0.7 2.1 0.7 -1.4 0.3 -0.5
Heart attack/myocardial infarction (self-reported) 0.5 0.7 1.8 0.6 0.6 0.5 -1.3
Deep venous thrombosis (DVT) (self-reported) 1.1 1.4 1.8 -1.2 1.3 -1.3 0.8
Heart disease (siblings) 0.3 0.4 1.1 -0.2 0.6 -1.1 -0.5
Alcohol drinker status: Previous 1.8 2.1 4.7 -1.0 2.2 -1.5 -0.5
Pack years of smoking 0.2 0.3 0.5 -0.3 -0.5 -0.6 0.7
Impedance of whole body 3.9 19.9 37.8 5.1 -3.6 6.2 -1.5
Leg fat mass (left) 0.9 3.6 6.8 2.6 -2.0 1.6 -1.1
Arm predicted mass (left) 6.8 34.4 79.9 8.9 -2.3 6.2 -3.8