[Hub]/) : Traits : Leg fat-free mass (left) :

chr7:91,046,993-93,160,671

Best TWAS P=2.73e-50 · Best GWAS P=2.6e-46 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex CDK6 0.12 0.10 lasso 2 0.10 1.9e-12 13.95 14.0 2.9e-44 0.89 0.03 0.97 FALSE
2 CommonMind Brain Pre-frontal Cortex KRIT1 0.04 0.01 blup 318 0.02 1.2e-03 4.03 -5.3 1.2e-07 -0.20 0.60 0.02 FALSE
3 GTEx Adipose Visceral Omentum GATAD1 0.12 0.08 lasso 5 0.06 7.5e-04 6.97 -6.8 9.3e-12 -0.51 0.80 0.08 FALSE
4 GTEx Adrenal Gland GATAD1 0.40 0.22 lasso 7 0.25 2.0e-09 6.97 -7.9 2.6e-15 -0.57 0.61 0.16 FALSE
5 GTEx Artery Aorta KRIT1 0.15 0.00 enet 24 0.03 1.3e-02 0.12 -6.6 3.5e-11 -0.27 0.12 0.05 FALSE
6 GTEx Artery Aorta GATAD1 0.09 0.08 enet 4 0.07 7.4e-05 6.97 -6.9 6.6e-12 -0.49 0.49 0.11 FALSE
7 GTEx Artery Coronary GATAD1 0.12 0.15 lasso 3 0.12 8.0e-05 7.05 -7.3 3.7e-13 -0.54 0.17 0.28 FALSE
8 GTEx Artery Tibial GATAD1 0.14 0.04 enet 17 0.04 4.1e-04 6.97 -6.6 5.3e-11 -0.45 0.69 0.12 FALSE
9 GTEx Artery Tibial AC007566.10 0.13 0.04 lasso 5 0.00 3.1e-01 4.42 -5.2 2.4e-07 -0.10 0.08 0.04 FALSE
10 GTEx Brain Caudate basal ganglia GATAD1 0.21 0.09 lasso 4 0.08 2.3e-03 5.69 -8.1 6.6e-16 -0.56 0.05 0.51 FALSE
11 GTEx Breast Mammary Tissue (Female) AC007566.10 0.04 -0.01 lasso 2 0.01 2.0e-01 1.02 -6.7 2.9e-11 -0.32 0.03 0.16 FALSE
12 GTEx Cells Transformed fibroblasts GATAD1 0.23 0.20 lasso 4 0.22 1.4e-16 6.97 -9.3 1.8e-20 -0.69 0.92 0.08 FALSE
13 GTEx Colon Transverse GATAD1 0.13 0.00 enet 16 0.05 3.0e-03 6.97 -7.8 4.8e-15 -0.52 0.17 0.30 FALSE
14 GTEx Esophagus Mucosa GATAD1 0.16 0.05 enet 16 0.08 7.3e-06 6.97 -7.2 6.5e-13 -0.46 0.68 0.21 FALSE
15 GTEx Esophagus Muscularis GATAD1 0.18 0.10 enet 33 0.13 1.6e-08 6.97 -5.6 1.9e-08 -0.38 0.97 0.00 FALSE
16 GTEx Esophagus Muscularis FAM133B 0.07 0.01 enet 2 0.01 1.2e-01 -9.74 -9.7 2.0e-22 -0.55 0.08 0.27 FALSE
17 GTEx Lung GATAD1 0.15 0.12 lasso 2 0.11 1.1e-08 6.97 -6.9 4.4e-12 -0.53 0.99 0.00 FALSE
18 GTEx Muscle Skeletal PEX1 0.06 0.03 lasso 5 0.02 2.7e-03 5.97 6.4 1.5e-10 0.42 0.41 0.34 FALSE
19 GTEx Muscle Skeletal GATAD1 0.05 0.00 enet 13 0.01 2.4e-02 3.22 -6.7 2.6e-11 -0.44 0.46 0.07 FALSE
20 GTEx Nerve Tibial GATAD1 0.30 0.19 lasso 5 0.23 1.8e-16 6.97 -5.2 2.3e-07 -0.44 1.00 0.00 FALSE
21 GTEx Pancreas GATAD1 0.12 0.13 lasso 2 0.14 2.0e-06 6.97 -6.0 1.8e-09 -0.49 0.09 0.73 FALSE
22 GTEx Pituitary KRIT1 0.21 -0.01 enet 14 0.20 1.1e-05 -0.12 -5.7 9.9e-09 -0.05 0.29 0.06 TRUE
23 GTEx Skin Not Sun Exposed Suprapubic GATAD1 0.22 0.27 lasso 4 0.26 1.1e-14 6.97 -7.1 1.2e-12 -0.53 1.00 0.00 FALSE
24 GTEx Skin Sun Exposed Lower leg PEX1 0.18 0.06 enet 41 0.03 1.5e-03 -7.90 -7.7 1.5e-14 -0.44 0.21 0.14 FALSE
25 GTEx Skin Sun Exposed Lower leg GATAD1 0.30 0.10 enet 14 0.16 7.0e-13 6.97 -6.8 1.2e-11 -0.44 1.00 0.00 FALSE
26 GTEx Spleen PEX1 0.18 0.00 enet 38 0.05 2.4e-02 3.58 -7.0 3.2e-12 -0.38 0.08 0.13 FALSE
27 GTEx Stomach GATAD1 0.30 0.13 lasso 5 0.15 8.6e-08 6.97 -6.9 6.6e-12 -0.52 0.97 0.00 FALSE
28 GTEx Testis CDK6 0.10 0.10 lasso 3 0.09 8.0e-05 14.29 -14.9 2.7e-50 -0.96 0.00 0.99 TRUE
29 GTEx Thyroid GATAD1 0.18 0.06 lasso 4 0.06 3.3e-05 6.97 -6.7 2.9e-11 -0.48 0.96 0.02 FALSE
30 METSIM Adipose GATAD1 0.10 0.05 lasso 7 0.06 9.4e-10 3.22 -5.1 2.9e-07 -0.40 1.00 0.00 FALSE
31 ROSMAP Brain Pre-frontal Cortex KRIT1 0.04 0.03 bslmm 311 0.01 9.0e-03 3.58 6.8 1.5e-11 0.51 0.74 0.06 FALSE
32 ROSMAP Brain Pre-frontal Cortex GATAD1 0.17 0.15 lasso 4 0.16 6.0e-20 6.92 -6.9 5.2e-12 -0.51 1.00 0.00 FALSE
33 YFS Blood CYP51A1 0.03 0.06 blup 288 0.05 1.2e-16 3.92 -5.4 6.1e-08 -0.32 1.00 0.00 FALSE
34 YFS Blood GATAD1 0.01 0.01 blup 297 0.01 5.1e-04 6.97 -8.8 8.8e-19 -0.53 0.74 0.09 FALSE
35 The Cancer Genome Atlas Breast Invasive Carcinoma GATAD1 0.06 0.04 lasso 6 0.04 2.2e-09 6.70 -6.3 2.4e-10 -0.40 0.58 0.42 FALSE
36 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma GATAD1 0.04 0.04 lasso 2 0.03 2.8e-04 6.70 -6.5 1.1e-10 -0.47 0.14 0.21 FALSE
37 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma C7orf64 0.06 0.02 blup 36 0.02 6.0e-02 6.04 5.5 3.8e-08 0.42 0.04 0.05 FALSE