Best TWAS P=8.66e-12 · Best GWAS P=1.47e-09 conditioned to 0.488
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | DNA2 | 0.32 | 0.18 | lasso | 9 | 0.20 | 1.9e-10 | -5.1 | 5.2 | 1.7e-07 | -0.81 | 0.60 | 0.40 | FALSE |
| 2 | GTEx | Artery Coronary | DNA2 | 0.12 | 0.12 | lasso | 5 | 0.12 | 5.3e-05 | -5.0 | 5.3 | 1.2e-07 | -0.85 | 0.06 | 0.85 | FALSE |
| 3 | GTEx | Brain Hypothalamus | SLC25A16 | 0.20 | 0.19 | lasso | 5 | 0.14 | 3.6e-04 | -5.1 | -5.2 | 2.4e-07 | 0.83 | 0.10 | 0.37 | FALSE |
| 4 | GTEx | Cells EBV-transformed lymphocytes | DNA2 | 0.32 | 0.14 | lasso | 2 | 0.10 | 2.9e-04 | -5.1 | 5.1 | 3.1e-07 | -0.84 | 0.09 | 0.81 | FALSE |
| 5 | GTEx | Cells Transformed fibroblasts | SLC25A16 | 0.10 | 0.02 | enet | 25 | 0.01 | 2.5e-02 | -3.5 | -5.2 | 2.1e-07 | 0.63 | 0.76 | 0.12 | FALSE |
| 6 | GTEx | Heart Atrial Appendage | PBLD | 0.08 | 0.02 | lasso | 2 | 0.02 | 6.1e-02 | -6.0 | -6.6 | 5.4e-11 | 0.86 | 0.02 | 0.83 | FALSE |
| 7 | GTEx | Lung | DNA2 | 0.22 | 0.17 | enet | 12 | 0.24 | 3.9e-18 | -5.0 | 5.2 | 2.3e-07 | -0.80 | 0.61 | 0.39 | FALSE |
| 8 | GTEx | Pancreas | DNA2 | 0.12 | 0.06 | enet | 9 | 0.08 | 4.1e-04 | -4.2 | 5.4 | 8.0e-08 | -0.84 | 0.07 | 0.87 | FALSE |
| 9 | GTEx | Skin Not Sun Exposed Suprapubic | DNA2 | 0.29 | 0.16 | lasso | 14 | 0.22 | 2.4e-12 | -4.5 | 5.2 | 2.0e-07 | -0.81 | 0.60 | 0.40 | FALSE |
| 10 | ROSMAP | Brain Pre-frontal Cortex | PBLD | 0.04 | 0.01 | bslmm | 388 | 0.02 | 1.3e-03 | -3.7 | -5.2 | 2.2e-07 | 0.64 | 0.16 | 0.83 | FALSE |
| 11 | ROSMAP | Brain Pre-frontal Cortex | SLC25A16 | 0.17 | 0.11 | lasso | 6 | 0.15 | 2.9e-19 | -4.2 | -5.4 | 8.6e-08 | 0.90 | 0.13 | 0.87 | FALSE |
| 12 | YFS | Blood | SLC25A16 | 0.09 | 0.13 | lasso | 3 | 0.13 | 6.8e-39 | -5.0 | -5.3 | 9.5e-08 | 0.89 | 0.09 | 0.91 | FALSE |
| 13 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | PBLD | 0.06 | 0.07 | lasso | 2 | 0.04 | 2.3e-04 | -5.7 | -5.7 | 9.2e-09 | 0.47 | 0.00 | 1.00 | FALSE |
| 14 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | DNA2 | 0.08 | 0.09 | lasso | 1 | 0.06 | 7.3e-04 | -6.0 | 6.0 | 1.7e-09 | -1.00 | 0.00 | 0.99 | FALSE |
| 15 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | PBLD | 0.03 | 0.03 | lasso | 9 | 0.02 | 1.6e-03 | -5.2 | -5.2 | 1.6e-07 | 0.51 | 0.02 | 0.86 | FALSE |
| 16 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PBLD | 0.10 | 0.03 | lasso | 3 | 0.04 | 2.2e-05 | -5.7 | -5.4 | 6.6e-08 | 0.46 | 0.00 | 1.00 | FALSE |
| 17 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | ATOH7 | 0.08 | 0.04 | enet | 19 | 0.06 | 3.1e-04 | -3.7 | 5.5 | 5.0e-08 | -0.46 | 0.04 | 0.86 | FALSE |
| 18 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | DNA2 | 0.05 | 0.00 | blup | 43 | 0.00 | 3.0e-01 | -5.1 | 5.4 | 8.0e-08 | -0.86 | 0.01 | 0.84 | FALSE |
| 19 | The Cancer Genome Atlas | Brain Lower Grade Glioma | SLC25A16 | 0.05 | 0.01 | blup | 42 | 0.02 | 2.9e-03 | -5.1 | -5.5 | 4.0e-08 | 0.76 | 0.06 | 0.83 | FALSE |
| 20 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | SLC25A16 | 0.02 | 0.02 | enet | 8 | 0.02 | 7.7e-04 | -6.0 | -5.9 | 3.6e-09 | 0.97 | 0.01 | 0.91 | FALSE |
| 21 | The Cancer Genome Atlas | Soft Tissue Sarcoma | SLC25A16 | 0.07 | 0.03 | blup | 42 | 0.02 | 1.7e-02 | -6.0 | -6.8 | 8.7e-12 | 0.92 | 0.01 | 0.93 | TRUE |
| 22 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | DNA2 | 0.14 | 0.07 | blup | 43 | 0.08 | 8.6e-04 | -5.6 | -5.5 | 3.4e-08 | 0.76 | 0.03 | 0.77 | FALSE |
| 23 | The Cancer Genome Atlas | Thyroid Carcinoma | SLC25A16 | 0.05 | 0.05 | lasso | 3 | 0.04 | 3.8e-05 | -5.0 | -5.2 | 1.7e-07 | 0.83 | 0.06 | 0.82 | FALSE |