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chr11:198,510-1,534,852

Best TWAS P=2.09e-11 · Best GWAS P=8.09e-11 conditioned to 0.131

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
21	GTEx	Testis	POLR2L	0.16	0.03	enet	10	0.03	1.9e-02	-6.5	-6.7	2.1e-11	0.85	0.00	0.99	TRUE
14	GTEx	Heart Left Ventricle	CD151	0.27	0.10	enet	47	0.10	5.5e-06	-5.8	6.4	1.2e-10	-0.49	0.13	0.85	FALSE
27	YFS	Blood	POLR2L	0.26	0.19	bslmm	383	0.30	2.4e-98	-4.1	6.2	4.6e-10	-0.78	0.85	0.13	FALSE
24	METSIM	Adipose	POLR2L	0.03	0.02	bslmm	413	0.01	5.0e-03	-5.1	-6.2	5.1e-10	0.57	0.21	0.25	FALSE
2	CommonMind	Brain Pre-frontal Cortex	POLR2L	0.09	0.09	enet	16	0.10	4.6e-12	-4.1	-6.1	1.4e-09	0.85	0.10	0.90	FALSE
36	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PNPLA2	0.07	0.00	blup	51	0.03	1.4e-04	-4.1	6.0	2.3e-09	-0.61	0.02	0.49	FALSE
31	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	CHID1	0.06	0.05	blup	67	0.03	2.0e-02	3.6	-5.7	1.1e-08	0.73	0.04	0.32	FALSE
20	GTEx	Testis	CD151	0.39	0.29	lasso	11	0.24	6.0e-11	-5.8	5.7	1.2e-08	-0.62	0.09	0.91	FALSE
19	GTEx	Skin Sun Exposed Lower leg	CD151	0.16	0.16	lasso	4	0.15	3.5e-12	-5.8	5.6	1.8e-08	-0.59	0.09	0.91	FALSE
10	GTEx	Colon Transverse	CD151	0.24	0.29	lasso	3	0.27	2.7e-13	-5.8	5.6	1.9e-08	-0.59	0.08	0.92	FALSE
32	The Cancer Genome Atlas	Colon Adenocarcinoma	CD151	0.07	0.06	lasso	3	0.05	9.1e-04	-5.7	5.6	2.0e-08	-0.63	0.09	0.52	FALSE
45	The Cancer Genome Atlas	Stomach Adenocarcinoma	CD151	0.03	0.00	blup	50	0.01	3.6e-02	-5.0	5.6	2.0e-08	-0.59	0.04	0.15	FALSE
33	The Cancer Genome Atlas	Glioblastoma Multiforme	CD151	0.13	0.02	blup	50	0.08	1.8e-03	-5.0	5.6	2.1e-08	-0.68	0.05	0.50	FALSE
44	The Cancer Genome Atlas	Soft Tissue Sarcoma	CD151	0.11	0.11	blup	52	0.13	4.2e-08	-4.2	5.6	2.2e-08	-0.76	0.05	0.95	FALSE
35	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	EFCAB4A	0.04	0.05	enet	7	0.05	6.1e-06	-5.8	5.6	2.3e-08	-0.65	0.24	0.75	FALSE
25	NTR	Blood	CD151	0.23	0.28	lasso	6	0.29	3.7e-96	-5.1	5.6	2.8e-08	-0.66	0.73	0.27	FALSE
17	GTEx	Nerve Tibial	CD151	0.32	0.24	lasso	6	0.21	6.3e-15	-5.8	5.5	2.9e-08	-0.63	0.08	0.92	FALSE
18	GTEx	Pancreas	EFCAB4A	0.23	0.19	enet	8	0.16	4.1e-07	-5.3	5.5	2.9e-08	-0.51	0.59	0.40	FALSE
42	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	CHID1	0.07	0.05	blup	68	0.01	8.0e-02	-6.5	-5.5	3.8e-08	0.76	0.01	0.86	FALSE
29	The Cancer Genome Atlas	Breast Invasive Carcinoma	CD151	0.06	0.07	lasso	4	0.06	8.5e-12	-5.0	5.5	5.0e-08	-0.66	0.79	0.20	FALSE
23	GTEx	Whole Blood	CD151	0.31	0.32	lasso	7	0.34	2.1e-32	-5.8	5.4	5.5e-08	-0.63	0.08	0.92	FALSE
37	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	POLR2L	0.02	0.02	blup	46	0.02	4.5e-03	-5.1	5.4	5.8e-08	-0.67	0.08	0.27	FALSE
39	The Cancer Genome Atlas	Brain Lower Grade Glioma	CD151	0.18	0.26	blup	52	0.27	1.4e-30	-5.0	5.4	6.0e-08	-0.63	0.48	0.52	FALSE
1	CommonMind	Brain Pre-frontal Cortex	CD151	0.16	0.16	lasso	4	0.15	3.2e-18	-5.0	5.4	6.3e-08	-0.65	0.47	0.53	FALSE
13	GTEx	Esophagus Muscularis	CD151	0.38	0.31	lasso	9	0.33	5.5e-21	-5.1	5.4	6.9e-08	-0.65	0.32	0.68	FALSE
11	GTEx	Esophagus Gastroesophageal Junction	CD151	0.39	0.28	lasso	3	0.28	1.5e-10	-5.1	5.4	7.4e-08	-0.67	0.43	0.57	FALSE
4	GTEx	Adrenal Gland	CD151	0.21	0.21	lasso	2	0.17	7.9e-07	-5.1	5.4	7.6e-08	-0.67	0.36	0.60	FALSE
22	GTEx	Thyroid	CD151	0.47	0.41	lasso	4	0.44	3.2e-36	-5.1	5.4	8.3e-08	-0.67	0.78	0.22	FALSE
30	The Cancer Genome Atlas	Breast Invasive Carcinoma	EFCAB4A	0.02	0.01	blup	48	0.01	7.3e-03	-4.2	5.4	8.3e-08	-0.69	0.04	0.22	FALSE
5	GTEx	Artery Tibial	CD151	0.25	0.14	lasso	4	0.15	1.3e-11	-5.1	5.4	8.5e-08	-0.68	0.68	0.32	FALSE
12	GTEx	Esophagus Mucosa	CD151	0.28	0.26	lasso	4	0.26	3.9e-17	-5.8	5.3	9.2e-08	-0.58	0.09	0.91	FALSE
26	YFS	Blood	CD151	0.44	0.46	lasso	9	0.52	2.5e-205	-5.8	5.3	9.3e-08	-0.66	0.00	1.00	FALSE
7	GTEx	Brain Hypothalamus	PNPLA2	0.23	-0.01	lasso	9	0.00	4.0e-01	-5.1	-5.3	1.2e-07	0.51	0.05	0.26	FALSE
34	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CD151	0.13	0.22	enet	13	0.22	1.1e-23	-5.1	5.3	1.3e-07	-0.68	0.72	0.28	FALSE
3	GTEx	Adipose Subcutaneous	POLR2L	0.19	0.12	enet	18	0.11	3.4e-09	-4.2	-5.3	1.4e-07	0.71	0.59	0.41	FALSE
6	GTEx	Brain Frontal Cortex BA9	AP006621.5	0.18	0.03	lasso	6	0.04	2.6e-02	-5.1	5.3	1.4e-07	-0.48	0.07	0.48	FALSE
41	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	CEND1	0.05	0.00	blup	52	0.02	1.1e-02	-5.1	5.2	1.5e-07	-0.59	0.02	0.61	FALSE
9	GTEx	Cells Transformed fibroblasts	POLR2L	0.12	0.11	lasso	5	0.12	5.2e-09	-4.2	-5.2	1.7e-07	0.73	0.61	0.39	FALSE
15	GTEx	Liver	CD151	0.37	0.25	enet	19	0.27	3.2e-08	-5.8	5.2	1.7e-07	-0.65	0.12	0.85	FALSE
8	GTEx	Cells EBV-transformed lymphocytes	CD151	0.36	0.30	enet	12	0.39	7.2e-14	-5.8	5.2	1.8e-07	-0.71	0.16	0.84	FALSE
38	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	POLR2L	0.04	0.02	blup	48	0.03	5.5e-04	-5.7	-5.2	1.8e-07	0.72	0.03	0.94	FALSE
43	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	CD151	0.14	0.15	lasso	4	0.14	3.8e-06	-5.0	5.2	2.2e-07	-0.66	0.26	0.68	FALSE
16	GTEx	Muscle Skeletal	POLR2L	0.08	0.10	enet	6	0.09	2.8e-09	-5.1	-5.2	2.3e-07	0.72	0.75	0.25	FALSE
46	The Cancer Genome Atlas	Thyroid Carcinoma	EFCAB4A	0.08	0.03	blup	48	0.03	9.1e-04	-4.2	5.1	2.9e-07	-0.67	0.01	0.87	FALSE
28	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	CD151	0.05	0.08	lasso	1	0.06	3.8e-06	-5.1	5.1	3.0e-07	-0.68	0.48	0.49	FALSE
40	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	LRDD	0.11	0.03	enet	14	0.04	4.0e-05	4.5	5.1	3.0e-07	-0.61	0.24	0.70	FALSE