Best TWAS P=1.92e-11 · Best GWAS P=2.83e-10 conditioned to 0.061
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | PRR13 | 0.13 | 0.10 | lasso | 7 | 0.09 | 9.2e-08 | 5.1 | -5.6 | 1.6e-08 | 0.35 | 0.77 | 0.22 | FALSE |
| 2 | GTEx | Artery Aorta | SP1 | 0.14 | 0.14 | lasso | 8 | 0.14 | 2.2e-08 | 4.9 | 5.1 | 2.8e-07 | -0.24 | 0.84 | 0.16 | FALSE |
| 3 | GTEx | Artery Aorta | PRR13 | 0.23 | 0.28 | enet | 39 | 0.30 | 4.3e-17 | 5.1 | -5.7 | 1.1e-08 | 0.32 | 0.68 | 0.32 | FALSE |
| 4 | GTEx | Artery Coronary | SP1 | 0.17 | 0.12 | lasso | 4 | 0.12 | 8.6e-05 | 4.8 | 6.0 | 1.9e-09 | -0.31 | 0.17 | 0.58 | FALSE |
| 5 | GTEx | Breast Mammary Tissue | SP1 | 0.12 | 0.13 | lasso | 5 | 0.08 | 9.5e-05 | 4.9 | 5.8 | 8.5e-09 | -0.23 | 0.80 | 0.14 | FALSE |
| 6 | GTEx | Esophagus Gastroesophageal Junction | PRR13 | 0.22 | 0.16 | lasso | 4 | 0.18 | 3.2e-07 | 5.1 | -6.0 | 1.6e-09 | 0.29 | 0.26 | 0.12 | FALSE |
| 7 | GTEx | Esophagus Muscularis | PRR13 | 0.13 | 0.15 | lasso | 2 | 0.14 | 9.2e-09 | 5.1 | -5.2 | 1.8e-07 | 0.23 | 0.65 | 0.34 | FALSE |
| 8 | GTEx | Skin Sun Exposed Lower leg | PRR13 | 0.22 | 0.08 | lasso | 5 | 0.17 | 6.5e-14 | 4.8 | -5.5 | 3.4e-08 | 0.30 | 0.81 | 0.19 | FALSE |
| 9 | GTEx | Thyroid | PRR13 | 0.22 | 0.18 | lasso | 9 | 0.24 | 4.8e-18 | 4.8 | -5.5 | 3.4e-08 | 0.31 | 0.85 | 0.15 | FALSE |
| 10 | METSIM | Adipose | SP7 | 0.03 | 0.02 | lasso | 2 | 0.01 | 6.1e-03 | 5.0 | -5.5 | 3.2e-08 | 0.15 | 0.24 | 0.06 | TRUE |
| 11 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | PRR13 | 0.13 | 0.04 | blup | 28 | 0.07 | 3.3e-06 | 4.8 | -6.2 | 7.6e-10 | 0.58 | 0.07 | 0.38 | FALSE |
| 12 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | PRR13 | 0.03 | 0.03 | blup | 28 | 0.04 | 4.6e-05 | 4.8 | -5.4 | 5.7e-08 | 0.37 | 0.42 | 0.13 | FALSE |
| 13 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | PRR13 | 0.05 | 0.03 | blup | 28 | 0.04 | 4.1e-03 | 5.1 | -6.2 | 6.8e-10 | 0.47 | 0.03 | 0.12 | FALSE |
| 14 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PRR13 | 0.07 | 0.04 | blup | 28 | 0.05 | 4.7e-06 | 5.1 | -6.7 | 1.9e-11 | 0.60 | 0.37 | 0.28 | TRUE |
| 15 | The Cancer Genome Atlas | Rectum Adenocarcinoma | PCBP2 | 0.25 | 0.04 | blup | 36 | 0.10 | 2.3e-03 | -6.3 | -6.3 | 3.5e-10 | 0.64 | 0.00 | 0.54 | FALSE |
| 16 | The Cancer Genome Atlas | Thyroid Carcinoma | PCBP2 | 0.04 | 0.01 | enet | 6 | 0.02 | 4.8e-03 | 3.6 | -6.4 | 1.8e-10 | 0.63 | 0.01 | 0.58 | FALSE |