TWAS
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Usage
Models
Genes
Traits
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Traits
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Leg fat-free mass (left)
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chr17:1,717,695-2,477,695
Best TWAS P=2.62e-09 · Best GWAS P=9.97e-12 conditioned to 1.88e-11
1.7M
1.8M
1.9M
2M
2.1M
2.2M
2.3M
2.4M
2.5M
0
2
4
6
8
10
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
The Cancer Genome Atlas
Breast Invasive Carcinoma
SMG6
0.03
0.01
blup
144
0.01
0.00478
5.8
6.0
2.6e-09
-0.02
0.08
0.66
TRUE
2
The Cancer Genome Atlas
Kidney Renal Papillary Cell Carcinoma
SMG6
0.08
0.05
blup
144
0.07
0.00013
6.5
5.7
1.2e-08
-0.01
0.01
0.99
FALSE
3
The Cancer Genome Atlas
Skin Cutaneous Melanoma
SRR
0.16
0.03
blup
61
0.02
0.08720
-3.0
5.3
9.9e-08
-0.07
0.03
0.23
FALSE