TWAS
hub
About
Usage
Models
Genes
Traits
[Hub]/) :
Traits
:
Leg fat-free mass (left)
:
←
→
chr19:46,923,752-48,406,374
Best TWAS P=6.93e-14 · Best GWAS P=2.77e-28 conditioned to 2.66e-15
47M
47.2M
47.4M
47.6M
47.8M
48M
48.2M
48.4M
0
5
10
15
20
25
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
METSIM
Adipose
SAE1
0.12
0.04
lasso
5
0.07
1.7e-10
-5.5
-7.5
6.9e-14
0.61
0.61
0.39
TRUE
4
The Cancer Genome Atlas
Lung Squamous Cell Carcinoma
GRLF1
0.04
0.04
blup
51
0.03
7.0e-05
4.0
5.5
3.3e-08
-0.04
0.46
0.03
TRUE
1
GTEx
Cells EBV-transformed lymphocytes
SAE1
0.21
0.09
lasso
3
0.07
2.0e-03
-5.3
-7.2
5.9e-13
0.77
0.06
0.67
FALSE
3
YFS
Blood
SAE1
0.07
0.02
enet
18
0.05
3.6e-16
-8.5
-6.1
1.2e-09
0.56
0.99
0.01
FALSE