Best TWAS P=1.68e-09 · Best GWAS P=2.83e-11 conditioned to 0.0314
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | TYW5 | 0.08 | 0.14 | lasso | 8 | 0.13 | 2.2e-15 | -5.0 | 5.2 | 2.3e-07 | -0.05 | 0.02 | 0.98 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | RFTN2 | 0.14 | 0.10 | enet | 11 | 0.13 | 5.3e-11 | -5.4 | -5.6 | 1.7e-08 | 0.86 | 0.40 | 0.60 | FALSE |
| 3 | GTEx | Lung | RFTN2 | 0.06 | 0.08 | lasso | 8 | 0.06 | 2.7e-05 | -5.8 | -5.6 | 2.2e-08 | 0.86 | 0.21 | 0.78 | FALSE |
| 4 | GTEx | Skin Sun Exposed Lower leg | MARS2 | 0.04 | 0.05 | enet | 8 | 0.03 | 1.2e-03 | -6.0 | 5.9 | 3.6e-09 | -0.86 | 0.15 | 0.84 | FALSE |
| 5 | GTEx | Spleen | RFTN2 | 0.11 | 0.03 | enet | 26 | 0.05 | 2.4e-02 | -6.1 | -5.3 | 9.1e-08 | 0.84 | 0.10 | 0.28 | FALSE |
| 6 | GTEx | Spleen | MARS2 | 0.12 | 0.04 | lasso | 5 | 0.00 | 3.4e-01 | -6.0 | 5.4 | 6.2e-08 | -0.82 | 0.08 | 0.28 | FALSE |
| 7 | GTEx | Thyroid | RFTN2 | 0.04 | 0.01 | enet | 11 | 0.01 | 9.5e-02 | -6.0 | -5.7 | 1.2e-08 | 0.80 | 0.11 | 0.67 | FALSE |
| 8 | GTEx | Whole Blood | PLCL1 | 0.08 | 0.08 | enet | 15 | 0.05 | 4.1e-05 | -5.6 | -6.0 | 1.7e-09 | 0.92 | 0.13 | 0.87 | TRUE |
| 9 | ROSMAP | Brain Pre-frontal Cortex | TYW5 | 0.11 | 0.12 | lasso | 5 | 0.11 | 5.5e-14 | -5.0 | 5.2 | 2.4e-07 | -0.04 | 0.02 | 0.98 | FALSE |
| 10 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PLCL1 | 0.04 | 0.00 | blup | 130 | 0.02 | 4.0e-03 | 1.1 | -5.3 | 8.7e-08 | 0.65 | 0.05 | 0.37 | FALSE |
| 11 | The Cancer Genome Atlas | Lung Adenocarcinoma | C2orf60 | 0.03 | 0.03 | blup | 44 | 0.03 | 1.8e-04 | -5.0 | 5.3 | 9.1e-08 | -0.05 | 0.01 | 0.97 | TRUE |