[Hub]/) : Traits : Leg fat-free mass (left) : ← →

chr4:105,373,669-107,092,169

Best TWAS P=1.42e-19 · Best GWAS P=6.78e-22 conditioned to 0.000473

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
6	GTEx	Esophagus Gastroesophageal Junction	PPA2	0.29	0.15	lasso	5	0.14	8.8e-06	-9.4	-9.1	1.4e-19	0.88	0.02	0.97	TRUE
4	GTEx	Brain Cortex	PPA2	0.14	0.09	lasso	9	0.09	1.6e-03	-8.0	-8.1	5.4e-16	0.88	0.04	0.70	FALSE
7	GTEx	Esophagus Mucosa	PPA2	0.18	0.06	enet	14	0.12	2.5e-08	6.6	-7.9	3.9e-15	0.72	0.02	0.97	FALSE
11	GTEx	Ovary	PPA2	0.18	0.10	lasso	3	0.14	2.2e-04	-6.7	-7.8	8.4e-15	0.76	0.04	0.76	FALSE
15	The Cancer Genome Atlas	Thyroid Carcinoma	PPA2	0.04	0.02	blup	84	0.04	6.1e-05	-7.9	-7.1	9.5e-13	0.77	0.14	0.66	FALSE
5	GTEx	Cells Transformed fibroblasts	PPA2	0.11	0.03	lasso	3	0.01	6.5e-02	-6.5	-7.0	2.1e-12	0.67	0.36	0.22	FALSE
12	GTEx	Skin Sun Exposed Lower leg	TET2	0.09	0.01	enet	18	0.02	3.6e-03	-9.5	-6.7	1.9e-11	0.69	0.01	0.93	FALSE
2	GTEx	Artery Aorta	PPA2	0.11	-0.01	enet	24	0.01	1.6e-01	-9.4	-6.6	3.7e-11	0.63	0.04	0.61	FALSE
1	CommonMind	Brain Pre-frontal Cortex	PPA2	0.08	0.03	bslmm	429	0.04	2.2e-05	-6.0	-6.5	7.5e-11	0.66	0.04	0.94	FALSE
10	GTEx	Nerve Tibial	PPA2	0.13	0.07	enet	23	0.07	2.1e-05	-6.7	-6.3	3.8e-10	0.66	0.36	0.46	FALSE
8	GTEx	Heart Atrial Appendage	PPA2	0.15	0.05	lasso	7	0.06	7.4e-04	-7.9	-6.2	5.9e-10	0.71	0.21	0.45	FALSE
3	GTEx	Brain Cerebellum	PPA2	0.22	0.01	lasso	4	0.03	3.7e-02	-6.7	-5.5	3.4e-08	0.62	0.09	0.15	FALSE
14	YFS	Blood	PPA2	0.22	0.05	lasso	19	0.12	9.7e-38	-2.9	5.3	1.2e-07	-0.51	1.00	0.00	FALSE
9	GTEx	Muscle Skeletal	PPA2	0.19	0.06	enet	28	0.11	8.7e-11	-7.9	-5.2	2.5e-07	0.60	0.71	0.28	FALSE
13	GTEx	Thyroid	PPA2	0.22	0.01	enet	18	0.12	2.9e-09	5.0	-5.1	2.8e-07	0.54	0.68	0.15	FALSE