TWAS
hub
About
Usage
Models
Genes
Traits
[Hub]/) :
Traits
:
Leg fat-free mass (left)
:
←
→
chr4:144,882,744-146,788,825
Best TWAS P=4.85e-33 · Best GWAS P=4.34e-39 conditioned to 0.0873
145M
145.5M
146M
146.5M
0
10
20
30
40
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
4
ROSMAP
Brain Pre-frontal Cortex
OTUD4
0.04
0.03
lasso
2
0.03
1.4e-04
11.8
-12.0
4.8e-33
-0.85
0.12
0.83
TRUE
3
GTEx
Pancreas
ANAPC10
0.14
0.10
lasso
3
0.10
4.3e-05
-11.5
11.1
1.1e-28
0.60
0.32
0.11
TRUE
2
GTEx
Brain Hypothalamus
HHIP-AS1
0.12
0.02
enet
16
0.04
4.6e-02
8.7
8.3
1.5e-16
0.21
0.07
0.08
TRUE
1
CommonMind
Brain Pre-frontal Cortex
OTUD4
0.06
0.04
bslmm
272
0.04
2.6e-05
-9.9
-7.6
3.4e-14
-0.39
0.84
0.04
TRUE