[Hub]/) : Traits : Leg fat-free mass (left) : ← →

chr4:122,028,784-124,538,705

Best TWAS P=5.32e-18 · Best GWAS P=2.79e-13 conditioned to 7.12e-05

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
25	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CCNA2	0.03	0.01	blup	34	0.02	1.5e-03	-6.88	8.7	5.3e-18	0.02	0.00	0.97	TRUE
27	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	FGF2	0.06	0.04	blup	65	0.05	4.4e-06	6.08	5.9	3.6e-09	0.85	0.01	0.98	TRUE
11	GTEx	Cells Transformed fibroblasts	BBS7	0.16	0.09	lasso	7	0.16	2.9e-12	-7.03	-7.4	1.4e-13	-0.03	0.00	1.00	FALSE
30	The Cancer Genome Atlas	Thyroid Carcinoma	EXOSC9	0.04	0.05	lasso	2	0.04	7.1e-05	6.58	7.4	1.6e-13	0.03	0.02	0.96	FALSE
1	CommonMind	Brain Pre-frontal Cortex	BBS7	0.19	0.21	bslmm	423	0.23	1.8e-27	-6.92	-7.3	2.0e-13	-0.01	0.00	1.00	FALSE
21	The Cancer Genome Atlas	Breast Invasive Carcinoma	EXOSC9	0.03	0.04	enet	9	0.04	2.8e-08	6.58	7.3	3.8e-13	0.02	0.10	0.90	FALSE
17	GTEx	Testis	EXOSC9	0.17	0.07	lasso	8	0.10	2.5e-05	-5.40	7.0	1.9e-12	0.04	0.02	0.98	FALSE
26	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	BBS7	0.04	0.04	lasso	2	0.03	6.1e-04	-6.92	-6.9	4.1e-12	-0.03	0.00	1.00	FALSE
24	The Cancer Genome Atlas	Colon Adenocarcinoma	BBS7	0.05	0.00	blup	47	0.02	1.9e-02	6.62	-6.9	5.7e-12	-0.03	0.02	0.21	FALSE
10	GTEx	Cells EBV-transformed lymphocytes	EXOSC9	0.29	0.17	lasso	7	0.16	6.6e-06	6.18	6.8	8.9e-12	0.01	0.22	0.75	FALSE
28	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	EXOSC9	0.03	0.02	lasso	2	0.02	1.0e-03	6.22	6.7	2.0e-11	0.01	0.07	0.43	FALSE
20	YFS	Blood	EXOSC9	0.06	0.09	bslmm	401	0.09	7.0e-28	6.20	6.7	2.3e-11	0.00	0.32	0.68	FALSE
6	GTEx	Brain Cerebellum	BBS7	0.20	-0.01	enet	24	0.01	2.2e-01	-5.33	-5.7	9.7e-09	-0.03	0.07	0.72	FALSE
13	GTEx	Muscle Skeletal	NUDT6	0.15	0.12	lasso	3	0.11	1.1e-10	5.68	5.7	1.0e-08	0.74	0.98	0.02	FALSE
2	CommonMind	Brain Pre-frontal Cortex	NUDT6	0.04	0.04	lasso	3	0.02	6.5e-04	5.68	5.7	1.6e-08	0.74	0.71	0.04	FALSE
14	GTEx	Muscle Skeletal	RP11-170N16.3	0.07	0.07	lasso	3	0.06	8.8e-07	4.93	5.6	1.9e-08	0.74	0.23	0.76	FALSE
8	GTEx	Breast Mammary Tissue (Male)	NUDT6	0.29	0.00	lasso	6	0.00	3.5e-01	5.48	5.5	2.9e-08	0.74	0.04	0.41	FALSE
4	GTEx	Artery Tibial	NUDT6	0.08	0.08	lasso	5	0.05	5.6e-05	5.49	5.5	3.1e-08	0.73	0.64	0.09	FALSE
7	GTEx	Breast Mammary Tissue	NUDT6	0.25	0.10	lasso	3	0.08	4.2e-05	5.51	5.5	3.2e-08	0.83	0.09	0.87	FALSE
16	GTEx	Skin Sun Exposed Lower leg	NUDT6	0.11	0.08	lasso	3	0.08	6.2e-07	5.48	5.5	3.6e-08	0.70	0.94	0.03	FALSE
23	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	CCNA2	0.11	-0.01	enet	14	0.02	4.4e-02	0.58	5.5	3.6e-08	0.09	0.00	0.27	FALSE
18	ROSMAP	Brain Pre-frontal Cortex	EXOSC9	0.05	0.02	lasso	7	0.02	5.3e-04	4.75	5.5	3.8e-08	-0.03	0.11	0.81	FALSE
22	The Cancer Genome Atlas	Breast Invasive Carcinoma	NUDT6	0.02	0.02	lasso	4	0.01	5.4e-03	5.48	5.5	4.3e-08	0.72	0.13	0.14	FALSE
5	GTEx	Brain Cerebellar Hemisphere	BBS7	0.27	0.05	lasso	3	0.08	4.7e-03	-5.39	-5.4	6.1e-08	-0.01	0.08	0.33	FALSE
12	GTEx	Colon Transverse	BBS12	0.12	0.05	enet	29	0.12	3.2e-06	0.39	5.3	9.2e-08	0.48	0.04	0.59	FALSE
29	The Cancer Genome Atlas	Prostate Adenocarcinoma	NUDT6	0.10	0.07	lasso	6	0.07	1.0e-07	5.49	5.3	1.4e-07	0.71	0.95	0.05	FALSE
3	GTEx	Artery Tibial	FGF2	0.18	0.05	lasso	3	0.02	1.3e-02	5.11	5.2	1.5e-07	0.36	0.08	0.11	FALSE
19	ROSMAP	Brain Pre-frontal Cortex	NUDT6	0.04	0.04	enet	9	0.03	2.0e-04	5.55	5.2	1.6e-07	0.64	0.61	0.17	FALSE
15	GTEx	Nerve Tibial	NUDT6	0.11	0.08	lasso	3	0.05	2.1e-04	5.22	5.2	1.7e-07	0.69	0.79	0.02	FALSE
9	GTEx	Breast Mammary Tissue (Female)	NUDT6	0.30	-0.01	enet	30	0.00	2.6e-01	5.69	5.2	2.2e-07	0.62	0.03	0.33	FALSE