[Hub]/) : Traits : Leg predicted mass (left) :

chr10:69,348,758-70,981,217

Best TWAS P=1.17e-11 · Best GWAS P=1.93e-09 conditioned to 0.481

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Visceral Omentum DNA2 0.32 0.18 lasso 9 0.20 1.9e-10 -5.1 5.3 1.4e-07 -0.81 0.52 0.48 FALSE
2 GTEx Artery Coronary DNA2 0.12 0.12 lasso 5 0.12 5.3e-05 -5.0 5.3 1.2e-07 -0.85 0.06 0.85 FALSE
3 GTEx Brain Hypothalamus SLC25A16 0.20 0.19 lasso 5 0.14 3.6e-04 -5.1 -5.2 2.2e-07 0.83 0.10 0.39 FALSE
4 GTEx Cells EBV-transformed lymphocytes DNA2 0.32 0.14 lasso 2 0.10 2.9e-04 -5.1 5.1 2.9e-07 -0.84 0.09 0.82 FALSE
5 GTEx Cells Transformed fibroblasts SLC25A16 0.10 0.02 enet 25 0.01 2.5e-02 -3.5 -5.2 2.1e-07 0.63 0.76 0.12 FALSE
6 GTEx Heart Atrial Appendage PBLD 0.08 0.02 lasso 2 0.02 6.1e-02 -6.0 -6.5 7.4e-11 0.86 0.02 0.84 FALSE
7 GTEx Lung DNA2 0.22 0.17 enet 12 0.24 3.9e-18 -5.0 5.2 2.1e-07 -0.80 0.54 0.46 FALSE
8 GTEx Pancreas DNA2 0.12 0.06 enet 9 0.08 4.1e-04 -4.2 5.4 7.4e-08 -0.84 0.07 0.87 FALSE
9 GTEx Skin Not Sun Exposed Suprapubic DNA2 0.29 0.16 lasso 14 0.22 2.4e-12 -4.5 5.2 1.7e-07 -0.81 0.52 0.48 FALSE
10 ROSMAP Brain Pre-frontal Cortex PBLD 0.04 0.01 bslmm 388 0.02 1.3e-03 -3.7 -5.2 2.2e-07 0.64 0.15 0.84 FALSE
11 ROSMAP Brain Pre-frontal Cortex SLC25A16 0.17 0.11 lasso 6 0.15 2.9e-19 -4.2 -5.4 8.3e-08 0.90 0.13 0.87 FALSE
12 YFS Blood SLC25A16 0.09 0.13 lasso 3 0.13 6.8e-39 -5.0 -5.3 9.6e-08 0.89 0.09 0.91 FALSE
13 The Cancer Genome Atlas Bladder Urothelial Carcinoma PBLD 0.06 0.07 lasso 2 0.04 2.3e-04 -5.7 -5.7 1.1e-08 0.47 0.00 1.00 FALSE
14 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma DNA2 0.08 0.09 lasso 1 0.06 7.3e-04 -6.0 6.0 2.2e-09 -1.00 0.00 0.99 FALSE
15 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma PBLD 0.03 0.03 lasso 9 0.02 1.6e-03 -5.2 -5.2 1.8e-07 0.51 0.02 0.86 FALSE
16 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma PBLD 0.10 0.03 lasso 3 0.04 2.2e-05 -5.7 -5.4 7.7e-08 0.46 0.00 1.00 FALSE
17 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma ATOH7 0.08 0.04 enet 19 0.06 3.1e-04 -3.7 5.4 6.0e-08 -0.46 0.04 0.86 FALSE
18 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma DNA2 0.05 0.00 blup 43 0.00 3.0e-01 -5.2 5.4 7.4e-08 -0.86 0.01 0.84 FALSE
19 The Cancer Genome Atlas Brain Lower Grade Glioma SLC25A16 0.05 0.01 blup 42 0.02 2.9e-03 -5.2 -5.5 4.5e-08 0.76 0.06 0.84 FALSE
20 The Cancer Genome Atlas Lung Squamous Cell Carcinoma SLC25A16 0.02 0.02 enet 8 0.02 7.7e-04 -6.0 -5.9 4.1e-09 0.97 0.01 0.91 FALSE
21 The Cancer Genome Atlas Soft Tissue Sarcoma SLC25A16 0.07 0.03 blup 42 0.02 1.7e-02 -6.0 -6.8 1.2e-11 0.92 0.01 0.94 TRUE
22 The Cancer Genome Atlas Testicular Germ Cell Tumors DNA2 0.14 0.07 blup 43 0.08 8.6e-04 -5.6 -5.5 3.4e-08 0.76 0.03 0.79 FALSE
23 The Cancer Genome Atlas Thyroid Carcinoma SLC25A16 0.05 0.05 lasso 3 0.04 3.8e-05 -5.0 -5.2 1.7e-07 0.83 0.06 0.82 FALSE