Best TWAS P=4.85e-09 · Best GWAS P=3.7e-09 conditioned to 0.000308
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | FIBP | 0.08 | 0.11 | enet | 20 | 0.12 | 8.1e-14 | 3.7 | 5.2 | 2.2e-07 | -0.47 | 0.98 | 0.01 | FALSE |
| 2 | GTEx | Adrenal Gland | CTSW | 0.13 | 0.08 | lasso | 12 | 0.06 | 3.0e-03 | 5.1 | -5.1 | 2.9e-07 | 0.26 | 0.26 | 0.29 | FALSE |
| 3 | GTEx | Brain Cerebellar Hemisphere | EFEMP2 | 0.35 | 0.15 | enet | 5 | 0.09 | 2.2e-03 | 5.4 | 5.7 | 9.8e-09 | -0.33 | 0.05 | 0.87 | FALSE |
| 4 | GTEx | Brain Cerebellum | EFEMP2 | 0.45 | 0.40 | enet | 8 | 0.39 | 1.6e-12 | 5.1 | 5.4 | 5.1e-08 | -0.31 | 0.07 | 0.93 | FALSE |
| 5 | GTEx | Cells Transformed fibroblasts | EFEMP2 | 0.06 | 0.06 | lasso | 3 | 0.07 | 7.8e-06 | 5.5 | 5.7 | 1.4e-08 | -0.27 | 0.07 | 0.92 | FALSE |
| 6 | GTEx | Colon Transverse | DPF2 | 0.19 | 0.01 | lasso | 4 | 0.05 | 1.6e-03 | 3.3 | 5.4 | 5.9e-08 | -0.07 | 0.08 | 0.11 | TRUE |
| 7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | EFEMP2 | 0.04 | 0.02 | lasso | 5 | 0.02 | 1.4e-05 | 5.6 | 5.5 | 4.1e-08 | -0.35 | 0.02 | 0.97 | FALSE |
| 8 | The Cancer Genome Atlas | Glioblastoma Multiforme | CTSW | 0.16 | 0.18 | enet | 16 | 0.19 | 2.3e-06 | 5.1 | -5.9 | 4.8e-09 | 0.37 | 0.08 | 0.83 | TRUE |
| 9 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | DKFZp761E198 | 0.07 | 0.02 | blup | 39 | 0.03 | 5.9e-04 | -4.7 | -5.5 | 4.8e-08 | 0.55 | 0.02 | 0.62 | FALSE |
| 10 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | DPF2 | 0.07 | 0.04 | blup | 28 | 0.04 | 2.9e-05 | -5.0 | 5.1 | 3.0e-07 | -0.12 | 0.00 | 0.97 | FALSE |
| 11 | The Cancer Genome Atlas | Brain Lower Grade Glioma | DPF2 | 0.03 | 0.02 | blup | 28 | 0.02 | 1.2e-03 | -5.0 | 5.3 | 1.5e-07 | -0.12 | 0.00 | 0.90 | FALSE |
| 12 | The Cancer Genome Atlas | Brain Lower Grade Glioma | EFEMP2 | 0.01 | 0.00 | blup | 45 | 0.01 | 3.0e-02 | 2.5 | 5.2 | 2.3e-07 | -0.37 | 0.03 | 0.20 | FALSE |
| 13 | The Cancer Genome Atlas | Lung Adenocarcinoma | FIBP | 0.02 | 0.01 | blup | 45 | 0.02 | 1.3e-03 | 3.9 | 5.3 | 1.2e-07 | -0.43 | 0.06 | 0.48 | FALSE |
| 14 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | CAPN1 | 0.03 | 0.02 | blup | 39 | 0.02 | 2.1e-03 | -4.8 | -5.2 | 2.5e-07 | 0.18 | 0.00 | 0.92 | FALSE |
| 15 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | POLA2 | 0.12 | 0.03 | enet | 9 | 0.05 | 2.5e-04 | -5.0 | 5.2 | 1.9e-07 | -0.16 | 0.01 | 0.67 | FALSE |
| 16 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | CTSW | 0.16 | 0.10 | enet | 24 | 0.15 | 1.9e-06 | 3.7 | -5.1 | 2.9e-07 | 0.31 | 0.52 | 0.27 | FALSE |
| 17 | The Cancer Genome Atlas | Soft Tissue Sarcoma | SNX32 | 0.08 | 0.08 | lasso | 2 | 0.10 | 1.5e-06 | 5.5 | 5.3 | 9.3e-08 | -0.29 | 0.05 | 0.94 | FALSE |