Best TWAS P=1.79e-10 · Best GWAS P=5.07e-11 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Esophagus Mucosa | ARAP1 | 0.27 | 0.25 | lasso | 5 | 0.26 | 2.6e-17 | 5.7 | 5.5 | 4.2e-08 | 0.54 | 0.20 | 0.80 | FALSE |
| 2 | GTEx | Esophagus Mucosa | ARAP1-AS2 | 0.12 | 0.08 | lasso | 6 | 0.08 | 3.1e-06 | 5.7 | 5.4 | 6.4e-08 | 0.53 | 0.16 | 0.69 | FALSE |
| 3 | GTEx | Esophagus Mucosa | ARAP1-AS1 | 0.15 | 0.12 | enet | 7 | 0.13 | 4.1e-09 | 5.7 | 5.2 | 1.7e-07 | 0.53 | 0.26 | 0.74 | FALSE |
| 4 | GTEx | Pituitary | PDE2A | 0.25 | 0.19 | lasso | 5 | 0.17 | 4.1e-05 | 6.1 | 6.1 | 1.2e-09 | 0.94 | 0.00 | 0.96 | FALSE |
| 5 | GTEx | Pituitary | RP11-169D4.2 | 0.19 | 0.20 | lasso | 2 | 0.16 | 7.3e-05 | 6.1 | 6.4 | 1.8e-10 | 0.98 | 0.00 | 0.97 | TRUE |
| 6 | GTEx | Skin Not Sun Exposed Suprapubic | ARAP1 | 0.24 | 0.20 | lasso | 4 | 0.16 | 3.6e-09 | 5.7 | 5.5 | 3.1e-08 | 0.55 | 0.20 | 0.80 | FALSE |
| 7 | GTEx | Skin Not Sun Exposed Suprapubic | ARAP1-AS2 | 0.20 | 0.08 | lasso | 5 | 0.05 | 1.5e-03 | 4.0 | 5.4 | 6.1e-08 | 0.58 | 0.15 | 0.75 | FALSE |
| 8 | GTEx | Skin Not Sun Exposed Suprapubic | ARAP1-AS1 | 0.14 | 0.13 | lasso | 4 | 0.07 | 9.1e-05 | 5.7 | 5.7 | 1.1e-08 | 0.59 | 0.18 | 0.81 | FALSE |
| 9 | GTEx | Skin Sun Exposed Lower leg | ARAP1 | 0.21 | 0.13 | lasso | 7 | 0.13 | 1.2e-10 | 5.7 | 5.3 | 1.3e-07 | 0.52 | 0.21 | 0.79 | FALSE |
| 10 | GTEx | Skin Sun Exposed Lower leg | ARAP1-AS1 | 0.18 | 0.07 | lasso | 7 | 0.06 | 1.0e-05 | 5.7 | 5.2 | 1.6e-07 | 0.52 | 0.24 | 0.72 | FALSE |
| 11 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PDE2A | 0.02 | 0.02 | lasso | 2 | 0.02 | 2.0e-04 | 6.1 | -6.1 | 1.2e-09 | -0.94 | 0.02 | 0.90 | FALSE |