Hub : Genes

ARAP1-AS1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adrenal Gland	0.164	0.0764	9.2e-03	-0.006	NA	-0.007	NA	-0.002	6.4e-01	NA	6.6e-01	NA	4.1e-01
2	GTEx	Artery Tibial	0.223	0.0611	8.4e-05	0.006	NA	0.015	NA	0.018	1.0e-01	NA	2.2e-02	NA	1.3e-02
3	GTEx	Esophagus Mucosa	0.148	0.0410	1.8e-05	0.115	NA	0.132	NA	0.124	4.5e-08	NA	4.1e-09	NA	1.1e-08
4	GTEx	Skin Not Sun Exposed Suprapubic	0.137	0.0530	7.5e-04	0.134	NA	0.043	NA	0.072	8.7e-08	NA	2.0e-03	NA	9.1e-05
5	GTEx	Skin Sun Exposed Lower leg	0.181	0.0530	5.3e-05	0.069	NA	0.055	NA	0.060	2.2e-06	NA	2.4e-05	NA	1.0e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.5	0.7	1.0	-0.9	-0.5	-1.0	-0.8	-0.9
Bipolar Disorder or Schizophrenia	1.0	2.4	4.3	-1.0	-0.3	-2.0	-1.6	-2.1
Depressed Affect (Nagel 2018)	0.3	0.7	1.9	-0.2	-0.3	0.8	1.4	1.0
Depression (Nagel 2018)	0.1	0.2	0.4	0.2	-0.3	0.5	0.7	0.4
Intelligence (Savage-Jansen 2018)	2.2	6.8	11.0	-1.7	1.8	-2.9	-3.3	-2.9
Neuroticism (Nagel 2018)	0.3	0.7	1.6	0.6	-0.7	0.6	1.3	0.7
Schizophrenia (2018)	0.9	1.8	3.6	-0.5	0.0	-1.8	-1.4	-1.9
Schizophrenia vs Biploar Disorder	0.4	0.5	2.4	-0.2	1.5	0.2	-0.0	0.2
Worry (Nagel 2018)	0.3	0.6	1.1	1.0	-0.6	0.6	1.0	0.5
Alzheimer’s Disease (in mother)	0.1	0.1	0.4	0.6	-0.5	-0.2	0.0	0.1
Alzheimer’s Disease (in father)	0.2	0.3	0.9	0.9	-0.3	0.2	0.3	0.4
Alzheimer’s Disease (including proxy)	0.1	0.2	0.7	0.8	-0.5	-0.4	0.0	0.0
Crohns Disease (2017)	3.2	7.1	9.5	3.1	-0.7	3.0	2.9	2.8
Irritable Bowel Disease (IBD)	1.0	2.3	5.5	2.3	-0.6	1.6	1.3	1.2
Ulcerative Colitis (UC)	0.2	0.3	0.6	0.8	-0.0	-0.3	-0.5	-0.8
Major Depression (MDD)	0.7	0.8	2.1	-1.1	-1.5	-0.7	-0.1	-0.3
Reaction Time	1.8	3.4	4.4	1.7	-1.3	2.1	1.9	2.1
Verbal and Numeric Reasoning (VNR)	0.8	2.0	3.3	-0.9	0.5	-1.7	-1.8	-1.6
Breast Cancer	3.0	7.2	13.6	-1.6	3.7	-2.3	-2.7	-2.6
Ovarian Cancer	0.2	0.2	1.1	0.2	-1.0	-0.1	0.2	-0.1
Prostate Cancer	0.2	0.3	1.0	-0.3	-1.0	0.3	0.4	0.2
Age at First Birth	3.4	4.9	7.8	-1.9	1.1	-2.4	-2.8	-2.4
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	1.8	2.4	3.9	1.8	-0.6	1.4	2.0	1.6
Coronary Artery Disease (CAD)	1.0	1.2	2.4	-1.5	0.1	1.1	1.1	1.1
Crohns Disease (2012)	1.3	2.1	3.9	2.0	-0.2	1.5	1.4	1.5
Mean Putamen Volume	0.3	0.3	1.1	-0.5	-1.1	0.3	-0.1	0.3
Fasting Glucose	7.4	8.8	13.5	-2.1	1.6	-3.5	-3.7	-3.5
HbA1C	4.4	4.9	7.4	-0.8	1.5	-2.7	-2.7	-2.6
HDL Cholesterol	0.6	0.9	3.7	-0.9	1.9	-0.1	-0.0	0.1
LDL Cholesterol	0.2	0.3	1.0	1.0	-0.6	-0.2	-0.1	-0.4
Lupus	1.3	2.0	7.5	0.4	-2.7	0.7	1.1	0.7
Neuroticism (2016)	0.9	1.3	1.9	0.3	-1.4	1.0	1.4	1.2
Primary Biliary Cirrhosis	0.3	0.4	0.5	0.6	-0.7	0.6	0.4	0.7
Rheumatoid Arthritis	0.7	0.9	1.9	1.4	-0.7	0.9	0.9	0.9
Schizophrenia (2014)	1.2	2.6	4.5	-1.3	-0.1	-2.1	-1.6	-2.1
Triglycerides	0.0	0.0	0.1	0.1	-0.2	0.4	0.2	0.0
Type 2 Diabetes (T2D) (2012)	8.1	9.4	12.7	-2.3	3.1	-3.1	-3.6	-3.1
Ulcerative Colitis	0.5	0.7	1.4	0.7	-1.2	-0.6	-0.6	-0.9
Blood Eosinophil Count	0.4	3.2	7.4	2.7	-0.0	1.7	1.6	1.8
Blood Platelet Count	1.2	13.7	26.6	0.4	-0.8	4.6	4.5	5.2
Blood Red Count	0.1	0.7	2.2	1.5	0.6	-0.6	-0.4	-0.7
Blood White Count	0.8	5.7	10.1	-1.1	0.2	2.8	3.0	3.2
Heel T-Score	2.8	22.0	33.8	-3.2	2.7	-5.6	-5.8	-5.2
BMI	2.6	14.8	22.6	1.7	-2.2	4.8	4.7	4.7
Height	1.0	19.3	29.2	2.6	-2.0	5.4	5.2	5.4
Waist Hip Ratio (WHR)	0.5	2.5	3.4	-0.6	1.8	-1.7	-1.8	-1.6
Systolic Blood Pressure	0.2	1.0	3.3	-1.8	-1.2	-0.3	0.0	-0.3
Smoking Status	4.6	10.9	17.1	1.5	-2.4	3.8	4.1	3.8
Allergy or Eczema	3.4	8.8	13.3	-2.2	1.3	-3.5	-3.6	-3.4
Cardiovascular Disease	0.1	0.3	0.4	-0.4	-0.6	0.4	0.7	0.5
Hypothyroidism (self reported)	0.5	1.3	3.6	1.3	-1.9	0.3	0.9	0.1
Respiratory disease	0.8	1.9	2.4	-0.9	-1.4	-1.4	-1.5	-1.5
Type 2 Diabetes (T2D) (2018)	9.0	16.9	25.3	-2.0	3.9	-4.7	-5.0	-4.2
Lung FEV1/FVC ratio	7.9	40.1	55.3	7.4	-3.8	6.6	7.1	6.1
Lung FVC	3.3	16.6	23.2	-4.8	2.9	-4.3	-4.3	-3.8
Neuroticism	0.5	1.1	3.6	0.9	-1.9	0.3	0.9	0.3
Chronotype (morning person)	3.7	8.6	11.9	2.9	-1.1	3.1	3.4	3.5
Hair Pigment	0.0	0.4	1.0	1.0	-0.8	0.4	0.3	0.2
Tanning	0.0	0.2	0.3	0.5	-0.4	-0.6	-0.5	-0.3
Hand grip strength (left)	0.1	0.3	0.8	0.2	-0.7	0.4	0.9	0.5
Number of treatments/medications taken	1.9	3.4	5.8	-2.4	1.4	-1.8	-1.9	-1.7
Average weekly spirits intake	0.2	0.3	1.0	1.0	0.1	0.2	0.6	0.2
Sensitivity / hurt feelings	0.6	1.0	3.9	0.6	-2.0	0.4	0.5	0.3
Frequency of depressed mood in last 2 weeks	0.0	0.1	0.2	0.3	-0.4	0.1	0.2	-0.1
Hearing difficulty/problems: Yes	0.5	0.7	3.3	1.8	0.4	0.1	0.2	0.2
Relative age of first facial hair	1.0	2.1	3.5	-0.2	1.3	-1.9	-1.5	-1.8
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	3.6	0.4	-1.9	-0.1	0.3	0.3
Ever used hormone-replacement therapy (HRT)	0.4	0.6	2.1	0.2	1.5	-0.6	-0.3	-0.4
Ever had hysterectomy (womb removed)	2.6	2.9	4.5	-0.6	1.5	-2.1	-1.9	-2.0
Systolic blood pressure, automated reading	0.8	2.4	3.9	-1.3	-2.0	1.4	1.5	1.4
Eye problems/disorders: Diabetes related eye disease	2.0	2.2	3.8	1.0	0.6	-1.9	-1.8	-1.7
Angina	1.0	1.3	2.0	0.5	-1.0	1.4	1.2	1.3
Medication for hormone replacement therapy	0.3	0.3	1.1	1.1	0.4	0.1	0.2	0.4
Vitamin and mineral supplements	0.4	0.6	1.1	0.0	1.1	0.5	0.8	1.0
Supplements: Zinc	0.1	0.2	0.5	-0.3	-0.7	-0.2	-0.3	-0.3
Medication: Co-codamol	0.3	0.4	1.3	1.1	-0.4	0.6	0.2	0.3
Medication: Metformin	8.9	12.5	18.2	-1.6	3.3	-4.0	-4.3	-3.9
Diabetes (father)	1.0	1.3	2.5	0.6	1.6	-1.1	-1.1	-1.0
Diabetes (mother)	9.0	11.5	14.7	-2.9	3.1	-3.7	-3.8	-3.4
Severe depression (siblings)	0.5	0.6	0.7	-0.9	-0.7	-0.8	-0.6	-0.8
Pack years adult smoking proportion	0.6	1.0	3.8	1.9	-0.7	0.2	0.5	0.6
Impedance of leg (right)	1.7	8.2	10.2	-3.2	2.4	-2.9	-3.1	-2.7
Leg fat-free mass (left)	4.0	21.4	33.2	3.3	-2.5	5.3	5.8	5.3
Trunk fat percentage	1.7	6.8	12.0	0.3	-0.3	3.1	3.5	3.5
Hand grip strength (right)	0.3	0.8	1.2	1.0	-0.6	0.9	1.1	0.9
Townsend deprivation index at recruitment	0.1	0.2	0.4	-0.0	-0.5	0.4	0.4	0.6
Current tobacco smoking	2.0	3.3	5.8	1.3	-0.6	2.0	2.4	2.1
Average weekly fortified wine intake	0.5	0.6	1.1	-0.7	0.2	-0.7	-1.1	-0.9
Maternal smoking around birth	2.5	3.7	6.7	0.4	-1.7	2.0	2.6	2.1
Fed-up feelings	0.8	1.4	2.6	0.4	-1.1	1.1	1.6	1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.5	0.2	-1.2	0.6	0.8	0.3
Relative age voice broke	2.6	4.0	5.4	-0.6	2.0	-2.2	-2.3	-2.3
Taking other prescription medications	1.3	1.9	5.6	-2.4	-0.8	-1.2	-0.9	-1.1
Age when periods started (menarche)	0.1	0.3	1.2	-1.1	-0.3	0.3	0.4	0.3
Bilateral oophorectomy (both ovaries removed)	1.7	1.9	4.7	-0.2	2.2	-1.5	-1.1	-1.3
Heel bone mineral density (BMD) T-score, automated (left)	1.1	2.4	3.8	-1.0	-0.2	-2.0	-1.9	-1.9
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	2.5	-1.6	0.6	1.0	0.9	1.2
Qualifications: CSEs or equivalent	1.2	1.5	3.1	0.4	-0.9	1.3	1.8	1.4
Serious illness, injury or assault to yourself	1.0	1.2	3.0	0.7	-1.7	0.8	1.0	0.8
High blood pressure	0.3	0.9	1.5	-0.9	0.3	1.0	1.0	1.2
Hayfever, allergic rhinitis or eczema	2.7	6.0	7.9	-2.3	1.6	-2.7	-2.8	-2.7
Multivitamins +/- minerals	0.3	0.4	1.4	-0.5	-1.2	-0.2	-0.5	-0.5
Stomach or abdominal pain in last month	0.4	0.5	1.7	-1.3	-0.9	0.3	0.1	0.3
Supplements: Glucosamine	0.2	0.2	0.5	-0.6	-0.7	0.3	0.3	0.1
Diverticular disease/diverticulitis (self-reported)	4.4	5.2	7.0	-2.6	2.3	-2.3	-2.0	-2.1
Medication: Atenolol	0.5	0.6	2.8	-0.5	1.7	0.2	0.1	0.2
Medication: Levothyroxine sodium	0.2	0.3	0.9	-0.2	-1.0	-0.2	0.5	-0.2
Sitting height	0.7	5.2	7.9	1.9	-0.7	2.8	2.7	2.6
Chronic bronchitis/emphysema (father)	1.0	1.2	1.8	-0.4	1.4	-1.1	-1.2	-1.1
High blood pressure (mother)	0.6	0.9	1.5	-1.1	1.2	-0.8	-0.7	-0.8
Body mass index (BMI)	1.6	6.9	12.0	0.9	-1.3	3.0	3.5	3.3
Impedance of leg (left)	1.9	9.3	11.7	-3.4	2.7	-3.0	-3.2	-2.8
Leg predicted mass (left)	4.0	21.0	32.6	3.4	-2.5	5.2	5.7	5.2
Trunk fat mass	2.6	11.3	19.4	1.1	-0.9	4.0	4.4	4.3
Waist circumference	2.1	7.5	13.0	1.3	-1.3	3.1	3.6	3.4
Number of incorrect matches in round	0.5	0.8	3.8	-0.4	1.9	0.1	-0.3	0.1
Past tobacco smoking	2.7	4.9	8.7	-0.8	3.0	-2.2	-2.4	-2.1
Alcohol usually taken with meals	0.9	1.5	2.5	-0.1	0.4	-1.6	-1.6	-1.5
Nervous feelings	0.3	0.6	2.2	1.5	-0.7	0.3	0.4	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	1.0	-0.3	-1.0	-0.4	-0.1	-0.4
Hearing difficulty/problems with background noise	1.5	2.4	5.4	2.3	-1.6	0.9	1.4	1.1
Hair/balding pattern: Pattern 2	1.1	1.4	3.5	0.7	1.9	1.2	0.6	1.1
Had menopause	4.1	5.2	8.1	-1.3	1.4	-2.8	-2.7	-2.6
Had other major operations	1.2	1.4	2.1	-1.3	0.8	-1.5	-0.8	-1.4
Forced vital capacity (FVC)	0.1	0.3	1.1	-1.1	0.2	-0.3	-0.4	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	1.2	2.8	4.9	-1.2	-0.2	-2.2	-1.9	-2.1
Ever unenthusiastic/disinterested for a whole week	1.4	1.8	2.1	-1.4	-1.0	-1.4	-1.4	-1.4
Qualifications: None of the above	1.1	2.4	4.1	1.2	-0.1	1.8	2.0	1.8
Financial difficulties in last 2 years	3.1	4.2	6.8	0.5	-2.2	2.0	2.6	2.3
Mouth/teeth dental problems	2.6	3.9	5.5	0.0	2.3	-2.1	-2.2	-2.2
Heart attack	0.3	0.4	1.5	1.2	-0.3	0.4	0.4	0.3
Allergy	2.6	6.0	7.9	2.4	-1.0	2.8	2.8	2.8
Pain all over the body in last month	0.6	0.6	1.3	-1.2	0.1	0.7	0.8	0.8
Diabetes (self-reported)	5.1	7.9	11.2	-1.4	2.8	-3.3	-3.4	-2.8
Hayfever/allergic rhinitis (self-reported)	0.8	1.0	4.0	-2.0	-0.1	-0.6	-0.7	-0.4
Medication: Ramipril	0.5	0.7	1.4	-1.2	1.1	-0.6	-0.5	-0.5
Medication: Simvastatin	0.3	0.4	1.1	-0.0	-0.3	0.8	0.4	1.0
Fluid intelligence score	1.4	2.9	5.1	-0.8	1.4	-1.8	-2.3	-1.8
Illnesses of siblings	0.7	1.0	3.6	1.9	0.5	0.6	0.8	0.6
Neuroticism score	0.6	1.3	2.8	1.2	-1.7	0.6	1.2	0.6
Weight	2.9	14.1	23.4	1.6	-1.8	4.5	4.8	4.6
Impedance of arm (right)	0.4	1.9	4.0	-0.9	2.0	-1.2	-1.4	-1.3
Arm fat percentage (right)	1.4	5.5	9.9	0.8	-0.1	2.8	3.1	3.1
Trunk fat-free mass	1.6	9.5	14.2	2.5	-1.5	3.5	3.8	3.5
Hip circumference	3.7	16.0	25.4	2.0	-2.3	4.7	5.0	4.9
Time employed in main current job	3.8	4.4	6.9	-1.4	1.8	-2.2	-2.6	-2.3
Alcohol intake versus 10 years previously	0.5	0.7	1.8	-1.3	1.4	0.0	-0.4	0.1
Father’s age at death	0.8	1.0	1.7	0.5	1.1	-1.1	-0.9	-1.3
Worrier / anxious feelings	0.3	0.6	1.8	1.4	-0.6	0.4	0.8	0.3
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	3.6	-0.6	-1.9	-0.2	0.1	-0.3
Falls in the last year	0.9	1.3	2.5	-1.6	-0.7	-1.3	-0.8	-0.9
Hair/balding pattern: Pattern 3	0.3	0.4	2.1	-1.5	0.2	0.1	0.0	0.1
Number of live births	0.1	0.2	0.4	-0.1	-0.6	0.4	0.4	0.2
Forced expiratory volume in 1-second (FEV1)	0.6	2.0	2.9	1.0	-0.7	1.6	1.7	1.7
Pulse rate	2.6	4.4	7.0	1.7	-0.3	2.6	2.3	2.6
Happiness	0.7	0.9	1.7	0.4	-1.3	0.8	1.1	0.9
Noisy workplace	0.5	0.6	1.9	-0.0	-1.4	0.3	0.8	0.5
Qualifications: A levels/AS levels or equivalent	1.8	4.1	7.0	-0.4	0.9	-2.4	-2.6	-2.6
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.2	3.7	-1.9	-0.3	1.2	0.5	0.8
Mouth/teeth dental problems: Dentures	5.3	9.0	13.8	1.6	-2.4	3.3	3.7	3.5
Asthma	0.7	1.4	3.9	-2.0	-1.2	-0.6	-0.9	-0.7
Medication: Ibuprofen (e.g. Nurofen)	2.3	3.0	4.9	1.6	-0.7	1.9	1.8	2.2
Medication: Cholesterol lowering	0.2	0.3	1.0	-0.4	0.3	-0.5	-1.0	-0.5
Depression (self-reported)	0.3	0.4	1.3	-0.1	-1.2	0.4	0.3	0.4
Medication: Lansoprazole	0.3	0.4	0.5	-0.6	-0.6	0.6	0.7	0.7
Prospective memory result	1.1	1.3	2.5	0.4	-0.6	1.4	1.6	1.3
Lung cancer (father)	1.3	1.5	2.8	-0.3	-0.0	1.5	1.6	1.7
Illnesses of mother	1.2	1.5	2.3	1.2	-1.5	1.2	1.1	0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	1.6	0.8	-0.5	1.1	1.3	1.2
Pulse wave Arterial Stiffness index	0.7	0.8	2.9	-1.1	1.7	0.1	0.0	-0.0
Impedance of arm (left)	0.1	0.6	1.2	-0.9	1.1	-0.5	-0.7	-0.5
Arm fat mass (right)	2.3	9.5	16.8	1.1	-0.8	3.7	4.1	4.0
Trunk predicted mass	1.6	9.4	14.4	2.5	-1.4	3.5	3.8	3.5
Standing height	1.1	11.1	17.2	2.2	-1.1	4.2	4.0	4.0
Length of working week for main job	1.1	1.2	4.2	2.1	0.1	0.7	0.7	0.8
Exposure to tobacco smoke at home	0.2	0.2	0.6	0.2	-0.5	-0.8	-0.5	-0.3
Breastfed as a baby	1.4	1.8	3.3	0.0	0.3	-1.8	-1.6	-1.7
Tense / ‘highly strung’	0.2	0.3	0.5	0.1	-0.4	-0.7	-0.7	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	2.7	4.1	7.6	-0.6	-2.8	2.1	2.1	1.9
Hair/balding pattern: Pattern 4	2.1	5.1	8.8	-0.3	0.6	-2.9	-3.0	-2.8
Birth weight of first child	0.3	0.5	1.4	-1.1	1.2	0.3	0.2	0.4
Peak expiratory flow (PEF)	0.5	1.3	2.0	1.2	0.2	1.1	1.4	1.3
Pulse wave reflection index	3.7	4.6	6.7	-2.6	1.7	-2.2	-1.9	-2.3
Ever highly irritable/argumentative for 2 days	0.2	0.3	1.1	0.0	1.1	-0.3	-0.3	-0.2
Loud music exposure frequency	1.2	1.3	4.4	0.9	2.1	-0.7	-0.5	-0.7
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.5	-0.7	-0.7	0.0	0.0	0.1
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.2	-0.5	-0.5	0.2	0.2	0.1
Blood clot in the leg (DVT)	0.1	0.1	0.4	0.7	0.1	0.1	0.2	0.0
Medication: Paracetamol	0.7	1.2	4.0	-2.0	-1.5	-0.2	0.1	-0.1
Headache pain in last month	2.2	3.8	9.2	-3.0	-1.3	-1.5	-1.8	-1.6
Medication for cholesterol, blood pressure or diabetes	0.3	0.4	0.9	0.7	-0.6	0.5	1.0	0.4
Glaucoma (self-reported)	0.4	0.5	1.1	1.0	1.1	-0.3	-0.1	-0.2
Gout (self-reported)	0.5	0.6	2.9	-1.7	-0.4	0.2	-0.2	0.0
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	1.8	0.2	-1.3	0.0	0.8	0.0
Medication: Amlodipine	0.1	0.2	0.4	-0.5	-0.7	-0.1	0.3	-0.2
Medication: Ventolin 100micrograms inhaler	0.4	0.5	2.5	-1.6	-0.1	0.0	-0.0	-0.1
Birth weight	0.0	0.1	0.2	0.1	-0.3	-0.2	-0.2	-0.4
Chronic bronchitis/emphysema (mother)	0.4	0.4	0.9	-1.0	1.0	-0.2	0.5	0.2
High blood pressure (siblings)	0.5	0.7	3.1	-1.8	-0.2	-0.2	-0.2	-0.2
Forced vital capacity (FVC), Best measure	0.2	0.7	1.6	-1.3	0.6	-0.8	-0.7	-0.7
Body fat percentage	1.4	5.5	10.0	0.1	-0.3	2.7	3.2	3.1
Leg fat percentage (right)	0.6	2.1	4.0	-0.7	-0.2	1.5	2.0	2.0
Arm fat-free mass (right)	2.5	12.8	19.6	2.5	-1.9	4.1	4.4	4.2
Exposure to tobacco smoke outside home	0.6	0.8	1.4	-0.3	0.5	-1.2	-1.1	-0.8
Comparative body size at age 10	0.3	0.9	2.0	-0.1	0.4	1.1	1.4	1.1
Number of full brothers	0.4	0.4	1.7	1.3	-0.7	0.0	-0.0	-0.3
Worry too long after embarrassment	1.6	2.6	3.9	1.0	-1.8	1.5	2.0	1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.0	0.4	-0.6	0.3	1.0	0.6
Wheeze or whistling in the chest in last year	1.1	2.0	6.3	-2.5	-1.9	-0.2	0.4	0.1
Number of children fathered	4.7	5.3	8.6	0.7	-0.6	2.9	2.9	2.9
Reason for reducing amount of alcohol drunk: Health precaution	3.3	3.8	7.5	-0.3	0.7	-2.5	-2.2	-2.7
Age at first live birth	2.4	4.3	6.2	-2.0	0.5	-2.3	-2.4	-2.5
Pulse wave peak to peak time	0.8	0.9	2.7	1.2	-1.6	0.2	0.3	0.4
Health satisfaction	1.6	2.1	6.4	-0.6	-2.5	1.2	1.0	1.0
Shortness of breath walking on level ground	1.0	1.2	3.6	-1.9	0.7	-1.0	-0.7	-0.6
Qualifications: College or University degree	2.6	8.2	13.9	-0.8	0.7	-3.5	-3.7	-3.7
Eye problems/disorders: None of the above	1.0	1.1	1.6	-0.8	-0.8	1.2	1.1	1.3
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.1	-0.2	0.2	-1.1	-1.0	-0.9
Emphysema/chronic bronchitis	1.3	1.5	2.2	-1.3	0.8	-1.5	-1.1	-1.3
Medication for pain relief, constipation, heartburn	0.6	1.0	4.7	2.2	0.5	0.2	-0.1	-0.2
Neck or shoulder pain in last month	0.1	0.1	0.3	-0.4	0.5	-0.1	-0.3	0.0
Medication: Blood pressure	0.4	0.8	1.6	-0.9	1.3	-0.6	-1.0	-0.3
Angina (self-reported)	1.4	1.9	3.3	0.5	-0.7	1.8	1.6	1.7
Migraine (self-reported)	1.1	1.4	2.3	0.5	0.3	-1.4	-1.5	-1.5
Medication: Ibuprofen	2.1	2.5	4.3	1.1	-0.7	1.8	1.8	2.1
Medication: Allopurinol	1.0	1.3	5.4	-2.3	0.8	0.5	0.1	0.6
Medication: Omeprazole	0.7	0.8	1.1	-0.2	-1.1	0.9	1.0	1.0
Medication: Seretide 50 evohaler	1.5	1.8	2.9	-0.7	0.7	-1.7	-1.5	-1.7
Mean time to correctly identify matches	0.2	0.3	0.5	0.6	-0.2	0.6	0.5	0.7
Heart disease (mother)	0.8	1.0	1.5	1.0	-0.4	1.2	1.0	1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.5	2.8	0.6	-0.0	1.7	1.5	1.5
Whole body fat mass	2.6	10.7	18.7	1.0	-1.1	3.9	4.3	4.2
Leg fat mass (right)	2.2	8.6	15.0	0.6	-1.6	3.4	3.9	3.8
Arm predicted mass (right)	2.2	11.1	17.0	2.3	-1.9	3.8	4.1	3.9
Pulse rate, automated reading	3.8	12.2	17.9	2.3	-1.9	4.2	4.1	4.2
Alcohol intake frequency.	0.9	2.2	3.0	1.3	-1.2	1.6	1.5	1.7
Comparative height size at age 10	0.5	2.6	4.4	1.2	0.3	1.9	1.9	2.1
Number of full sisters	2.3	2.8	3.6	0.8	-1.8	1.7	1.9	1.8
Suffer from ‘nerves’	0.4	0.7	1.3	1.1	-0.7	0.9	0.7	0.6
Overall health rating	2.2	4.7	8.5	-0.8	-2.9	1.8	2.5	2.2
Chest pain or discomfort	0.3	0.5	0.8	-0.9	-0.0	0.8	0.6	0.7
Had major operations	0.7	0.8	1.8	1.3	0.1	0.9	1.0	0.8
Age at last live birth	0.4	0.6	1.9	-1.4	0.2	-0.4	-0.8	-0.7
Family relationship satisfaction	0.4	0.5	2.6	-0.0	-1.6	0.2	0.3	0.1
Leg pain on walking	0.1	0.1	0.4	0.3	0.7	0.1	0.3	0.3
Qualifications: NVQ or HND or HNC or equivalent	0.0	0.0	0.0	-0.2	0.0	-0.1	-0.1	0.1
Commuting to job workplace: Car/motor vehicle	0.6	0.7	2.7	0.6	-1.6	0.2	0.6	0.2
Illness, injury, bereavement, stress in last 2 years	8.8	10.7	15.0	-1.3	3.0	-3.8	-3.7	-3.9
Medication: Aspirin	0.8	1.0	1.7	-1.3	1.0	-0.9	-0.9	-0.9
Supplements: Vitamin C	1.1	1.3	2.0	1.1	-0.7	-1.3	-1.0	-1.4
Knee pain experienced in last month	0.4	0.6	0.9	-0.3	-0.6	0.8	1.0	0.9
Hypertension (Self-reported)	0.4	1.0	1.7	-0.8	0.1	1.1	1.1	1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	0.9	-1.0	-0.1	-0.6	-0.6	-0.7
Illnesses of father: Heart disease	2.9	4.0	8.0	-2.8	0.4	-2.0	-2.1	-1.8
Illnesses of siblings: Diabetes	7.1	8.7	13.9	-2.0	1.2	-3.4	-3.7	-3.5
Smoking status: Previous	0.9	1.3	2.6	-0.5	-1.6	1.2	1.2	1.0
Forced expiratory volume in 1-second (FEV1), predicted	1.3	2.7	5.1	0.4	-1.4	1.8	2.3	1.8
Whole body fat-free mass	2.5	14.5	22.2	2.9	-1.9	4.4	4.7	4.3
Leg fat-free mass (right)	3.8	20.2	31.2	3.4	-2.4	5.2	5.6	5.1
Arm fat percentage (left)	1.7	6.9	12.2	1.0	-0.5	3.1	3.5	3.4
Average weekly red wine intake	0.2	0.2	1.1	0.1	1.0	-0.1	-0.3	-0.1
Handedness (chirality/laterality): Left-handed	0.4	0.5	2.2	0.4	-1.5	0.1	0.3	0.1
Mood swings	1.1	2.1	5.8	1.0	-2.4	0.9	1.4	0.9
Loneliness, isolation	0.3	0.4	0.6	-0.5	-0.7	0.6	0.7	0.8
Long-standing illness, disability or infirmity	1.5	2.3	4.6	-2.1	-0.3	-1.6	-1.6	-1.3
Ever had bowel cancer screening	1.1	1.3	1.9	-0.9	-0.7	-1.3	-1.1	-1.4
Diabetes diagnosed by doctor	7.5	12.3	17.5	-1.8	3.3	-4.0	-4.2	-3.7
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	2.0	0.6	1.4	-0.5	-0.7	-0.2
Friendships satisfaction	0.6	0.7	2.0	1.1	-1.4	0.3	0.5	0.3
Qualifications: nursing, teaching	3.8	6.0	9.2	0.1	2.0	-2.9	-2.8	-3.0
Commuting to job workplace: Walk	0.1	0.1	0.4	-0.0	0.6	0.3	-0.0	0.1
Eye problems/disorders: Cataract	0.3	0.4	0.8	-0.0	-0.1	-0.9	-0.7	-0.8
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.7	-0.4	-0.8	-0.4	-0.6	-0.6
Medication for cholesterol	0.1	0.2	0.3	0.4	-0.4	0.5	0.4	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.4	2.0	-1.0	1.4	-1.4	-1.0	-1.0
Back pain experienced in last month	0.6	0.9	1.6	-0.1	-0.9	1.1	1.3	1.0
Mineral and other dietary supplements	0.3	0.4	0.8	0.7	0.9	0.3	0.5	0.6
Breast cancer (self-reported)	1.6	1.9	2.7	1.4	-0.7	1.4	1.6	1.5
Asthma (self-reported)	0.7	1.4	4.0	-2.0	-1.5	-0.4	-0.6	-0.5
Osteoporosis (self-reported)	0.4	0.6	2.1	-1.4	-0.1	0.5	0.5	0.4
Osteoarthritis (self-reported)	0.2	0.2	0.6	-0.8	-0.8	0.1	-0.1	0.1
Medication: Aspirin	1.1	1.4	2.9	-1.7	1.3	-0.9	-1.0	-0.9
Medication: Gliclazide	6.7	7.6	11.8	-0.2	2.9	-3.1	-3.4	-2.9
Illnesses of father: None of the above (group 1)	3.8	4.7	8.5	2.9	-0.9	2.4	2.2	1.9
Smoking status: Current	2.6	4.1	7.1	1.5	-0.8	2.2	2.7	2.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	0.5	0.5	0.7	-0.7	-0.5	-0.6
Whole body water mass	2.5	14.3	22.0	2.9	-1.9	4.3	4.7	4.3
Leg predicted mass (right)	3.8	20.3	31.5	3.4	-2.3	5.2	5.6	5.1
Arm fat mass (left)	2.2	9.1	16.1	1.1	-1.0	3.5	4.0	3.8
Number of self-reported non-cancer illnesses	0.6	1.1	2.3	-1.5	0.3	-1.0	-1.0	-1.0
Average weekly champagne plus white wine intake	0.4	0.5	0.9	-0.6	0.2	-1.0	-0.7	-0.8
Miserableness	2.4	4.1	10.2	0.3	-3.2	1.6	2.2	1.6
Guilty feelings	0.4	0.6	2.6	1.6	-0.4	-0.2	0.2	-0.2
Wears glasses or contact lenses	1.6	1.9	3.3	0.7	1.1	-1.4	-1.5	-1.8
Ever taken oral contraceptive pill	0.6	0.7	1.4	-0.0	0.4	-1.2	-0.9	-1.0
Hearing aid user	0.1	0.1	0.3	0.6	-0.5	0.2	0.1	0.1
Mother’s age at death	5.3	6.7	9.5	-0.6	3.1	-2.6	-3.0	-2.7
Financial situation satisfaction	0.6	0.8	3.0	0.9	-1.7	-0.1	0.2	-0.3
Tinnitus: Yes, now most or all of the time	1.0	1.1	1.8	1.0	-0.2	1.2	1.4	1.1
Commuting to job workplace: Public transport	1.7	2.1	3.2	1.1	1.8	-1.3	-1.4	-1.5
Eye problems/disorders: Glaucoma	0.5	0.6	2.0	1.4	0.2	-0.6	-0.4	-0.6
Medication: Blood pressure	0.6	1.2	2.2	-1.5	1.4	-0.8	-0.7	-0.6
Pain type(s) experienced in last month: Hip pain	0.6	0.7	2.9	1.7	-0.7	-0.0	0.4	0.2
Supplements: Fish oil (including cod liver oil)	2.1	2.7	4.2	-2.0	-0.3	-1.5	-2.0	-1.7
High cholesterol (Self-reported)	0.7	1.3	2.1	0.9	0.5	-1.2	-1.4	-1.4
Medication: Bendroflumethiazide	1.2	1.9	5.0	-2.2	1.5	-0.8	-0.9	-0.7
Medication: Paracetamol	0.3	0.5	1.6	-1.3	-0.8	-0.1	0.1	-0.2
Medication: Lisinopril	0.4	0.6	2.1	0.2	1.5	-0.2	-0.6	-0.5
Medication: Atorvastatin	1.0	1.2	2.1	-1.1	0.1	-1.2	-1.4	-1.3
Illnesses of father: High blood pressure	0.7	0.8	3.6	-1.9	-0.8	-0.2	0.2	-0.1
Alcohol drinker status: Never	0.8	1.0	4.8	2.2	-0.4	0.3	0.0	0.2
Ever smoked	1.3	2.3	4.0	0.6	-2.0	1.5	1.7	1.5
Basal metabolic rate	2.9	15.9	25.1	2.7	-1.9	4.7	5.0	4.7
Leg fat percentage (left)	0.6	2.2	4.2	-0.6	0.0	1.5	2.0	2.0
Arm fat-free mass (left)	1.9	9.9	16.0	1.9	-1.3	3.7	4.0	3.8
Number of operations (self-reported)	0.2	0.3	0.7	0.6	0.1	0.5	0.9	0.5
Average weekly beer plus cider intake	1.2	1.8	6.1	1.2	-2.5	0.6	0.8	0.5
Irritability	0.0	0.0	0.1	0.2	0.3	-0.0	-0.1	-0.0
Risk taking	1.1	1.5	2.5	0.9	0.6	1.5	1.3	1.6
Ever had prostate specific antigen (PSA) test	3.9	4.5	7.0	-1.3	1.1	-2.4	-2.6	-2.6
Fractured/broken bones in last 5 years	1.4	1.8	4.7	-2.2	0.4	-1.1	-1.3	-1.2
Age started oral contraceptive pill	6.8	8.5	10.8	-2.6	2.4	-3.1	-3.3	-3.0
Diastolic blood pressure, automated reading	1.1	3.3	6.8	-1.7	-2.6	1.4	1.8	1.4
Ever depressed for a whole week	0.8	1.0	2.2	-0.3	-0.2	-1.1	-1.5	-1.1
Unable to work because of sickness or disability	0.9	1.1	3.1	0.5	-1.8	0.6	1.1	0.9
Commuting to job workplace: Cycle	2.3	2.8	4.5	-0.8	0.9	-2.0	-2.0	-2.1
Myopia	1.2	1.7	2.6	1.6	0.6	-1.2	-1.3	-1.5
Vascular/heart problems diagnosed by doctor	0.5	1.3	1.8	1.3	0.1	-1.3	-1.1	-1.4
Cholesterol lowering medication	0.1	0.2	0.3	-0.1	0.1	-0.5	-0.5	-0.5
Medication: Omeprazole (e.g. Zanprol)	1.4	1.7	3.2	0.3	-1.8	1.3	1.2	1.4
Pain experienced in last month	0.6	1.0	1.5	0.7	0.9	-1.0	-1.0	-1.2
Supplements: Calcium	1.9	2.1	3.2	0.8	1.0	-1.6	-1.8	-1.8
Basal cell carcinoma (self-reported)	2.3	2.7	4.8	-0.2	1.3	-1.9	-1.8	-2.2
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.9	1.4	-0.3	0.3	0.4	0.2
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.7	0.8	-0.1	0.4	0.6	0.4
Heart disease (siblings)	2.0	2.4	3.9	-0.9	-1.1	1.8	1.8	2.0
Alcohol drinker status: Previous	0.6	0.7	2.7	-0.8	-1.6	0.5	0.2	0.2
Pack years of smoking	0.3	0.5	2.0	1.4	-0.5	-0.1	0.1	0.3
Impedance of whole body	0.8	4.0	4.8	-2.2	2.0	-1.8	-2.1	-1.8
Leg fat mass (left)	2.2	8.5	14.9	0.6	-1.4	3.4	3.9	3.7
Arm predicted mass (left)	2.0	10.3	16.2	2.2	-1.6	3.7	4.0	3.8