Hub : Genes

ARAP1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.1209	0.0431	1.5e-03	0.000	NA	0.002	NA	0.003	2.9e-01	NA	1.9e-01	NA	1.7e-01
2	GTEx	Esophagus Mucosa	0.2730	0.0510	8.0e-11	0.248	NA	0.216	NA	0.257	1.1e-16	NA	1.7e-14	NA	2.7e-17
3	GTEx	Skin Not Sun Exposed Suprapubic	0.2380	0.0720	1.6e-05	0.195	NA	0.099	NA	0.161	6.0e-11	NA	4.3e-06	NA	3.6e-09
4	GTEx	Skin Sun Exposed Lower leg	0.2100	0.0520	1.6e-06	0.127	NA	0.124	NA	0.127	1.2e-10	NA	2.0e-10	NA	1.2e-10
5	ROSMAP	Brain Pre-frontal Cortex	0.0530	0.0213	1.4e-03	0.040	0.017	0.022	0.021	0.026	5.5e-06	0.00250	6.3e-04	0.00076	2.2e-04
6	YFS	Blood	0.0171	0.0087	5.8e-03	0.011	0.005	0.001	0.005	0.007	8.1e-05	0.00790	1.5e-01	0.00790	2.3e-03
7	TCGA	Thyroid Carcinoma	0.2620	0.0940	5.0e-05	0.007	0.038	0.044	NA	0.018	5.9e-02	0.00011	3.9e-05	NA	6.8e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.3	0.5	0.9	-0.2	-0.8	-0.9	-1.0	0.8	-0.0	0.7
Bipolar Disorder or Schizophrenia	1.1	2.6	5.0	0.6	-1.8	-1.9	-2.2	2.2	0.5	1.1
Depressed Affect (Nagel 2018)	0.3	0.7	1.3	-0.8	1.1	1.1	0.9	0.3	0.7	0.7
Depression (Nagel 2018)	0.1	0.2	0.5	-0.7	0.6	0.6	0.4	0.1	0.3	0.1
Intelligence (Savage-Jansen 2018)	2.1	6.6	10.3	2.9	-3.2	-3.2	-3.0	2.1	-1.5	1.0
Neuroticism (Nagel 2018)	0.3	0.7	1.1	-1.0	0.9	0.9	0.6	1.0	0.7	0.7
Schizophrenia (2018)	1.2	2.4	5.6	0.8	-1.7	-1.7	-2.0	2.4	0.7	0.9
Schizophrenia vs Biploar Disorder	0.2	0.3	1.5	1.2	0.1	0.1	0.1	-0.6	-0.2	0.5
Worry (Nagel 2018)	0.4	0.8	2.1	-0.9	0.5	0.6	0.4	1.3	1.4	0.4
Alzheimer’s Disease (in mother)	0.5	0.5	1.5	-1.1	0.1	0.0	-0.1	0.8	1.2	0.6
Alzheimer’s Disease (in father)	0.3	0.3	1.9	-0.5	0.1	0.1	0.3	0.3	1.4	-0.4
Alzheimer’s Disease (including proxy)	0.3	0.4	1.3	-1.0	-0.1	-0.1	-0.1	0.5	1.1	0.3
Crohns Disease (2017)	2.6	5.6	7.3	-2.4	2.5	2.7	2.7	-2.0	1.6	2.5
Irritable Bowel Disease (IBD)	1.0	2.3	6.3	-1.9	1.1	1.2	1.1	-1.1	1.0	2.5
Ulcerative Colitis (UC)	0.3	0.6	2.5	-0.8	-0.5	-0.5	-0.7	-0.1	-0.0	1.6
Major Depression (MDD)	0.5	0.5	2.4	-1.0	0.2	-0.1	-0.3	-0.0	-1.6	0.6
Reaction Time	1.2	2.4	5.5	-2.4	1.7	1.8	1.9	-0.1	0.1	1.1
Verbal and Numeric Reasoning (VNR)	1.4	3.3	7.2	1.1	-2.1	-2.0	-1.8	1.9	-0.4	2.7
Breast Cancer	2.0	4.7	7.4	2.5	-2.7	-2.7	-2.6	1.3	-0.7	-1.6
Ovarian Cancer	0.2	0.2	1.0	-0.5	0.0	0.0	-0.1	-0.5	0.5	-1.0
Prostate Cancer	0.6	0.9	2.6	-0.4	0.2	0.2	0.1	1.3	1.6	1.3
Age at First Birth	2.7	4.0	7.5	2.1	-2.7	-2.7	-2.5	1.4	-0.3	-0.4
Bipolar Disorder (2011)	0.0	0.0	0.1	0.0	0.0	0.0	0.0	0.0	0.0	0.3
Body Mass Index (BMI) (2010)	1.5	2.1	3.7	-1.6	1.9	1.9	1.6	-0.4	0.4	1.4
Coronary Artery Disease (CAD)	0.8	1.0	1.4	0.5	1.2	1.2	1.2	-1.0	-0.9	-0.9
Crohns Disease (2012)	1.1	1.8	4.8	-0.9	1.4	1.4	1.4	-2.2	1.0	0.6
Mean Putamen Volume	0.2	0.3	1.3	-0.4	-0.1	0.0	0.2	-0.5	-1.1	0.3
Fasting Glucose	8.1	9.7	20.9	3.0	-2.6	-3.1	-3.0	-1.2	-3.4	-4.6
HbA1C	4.2	4.7	6.5	2.0	-2.4	-2.5	-2.5	1.4	-2.2	-2.0
HDL Cholesterol	0.4	0.7	3.2	1.8	0.3	0.2	0.2	-0.2	-1.3	-0.2
LDL Cholesterol	0.2	0.3	1.4	0.2	0.1	-0.0	-0.2	0.3	-0.6	-1.2
Lupus	1.3	2.0	5.8	-2.3	0.8	0.9	0.6	0.1	1.1	2.4
Neuroticism (2016)	1.1	1.5	4.0	-2.0	1.4	1.3	1.2	-1.0	0.5	-0.7
Primary Biliary Cirrhosis	1.5	2.1	9.1	-0.7	1.2	0.9	0.9	-3.0	-1.1	-1.1
Rheumatoid Arthritis	1.1	1.5	7.0	-1.1	0.6	0.8	0.7	-0.2	0.9	2.7
Schizophrenia (2014)	1.1	2.4	4.6	1.0	-1.8	-1.8	-2.1	1.9	0.1	1.1
Triglycerides	0.3	0.5	2.2	-0.1	0.0	0.0	-0.0	0.2	1.5	0.9
Type 2 Diabetes (T2D) (2012)	8.0	9.2	16.7	4.1	-2.6	-3.0	-2.8	0.1	-3.2	-3.8
Ulcerative Colitis	0.5	0.7	2.0	-0.9	-0.6	-0.6	-0.9	0.6	-0.1	1.4
Blood Eosinophil Count	0.5	3.9	9.2	-0.5	1.8	1.8	1.9	-3.0	2.2	-1.9
Blood Platelet Count	1.8	21.4	35.3	-2.0	5.9	5.5	5.6	-5.6	-3.6	-2.2
Blood Red Count	0.0	0.2	0.7	0.2	-0.3	-0.4	-0.5	-0.9	0.2	0.2
Blood White Count	0.9	6.8	12.4	-0.5	3.5	3.3	3.3	-3.4	-1.2	-0.7
Heel T-Score	2.2	17.6	31.9	3.6	-5.6	-5.7	-5.2	2.9	-2.4	-2.4
BMI	2.1	12.1	22.4	-2.8	4.6	4.7	4.7	-2.7	1.5	1.1
Height	0.9	16.7	31.5	-3.9	5.6	5.5	5.6	-3.0	0.1	0.6
Waist Hip Ratio (WHR)	0.5	2.1	4.5	2.1	-1.2	-1.4	-1.4	1.5	-0.5	-1.5
Systolic Blood Pressure	0.1	0.5	2.2	-0.1	-0.4	-0.3	-0.4	-0.0	-0.9	1.5
Smoking Status	3.8	9.0	16.3	-3.0	4.0	4.0	3.8	-2.2	0.6	1.3
Allergy or Eczema	2.8	7.3	10.6	2.1	-3.0	-3.3	-3.2	1.7	-1.9	-3.1
Cardiovascular Disease	0.2	0.7	1.6	-1.2	0.5	0.5	0.6	0.5	-1.0	1.2
Hypothyroidism (self reported)	1.0	2.4	7.7	-2.2	-0.1	0.2	-0.1	1.7	2.8	1.2
Respiratory disease	0.5	1.2	2.2	-0.1	-1.0	-1.3	-1.4	1.3	-1.5	-0.1
Type 2 Diabetes (T2D) (2018)	8.5	15.9	29.4	5.4	-3.3	-3.9	-3.7	-1.3	-3.6	-5.2
Lung FEV1/FVC ratio	6.3	31.8	43.8	-6.0	6.4	6.6	6.1	-4.8	5.3	3.6
Lung FVC	2.3	11.8	17.0	3.7	-4.0	-4.1	-3.8	1.8	-4.1	-1.4
Neuroticism	0.5	1.1	2.8	-1.7	0.4	0.5	0.1	1.1	1.3	1.3
Chronotype (morning person)	2.9	6.7	10.3	-2.4	3.0	3.2	3.2	-0.8	3.0	1.3
Hair Pigment	0.0	0.2	0.7	-0.5	0.5	0.4	0.4	0.2	0.3	-0.8
Tanning	0.0	0.4	1.2	1.1	-0.2	-0.3	-0.3	0.2	1.0	-0.3
Hand grip strength (left)	0.2	0.4	1.7	-0.8	0.4	0.5	0.4	-0.4	0.2	1.3
Number of treatments/medications taken	1.5	2.7	4.1	0.6	-2.0	-2.0	-1.8	2.0	-1.7	-0.5
Average weekly spirits intake	0.8	0.9	4.2	-0.2	0.4	0.4	0.2	0.8	2.1	1.2
Sensitivity / hurt feelings	0.2	0.4	1.9	-1.4	0.2	0.3	0.3	0.4	0.4	-0.7
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.7	-0.7	0.2	0.2	-0.0	-0.7	0.4	-0.8
Hearing difficulty/problems: Yes	0.2	0.3	1.8	-0.1	0.2	0.2	0.1	-0.2	1.3	0.2
Relative age of first facial hair	1.3	2.7	6.8	1.3	-1.8	-1.8	-1.9	2.6	0.7	-0.0
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	3.4	-1.9	0.5	0.4	0.3	1.2	-0.4	0.3
Ever used hormone-replacement therapy (HRT)	1.0	1.3	3.3	0.6	-0.5	-0.4	-0.6	1.8	1.3	1.7
Ever had hysterectomy (womb removed)	2.3	2.5	4.0	1.8	-1.7	-1.9	-2.0	1.5	0.6	-1.2
Systolic blood pressure, automated reading	0.5	1.3	3.1	-1.1	1.1	1.3	1.3	-0.5	0.1	1.8
Eye problems/disorders: Diabetes related eye disease	1.6	1.7	2.9	0.7	-1.6	-1.7	-1.7	1.5	0.9	-0.2
Angina	1.0	1.4	2.1	-1.4	1.3	1.3	1.4	-0.6	-0.0	-1.4
Medication for hormone replacement therapy	0.3	0.3	0.9	-0.8	0.4	0.3	0.3	-0.2	-0.3	0.9
Vitamin and mineral supplements	0.4	0.5	0.7	-0.1	0.8	0.8	0.9	-0.8	0.8	0.2
Supplements: Zinc	0.1	0.1	0.3	0.2	-0.1	-0.2	-0.2	0.5	-0.4	-0.2
Medication: Co-codamol	0.0	0.0	0.1	-0.1	0.3	0.3	0.3	-0.2	0.0	0.0
Medication: Metformin	7.1	10.0	20.2	4.5	-3.3	-3.7	-3.5	0.2	-1.1	-3.5
Diabetes (father)	1.3	1.6	4.3	2.1	-0.9	-1.0	-0.9	-0.2	-1.4	-1.5
Diabetes (mother)	9.4	12.0	22.8	4.8	-2.9	-3.2	-3.0	1.3	-3.1	-4.7
Severe depression (siblings)	0.7	0.8	1.9	-0.8	-0.8	-0.8	-0.8	1.4	0.8	-0.5
Pack years adult smoking proportion	0.5	0.8	2.4	-0.7	0.5	0.5	0.5	-0.7	1.5	1.2
Impedance of leg (right)	1.4	6.6	10.9	2.4	-2.8	-2.9	-2.7	2.2	-3.3	-1.1
Leg fat-free mass (left)	3.5	18.3	31.3	-3.9	5.5	5.6	5.3	-3.3	2.8	1.8
Trunk fat percentage	1.6	6.2	12.9	-1.9	3.6	3.5	3.4	-1.1	1.2	0.5
Hand grip strength (right)	0.3	0.9	2.4	-0.9	0.7	0.8	0.8	-0.8	1.0	1.6
Townsend deprivation index at recruitment	0.2	0.2	0.5	-0.6	0.7	0.6	0.6	0.1	0.0	0.3
Current tobacco smoking	1.7	2.7	5.6	-0.9	2.4	2.3	2.2	-0.5	1.5	0.1
Average weekly fortified wine intake	0.5	0.6	0.9	0.4	-0.8	-0.9	-0.8	-0.8	-0.4	-0.9
Maternal smoking around birth	2.3	3.4	6.1	-2.0	2.5	2.4	2.1	-1.5	0.8	0.7
Fed-up feelings	0.9	1.7	3.3	-1.0	1.7	1.6	1.4	-1.8	-0.6	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	1.2	-1.0	0.7	0.7	0.3	-1.1	0.5	0.6
Relative age voice broke	2.6	3.9	6.3	2.5	-2.3	-2.3	-2.2	1.9	-0.5	-1.4
Taking other prescription medications	1.0	1.5	6.4	-0.6	-1.0	-1.0	-1.1	2.5	-0.7	0.3
Age when periods started (menarche)	0.0	0.1	0.4	-0.3	0.1	0.2	0.3	0.6	-0.2	-0.2
Bilateral oophorectomy (both ovaries removed)	0.9	1.0	2.0	1.4	-1.2	-1.2	-1.3	0.4	0.6	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.8	5.2	-0.3	-2.3	-2.2	-2.1	2.1	0.2	0.9
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	1.5	-0.9	0.7	0.8	1.0	0.4	1.2	-0.1
Qualifications: CSEs or equivalent	1.2	1.6	2.9	-1.4	1.7	1.6	1.4	-1.1	0.6	0.0
Serious illness, injury or assault to yourself	0.7	0.8	2.8	-1.7	0.8	0.9	0.8	0.5	0.6	0.6
High blood pressure	0.3	0.8	1.5	-0.5	1.0	1.1	1.2	-0.1	-1.1	0.4
Hayfever, allergic rhinitis or eczema	2.4	5.2	9.2	2.2	-2.0	-2.4	-2.4	1.5	-2.1	-3.0
Multivitamins +/- minerals	0.2	0.2	0.6	-0.0	-0.5	-0.5	-0.5	0.8	-0.6	0.3
Stomach or abdominal pain in last month	0.4	0.5	2.2	0.1	0.2	0.2	0.3	-1.5	-0.4	-1.1
Supplements: Glucosamine	0.3	0.4	1.2	0.2	-0.0	0.1	0.1	1.1	0.5	1.0
Diverticular disease/diverticulitis (self-reported)	3.6	4.2	6.8	2.1	-1.9	-2.0	-2.1	2.6	-2.4	0.0
Medication: Atenolol	0.1	0.1	0.6	0.2	0.0	0.0	0.1	-0.0	-0.8	0.1
Medication: Levothyroxine sodium	0.7	1.2	3.9	-0.9	-0.2	-0.1	-0.4	1.7	2.0	1.0
Sitting height	0.7	4.8	7.2	-1.7	2.6	2.7	2.7	-2.3	1.6	1.2
Chronic bronchitis/emphysema (father)	1.2	1.4	2.7	1.6	-1.1	-1.2	-1.1	1.5	0.7	-0.6
High blood pressure (mother)	0.9	1.3	4.4	1.3	-1.1	-0.9	-0.9	0.5	0.2	2.1
Body mass index (BMI)	1.4	6.2	12.0	-2.0	3.5	3.4	3.2	-1.6	1.4	0.5
Impedance of leg (left)	1.4	7.0	10.7	2.7	-2.9	-3.0	-2.9	1.9	-3.3	-1.4
Leg predicted mass (left)	3.4	17.9	30.7	-3.9	5.5	5.5	5.3	-3.2	2.9	1.9
Trunk fat mass	2.4	10.2	20.2	-2.5	4.5	4.5	4.3	-1.8	1.6	0.8
Waist circumference	1.8	6.7	13.5	-2.3	3.7	3.6	3.4	-1.2	1.2	0.8
Number of incorrect matches in round	0.4	0.7	2.6	1.1	-0.1	-0.2	0.1	0.4	-0.9	-1.6
Past tobacco smoking	2.0	3.8	7.3	2.7	-2.3	-2.3	-2.1	0.4	0.7	-1.8
Alcohol usually taken with meals	0.7	1.2	2.2	1.0	-1.4	-1.5	-1.4	0.6	-0.7	-0.4
Nervous feelings	0.1	0.1	0.4	-0.6	0.2	0.3	0.1	-0.3	0.5	-0.1
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.6	-0.7	-0.2	-0.2	-0.5	0.2	0.4	0.4
Hearing difficulty/problems with background noise	0.9	1.4	3.3	-1.8	1.3	1.3	1.1	-1.3	-0.2	-0.1
Hair/balding pattern: Pattern 2	0.6	0.8	2.2	0.7	0.9	0.9	1.1	-1.5	0.4	-0.3
Had menopause	3.6	4.4	7.0	2.6	-2.5	-2.6	-2.6	1.7	-1.3	0.3
Had other major operations	1.1	1.3	2.5	0.6	-0.9	-1.0	-1.3	1.6	-1.5	0.8
Forced vital capacity (FVC)	0.2	0.6	3.2	0.3	-0.2	-0.3	-0.0	-0.7	-1.8	-0.8
Heel bone mineral density (BMD) T-score, automated (right)	1.8	4.0	8.7	-0.3	-2.5	-2.3	-2.4	3.0	0.6	1.4
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	1.7	0.1	-1.1	-1.3	-1.3	0.9	-1.1	-1.0
Qualifications: None of the above	0.9	1.9	3.4	-1.3	1.8	1.9	1.7	0.3	1.2	0.7
Financial difficulties in last 2 years	3.1	4.1	8.8	-2.4	3.0	2.7	2.3	-0.8	-0.6	0.6
Mouth/teeth dental problems	2.3	3.5	7.8	2.8	-2.0	-2.0	-2.1	1.8	-1.0	-0.6
Heart attack	0.3	0.4	1.8	-0.7	0.6	0.5	0.4	0.1	0.0	-1.3
Allergy	1.9	4.3	6.3	-1.7	2.0	2.4	2.5	-1.9	2.0	2.0
Pain all over the body in last month	2.0	2.1	7.3	-0.6	1.4	1.1	0.9	-0.8	-2.7	-1.6
Diabetes (self-reported)	5.1	7.8	19.5	4.0	-2.1	-2.5	-2.4	-0.8	-1.5	-4.4
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	2.5	0.3	-0.4	-0.5	-0.4	-0.5	-1.6	-0.3
Medication: Ramipril	0.3	0.3	0.8	0.9	-0.5	-0.5	-0.5	-0.4	-0.0	-0.7
Medication: Simvastatin	0.3	0.4	0.9	-0.7	0.5	0.6	1.0	0.0	-0.3	-0.8
Fluid intelligence score	1.6	3.4	4.2	2.0	-2.1	-2.1	-1.8	2.0	-0.9	1.8
Illnesses of siblings	0.6	0.8	1.7	-0.2	0.8	0.8	0.6	-0.8	1.2	1.3
Neuroticism score	0.3	0.7	2.1	-1.4	0.9	0.9	0.6	0.0	0.8	0.3
Weight	2.5	12.5	23.8	-3.1	4.9	4.8	4.7	-2.3	1.6	0.9
Impedance of arm (right)	0.3	1.3	2.3	1.5	-1.2	-1.2	-1.2	1.4	-0.5	-0.1
Arm fat percentage (right)	1.3	5.0	10.3	-1.2	3.2	3.2	3.0	-0.7	1.7	0.4
Trunk fat-free mass	1.4	8.1	14.4	-2.2	3.8	3.8	3.6	-2.6	1.4	1.1
Hip circumference	3.2	14.0	24.6	-3.7	4.9	5.0	4.8	-2.9	1.8	0.8
Time employed in main current job	3.8	4.3	7.6	2.2	-2.5	-2.5	-2.3	2.8	0.0	-0.4
Alcohol intake versus 10 years previously	0.1	0.1	0.2	0.4	-0.3	-0.3	0.1	0.1	0.4	-0.4
Father’s age at death	0.8	1.0	1.8	1.3	-1.1	-1.1	-1.2	1.4	0.3	0.5
Worrier / anxious feelings	0.2	0.4	1.2	-0.5	0.5	0.6	0.4	0.7	1.1	-0.0
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	2.4	-0.7	-0.2	-0.1	-0.4	0.0	1.5	1.1
Falls in the last year	0.5	0.7	1.3	0.4	-0.7	-0.8	-0.9	1.0	-1.1	0.5
Hair/balding pattern: Pattern 3	0.2	0.3	0.6	0.8	-0.1	-0.0	0.1	0.5	-0.6	-0.8
Number of live births	0.2	0.3	0.7	-0.8	0.3	0.3	0.2	0.7	0.8	-0.2
Forced expiratory volume in 1-second (FEV1)	0.6	2.1	4.2	-1.4	1.6	1.7	1.8	-2.1	-0.1	0.1
Pulse rate	2.4	4.1	7.4	-1.2	2.5	2.5	2.7	-2.5	0.6	-0.9
Happiness	0.7	0.8	2.0	-1.4	1.1	1.1	0.9	-0.6	-0.6	-0.1
Noisy workplace	0.7	0.8	1.9	-1.4	0.8	0.7	0.6	-1.2	-0.6	-0.8
Qualifications: A levels/AS levels or equivalent	1.7	3.7	7.5	1.4	-2.7	-2.7	-2.6	0.9	-0.4	1.1
Serious illness, injury or assault of a close relative in last 2 years	1.5	1.7	6.6	0.5	0.8	0.8	1.0	-1.7	-2.6	-0.3
Mouth/teeth dental problems: Dentures	4.9	8.2	11.7	-3.2	3.3	3.4	3.3	-1.6	2.9	1.9
Asthma	0.3	0.6	2.0	-0.5	-0.5	-0.6	-0.6	0.9	-1.4	-0.1
Medication: Ibuprofen (e.g. Nurofen)	1.7	2.2	4.3	-1.0	1.9	1.9	2.1	-1.3	-0.4	0.6
Medication: Cholesterol lowering	0.8	1.3	5.7	0.3	-0.8	-0.8	-0.4	0.2	-1.3	-2.4
Depression (self-reported)	0.3	0.3	1.0	-0.8	0.3	0.3	0.3	0.4	1.0	0.4
Medication: Lansoprazole	0.3	0.3	0.9	-0.5	0.6	0.6	0.6	0.4	-0.9	0.1
Prospective memory result	0.9	1.2	2.1	-0.6	1.4	1.5	1.4	-0.5	0.7	-1.0
Lung cancer (father)	1.1	1.3	2.3	-1.0	1.5	1.5	1.5	-0.3	-0.1	0.9
Illnesses of mother	0.9	1.1	4.3	-2.1	1.1	1.1	1.0	-0.2	0.0	0.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	3.7	-0.8	1.1	1.2	1.2	-1.9	-0.3	0.5
Pulse wave Arterial Stiffness index	0.3	0.3	1.6	1.3	0.2	0.1	0.0	-0.4	0.3	-0.4
Impedance of arm (left)	0.1	0.3	0.6	0.6	-0.5	-0.6	-0.4	0.8	-0.7	-0.3
Arm fat mass (right)	2.1	8.5	17.6	-2.0	4.2	4.1	4.0	-1.8	1.4	0.5
Trunk predicted mass	1.4	8.1	14.7	-2.2	3.8	3.8	3.6	-2.6	1.4	1.1
Standing height	1.0	9.5	17.2	-2.7	4.1	4.2	4.1	-2.4	0.8	1.0
Length of working week for main job	0.9	1.0	4.8	-0.5	0.6	0.7	0.7	0.3	2.2	0.8
Exposure to tobacco smoke at home	0.2	0.2	0.7	0.5	-0.4	-0.5	-0.4	0.8	0.3	-0.2
Breastfed as a baby	1.3	1.6	3.1	0.8	-1.7	-1.7	-1.8	0.9	1.0	0.3
Tense / ‘highly strung’	0.4	0.7	1.8	-0.0	-0.9	-0.8	-0.9	1.3	0.8	-0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.7	2.7	7.4	-2.7	1.7	1.9	1.8	-0.6	-0.3	1.0
Hair/balding pattern: Pattern 4	1.7	4.2	8.8	1.1	-2.9	-3.0	-3.0	1.4	-0.6	-0.3
Birth weight of first child	0.6	1.0	4.1	1.0	0.6	0.5	0.5	-2.0	-0.6	-0.9
Peak expiratory flow (PEF)	0.7	1.5	3.0	-0.8	1.5	1.4	1.4	-1.7	0.8	-0.1
Pulse wave reflection index	2.5	3.0	5.0	1.7	-1.9	-2.0	-2.2	1.9	-1.6	0.2
Ever highly irritable/argumentative for 2 days	1.0	1.2	5.4	0.8	0.3	0.1	0.0	-0.5	-1.4	-2.3
Loud music exposure frequency	1.2	1.4	4.3	2.1	-0.2	-0.4	-0.5	-0.9	1.2	-1.6
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	2.6	-0.4	0.1	0.1	0.1	-0.7	-1.6	0.8
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.4	-0.3	0.1	0.1	0.1	-0.1	0.1	-0.6
Blood clot in the leg (DVT)	0.3	0.4	1.3	-0.5	0.4	0.3	0.2	1.2	-0.9	-0.5
Medication: Paracetamol	0.5	0.9	3.0	-1.0	0.3	0.1	-0.0	0.4	-1.7	-1.3
Headache pain in last month	1.2	2.1	5.3	0.4	-1.8	-1.8	-1.6	0.4	-2.3	-0.5
Medication for cholesterol, blood pressure or diabetes	1.1	1.8	6.8	-0.5	0.7	0.7	0.2	0.2	2.0	2.6
Glaucoma (self-reported)	0.0	0.0	0.1	0.1	-0.1	-0.2	-0.3	-0.3	0.3	0.2
Gout (self-reported)	0.4	0.5	1.4	-0.6	-0.1	-0.0	0.0	0.5	-1.1	-1.2
Hypothyroidism/myxoedema (self-reported)	1.0	2.0	6.3	-1.5	-0.2	0.0	-0.2	1.7	2.5	1.6
Medication: Amlodipine	0.7	0.9	4.3	-1.1	-0.3	-0.1	-0.3	0.3	0.9	2.1
Medication: Ventolin 100micrograms inhaler	0.3	0.3	1.2	0.0	0.5	0.2	-0.0	0.9	-1.1	0.0
Birth weight	0.1	0.3	0.8	-0.2	0.1	-0.1	-0.3	-0.9	-0.4	-0.9
Chronic bronchitis/emphysema (mother)	1.0	1.2	5.8	0.5	0.3	0.3	0.1	2.4	-0.2	1.4
High blood pressure (siblings)	0.1	0.2	0.5	0.4	-0.4	-0.3	-0.3	0.3	-0.7	-0.6
Forced vital capacity (FVC), Best measure	0.2	0.9	3.7	0.9	-0.6	-0.6	-0.5	-0.7	-1.9	-0.5
Body fat percentage	1.3	5.0	10.6	-1.7	3.3	3.2	3.1	-0.7	1.1	0.4
Leg fat percentage (right)	0.5	1.8	4.3	-0.9	2.1	2.0	1.9	0.1	0.4	0.2
Arm fat-free mass (right)	2.2	11.2	19.6	-3.0	4.4	4.4	4.2	-3.2	1.2	1.1
Exposure to tobacco smoke outside home	0.7	0.9	2.2	1.5	-1.1	-1.1	-1.0	0.7	0.1	-0.5
Comparative body size at age 10	0.5	1.3	2.8	0.2	1.7	1.5	1.1	-1.5	-0.8	0.1
Number of full brothers	1.0	1.3	7.0	-0.5	-0.5	-0.4	-0.4	0.3	2.6	0.9
Worry too long after embarrassment	1.3	2.2	4.1	-1.9	2.0	2.0	1.8	-0.7	-0.4	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	1.3	-0.9	0.8	0.8	0.5	-0.5	1.2	0.8
Wheeze or whistling in the chest in last year	0.4	0.7	3.1	-0.7	0.7	0.5	0.2	1.8	-0.7	0.1
Number of children fathered	4.2	4.8	8.5	-1.8	2.6	2.8	2.9	-2.2	1.1	0.9
Reason for reducing amount of alcohol drunk: Health precaution	2.9	3.3	7.8	0.7	-2.5	-2.5	-2.8	1.6	-0.4	0.1
Age at first live birth	2.2	3.9	7.3	1.4	-2.7	-2.6	-2.6	1.6	-0.4	1.4
Pulse wave peak to peak time	0.3	0.3	2.0	-1.4	0.1	0.2	0.3	0.1	-0.2	0.5
Health satisfaction	1.1	1.4	4.3	-2.1	1.2	1.2	1.2	-0.6	-0.8	-0.4
Shortness of breath walking on level ground	0.7	0.9	2.7	1.4	0.1	-0.3	-0.4	0.2	-1.6	-1.1
Qualifications: College or University degree	2.5	7.8	15.5	1.5	-3.9	-3.8	-3.8	2.6	0.4	0.9
Eye problems/disorders: None of the above	0.8	0.9	2.1	-1.5	0.9	1.0	1.1	-0.6	-0.9	0.4
Mouth/teeth dental problems: Loose teeth	0.7	0.8	1.4	0.3	-1.1	-1.0	-1.0	1.2	0.9	-0.1
Emphysema/chronic bronchitis	0.9	1.0	1.6	1.2	-1.0	-1.1	-1.3	1.0	-0.5	0.4
Medication for pain relief, constipation, heartburn	1.2	2.0	9.0	0.8	-0.5	-0.3	-0.2	0.1	3.0	2.1
Neck or shoulder pain in last month	0.4	0.6	3.0	0.6	-0.0	-0.0	0.1	-0.5	-1.7	-0.8
Medication: Blood pressure	0.8	1.4	4.7	1.1	-0.7	-0.7	-0.3	-0.4	-2.2	-1.5
Angina (self-reported)	1.6	2.1	3.3	-1.4	1.7	1.7	1.8	-0.9	-0.3	-1.6
Migraine (self-reported)	2.2	2.7	6.5	0.8	-1.8	-1.7	-1.6	2.5	1.0	1.5
Medication: Ibuprofen	1.6	1.9	3.5	-1.2	1.7	1.8	1.9	-1.3	-0.0	0.8
Medication: Allopurinol	0.8	1.1	3.4	0.2	0.4	0.4	0.6	0.2	-1.9	-1.8
Medication: Omeprazole	1.2	1.4	2.9	-1.5	1.2	1.0	1.1	0.2	-1.1	-1.7
Medication: Seretide 50 evohaler	1.3	1.5	2.5	1.1	-1.3	-1.4	-1.6	1.1	-1.0	0.8
Mean time to correctly identify matches	0.2	0.5	1.2	-1.1	0.3	0.4	0.5	0.8	0.0	0.9
Heart disease (mother)	0.6	0.7	1.3	-0.5	1.2	1.1	1.2	-0.9	0.0	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	2.5	-1.0	1.4	1.5	1.6	-0.2	0.2	-0.4
Whole body fat mass	2.3	9.6	18.8	-2.5	4.3	4.3	4.2	-1.7	1.6	0.6
Leg fat mass (right)	1.9	7.5	14.5	-2.6	3.8	3.8	3.6	-1.1	1.2	0.7
Arm predicted mass (right)	1.9	9.7	16.7	-2.8	4.1	4.1	3.9	-3.0	1.2	0.9
Pulse rate, automated reading	3.2	10.2	16.6	-3.3	3.8	4.0	4.1	-2.3	2.8	0.6
Alcohol intake frequency.	1.0	2.2	4.1	-2.0	1.4	1.5	1.5	-1.6	1.0	1.2
Comparative height size at age 10	0.4	2.3	5.5	-0.3	2.3	2.2	2.2	-0.8	0.5	-0.1
Number of full sisters	2.3	2.8	5.1	-2.3	2.1	2.0	1.9	-1.3	-0.5	-0.8
Suffer from ‘nerves’	0.3	0.5	1.4	-0.3	0.7	0.7	0.7	-0.5	0.4	-1.2
Overall health rating	1.9	4.1	9.6	-3.1	2.5	2.4	2.3	-1.3	-0.3	0.6
Chest pain or discomfort	0.2	0.2	0.5	-0.1	0.7	0.7	0.6	0.3	-0.2	0.1
Had major operations	0.5	0.6	2.1	-0.3	0.6	0.7	0.7	-0.4	1.4	0.7
Age at last live birth	0.5	0.7	1.6	0.3	-1.2	-1.0	-0.8	0.6	0.6	0.9
Family relationship satisfaction	0.2	0.3	1.9	-1.4	0.2	0.2	0.1	-0.2	-0.2	0.1
Leg pain on walking	0.3	0.4	1.8	-0.1	0.4	0.4	0.4	-1.4	0.2	-0.8
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	2.4	0.1	0.1	0.0	0.2	-0.5	-1.6	-0.9
Commuting to job workplace: Car/motor vehicle	1.1	1.2	2.7	-1.4	0.1	0.2	0.0	1.6	1.6	1.2
Illness, injury, bereavement, stress in last 2 years	7.1	8.6	14.4	3.2	-3.8	-3.8	-3.8	2.6	0.7	-0.7
Medication: Aspirin	0.6	0.8	2.2	0.9	-0.6	-0.7	-0.7	0.5	-1.5	-1.1
Supplements: Vitamin C	0.5	0.6	1.8	-0.0	-1.0	-1.1	-1.4	-0.0	-0.2	-0.6
Knee pain experienced in last month	0.8	1.2	2.3	-0.8	1.1	1.0	1.1	-0.9	-1.3	-1.5
Hypertension (Self-reported)	0.3	0.9	1.7	-0.8	1.1	1.2	1.3	-0.1	-1.0	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	3.1	0.3	-0.4	-0.6	-0.6	-0.3	-1.4	-1.8
Illnesses of father: Heart disease	1.5	2.1	4.7	0.8	-2.2	-2.1	-1.9	0.6	-0.9	0.6
Illnesses of siblings: Diabetes	6.3	7.8	11.6	2.4	-3.2	-3.4	-3.2	1.6	-1.6	-3.4
Smoking status: Previous	1.0	1.5	2.6	-1.3	1.4	1.3	1.1	-0.8	-1.6	0.8
Forced expiratory volume in 1-second (FEV1), predicted	1.4	2.8	4.9	-2.0	1.7	1.8	1.8	-0.9	0.8	2.2
Whole body fat-free mass	2.2	12.3	21.5	-3.0	4.6	4.6	4.4	-3.0	2.1	1.4
Leg fat-free mass (right)	3.3	17.4	29.4	-3.8	5.3	5.4	5.2	-3.4	3.0	1.6
Arm fat percentage (left)	1.6	6.2	12.3	-1.6	3.5	3.5	3.4	-1.1	1.8	0.5
Average weekly red wine intake	0.2	0.4	1.1	1.1	0.0	-0.1	-0.0	-0.6	-1.0	-0.4
Handedness (chirality/laterality): Left-handed	0.1	0.2	0.9	-0.9	0.2	0.1	0.0	0.4	-0.2	0.4
Mood swings	0.7	1.2	3.5	-1.9	1.3	1.2	0.9	-0.4	0.5	0.7
Loneliness, isolation	0.6	0.9	2.6	-0.9	0.6	0.6	0.5	0.5	1.6	1.3
Long-standing illness, disability or infirmity	1.0	1.5	3.0	0.6	-1.2	-1.4	-1.3	1.5	-1.7	-0.4
Ever had bowel cancer screening	0.8	0.9	2.1	0.0	-1.4	-1.3	-1.4	0.2	0.9	0.2
Diabetes diagnosed by doctor	6.6	10.8	21.2	4.6	-2.9	-3.3	-3.2	-0.3	-2.0	-4.5
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.8	2.3	1.5	-0.2	-0.4	-0.2	-0.7	-0.6	-1.4
Friendships satisfaction	0.6	0.8	2.4	-1.5	0.1	0.2	0.1	0.7	0.5	1.6
Qualifications: nursing, teaching	3.2	5.0	9.2	2.8	-3.0	-2.9	-3.0	0.8	-0.2	0.0
Commuting to job workplace: Walk	0.4	0.5	2.4	0.1	0.2	0.2	0.2	-0.6	-1.5	-0.8
Eye problems/disorders: Cataract	0.4	0.4	1.0	0.9	-0.4	-0.6	-0.7	1.0	0.2	-0.2
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.8	-0.6	-0.4	-0.4	-0.5	-0.4	-0.6	-0.9
Medication for cholesterol	0.2	0.4	1.7	0.3	0.4	0.4	0.4	-0.4	0.4	-1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	2.3	1.5	-0.9	-1.0	-1.0	0.8	-1.3	0.1
Back pain experienced in last month	0.4	0.6	1.0	-0.6	0.8	1.0	0.9	0.3	0.6	1.0
Mineral and other dietary supplements	0.3	0.3	0.7	0.3	0.5	0.5	0.5	-0.7	0.8	0.6
Breast cancer (self-reported)	1.4	1.6	2.7	-1.1	1.6	1.6	1.5	-1.5	0.2	0.8
Asthma (self-reported)	0.3	0.6	2.4	-0.8	-0.2	-0.4	-0.4	0.6	-1.6	0.0
Osteoporosis (self-reported)	0.1	0.1	0.4	-0.0	0.6	0.6	0.5	-0.2	0.1	0.1
Osteoarthritis (self-reported)	0.1	0.1	0.3	-0.5	-0.0	-0.0	0.1	0.3	-0.6	0.2
Medication: Aspirin	0.8	1.0	3.0	1.1	-0.7	-0.8	-0.8	0.8	-1.7	-0.8
Medication: Gliclazide	6.3	7.1	11.9	3.5	-3.0	-3.1	-2.7	1.4	-1.1	-3.0
Illnesses of father: None of the above (group 1)	2.5	3.0	5.0	-1.9	2.2	2.2	2.0	-1.0	1.8	-0.0
Smoking status: Current	2.0	3.2	6.7	-1.2	2.6	2.5	2.4	-0.6	1.3	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	1.8	1.3	-0.7	-0.6	-0.6	-0.3	0.3	0.2
Whole body water mass	2.1	12.2	21.3	-3.0	4.6	4.6	4.4	-3.0	2.0	1.4
Leg predicted mass (right)	3.3	17.4	29.5	-3.7	5.3	5.4	5.2	-3.4	3.0	1.6
Arm fat mass (left)	2.0	8.2	16.2	-2.1	4.0	4.0	3.8	-1.9	1.5	0.6
Number of self-reported non-cancer illnesses	0.6	1.0	3.2	-0.3	-0.9	-1.0	-1.0	1.8	-1.1	0.1
Average weekly champagne plus white wine intake	0.5	0.6	1.8	0.7	-0.5	-0.6	-0.7	-0.1	-1.0	-1.3
Miserableness	1.8	3.2	8.4	-2.9	2.0	2.0	1.6	-0.3	0.9	1.6
Guilty feelings	0.1	0.1	0.3	-0.1	0.4	0.3	-0.0	-0.1	-0.6	-0.3
Wears glasses or contact lenses	2.4	2.7	3.8	1.7	-1.6	-1.6	-1.7	1.9	1.9	-0.8
Ever taken oral contraceptive pill	0.6	0.7	1.9	0.3	-0.8	-0.9	-1.0	1.4	-0.4	0.4
Hearing aid user	0.1	0.2	0.9	-0.4	0.1	0.1	0.0	-0.2	0.9	-0.1
Mother’s age at death	4.1	5.2	8.6	2.9	-2.7	-2.8	-2.7	1.1	-0.9	-1.9
Financial situation satisfaction	0.4	0.5	1.4	-1.2	-0.1	-0.0	-0.3	0.9	0.4	1.0
Tinnitus: Yes, now most or all of the time	1.2	1.4	2.4	-0.7	1.4	1.4	1.1	-1.0	1.6	1.0
Commuting to job workplace: Public transport	1.4	1.7	5.1	2.3	-1.2	-1.3	-1.5	0.6	0.0	0.9
Eye problems/disorders: Glaucoma	0.1	0.2	0.3	-0.1	-0.4	-0.4	-0.6	0.0	-0.4	-0.6
Medication: Blood pressure	0.3	0.6	1.7	0.6	-0.5	-0.6	-0.6	0.8	-1.3	0.6
Pain type(s) experienced in last month: Hip pain	0.8	1.0	3.1	-1.1	-0.1	0.0	-0.0	0.7	1.8	1.4
Supplements: Fish oil (including cod liver oil)	1.7	2.3	4.1	0.3	-1.9	-1.9	-1.7	1.3	-2.0	-0.3
High cholesterol (Self-reported)	0.9	1.6	2.6	0.8	-1.6	-1.5	-1.3	1.6	0.3	-1.2
Medication: Bendroflumethiazide	0.7	1.1	3.5	1.3	-0.9	-0.9	-0.7	0.2	-1.9	-0.4
Medication: Paracetamol	0.5	0.7	2.8	-0.5	0.3	0.1	-0.1	0.3	-1.7	-1.4
Medication: Lisinopril	0.7	0.9	3.3	0.9	-0.7	-0.6	-0.5	1.8	0.8	0.6
Medication: Atorvastatin	1.2	1.5	3.8	0.5	-1.2	-1.3	-1.1	-0.2	-1.4	-1.9
Illnesses of father: High blood pressure	0.6	0.7	4.0	0.0	-0.2	-0.1	-0.2	0.8	0.5	2.0
Alcohol drinker status: Never	0.5	0.6	3.0	-0.5	0.3	0.2	0.3	-1.7	-0.4	-0.6
Ever smoked	1.0	1.8	3.0	-1.4	1.5	1.6	1.5	0.6	-0.2	1.7
Basal metabolic rate	2.5	13.8	24.6	-3.2	5.0	5.0	4.7	-3.0	2.0	1.3
Leg fat percentage (left)	0.5	2.0	4.7	-0.8	2.2	2.1	1.9	-0.2	0.5	-0.1
Arm fat-free mass (left)	1.8	9.0	16.2	-2.3	4.0	4.0	3.8	-2.8	1.3	0.8
Number of operations (self-reported)	0.3	0.5	1.4	-0.4	0.7	0.7	0.6	-1.2	-0.8	-0.1
Average weekly beer plus cider intake	0.5	0.7	3.0	-1.7	0.5	0.6	0.5	-0.7	0.7	-0.2
Irritability	0.0	0.0	0.1	-0.3	0.0	-0.0	-0.1	-0.2	0.2	-0.1
Risk taking	1.3	1.9	4.3	-0.2	1.8	1.6	1.7	-2.1	0.2	-0.6
Ever had prostate specific antigen (PSA) test	3.2	3.7	6.2	1.8	-2.4	-2.5	-2.5	1.2	-1.0	-1.4
Fractured/broken bones in last 5 years	0.9	1.1	1.6	1.3	-1.2	-1.2	-1.3	0.8	-0.9	0.4
Age started oral contraceptive pill	5.1	6.3	9.7	2.9	-3.0	-3.1	-3.0	1.8	-2.2	0.1
Diastolic blood pressure, automated reading	0.6	1.7	4.0	-1.4	1.4	1.5	1.3	-0.4	0.1	2.0
Ever depressed for a whole week	0.8	1.0	1.9	0.7	-1.0	-1.1	-1.1	0.7	-0.7	-1.4
Unable to work because of sickness or disability	1.4	1.8	4.3	-2.1	1.0	1.0	0.8	1.2	2.0	0.3
Commuting to job workplace: Cycle	2.0	2.4	3.9	1.5	-1.8	-1.9	-2.0	0.1	-1.3	-1.3
Myopia	1.8	2.6	7.7	0.3	-1.4	-1.4	-1.5	2.1	2.8	0.1
Vascular/heart problems diagnosed by doctor	0.3	0.9	1.8	0.9	-1.1	-1.1	-1.3	-0.1	1.1	-0.2
Cholesterol lowering medication	0.2	0.3	0.8	0.2	-0.6	-0.6	-0.5	0.5	0.9	-0.1
Medication: Omeprazole (e.g. Zanprol)	1.7	2.0	5.3	-2.3	1.4	1.3	1.4	-0.5	-1.1	-1.4
Pain experienced in last month	1.3	2.2	4.1	0.6	-1.2	-1.2	-1.3	1.9	2.0	1.6
Supplements: Calcium	1.5	1.6	3.0	1.2	-1.3	-1.4	-1.5	-0.2	-0.8	-1.7
Basal cell carcinoma (self-reported)	1.9	2.3	4.2	2.0	-1.7	-1.8	-2.0	1.0	0.2	-0.8
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.3	-0.6	0.7	0.5	0.4	-0.0	0.3	-1.1
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	0.9	-0.7	0.8	0.7	0.5	1.0	-0.7	-0.7
Heart disease (siblings)	1.7	2.0	3.7	-1.7	1.7	1.8	1.9	-1.2	0.5	-0.1
Alcohol drinker status: Previous	0.6	0.7	3.8	-2.0	0.1	0.2	0.1	0.2	-0.1	1.0
Pack years of smoking	0.5	0.7	2.6	-0.4	0.2	0.2	0.1	-0.6	1.6	1.2
Impedance of whole body	0.5	2.7	4.3	1.8	-1.8	-1.9	-1.7	1.1	-2.1	-1.0
Leg fat mass (left)	1.9	7.5	14.3	-2.6	3.8	3.8	3.6	-1.2	1.3	0.7
Arm predicted mass (left)	1.8	9.1	16.3	-2.5	4.0	4.0	3.8	-2.8	1.4	1.0