[Hub]/) : Traits : Leg predicted mass (left) :

chr16:19,022,448-21,147,999

Best TWAS P=3.77e-17 · Best GWAS P=4.54e-15 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous GPRC5B 0.07 0.04 lasso 4 0.03 1.3e-03 -7.8 8.4 3.8e-17 -0.96 0.01 0.98 TRUE
2 GTEx Adipose Subcutaneous ACSM5 0.14 0.00 lasso 8 0.02 6.4e-03 6.4 -5.8 6.2e-09 0.23 0.07 0.65 FALSE
3 GTEx Adrenal Gland KNOP1 0.40 0.34 lasso 4 0.40 1.1e-15 -5.5 -5.4 8.4e-08 0.79 0.75 0.25 FALSE
4 GTEx Adrenal Gland AC002550.5 0.37 0.39 enet 28 0.40 1.6e-15 -4.7 -5.5 5.2e-08 0.75 0.98 0.02 FALSE
5 GTEx Artery Aorta KNOP1 0.50 0.48 lasso 8 0.49 4.0e-30 -4.7 -5.6 1.7e-08 0.76 1.00 0.00 FALSE
6 GTEx Artery Aorta AC002550.5 0.52 0.52 lasso 7 0.49 1.9e-30 -4.7 -5.5 4.2e-08 0.75 1.00 0.00 FALSE
7 GTEx Artery Coronary KNOP1 0.28 0.25 lasso 7 0.32 2.5e-11 -4.8 -5.7 1.4e-08 0.82 0.12 0.88 FALSE
8 GTEx Artery Coronary AC002550.5 0.30 0.34 enet 11 0.37 1.5e-13 -4.7 -5.5 3.6e-08 0.79 0.58 0.42 FALSE
9 GTEx Brain Frontal Cortex BA9 KNOP1 0.43 0.33 lasso 14 0.30 1.0e-08 -4.8 -5.3 1.2e-07 0.76 0.95 0.01 FALSE
10 GTEx Brain Frontal Cortex BA9 AC002550.5 0.53 0.40 enet 15 0.43 9.0e-13 -4.7 -5.2 1.7e-07 0.71 1.00 0.00 FALSE
11 GTEx Brain Putamen basal ganglia AC002550.5 0.59 0.48 enet 23 0.58 1.2e-16 -4.7 -5.7 1.2e-08 0.62 1.00 0.00 FALSE
12 GTEx Breast Mammary Tissue AC002550.5 0.37 0.49 enet 13 0.50 3.3e-29 -4.7 -5.6 2.4e-08 0.80 1.00 0.00 FALSE
13 GTEx Breast Mammary Tissue (Male) AC002550.5 0.37 0.29 lasso 3 0.35 4.8e-09 -6.5 -6.2 4.8e-10 0.90 0.07 0.92 FALSE
14 GTEx Breast Mammary Tissue (Female) AC002550.5 0.36 0.26 enet 19 0.33 1.3e-10 -5.5 -5.8 7.3e-09 0.75 0.50 0.50 FALSE
15 GTEx Colon Sigmoid KNOP1 0.32 0.35 lasso 6 0.32 4.9e-12 -4.7 -5.7 1.2e-08 0.80 0.28 0.72 FALSE
16 GTEx Colon Transverse KNOP1 0.22 0.23 enet 19 0.24 9.8e-12 -4.7 -5.8 6.0e-09 0.81 0.60 0.40 FALSE
17 GTEx Colon Transverse AC002550.5 0.35 0.36 enet 15 0.41 5.0e-21 -4.7 -5.8 5.1e-09 0.81 0.92 0.08 FALSE
18 GTEx Esophagus Gastroesophageal Junction KNOP1 0.51 0.44 enet 22 0.56 5.3e-24 -5.5 -6.1 9.6e-10 0.84 0.19 0.81 FALSE
19 GTEx Esophagus Gastroesophageal Junction AC002550.5 0.62 0.54 enet 35 0.63 4.4e-29 -4.5 -6.1 1.2e-09 0.77 0.90 0.10 FALSE
20 GTEx Esophagus Muscularis KNOP1 0.47 0.51 lasso 10 0.56 1.9e-40 -4.7 -5.3 9.8e-08 0.74 1.00 0.00 FALSE
21 GTEx Liver KNOP1 0.23 0.21 lasso 7 0.25 1.4e-07 -4.5 -6.0 1.6e-09 0.81 0.61 0.28 FALSE
22 GTEx Liver AC002550.5 0.43 0.42 enet 13 0.47 1.1e-14 -4.5 -5.8 6.9e-09 0.85 0.97 0.03 FALSE
23 GTEx Lung KNOP1 0.34 0.48 lasso 8 0.49 4.0e-42 -4.7 -5.2 1.7e-07 0.76 1.00 0.00 FALSE
24 GTEx Lung GPRC5B 0.08 0.05 lasso 4 0.06 2.4e-05 -4.5 5.4 7.9e-08 -0.73 0.87 0.05 FALSE
25 GTEx Ovary KNOP1 0.61 0.64 lasso 7 0.57 4.4e-17 -4.7 -5.4 6.1e-08 0.77 0.80 0.20 FALSE
26 GTEx Pancreas KNOP1 0.42 0.37 lasso 11 0.40 4.2e-18 -4.5 -5.8 6.6e-09 0.84 0.71 0.29 FALSE
27 GTEx Pancreas AC002550.5 0.37 0.36 lasso 12 0.36 3.2e-16 -4.7 -5.4 6.9e-08 0.76 0.95 0.05 FALSE
28 GTEx Prostate AC002550.5 0.49 0.25 lasso 8 0.33 5.7e-09 -4.7 -5.2 2.2e-07 0.74 0.98 0.02 FALSE
29 GTEx Skin Not Sun Exposed Suprapubic AC002550.5 0.44 0.43 enet 24 0.43 1.2e-25 -4.5 -5.8 6.9e-09 0.79 0.99 0.01 FALSE
30 GTEx Skin Sun Exposed Lower leg KNOP1 0.33 0.47 lasso 9 0.48 5.4e-44 -4.7 -5.2 1.8e-07 0.76 1.00 0.00 FALSE
31 GTEx Skin Sun Exposed Lower leg ACSM5 0.21 0.04 lasso 9 0.07 3.6e-06 1.4 -5.5 4.4e-08 0.16 0.30 0.27 TRUE
32 GTEx Spleen KNOP1 0.45 0.36 lasso 7 0.41 1.2e-11 -4.7 -5.2 2.1e-07 0.74 0.46 0.54 FALSE
33 GTEx Stomach KNOP1 0.28 0.21 lasso 6 0.21 1.8e-10 -4.5 -5.8 6.2e-09 0.77 0.15 0.85 FALSE
34 GTEx Stomach AC002550.5 0.36 0.26 lasso 7 0.32 4.8e-16 -4.7 -5.2 1.9e-07 0.73 0.96 0.04 FALSE
35 GTEx Testis AC002550.5 0.49 0.57 lasso 5 0.56 7.7e-30 -4.7 -5.3 1.2e-07 0.77 1.00 0.00 FALSE
36 GTEx Uterus AC002550.5 0.51 0.40 lasso 12 0.36 2.3e-08 -4.7 -5.1 2.8e-07 0.76 0.44 0.48 FALSE
37 GTEx Vagina KNOP1 0.43 0.35 lasso 5 0.36 4.2e-09 -4.7 -5.5 4.4e-08 0.74 0.57 0.42 FALSE
38 GTEx Whole Blood KNOP1 0.08 0.04 lasso 3 0.04 1.7e-04 -4.7 -6.0 1.6e-09 0.86 0.41 0.56 FALSE
39 The Cancer Genome Atlas Bladder Urothelial Carcinoma IQCK 0.05 0.02 blup 73 0.03 1.0e-03 -6.7 -5.9 3.6e-09 0.84 0.04 0.86 FALSE
40 The Cancer Genome Atlas Breast Invasive Carcinoma C16orf88 0.10 0.08 lasso 3 0.08 7.1e-17 -4.7 -5.1 2.9e-07 0.76 0.05 0.94 FALSE
41 The Cancer Genome Atlas Breast Invasive Carcinoma IQCK 0.03 0.03 blup 73 0.03 1.6e-07 -4.5 -5.8 6.9e-09 0.81 0.78 0.22 FALSE
42 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma C16orf88 0.16 0.09 enet 10 0.14 2.2e-07 -4.6 -5.1 2.9e-07 0.74 0.03 0.97 FALSE
43 The Cancer Genome Atlas Glioblastoma Multiforme C16orf88 0.34 0.07 lasso 3 0.12 1.5e-04 -5.5 -5.2 1.8e-07 0.78 0.00 0.93 FALSE
44 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma C16orf88 0.22 0.08 lasso 3 0.08 2.0e-09 -5.5 -5.4 7.2e-08 0.82 0.00 1.00 FALSE
45 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma IQCK 0.04 0.03 lasso 2 0.04 7.5e-05 -4.7 -5.6 2.2e-08 0.69 0.26 0.21 FALSE
46 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma C16orf88 0.07 0.05 lasso 2 0.05 7.7e-04 -5.5 -5.5 3.0e-08 0.83 0.00 0.93 FALSE
47 The Cancer Genome Atlas Lung Squamous Cell Carcinoma C16orf88 0.10 0.10 lasso 3 0.13 3.7e-14 -5.5 -5.6 2.8e-08 0.80 0.01 0.99 FALSE
48 The Cancer Genome Atlas Lung Squamous Cell Carcinoma IQCK 0.03 0.03 lasso 3 0.02 7.2e-04 -6.5 -6.9 4.0e-12 0.94 0.03 0.94 FALSE
49 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma C16orf88 0.34 0.21 lasso 4 0.17 3.1e-07 -5.5 -5.6 2.4e-08 0.82 0.00 1.00 FALSE
50 The Cancer Genome Atlas Prostate Adenocarcinoma IQCK 0.04 0.01 blup 73 0.01 1.8e-02 -4.6 -5.8 8.6e-09 0.77 0.08 0.38 FALSE
51 The Cancer Genome Atlas Thyroid Carcinoma GPRC5B 0.06 0.01 blup 38 0.01 2.4e-02 -4.5 -7.0 2.5e-12 0.67 0.01 0.08 FALSE