TWAS hub - C16orf88

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	NTR	Blood	0.0293	0.0089	2.4e-06	0.029	0.022	0.025	0.028	0.026	9.8e-10	7.1e-08	1.1e-08	2.2e-09	5.2e-09
2	TCGA	Bladder Urothelial Carcinoma	0.0800	0.0430	7.5e-07	0.076	0.067	0.076	NA	0.077	5.4e-07	2.3e-06	5.1e-07	NA	4.9e-07
3	TCGA	Breast Invasive Carcinoma	0.1005	0.0440	0.0e+00	0.082	0.082	0.081	NA	0.085	2.0e-16	2.4e-16	2.8e-16	NA	7.1e-17
4	TCGA	Cervical Squamous Cell Carcinoma	0.1560	0.0650	8.3e-08	0.088	0.134	0.140	NA	0.130	4.2e-05	3.9e-07	2.2e-07	NA	6.0e-07
5	TCGA	Colon Adenocarcinoma	0.0980	0.0470	2.5e-05	0.035	0.043	0.027	NA	0.029	4.1e-03	1.6e-03	1.0e-02	NA	8.1e-03
6	TCGA	Glioblastoma Multiforme	0.3450	0.1640	6.9e-06	0.073	0.101	0.089	NA	0.122	3.2e-03	5.6e-04	1.2e-03	NA	1.6e-04
7	TCGA	Head and Neck Squamous Cell Carcinoma	0.2229	0.0977	2.9e-08	0.085	0.064	0.078	NA	0.081	8.5e-10	9.7e-08	4.1e-09	NA	2.0e-09
8	TCGA	Kidney Renal Clear Cell Carcinoma	0.1498	0.0601	3.4e-13	0.096	0.090	0.086	NA	0.105	5.7e-11	2.4e-10	6.5e-10	NA	8.2e-12
9	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0710	0.0430	1.3e-03	0.050	0.028	0.041	NA	0.050	7.3e-04	9.1e-03	2.2e-03	NA	7.7e-04
10	TCGA	Brain Lower Grade Glioma	0.2200	0.0607	0.0e+00	0.298	0.291	0.294	NA	0.301	3.5e-34	2.7e-33	1.1e-33	NA	1.2e-34
11	TCGA	Liver Hepatocellular Carcinoma	0.0980	0.0580	1.5e-04	0.115	0.063	0.083	NA	0.083	4.8e-06	6.3e-04	1.0e-04	NA	9.5e-05
12	TCGA	Lung Adenocarcinoma	0.1522	0.0560	0.0e+00	0.116	0.118	0.116	NA	0.116	1.8e-13	1.1e-13	1.8e-13	NA	1.9e-13
13	TCGA	Lung Squamous Cell Carcinoma	0.0983	0.0457	2.3e-12	0.105	0.115	0.111	NA	0.126	5.9e-12	5.2e-13	1.3e-12	NA	3.7e-14
14	TCGA	Pancreatic Adenocarcinoma	0.1180	0.0650	2.6e-04	0.060	0.046	0.044	NA	0.053	1.6e-03	5.4e-03	5.9e-03	NA	2.8e-03
15	TCGA	Pheochromocytoma and Paraganglioma	0.3440	0.1580	1.4e-08	0.212	0.121	0.157	NA	0.168	7.2e-09	1.6e-05	8.4e-07	NA	3.1e-07
16	TCGA	Prostate Adenocarcinoma	0.1768	0.0632	0.0e+00	0.136	0.132	0.118	NA	0.139	4.3e-14	1.1e-13	2.5e-12	NA	2.4e-14
17	TCGA	Soft Tissue Sarcoma	0.1560	0.0780	1.5e-07	0.137	0.110	0.102	NA	0.128	1.6e-08	4.6e-07	1.2e-06	NA	5.3e-08
18	TCGA	Testicular Germ Cell Tumors	0.0950	0.0540	9.5e-04	0.082	0.054	0.052	NA	0.058	7.8e-04	5.4e-03	6.5e-03	NA	4.2e-03
19	TCGA	Thyroid Carcinoma	0.2000	0.0700	0.0e+00	0.175	0.187	0.187	NA	0.178	9.3e-17	6.3e-18	6.7e-18	NA	4.2e-17

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19
Comparative body size at age 10	24.5	67.5	88.4	-7.7	-8.1	-8.5	-8.7	-7.9	-8.8	-9.3	-7.5	-9.4	-7.8	-8.1	-7.9	-9.0	-7.8	-9.4	-8.0	-6.4	-7.7	-7.8
Body Mass Index (BMI) (2010)	16.4	22.4	27.2	-4.4	-4.8	-5.0	-4.5	-4.6	-5.1	-5.1	-4.6	-5.2	-4.6	-4.4	-4.8	-5.2	-4.7	-5.2	-4.5	-3.7	-4.7	-4.6
Impedance of whole body	14.1	71.7	87.2	8.0	8.6	8.8	8.4	8.4	8.8	9.1	8.2	9.2	8.3	8.2	8.2	9.2	8.3	9.3	8.2	6.3	8.4	8.3
Impedance of leg (left)	13.4	65.1	81.9	7.5	8.1	8.4	8.2	7.8	8.6	8.9	7.7	9.0	7.8	7.8	7.7	8.9	7.8	9.1	7.8	5.9	7.8	7.8
BMI	13.2	76.3	91.4	-8.2	-8.8	-9.1	-9.0	-8.7	-8.8	-9.4	-8.2	-9.4	-8.5	-8.7	-8.6	-9.4	-8.5	-9.6	-8.6	-7.5	-8.5	-8.3
Impedance of leg (right)	12.9	62.4	75.5	7.4	8.0	8.3	7.8	7.8	8.2	8.7	7.3	8.6	7.8	7.7	7.8	8.7	7.8	8.7	7.7	5.7	7.8	7.7
Impedance of arm (left)	12.2	56.4	65.9	7.1	7.7	7.9	7.2	7.6	7.5	7.9	7.4	8.0	7.5	7.3	7.4	8.1	7.5	8.1	7.3	5.7	7.6	7.5
Impedance of arm (right)	10.1	47.3	55.2	6.6	7.1	7.2	6.5	7.1	6.6	7.4	6.7	7.4	6.9	6.7	6.7	7.4	6.9	7.4	6.6	5.2	7.0	6.9
HDL Cholesterol	7.9	13.2	15.4	3.9	3.6	3.9	3.7	3.8	3.1	3.5	3.6	3.5	3.7	3.8	3.6	3.8	3.5	3.6	3.6	3.3	3.6	3.6
Hand grip strength (left)	7.7	20.3	22.0	-4.2	-4.6	-4.6	-4.4	-4.7	-4.3	-4.4	-4.5	-4.4	-4.6	-4.5	-4.6	-4.7	-4.6	-4.6	-4.4	-4.4	-4.6	-4.6
Age when periods started (menarche)	7.7	18.6	26.2	3.8	4.1	4.4	4.6	4.0	5.1	4.9	3.7	4.9	4.0	4.2	4.3	4.9	3.9	4.9	4.0	3.8	3.9	4.0
Body mass index (BMI)	7.0	29.9	36.9	-5.0	-5.6	-5.8	-5.3	-5.5	-5.4	-6.0	-5.2	-6.0	-5.4	-5.3	-5.4	-6.1	-5.4	-6.0	-5.3	-4.2	-5.6	-5.2
Nervous feelings	6.4	11.9	13.7	3.7	3.5	3.5	3.7	3.5	3.3	3.3	3.4	3.3	3.4	3.5	3.4	3.5	3.4	3.5	3.6	3.0	3.5	3.5
Diverticular disease/diverticulitis (self-reported)	5.5	6.6	8.2	2.3	2.7	2.7	2.6	2.8	2.0	2.2	2.5	2.0	2.8	2.7	2.9	2.5	2.8	2.2	2.7	2.7	2.8	2.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	5.4	6.3	9.0	-2.5	-2.5	-2.5	-2.7	-2.3	-3.0	-2.7	-2.3	-2.8	-2.3	-2.4	-2.5	-2.8	-2.4	-2.8	-2.4	-2.2	-2.3	-2.3
Type 2 Diabetes (T2D) (2012)	5.2	6.0	9.1	-2.8	-2.5	-2.4	-2.5	-2.6	-1.6	-1.7	-3.0	-1.9	-2.6	-2.7	-2.4	-2.3	-2.6	-2.0	-2.6	-2.5	-2.6	-2.6
Had major operations	4.9	5.7	6.6	2.4	2.5	2.5	2.3	2.5	2.4	2.2	2.4	2.2	2.5	2.4	2.6	2.6	2.5	2.3	2.4	1.8	2.6	2.5
Leg fat-free mass (left)	4.7	25.0	31.9	-4.3	-5.0	-5.2	-5.2	-4.9	-5.3	-5.4	-4.9	-5.6	-4.8	-4.9	-4.7	-5.6	-4.8	-5.7	-4.9	-3.8	-4.9	-4.7
Leg fat-free mass (right)	4.7	25.1	31.0	-4.3	-5.1	-5.3	-5.1	-5.0	-5.2	-5.4	-4.8	-5.5	-5.0	-5.0	-4.8	-5.6	-4.9	-5.5	-5.0	-3.8	-5.0	-4.8
Leg predicted mass (left)	4.6	24.4	31.1	-4.2	-4.9	-5.1	-5.1	-4.8	-5.2	-5.4	-4.8	-5.5	-4.8	-4.8	-4.6	-5.6	-4.7	-5.6	-4.8	-3.8	-4.9	-4.7
Leg predicted mass (right)	4.6	24.7	30.7	-4.3	-5.0	-5.2	-5.1	-4.9	-5.1	-5.4	-4.8	-5.4	-4.9	-4.9	-4.8	-5.5	-4.8	-5.5	-4.9	-3.7	-5.0	-4.8
Supplements: Glucosamine	4.4	5.7	7.2	-2.4	-2.6	-2.6	-2.2	-2.4	-1.7	-2.3	-2.6	-2.3	-2.5	-2.3	-2.4	-2.1	-2.6	-2.4	-2.4	-2.2	-2.4	-2.7
High blood pressure (mother)	4.4	6.2	8.7	-2.5	-2.5	-2.7	-2.5	-2.5	-2.2	-2.9	-2.0	-2.8	-2.5	-2.5	-2.4	-2.6	-2.4	-2.8	-2.5	-2.0	-2.4	-2.3
Family relationship satisfaction	4.3	5.3	8.2	-2.1	-2.4	-2.5	-2.1	-2.4	-2.1	-2.9	-1.7	-2.6	-2.4	-2.2	-2.4	-2.4	-2.3	-2.5	-2.1	-2.0	-2.3	-2.2
Mean Putamen Volume	4.0	4.5	6.4	-2.5	-2.0	-2.2	-2.1	-2.2	-1.7	-2.1	-2.2	-2.1	-2.2	-2.3	-1.9	-2.2	-2.0	-2.2	-2.0	-2.1	-2.0	-2.2
Whole body fat-free mass	4.0	22.7	28.5	-4.1	-4.8	-4.9	-4.9	-4.8	-4.8	-5.1	-4.8	-5.3	-4.7	-4.7	-4.4	-5.3	-4.6	-5.3	-4.7	-3.7	-4.8	-4.6
Whole body water mass	4.0	22.9	28.4	-4.1	-4.8	-5.0	-4.9	-4.8	-4.8	-5.1	-4.8	-5.3	-4.7	-4.7	-4.4	-5.3	-4.6	-5.3	-4.7	-3.7	-4.8	-4.6
Arm fat mass (left)	3.9	16.0	20.7	-3.5	-4.1	-4.2	-4.0	-4.0	-4.0	-4.5	-3.7	-4.5	-3.9	-3.8	-3.9	-4.5	-3.9	-4.5	-3.9	-3.2	-4.0	-3.6
Eye problems/disorders: Diabetes related eye disease	3.8	4.1	5.2	-1.9	-2.2	-2.3	-1.7	-2.0	-1.7	-2.3	-2.0	-2.3	-2.1	-1.8	-2.0	-2.1	-2.1	-2.2	-1.9	-1.9	-2.1	-1.9
Basal metabolic rate	3.8	20.8	26.2	-3.9	-4.6	-4.7	-4.7	-4.6	-4.6	-4.9	-4.5	-5.1	-4.5	-4.5	-4.2	-5.1	-4.4	-5.1	-4.5	-3.6	-4.6	-4.3
Diabetes (mother)	3.7	4.7	7.0	-2.5	-2.4	-2.2	-1.9	-2.3	-1.4	-1.6	-2.6	-1.8	-2.3	-2.1	-2.1	-1.9	-2.4	-1.9	-2.3	-2.0	-2.4	-2.4
Arm fat mass (right)	3.7	15.3	20.2	-3.4	-4.0	-4.1	-3.9	-3.9	-4.0	-4.5	-3.6	-4.5	-3.8	-3.7	-3.8	-4.5	-3.8	-4.4	-3.7	-3.1	-3.9	-3.5
Arm predicted mass (right)	3.7	19.0	23.6	-3.7	-4.4	-4.6	-4.3	-4.5	-4.2	-4.7	-4.4	-4.8	-4.3	-4.3	-4.0	-4.8	-4.3	-4.9	-4.2	-3.4	-4.5	-4.3
Peak expiratory flow (PEF)	3.6	8.4	12.4	3.5	3.2	3.1	2.4	3.4	0.9	2.0	3.2	1.9	3.3	3.0	3.0	2.3	3.4	2.2	3.2	2.5	3.4	3.3
Emphysema/chronic bronchitis	3.6	4.1	6.5	1.7	1.9	2.0	2.3	1.8	2.5	2.3	1.5	2.2	1.8	1.8	2.1	2.1	1.8	2.3	2.0	2.3	1.8	1.6
Smoking status: Previous	3.6	5.3	8.4	2.1	2.2	2.3	2.5	2.4	2.1	2.3	1.8	2.0	2.4	2.5	2.6	2.6	2.2	2.1	2.2	2.9	2.3	2.0
Mouth/teeth dental problems: Mouth ulcers	3.6	5.7	7.5	2.1	2.4	2.5	2.7	2.2	2.5	2.3	2.3	2.4	2.4	2.4	2.4	2.4	2.4	2.5	2.6	2.0	2.3	2.3
Arm fat-free mass (right)	3.5	18.1	22.7	-3.6	-4.3	-4.5	-4.1	-4.4	-4.0	-4.6	-4.3	-4.8	-4.2	-4.2	-3.9	-4.7	-4.2	-4.8	-4.1	-3.1	-4.4	-4.2
Arm fat-free mass (left)	3.5	17.6	22.0	-3.5	-4.3	-4.3	-4.2	-4.3	-4.3	-4.4	-4.2	-4.6	-4.1	-4.1	-3.9	-4.7	-4.1	-4.6	-4.1	-3.2	-4.3	-4.1
Arm predicted mass (left)	3.5	17.9	21.6	-3.8	-4.3	-4.4	-4.2	-4.4	-4.0	-4.3	-4.3	-4.5	-4.2	-4.2	-4.0	-4.7	-4.2	-4.6	-4.2	-3.3	-4.4	-4.2
Heel T-Score	3.3	26.0	31.0	-5.5	-5.2	-5.4	-4.7	-5.3	-4.2	-5.3	-5.5	-5.6	-5.1	-5.0	-4.8	-5.1	-5.1	-5.5	-4.7	-4.2	-5.0	-5.5
Heart disease (mother)	3.3	4.0	5.4	2.1	2.0	2.0	2.2	2.2	1.4	1.6	2.1	1.6	2.1	2.3	2.0	1.9	2.0	1.8	2.2	1.8	2.1	2.2
Loneliness, isolation	3.2	4.4	6.4	-2.2	-2.2	-2.1	-2.2	-2.4	-1.1	-1.3	-1.9	-0.9	-2.4	-2.5	-2.3	-1.8	-2.4	-1.3	-2.5	-2.2	-2.5	-2.2
Ovarian Cancer	3.1	4.1	6.7	1.7	2.0	2.1	1.9	1.8	2.6	2.2	2.2	2.5	1.8	1.8	1.9	2.3	1.8	2.4	1.8	1.5	1.8	2.0
Serious illness, injury or assault to yourself	3.1	3.7	6.9	1.8	1.7	1.9	2.4	1.6	2.6	2.4	1.2	2.2	1.7	1.9	1.9	2.2	1.6	2.3	1.9	1.6	1.5	1.5
Lung FEV1/FVC ratio	3.0	15.4	23.3	4.6	4.1	4.0	3.7	4.4	2.2	2.8	4.8	3.1	4.2	4.1	3.8	3.4	4.2	3.4	4.2	3.4	4.3	4.7
Past tobacco smoking	3.0	5.5	8.6	-2.2	-2.3	-2.4	-2.4	-2.5	-1.9	-2.2	-2.0	-2.0	-2.5	-2.6	-2.6	-2.6	-2.3	-2.1	-2.2	-2.9	-2.3	-2.2
Trunk fat-free mass	3.0	17.4	22.6	-3.6	-4.1	-4.3	-4.3	-4.2	-4.3	-4.5	-4.2	-4.7	-4.0	-4.1	-3.8	-4.7	-4.0	-4.8	-4.0	-3.4	-4.1	-4.0
Friendships satisfaction	3.0	3.7	4.8	-1.9	-2.0	-2.0	-1.9	-2.0	-1.9	-2.2	-1.4	-1.9	-2.0	-2.0	-2.1	-2.0	-1.9	-2.0	-1.9	-1.7	-1.9	-1.9
HbA1C	2.9	3.2	4.7	-1.8	-2.1	-1.8	-1.7	-1.8	-1.2	-1.6	-1.9	-1.6	-1.9	-1.6	-1.9	-1.5	-2.2	-1.7	-2.0	-1.5	-2.1	-1.8
Weight	2.9	14.2	18.1	-3.2	-3.8	-3.9	-3.8	-3.8	-3.7	-4.1	-3.7	-4.2	-3.7	-3.7	-3.6	-4.3	-3.7	-4.2	-3.7	-3.0	-3.9	-3.5
Medication: Ibuprofen (e.g. Nurofen)	2.9	3.7	6.0	2.4	2.0	2.0	1.8	2.1	1.0	1.2	2.5	1.4	2.1	2.1	1.8	1.8	2.1	1.6	2.1	1.4	2.2	2.3
Trunk predicted mass	2.9	16.8	21.8	-3.5	-4.1	-4.2	-4.2	-4.1	-4.2	-4.4	-4.2	-4.6	-4.0	-4.0	-3.7	-4.6	-3.9	-4.7	-4.0	-3.3	-4.1	-4.0
Neck or shoulder pain in last month	2.9	4.1	7.7	2.0	1.8	2.0	1.9	1.8	2.7	2.5	2.0	2.8	1.6	1.7	1.8	2.4	1.6	2.6	1.5	1.7	1.5	1.9
Supplements: Vitamin C	2.9	3.4	5.6	2.0	1.9	2.0	1.2	1.8	2.4	2.2	1.9	2.3	1.7	1.4	1.9	2.2	1.8	2.1	1.3	0.7	1.7	1.9
Alcohol drinker status: Never	2.9	3.5	4.6	1.8	1.8	2.0	2.1	1.8	1.6	1.8	2.0	1.9	1.9	2.1	1.8	2.0	1.8	2.0	2.0	1.0	1.8	2.0
Worry (Nagel 2018)	2.8	5.8	7.9	2.4	2.3	2.4	2.5	2.3	2.8	2.8	2.2	2.7	2.2	2.2	2.3	2.8	2.2	2.8	2.3	2.0	2.3	2.2
Ever had hysterectomy (womb removed)	2.8	3.1	6.0	1.9	1.9	1.8	1.6	2.1	0.5	0.7	2.4	0.9	2.1	2.0	1.8	1.5	2.0	1.1	2.0	1.6	2.1	2.1
Pulse rate	2.8	4.7	7.2	1.9	2.3	2.4	2.0	2.0	2.0	2.1	2.7	2.4	2.2	2.0	2.0	2.2	2.2	2.4	2.2	1.3	2.2	2.3
Medication: Ibuprofen	2.8	3.3	5.9	2.4	1.8	1.9	1.6	2.1	0.8	1.3	2.4	1.6	1.9	2.0	1.5	1.8	1.8	1.6	1.7	1.4	2.0	2.1
Age at First Birth	2.7	4.0	8.4	1.9	1.7	2.0	1.8	1.8	2.7	2.8	1.5	2.9	1.8	1.4	1.8	2.2	1.5	2.8	1.4	1.2	1.5	1.7
Waist circumference	2.7	9.7	12.4	-2.8	-3.3	-3.3	-2.9	-3.2	-2.8	-3.2	-3.2	-3.3	-3.2	-3.0	-3.0	-3.5	-3.2	-3.3	-3.1	-2.4	-3.4	-2.9
Tense / ‘highly strung’	2.6	4.4	9.2	1.9	1.8	1.9	2.5	1.9	3.0	2.4	1.7	2.5	1.8	2.0	2.1	2.5	1.7	2.5	1.9	1.5	1.7	1.8
Commuting to job workplace: Car/motor vehicle	2.6	3.0	4.2	-1.9	-1.9	-1.9	-1.4	-2.0	-0.6	-1.6	-2.0	-1.6	-1.9	-1.8	-1.6	-1.6	-1.9	-1.7	-1.7	-1.6	-1.9	-1.8
Severe depression (siblings)	2.5	2.7	3.9	-1.7	-1.9	-1.8	-1.6	-1.7	-0.6	-1.4	-2.0	-1.4	-1.8	-1.8	-1.4	-1.4	-1.9	-1.6	-1.9	-1.5	-1.9	-1.8
Hair/balding pattern: Pattern 2	2.5	3.2	4.2	1.5	1.9	1.9	1.7	1.7	2.0	1.7	1.6	1.6	1.9	1.6	1.9	1.8	1.9	1.7	1.9	1.5	1.9	1.8
Arm fat percentage (right)	2.5	10.1	14.4	-2.7	-3.2	-3.3	-3.1	-3.1	-3.5	-3.8	-2.8	-3.8	-3.0	-2.9	-3.1	-3.7	-3.0	-3.7	-2.9	-2.4	-3.1	-2.7
Medication for pain relief, constipation, heartburn	2.5	4.2	5.3	-1.9	-2.1	-2.2	-2.1	-2.1	-2.0	-1.7	-2.3	-1.8	-2.2	-2.2	-2.2	-2.2	-2.1	-1.9	-2.1	-1.8	-2.0	-2.2
Alcohol intake frequency.	2.5	5.8	13.4	1.9	2.1	2.4	2.7	1.9	3.7	2.7	2.5	3.1	2.0	2.2	2.2	2.9	1.9	3.0	2.1	1.2	1.8	2.3
Commuting to job workplace: Public transport	2.5	2.9	4.3	1.8	2.0	2.0	1.1	1.9	0.6	1.8	2.1	2.0	1.9	1.5	1.3	1.6	1.9	1.9	1.6	0.9	2.0	1.8
Leg fat mass (left)	2.5	9.9	13.2	-2.6	-3.2	-3.3	-3.0	-3.2	-3.1	-3.6	-2.9	-3.6	-3.1	-3.0	-3.1	-3.6	-3.1	-3.5	-3.0	-2.5	-3.3	-2.8
Townsend deprivation index at recruitment	2.4	3.4	6.1	1.3	1.8	1.8	2.0	1.7	2.1	1.5	2.1	1.8	1.8	1.8	1.9	2.0	1.7	1.8	1.8	2.5	1.7	1.7
Ever highly irritable/argumentative for 2 days	2.4	2.8	4.9	1.2	1.5	1.7	1.9	1.4	2.1	1.8	1.9	2.2	1.4	1.4	1.4	2.0	1.4	2.1	1.5	1.4	1.4	1.5
Leg fat mass (right)	2.4	9.1	13.0	-2.4	-3.0	-3.2	-2.9	-3.0	-3.2	-3.6	-2.8	-3.6	-2.9	-2.8	-2.9	-3.6	-2.9	-3.5	-2.8	-2.3	-3.1	-2.6
Arm fat percentage (left)	2.4	9.4	14.1	-2.6	-3.1	-3.2	-3.0	-3.0	-3.2	-3.8	-2.6	-3.7	-2.9	-2.8	-3.0	-3.6	-2.9	-3.6	-2.8	-2.4	-3.0	-2.6
Blood Platelet Count	2.3	26.4	33.1	4.9	5.2	5.4	4.8	5.0	5.5	5.6	5.1	5.8	5.0	4.8	5.1	5.6	5.0	5.7	4.7	4.0	5.0	5.2
Fasting Glucose	2.2	2.7	3.2	-1.6	-1.7	-1.6	-1.8	-1.6	-1.4	-1.5	-1.7	-1.5	-1.6	-1.7	-1.7	-1.7	-1.7	-1.6	-1.7	-1.8	-1.7	-1.5
Vitamin and mineral supplements	2.2	3.0	5.5	-1.5	-1.9	-1.8	-1.3	-1.7	-2.3	-1.6	-1.9	-1.7	-1.8	-1.4	-2.1	-2.1	-1.8	-1.6	-1.5	-0.8	-1.9	-1.8
Hand grip strength (right)	2.2	5.9	7.0	-2.4	-2.3	-2.4	-2.6	-2.4	-2.6	-2.5	-2.2	-2.4	-2.4	-2.5	-2.5	-2.6	-2.3	-2.5	-2.3	-2.7	-2.2	-2.3
Hair/balding pattern: Pattern 3	2.2	3.2	4.3	-1.4	-1.9	-1.9	-1.8	-1.6	-2.1	-1.8	-1.8	-1.9	-1.7	-1.5	-1.9	-1.8	-1.9	-2.0	-1.9	-1.6	-1.8	-1.7
Number of full sisters	2.2	2.7	4.1	-1.5	-1.6	-1.7	-1.8	-1.5	-1.9	-1.8	-1.8	-2.0	-1.4	-1.5	-1.4	-1.8	-1.5	-2.0	-1.6	-1.1	-1.5	-1.5
Chest pain or discomfort	2.1	3.0	4.6	1.8	1.5	1.6	2.0	1.7	1.8	1.6	1.9	1.8	1.6	1.8	1.9	1.9	1.5	1.7	1.5	2.1	1.4	1.8
Financial situation satisfaction	2.1	2.6	3.6	-1.8	-1.5	-1.6	-1.8	-1.7	-1.4	-1.7	-1.4	-1.6	-1.7	-1.9	-1.5	-1.8	-1.5	-1.6	-1.5	-1.5	-1.5	-1.6
Relative age voice broke	2.0	3.0	7.6	1.6	1.7	1.7	2.0	1.8	1.3	1.5	1.7	1.5	1.6	1.8	1.7	1.6	1.7	1.7	1.9	2.8	1.7	1.4
Father’s age at death	2.0	2.7	4.1	-1.6	-1.7	-1.7	-2.0	-1.5	-1.4	-1.4	-1.5	-1.4	-1.6	-1.8	-1.7	-1.4	-1.7	-1.6	-2.0	-1.9	-1.7	-1.6
Happiness	2.0	2.4	3.2	-1.6	-1.5	-1.6	-1.7	-1.6	-1.7	-1.6	-1.2	-1.4	-1.7	-1.8	-1.8	-1.7	-1.5	-1.5	-1.5	-1.4	-1.4	-1.5
Illnesses of mother	2.0	2.4	2.9	1.5	1.6	1.7	1.4	1.6	1.5	1.7	1.3	1.5	1.6	1.5	1.6	1.7	1.6	1.6	1.6	1.2	1.7	1.5
Whole body fat mass	2.0	8.3	11.3	-2.3	-2.9	-3.0	-2.8	-2.9	-2.8	-3.4	-2.7	-3.4	-2.8	-2.7	-2.7	-3.4	-2.8	-3.3	-2.8	-2.3	-3.0	-2.5
Deep venous thrombosis (DVT) (self-reported)	2.0	2.6	3.8	-1.5	-1.5	-1.5	-2.0	-1.5	-1.9	-1.8	-1.3	-1.7	-1.5	-1.7	-1.7	-1.8	-1.5	-1.8	-1.6	-1.5	-1.5	-1.4
Pulse wave Arterial Stiffness index	1.9	2.2	4.1	1.7	1.6	1.5	1.5	1.6	1.2	1.0	1.3	0.8	1.6	1.6	1.9	1.2	1.7	1.0	1.6	2.0	1.6	1.5
Medication: Seretide 50 evohaler	1.9	2.2	4.1	1.4	1.5	1.5	1.2	1.5	1.5	1.9	1.4	2.0	1.4	1.2	1.4	1.7	1.3	1.8	1.1	1.6	1.3	1.4
Diastolic blood pressure, automated reading	1.9	5.9	7.9	-2.0	-2.4	-2.4	-2.8	-2.3	-2.8	-2.6	-2.1	-2.5	-2.4	-2.5	-2.6	-2.8	-2.3	-2.5	-2.4	-2.1	-2.3	-2.3
Height	1.8	34.1	40.1	6.3	6.0	6.1	5.7	5.8	5.5	6.3	5.3	6.2	5.8	5.7	6.0	6.0	5.8	6.2	5.7	5.3	5.6	5.6
Relative age of first facial hair	1.8	3.7	6.1	1.6	1.9	1.9	1.8	1.8	2.1	2.3	1.8	2.5	1.6	1.5	1.7	2.1	1.7	2.4	1.7	2.2	1.8	1.5
Reason for reducing amount of alcohol drunk: Health precaution	1.8	2.1	5.2	-1.4	-1.3	-1.4	-1.2	-1.3	-2.0	-2.0	-1.4	-2.3	-1.0	-1.0	-1.0	-1.7	-1.1	-2.1	-1.0	-0.9	-1.1	-1.2
Pulse rate, automated reading	1.8	5.9	8.2	1.9	2.5	2.6	2.6	2.3	1.8	2.3	2.9	2.6	2.4	2.4	2.1	2.3	2.5	2.7	2.6	2.3	2.4	2.4
Illnesses of father: Heart disease	1.8	2.5	4.3	1.3	1.6	1.6	1.5	1.7	1.4	1.4	1.6	1.4	1.6	1.5	1.7	1.5	1.6	1.5	1.6	2.1	1.6	1.6
Wears glasses or contact lenses	1.8	2.1	2.6	1.5	1.5	1.5	1.4	1.5	1.5	1.2	1.5	1.2	1.6	1.5	1.6	1.5	1.5	1.3	1.4	1.4	1.5	1.6
Number of live births	1.7	2.4	5.8	-1.1	-1.5	-1.7	-1.3	-1.5	-1.4	-2.4	-0.8	-2.2	-1.5	-1.4	-1.4	-1.8	-1.4	-2.0	-1.2	-1.6	-1.4	-1.1
Blood clot in the leg (DVT)	1.7	2.2	3.4	-1.3	-1.4	-1.4	-1.8	-1.4	-1.8	-1.7	-1.1	-1.6	-1.3	-1.6	-1.6	-1.7	-1.3	-1.6	-1.5	-1.5	-1.3	-1.2
Ever had stillbirth, spontaneous miscarriage or termination	1.7	1.8	2.8	-1.3	-1.4	-1.3	-1.3	-1.4	-1.0	-1.2	-1.7	-1.4	-1.4	-1.4	-1.2	-1.4	-1.3	-1.4	-1.2	-1.2	-1.3	-1.5
Pain type(s) experienced in last month: Hip pain	1.7	2.1	2.9	-1.6	-1.6	-1.6	-1.2	-1.5	-1.1	-1.1	-1.7	-1.1	-1.6	-1.4	-1.6	-1.2	-1.6	-1.2	-1.5	-1.5	-1.5	-1.7
Reaction Time	1.6	3.1	3.7	1.9	1.9	1.9	1.5	1.7	1.6	1.8	1.9	1.9	1.8	1.5	1.8	1.7	1.9	1.9	1.6	1.4	1.8	1.8
Medication: Metformin	1.6	2.3	3.4	-1.8	-1.4	-1.5	-1.5	-1.6	-0.9	-1.4	-1.7	-1.6	-1.5	-1.7	-1.2	-1.6	-1.4	-1.6	-1.3	-1.8	-1.4	-1.4
Medication: Amlodipine	1.6	2.3	4.8	1.0	1.4	1.5	1.6	1.3	2.2	1.8	1.3	1.9	1.3	1.2	1.5	1.8	1.3	1.9	1.4	1.1	1.3	1.2
Qualifications: NVQ or HND or HNC or equivalent	1.6	1.9	3.4	1.7	1.2	1.3	1.5	1.3	1.4	1.4	1.3	1.4	1.3	1.5	1.3	1.4	1.1	1.4	1.2	1.8	1.1	1.3
Ever smoked	1.6	2.8	4.3	1.5	1.6	1.8	1.5	1.8	1.3	1.7	1.7	1.7	1.8	1.8	1.7	1.9	1.6	1.6	1.4	2.1	1.6	1.6
Triglycerides	1.5	2.4	4.2	-1.9	-1.6	-1.7	-1.3	-1.7	-0.7	-1.2	-2.1	-1.5	-1.6	-1.6	-1.4	-1.4	-1.6	-1.4	-1.5	-1.2	-1.6	-1.8
Medication for hormone replacement therapy	1.5	1.7	2.4	-1.5	-1.2	-1.3	-1.4	-1.4	-1.4	-1.4	-0.9	-1.3	-1.2	-1.5	-1.3	-1.4	-1.1	-1.3	-1.2	-1.3	-1.1	-1.2
Chronic bronchitis/emphysema (father)	1.5	1.8	3.6	-1.1	-1.3	-1.3	-1.3	-1.2	-1.7	-1.4	-1.1	-1.4	-1.2	-1.1	-1.3	-1.5	-1.2	-1.5	-1.2	-1.9	-1.3	-0.9
Worrier / anxious feelings	1.5	2.8	4.3	1.9	1.7	1.7	1.5	1.6	1.8	1.9	1.8	2.1	1.5	1.4	1.5	1.8	1.6	2.0	1.5	0.5	1.6	1.7
Medication: Paracetamol	1.5	2.5	3.6	1.3	1.5	1.6	1.8	1.3	1.8	1.7	1.8	1.9	1.5	1.6	1.3	1.8	1.4	1.9	1.5	0.6	1.4	1.6
Eye problems/disorders: Cataract	1.5	1.7	2.7	1.5	1.3	1.4	1.5	1.3	0.6	1.7	0.7	1.4	1.3	1.4	1.2	1.1	1.3	1.5	1.5	1.5	1.3	1.0
Angina	1.4	1.9	3.3	1.4	1.3	1.4	1.1	1.3	1.8	1.5	1.3	1.6	1.3	1.1	1.4	1.4	1.2	1.5	1.1	1.3	1.2	1.5
Pulse wave peak to peak time	1.4	1.6	3.4	-1.4	-1.3	-1.2	-1.4	-1.3	-1.2	-0.8	-1.0	-0.6	-1.4	-1.3	-1.7	-1.0	-1.4	-0.8	-1.4	-1.8	-1.3	-1.3
Health satisfaction	1.4	1.8	3.2	-1.8	-1.3	-1.2	-1.5	-1.5	-0.9	-1.0	-1.2	-0.9	-1.5	-1.7	-1.4	-1.3	-1.3	-1.0	-1.4	-1.5	-1.3	-1.4
Mouth/teeth dental problems: Loose teeth	1.4	1.7	3.6	-1.9	-1.5	-1.5	-0.6	-1.6	-0.4	-1.4	-0.9	-1.1	-1.5	-1.2	-1.3	-1.3	-1.5	-1.1	-1.1	-0.6	-1.6	-1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.4	2.9	4.7	2.2	1.9	1.7	1.4	2.1	-0.3	0.6	1.8	0.3	2.1	1.8	1.9	0.8	2.1	0.7	2.0	2.1	2.1	1.9
Depression (Nagel 2018)	1.2	1.8	2.8	-1.3	-1.5	-1.4	-1.0	-1.6	-0.1	-0.9	-1.4	-0.8	-1.6	-1.4	-1.5	-0.9	-1.6	-0.9	-1.4	-1.7	-1.6	-1.4
Number of treatments/medications taken	1.2	2.1	2.9	1.2	1.5	1.5	1.5	1.4	1.6	1.1	1.6	1.1	1.6	1.6	1.7	1.7	1.5	1.2	1.5	0.8	1.6	1.6
Medication for cholesterol, blood pressure or diabetes	1.2	1.9	2.5	-1.1	-1.5	-1.5	-1.4	-1.4	-1.5	-1.4	-1.4	-1.4	-1.4	-1.3	-1.6	-1.5	-1.5	-1.4	-1.4	-0.8	-1.4	-1.4
Qualifications: College or University degree	1.2	3.9	6.3	-1.9	-1.6	-1.8	-2.3	-1.8	-2.4	-2.5	-1.5	-2.5	-1.7	-2.1	-1.6	-2.3	-1.4	-2.5	-1.6	-2.0	-1.4	-1.8
Migraine (self-reported)	1.2	1.5	2.5	1.1	1.3	1.4	0.7	1.3	1.0	1.6	1.3	1.6	1.3	1.0	1.1	1.3	1.3	1.5	1.0	0.6	1.3	1.3
Medication: Allopurinol	1.2	1.6	2.4	-1.4	-1.3	-1.2	-1.2	-1.5	-1.3	-0.9	-1.2	-0.8	-1.4	-1.2	-1.6	-1.1	-1.4	-1.0	-1.4	-1.2	-1.4	-1.5
Knee pain experienced in last month	1.2	1.8	2.3	-1.5	-1.4	-1.4	-1.2	-1.3	-1.4	-1.5	-1.3	-1.5	-1.3	-1.1	-1.4	-1.4	-1.3	-1.4	-1.2	-1.3	-1.3	-1.2
Breast cancer (self-reported)	1.2	1.4	3.8	-0.7	-1.1	-1.2	-1.0	-1.0	-2.0	-1.7	-0.8	-1.7	-0.9	-0.8	-1.1	-1.4	-0.9	-1.6	-0.9	-0.6	-0.9	-1.1
Osteoarthritis (self-reported)	1.2	1.6	2.0	-1.3	-1.3	-1.4	-1.2	-1.3	-0.9	-1.4	-1.1	-1.4	-1.3	-1.2	-1.2	-1.2	-1.3	-1.4	-1.2	-1.2	-1.2	-1.2
Leg fat percentage (left)	1.2	4.5	6.2	-1.7	-2.2	-2.3	-1.8	-2.3	-2.0	-2.5	-1.9	-2.4	-2.1	-1.9	-2.2	-2.5	-2.1	-2.3	-1.9	-1.8	-2.3	-1.8
Frequency of depressed mood in last 2 weeks	1.1	1.6	2.6	-1.4	-1.5	-1.4	-0.8	-1.6	-0.1	-1.0	-0.9	-0.6	-1.6	-1.4	-1.6	-1.0	-1.6	-0.7	-1.3	-1.4	-1.6	-1.3
Medication: Atenolol	1.1	1.4	2.7	-1.3	-1.2	-1.2	-1.2	-1.3	-0.1	-1.0	-1.2	-1.0	-1.2	-1.3	-0.9	-0.9	-1.2	-1.1	-1.3	-1.7	-1.2	-1.0
Fluid intelligence score	1.1	2.3	3.6	1.9	1.7	1.6	1.4	1.8	0.5	1.1	1.9	1.2	1.7	1.6	1.3	1.2	1.7	1.3	1.7	1.3	1.7	1.7
Hip circumference	1.1	4.5	6.3	-1.6	-2.1	-2.2	-2.3	-2.1	-2.4	-2.4	-2.0	-2.5	-2.0	-2.0	-2.0	-2.5	-2.0	-2.5	-2.1	-1.7	-2.1	-1.8
Headache pain in last month	1.1	1.8	3.6	1.5	1.5	1.4	1.2	1.4	0.9	0.8	1.9	1.1	1.4	1.3	1.2	1.2	1.5	1.2	1.4	1.4	1.5	1.5
Birth weight	1.1	2.4	6.0	1.3	1.3	1.5	1.6	1.1	2.4	2.2	0.8	2.1	1.1	1.2	1.5	1.8	1.1	2.0	1.2	2.1	1.1	0.9
High blood pressure	1.0	2.8	4.4	-1.4	-1.6	-1.8	-1.7	-1.5	-1.6	-2.1	-1.4	-2.0	-1.6	-1.8	-1.5	-2.0	-1.5	-1.9	-1.5	-1.4	-1.5	-1.4
Pain all over the body in last month	1.0	1.1	2.6	0.7	0.9	0.9	1.2	0.8	1.6	1.0	1.2	1.2	0.8	0.8	1.1	1.2	0.8	1.2	0.8	1.6	0.7	0.8
Forced expiratory volume in 1-second (FEV1)	1.0	3.4	6.0	2.4	2.2	2.0	1.4	2.2	0.2	1.1	1.9	0.9	2.2	1.8	2.1	1.2	2.3	1.1	2.1	1.9	2.3	2.0
Hair/balding pattern: Pattern 4	1.0	2.4	3.3	1.7	1.6	1.7	1.8	1.5	1.0	1.4	1.6	1.3	1.7	1.7	1.6	1.4	1.7	1.5	1.8	1.4	1.6	1.5
Leg fat percentage (right)	1.0	3.8	5.6	-1.5	-2.0	-2.0	-1.8	-2.0	-1.9	-2.3	-1.8	-2.4	-1.8	-1.7	-1.9	-2.3	-1.9	-2.3	-1.8	-1.7	-2.0	-1.6
Angina (self-reported)	1.0	1.4	3.1	1.2	1.1	1.2	0.9	1.1	1.8	1.4	1.0	1.5	1.0	0.8	1.1	1.3	1.0	1.4	0.8	1.0	0.9	1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.1	2.0	1.3	0.9	0.9	1.4	1.0	1.2	1.4	0.5	1.2	0.9	1.1	0.9	1.1	0.8	1.3	1.0	1.4	0.8	0.8
Suffer from ‘nerves’	1.0	1.5	2.8	1.1	1.1	1.1	1.5	1.0	1.7	1.6	0.9	1.6	0.9	1.0	1.1	1.4	0.9	1.6	1.1	1.1	1.0	0.9
Medication: Aspirin	1.0	1.4	2.3	1.0	1.2	1.3	0.9	1.2	1.2	1.2	0.9	1.0	1.3	1.1	1.5	1.2	1.2	1.0	1.0	1.1	1.2	1.2
Mood swings	1.0	1.8	3.5	1.3	1.1	1.2	1.6	1.1	1.9	1.3	1.6	1.6	1.0	1.1	1.2	1.4	1.0	1.6	1.2	1.5	0.9	1.3
Medication: Bendroflumethiazide	1.0	1.5	2.9	-1.0	-1.1	-1.2	-1.3	-1.3	-1.2	-1.1	-1.2	-1.1	-1.2	-1.3	-1.2	-1.4	-1.1	-1.2	-1.2	-1.7	-1.2	-1.0
Illnesses of father: High blood pressure	1.0	1.2	1.9	-1.2	-1.3	-1.2	-0.7	-1.2	-0.6	-0.7	-1.4	-0.7	-1.3	-1.1	-1.1	-1.1	-1.4	-0.8	-1.1	0.3	-1.4	-1.4
Commuting to job workplace: Cycle	1.0	1.2	2.2	1.2	1.3	1.1	0.8	1.3	0.4	0.7	1.1	0.5	1.3	1.0	1.2	0.9	1.4	0.7	1.3	0.9	1.5	1.0
Myopia	1.0	1.5	2.1	1.4	1.3	1.3	1.0	1.3	1.2	1.2	1.4	1.3	1.2	1.1	1.2	1.3	1.3	1.3	1.2	0.4	1.3	1.5
Basal cell carcinoma (self-reported)	1.0	1.2	1.8	-1.0	-1.2	-1.0	-0.9	-1.2	-1.2	-0.7	-1.4	-0.9	-1.1	-1.1	-1.3	-1.3	-1.2	-0.9	-1.0	-1.4	-1.2	-1.1
Intelligence (Savage-Jansen 2018)	0.9	2.8	5.2	1.9	1.7	1.5	1.9	1.9	0.4	0.8	1.9	0.7	1.8	2.0	1.6	1.1	1.8	1.1	2.0	2.3	1.8	1.8
Blood Eosinophil Count	0.9	7.3	9.3	-3.0	-2.7	-2.8	-3.0	-2.7	-1.9	-2.8	-2.6	-2.9	-2.6	-2.8	-2.4	-2.6	-2.6	-3.0	-2.8	-2.8	-2.6	-2.5
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	2.2	-0.9	-0.9	-0.9	-1.2	-1.0	-1.4	-0.4	-1.5	-0.7	-0.9	-1.1	-1.1	-1.1	-0.9	-0.8	-1.0	-0.9	-0.9	-1.1
Had menopause	0.9	1.1	1.5	1.2	1.1	1.1	1.0	1.1	1.0	1.1	1.1	1.1	1.1	0.9	1.0	0.9	1.1	1.2	1.0	1.2	1.0	1.1
Heart attack	0.9	1.2	3.0	0.7	1.0	1.0	1.0	0.8	1.7	1.7	0.5	1.6	0.8	0.8	1.2	1.3	0.8	1.4	0.7	1.3	0.7	0.7
Standing height	0.9	9.4	12.5	3.4	3.2	3.3	2.6	3.0	3.2	3.5	2.6	3.4	3.0	2.8	3.3	3.3	3.1	3.3	2.8	2.0	3.0	3.0
Loud music exposure frequency	0.9	0.9	1.4	-1.1	-1.0	-1.0	-0.8	-1.2	-0.5	-0.7	-0.9	-0.5	-1.2	-1.2	-1.1	-0.9	-1.1	-0.7	-1.1	-0.8	-1.1	-1.1
Mouth/teeth dental problems: Bleeding gums	0.9	1.2	1.9	-1.3	-1.2	-1.2	-0.7	-1.4	0.2	-1.3	-0.9	-1.2	-1.2	-1.1	-0.8	-0.9	-1.2	-1.1	-1.0	-1.3	-1.4	-1.0
Mean time to correctly identify matches	0.9	1.8	2.6	1.6	1.5	1.4	1.1	1.3	1.1	1.3	1.5	1.3	1.4	1.2	1.4	1.3	1.4	1.3	1.2	0.9	1.3	1.5
Hypertension (Self-reported)	0.9	2.5	4.5	-1.3	-1.5	-1.6	-1.7	-1.4	-1.6	-2.1	-1.3	-2.1	-1.5	-1.6	-1.4	-1.9	-1.4	-1.9	-1.4	-1.4	-1.4	-1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.0	2.1	1.0	1.0	0.9	1.2	1.1	0.2	-0.1	1.4	-0.0	1.1	1.2	1.0	0.6	1.2	0.3	1.5	0.8	1.3	1.2
Eye problems/disorders: Glaucoma	0.9	1.0	5.1	0.5	1.0	1.0	1.1	0.9	0.9	1.0	0.6	0.8	0.9	0.9	1.3	0.9	1.0	0.9	1.0	2.2	0.9	0.6
Heart attack/myocardial infarction (self-reported)	0.9	1.2	3.0	0.6	1.0	1.0	0.9	0.8	1.7	1.6	0.6	1.6	0.8	0.7	1.2	1.3	0.9	1.4	0.6	1.2	0.7	0.8
Alzheimer’s Disease (including proxy)	0.8	1.2	3.7	-1.7	-0.9	-0.6	-1.0	-1.3	0.3	0.2	-1.6	0.5	-1.3	-1.9	-0.9	-0.7	-1.0	-0.1	-1.1	-0.7	-1.1	-1.4
Rheumatoid Arthritis	0.8	1.1	1.8	1.2	1.0	1.1	1.2	1.1	0.8	0.7	1.4	0.8	1.1	1.2	1.0	1.0	1.0	0.9	1.1	1.1	1.0	1.2
Multivitamins +/- minerals	0.8	1.0	2.9	0.6	1.0	1.0	0.8	0.9	1.7	1.0	1.2	1.2	0.9	0.7	1.2	1.4	0.9	1.1	0.7	0.4	0.9	0.9
Had other major operations	0.8	0.9	1.8	-1.3	-1.0	-1.0	-0.7	-1.2	-0.4	-0.7	-0.9	-0.5	-1.1	-1.0	-1.2	-0.7	-1.1	-0.6	-0.9	-1.3	-1.0	-1.2
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	2.0	1.1	1.2	1.1	0.9	1.1	0.4	0.6	1.0	0.3	1.4	1.3	1.4	0.9	1.3	0.4	1.2	0.7	1.3	1.2
Neuroticism score	0.8	1.6	2.4	1.6	1.2	1.2	1.3	1.3	1.5	1.2	1.5	1.4	1.1	1.1	1.1	1.3	1.1	1.4	1.2	0.8	1.1	1.5
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.4	7.6	0.5	0.6	0.9	1.3	0.3	2.8	1.7	0.8	2.0	0.4	0.6	0.7	1.5	0.4	1.8	0.6	-0.2	0.3	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.4	4.1	1.8	1.9	1.7	1.1	1.9	0.4	1.0	1.6	0.8	1.9	1.4	1.9	1.0	2.0	0.9	1.7	1.5	1.9	1.8
High blood pressure (siblings)	0.8	1.2	2.0	-1.2	-1.3	-1.3	-0.6	-1.2	-0.6	-0.8	-1.2	-0.8	-1.3	-1.1	-1.2	-1.1	-1.4	-0.8	-1.1	-0.1	-1.4	-1.3
Medication: Omeprazole	0.8	1.0	2.2	-1.2	-0.9	-0.9	-1.3	-0.8	-1.1	-1.5	-0.5	-1.4	-0.8	-1.0	-0.7	-1.1	-0.8	-1.4	-1.0	-0.5	-0.9	-0.6
Medication for cholesterol	0.8	1.1	1.6	1.3	1.0	1.1	1.1	1.1	0.9	1.2	0.8	1.1	1.1	1.3	1.1	1.2	0.9	1.0	1.0	1.3	0.9	0.9
Neuroticism (Nagel 2018)	0.7	1.7	2.6	1.4	1.2	1.2	1.3	1.2	1.6	1.5	1.1	1.6	1.1	1.0	1.2	1.4	1.1	1.6	1.2	1.2	1.2	1.1
Neuroticism	0.7	1.6	2.8	1.4	1.1	1.2	1.2	1.2	1.7	1.3	1.5	1.6	1.0	1.0	1.0	1.5	1.0	1.6	1.0	0.9	1.1	1.3
Chronotype (morning person)	0.7	1.7	3.2	1.4	1.4	1.3	1.7	1.2	0.7	0.7	1.2	0.5	1.4	1.6	1.5	1.0	1.5	0.8	1.8	1.5	1.5	1.2
Trunk fat mass	0.7	2.9	4.4	-1.1	-1.7	-1.8	-1.6	-1.7	-1.6	-2.1	-1.6	-2.1	-1.6	-1.6	-1.6	-2.1	-1.6	-2.0	-1.6	-1.3	-1.8	-1.3
Time employed in main current job	0.7	0.8	1.4	0.7	0.9	1.0	0.9	0.8	1.2	1.1	0.9	1.2	0.8	0.9	0.8	0.9	0.8	1.2	0.8	0.3	0.7	1.0
Mouth/teeth dental problems: Dentures	0.7	1.1	2.8	-1.1	-0.9	-1.0	-1.0	-0.8	-1.6	-1.6	-0.7	-1.7	-0.8	-0.8	-0.7	-1.4	-0.8	-1.5	-0.8	-0.1	-0.7	-0.7
Chronic bronchitis/emphysema (mother)	0.7	0.8	3.1	-0.8	-0.7	-0.9	-0.7	-0.6	-1.8	-1.5	-0.4	-1.5	-0.6	-0.6	-0.7	-1.2	-0.5	-1.4	-0.5	-0.3	-0.5	-0.6
Eye problems/disorders: None of the above	0.7	0.8	1.9	-0.8	-0.8	-0.8	-1.2	-0.8	-1.0	-1.1	-0.4	-0.9	-0.8	-1.0	-1.0	-1.0	-0.7	-0.9	-0.9	-1.4	-0.7	-0.5
Qualifications: nursing, teaching	0.7	1.0	2.3	-0.7	-0.9	-0.9	-1.3	-0.8	-1.5	-0.7	-1.0	-0.7	-0.9	-1.1	-1.2	-1.1	-0.9	-0.8	-1.1	-1.3	-0.9	-0.9
Medication: Lisinopril	0.7	0.9	3.2	-0.4	-0.6	-0.8	-0.9	-0.6	-1.8	-1.3	-0.7	-1.4	-0.7	-0.8	-0.9	-1.5	-0.5	-1.2	-0.4	-1.0	-0.4	-0.5
Pain experienced in last month	0.7	1.1	2.2	-0.9	-0.9	-1.0	-1.1	-1.0	-1.5	-1.4	-0.9	-1.5	-0.8	-0.9	-0.9	-1.3	-0.7	-1.3	-0.7	-1.3	-0.8	-0.9
Crohns Disease (2017)	0.6	1.3	2.7	-1.2	-1.1	-1.3	-1.1	-1.1	-1.1	-1.7	-0.7	-1.5	-1.1	-0.9	-0.9	-1.1	-1.0	-1.5	-1.1	-0.7	-1.0	-1.0
Ulcerative Colitis (UC)	0.6	1.2	1.7	-1.1	-1.3	-1.2	-0.7	-1.3	-0.3	-1.1	-1.1	-1.1	-1.2	-1.0	-1.3	-0.8	-1.3	-1.0	-1.0	-1.2	-1.2	-1.2
Bipolar Disorder (2011)	0.6	0.6	1.1	1.0	0.8	0.8	0.8	0.9	0.4	0.3	0.9	0.3	0.9	1.0	0.8	0.6	0.8	0.0	0.0	0.9	0.8	0.9
Neuroticism (2016)	0.6	0.9	1.4	1.0	1.0	1.2	0.7	0.9	1.1	0.9	1.0	0.9	0.7	0.7	1.1	0.9	1.0	0.9	0.9	0.9	0.9	1.1
Ever used hormone-replacement therapy (HRT)	0.6	0.8	1.4	0.8	0.8	0.8	1.0	0.8	1.2	0.8	1.1	1.1	0.8	0.9	0.7	1.0	0.7	1.1	0.8	0.4	0.7	1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	2.3	-0.9	-1.0	-0.9	-0.7	-1.2	0.3	-0.5	-0.5	-0.2	-1.1	-1.0	-1.1	-0.5	-1.1	-0.3	-0.9	-1.5	-1.1	-0.8
Diabetes (self-reported)	0.6	0.9	2.3	-1.1	-0.8	-0.9	-0.7	-0.9	-1.0	-1.3	-1.0	-1.5	-0.7	-0.8	-0.6	-1.3	-0.6	-1.3	-0.5	-0.2	-0.6	-0.8
Asthma	0.6	1.1	2.5	1.2	1.2	1.1	0.8	1.2	0.0	0.8	1.1	0.8	1.2	1.1	1.1	0.9	1.2	0.7	1.0	1.6	1.2	1.0
Medication: Cholesterol lowering	0.6	0.9	1.1	0.8	1.0	1.0	1.0	0.9	0.8	1.0	0.8	0.9	1.0	1.0	1.0	1.0	1.0	1.0	1.0	0.6	1.0	0.9
Birth weight of first child	0.6	1.2	2.4	1.1	1.3	1.1	1.0	1.1	0.1	0.4	1.2	0.3	1.3	1.3	1.0	0.9	1.4	0.5	1.5	1.0	1.5	1.1
Worry too long after embarrassment	0.6	1.0	3.8	-0.9	-0.8	-0.8	-1.5	-1.0	-0.9	-1.1	-0.4	-0.9	-0.9	-1.3	-0.9	-1.1	-0.8	-1.0	-1.0	-1.9	-0.8	-0.5
Mineral and other dietary supplements	0.6	0.8	1.4	0.5	0.8	0.9	1.0	0.7	0.7	1.1	0.9	1.2	0.7	0.8	0.7	0.7	0.8	1.1	0.9	1.2	0.7	0.8
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.9	0.7	0.9	0.8	0.9	0.9	-0.0	0.4	1.1	0.4	1.0	1.1	0.9	0.6	1.0	0.5	0.9	1.4	0.9	0.9
Medication: Paracetamol	0.6	0.9	2.1	0.5	0.8	1.0	1.1	0.7	1.4	1.2	1.1	1.5	0.8	0.9	0.5	1.3	0.7	1.4	0.8	-0.0	0.6	0.9
Age started oral contraceptive pill	0.6	0.8	1.3	1.2	1.0	1.0	0.5	0.9	0.2	1.0	1.0	1.1	1.0	0.7	0.6	0.8	1.0	1.0	0.7	0.3	0.9	1.0
Irritable Bowel Disease (IBD)	0.5	1.1	1.9	-1.0	-1.2	-1.2	-0.8	-1.1	-0.7	-1.4	-0.7	-1.2	-1.1	-0.8	-1.1	-0.9	-1.2	-1.2	-1.0	-1.0	-1.1	-1.0
Major Depression (MDD)	0.5	0.6	2.8	0.6	0.4	0.4	1.4	0.5	1.7	0.6	0.6	0.7	0.2	0.5	0.8	0.8	0.3	0.8	0.8	0.7	0.4	0.5
Verbal and Numeric Reasoning (VNR)	0.5	1.2	1.8	1.1	1.1	1.1	1.3	1.1	0.7	0.9	1.3	1.0	1.1	1.2	0.9	1.0	1.1	1.1	1.2	1.1	1.1	1.1
Primary Biliary Cirrhosis	0.5	0.8	1.4	-0.9	-1.1	-1.0	-0.4	-1.1	-0.3	-0.6	-1.0	-0.6	-1.0	-0.6	-0.9	-0.6	-1.1	-0.7	-0.9	-0.9	-1.2	-1.0
Hypothyroidism (self reported)	0.5	1.1	1.6	-0.8	-1.1	-1.0	-1.1	-1.1	-1.3	-1.0	-1.0	-1.0	-1.0	-0.9	-1.2	-1.0	-1.1	-1.0	-1.1	-0.8	-1.1	-1.0
Current tobacco smoking	0.5	0.9	1.7	-1.3	-1.0	-1.0	-0.9	-1.0	-0.6	-0.9	-0.6	-0.7	-1.1	-1.1	-1.0	-0.9	-1.0	-0.8	-1.1	-0.3	-1.1	-0.9
Number of incorrect matches in round	0.5	0.8	1.7	-0.8	-1.0	-1.1	-0.4	-0.9	-0.2	-1.2	-1.0	-1.3	-0.8	-0.6	-0.7	-0.8	-0.9	-1.1	-0.6	-0.7	-0.9	-0.8
Forced vital capacity (FVC)	0.5	2.0	3.4	1.8	1.6	1.5	1.0	1.7	-0.0	0.8	1.3	0.5	1.7	1.3	1.7	0.7	1.8	0.7	1.6	1.8	1.7	1.4
Alcohol intake versus 10 years previously	0.5	0.7	3.1	0.2	0.5	0.8	0.4	0.5	1.6	1.5	0.6	1.8	0.3	0.2	0.4	1.2	0.3	1.5	0.1	0.3	0.3	0.5
Qualifications: A levels/AS levels or equivalent	0.5	1.0	4.6	-0.8	-0.7	-0.8	-1.1	-0.7	-2.1	-1.3	-0.5	-1.3	-0.7	-0.8	-0.9	-1.2	-0.5	-1.3	-0.6	-0.7	-0.5	-0.8
Glaucoma (self-reported)	0.5	0.6	3.2	0.2	0.5	0.6	1.0	0.4	1.2	1.0	0.2	0.9	0.4	0.5	0.8	0.8	0.4	0.9	0.6	1.8	0.4	0.1
Medication: Ventolin 100micrograms inhaler	0.5	0.7	2.6	0.9	0.8	0.7	0.7	0.9	0.2	0.3	0.9	0.3	0.8	0.8	0.9	0.6	0.9	0.4	0.8	1.6	0.9	0.9
Body fat percentage	0.5	1.9	3.0	-1.0	-1.4	-1.5	-1.2	-1.4	-1.2	-1.7	-1.2	-1.7	-1.4	-1.2	-1.3	-1.7	-1.4	-1.6	-1.3	-1.0	-1.5	-1.0
Overall health rating	0.5	1.0	2.4	-1.4	-1.0	-0.9	-1.1	-1.2	0.7	-0.6	-0.6	-0.3	-1.1	-1.4	-0.8	-0.7	-1.1	-0.4	-1.2	-1.5	-1.2	-0.6
Age at last live birth	0.5	0.7	1.5	-1.1	-0.8	-0.7	-0.9	-1.0	0.2	-0.1	-1.2	-0.1	-1.0	-1.2	-0.7	-0.7	-0.9	-0.3	-0.9	-1.2	-1.0	-1.0
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	2.0	-0.9	-0.6	-0.7	-1.0	-0.8	-0.9	-0.6	-0.6	-0.6	-0.7	-0.9	-0.8	-0.7	-0.6	-0.7	-0.8	-1.4	-0.6	-0.8
Handedness (chirality/laterality): Left-handed	0.5	0.6	4.2	0.3	0.2	0.5	0.8	0.2	2.1	1.4	-0.3	1.3	0.1	0.3	0.5	1.2	0.1	1.1	0.2	0.3	0.1	-0.0
Asthma (self-reported)	0.5	0.9	2.6	1.0	1.1	0.9	0.7	1.1	0.0	0.7	1.0	0.7	1.1	0.9	0.9	0.8	1.1	0.6	0.9	1.6	1.1	0.9
Medication: Aspirin	0.5	0.7	1.2	0.6	0.9	0.9	0.6	0.9	0.9	0.9	0.6	0.8	0.9	0.8	1.1	0.9	0.9	0.7	0.7	0.7	0.8	0.9
Vascular/heart problems diagnosed by doctor	0.5	1.4	2.3	1.1	1.1	1.3	1.3	1.1	0.7	1.5	1.0	1.5	1.2	1.4	0.9	1.4	1.1	1.4	1.1	0.9	1.1	0.9
Supplements: Calcium	0.5	0.6	1.3	0.9	0.8	0.7	0.7	0.6	1.1	0.7	0.3	0.4	0.8	0.9	1.0	0.9	0.9	0.5	0.8	0.3	0.8	0.7
Schizophrenia (2018)	0.4	0.8	1.4	0.7	0.9	0.9	1.0	0.7	1.2	0.6	1.1	0.6	1.0	1.0	0.9	0.9	0.9	0.8	1.0	1.0	0.9	0.9
Schizophrenia vs Biploar Disorder	0.4	0.5	3.4	-0.1	0.2	0.4	0.9	0.0	1.8	1.0	-0.1	1.0	0.2	0.5	0.4	0.9	0.1	0.9	0.3	0.3	0.1	0.1
LDL Cholesterol	0.4	0.6	1.3	-0.6	-0.8	-0.9	-0.4	-0.7	-1.0	-1.0	-0.8	-1.1	-0.5	-0.3	-0.7	-0.9	-0.7	-1.0	-0.5	-0.4	-0.8	-0.7
Schizophrenia (2014)	0.4	0.9	4.3	0.3	0.8	0.9	1.0	0.6	2.1	0.9	0.9	1.0	0.8	0.7	1.0	1.2	0.8	1.0	0.8	0.7	0.8	0.8
Sensitivity / hurt feelings	0.4	0.6	1.0	1.0	0.7	0.7	0.9	0.7	0.7	0.6	1.0	0.7	0.7	0.8	0.8	0.8	0.7	0.7	0.8	0.8	0.8	0.8
Diabetes (father)	0.4	0.5	2.1	-0.3	-0.6	-0.7	0.1	-0.6	-0.4	-0.9	-1.3	-1.4	-0.4	-0.1	0.0	-0.7	-0.5	-1.1	-0.0	0.1	-0.5	-0.8
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	1.7	-0.4	-0.6	-0.7	-0.6	-0.3	-1.3	-0.9	-0.4	-0.8	-0.5	-0.4	-0.7	-0.7	-0.5	-0.9	-0.5	-0.4	-0.4	-0.5
Alcohol usually taken with meals	0.4	0.6	3.0	-0.1	-0.2	-0.5	-0.9	-0.2	-1.7	-1.5	0.1	-1.4	-0.2	-0.4	-0.3	-1.1	-0.0	-1.3	-0.2	-0.1	-0.0	-0.2
Medication: Ramipril	0.4	0.5	1.1	0.7	0.7	0.7	0.7	0.8	0.7	0.7	0.7	0.7	0.7	0.6	0.9	0.9	0.7	0.6	0.7	1.1	0.8	0.5
Falls in the last year	0.4	0.5	1.4	-0.8	-0.7	-0.7	-0.8	-0.8	-0.4	-0.5	-0.7	-0.5	-0.7	-0.7	-0.8	-0.6	-0.8	-0.6	-0.8	-1.2	-0.7	-0.6
Noisy workplace	0.4	0.5	0.9	-0.9	-0.8	-0.7	-0.7	-0.9	-0.0	-0.4	-0.7	-0.3	-0.8	-0.9	-0.5	-0.7	-0.8	-0.4	-0.9	-0.4	-1.0	-0.7
Forced vital capacity (FVC), Best measure	0.4	1.5	2.8	1.3	1.5	1.4	0.8	1.4	0.5	0.9	1.1	0.7	1.5	1.0	1.7	0.8	1.6	0.8	1.3	1.3	1.5	1.3
Comparative height size at age 10	0.4	2.4	3.9	-1.1	-1.4	-1.6	-1.7	-1.4	-1.6	-1.7	-1.7	-2.0	-1.4	-1.4	-1.1	-1.8	-1.3	-2.0	-1.5	-1.6	-1.4	-1.3
Average weekly red wine intake	0.4	0.6	2.1	-0.4	-0.5	-0.6	-0.3	-0.2	-1.4	-1.2	-0.6	-1.5	-0.3	-0.1	-0.2	-1.0	-0.3	-1.2	-0.2	1.1	-0.4	-0.4
Smoking status: Current	0.4	0.7	1.4	-1.2	-0.9	-0.9	-0.8	-0.9	-0.5	-0.7	-0.6	-0.5	-0.9	-0.9	-0.8	-0.7	-0.9	-0.6	-1.0	-0.2	-1.0	-0.8
Miserableness	0.4	0.7	1.6	0.9	0.7	0.8	0.9	0.7	1.2	1.1	0.7	1.2	0.5	0.5	0.6	0.8	0.6	1.3	0.7	0.7	0.5	0.7
Hearing aid user	0.4	0.5	1.4	-0.7	-0.6	-0.6	-0.7	-0.6	-1.2	-0.1	-0.8	-0.1	-0.7	-0.7	-1.0	-0.7	-0.7	-0.3	-0.7	-0.5	-0.7	-0.7
High cholesterol (Self-reported)	0.4	0.7	1.6	0.2	0.7	0.8	1.3	0.6	1.1	1.2	0.3	1.0	0.6	0.9	0.8	1.0	0.6	1.1	0.9	0.5	0.6	0.4
Risk taking	0.4	0.6	1.5	-1.2	-0.8	-0.7	-0.8	-0.9	0.7	-0.3	-0.6	-0.1	-0.9	-1.1	-0.4	-0.3	-0.8	-0.3	-1.0	-0.4	-0.9	-0.9
Cholesterol lowering medication	0.4	0.5	1.1	-1.0	-0.8	-0.7	-0.5	-0.8	-0.1	-0.2	-0.9	-0.2	-0.9	-0.8	-0.7	-0.4	-0.9	-0.3	-0.8	-0.9	-0.9	-0.8
Depressed Affect (Nagel 2018)	0.3	0.5	1.5	0.7	0.6	0.6	0.8	0.6	1.2	0.8	0.8	1.0	0.5	0.4	0.6	0.8	0.5	1.0	0.6	0.6	0.5	0.7
Breast Cancer	0.3	0.6	2.5	-0.9	-0.5	-0.6	-1.0	-0.6	-1.6	-1.1	-0.2	-0.9	-0.5	-0.7	-0.9	-0.9	-0.5	-1.0	-0.6	-0.7	-0.5	-0.5
Prostate Cancer	0.3	0.4	1.3	0.5	0.4	0.7	0.8	0.4	0.6	1.1	0.2	1.0	0.5	0.7	0.5	0.8	0.3	0.9	0.4	0.9	0.2	0.2
Crohns Disease (2012)	0.3	0.5	1.7	-0.8	-0.6	-0.7	-0.4	-0.5	-1.0	-1.3	-0.4	-1.3	-0.5	-0.3	-0.2	-0.8	-0.5	-1.2	-0.4	0.3	-0.5	-0.5
Lupus	0.3	0.5	1.3	-0.4	-1.0	-0.7	-0.1	-0.9	-0.1	-0.5	-1.0	-0.6	-0.8	-0.4	-0.7	-0.6	-1.1	-0.5	-0.6	0.5	-1.1	-0.9
Blood Red Count	0.3	2.6	3.8	-1.4	-1.6	-1.7	-1.7	-1.5	-1.8	-1.6	-1.3	-1.5	-1.6	-1.5	-1.8	-1.7	-1.6	-1.6	-1.7	-2.0	-1.6	-1.3
Blood White Count	0.3	1.9	3.1	1.1	1.2	1.3	1.5	1.3	1.7	1.6	1.5	1.8	1.2	1.4	1.2	1.6	1.1	1.7	1.1	1.4	1.1	1.4
Cardiovascular Disease	0.3	1.0	1.5	-1.1	-1.0	-1.0	-1.1	-1.0	-0.8	-1.0	-0.9	-0.9	-1.1	-1.2	-1.1	-1.0	-1.0	-0.9	-0.9	-1.0	-0.9	-1.1
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.5	-1.2	-0.5	-0.6	-1.1	-0.8	-0.4	-0.8	-0.7	-0.9	-0.6	-1.1	-0.5	-0.8	-0.5	-0.8	-0.6	-1.2	-0.4	-0.6
Average weekly fortified wine intake	0.3	0.4	0.7	0.7	0.5	0.3	0.4	0.7	-0.6	-0.4	0.4	-0.7	0.8	0.8	0.7	-0.0	0.7	-0.4	0.6	0.8	0.6	0.8
Medication: Levothyroxine sodium	0.3	0.6	1.2	1.1	0.8	0.7	0.8	0.8	0.3	0.5	0.8	0.5	0.9	1.0	0.8	0.7	0.8	0.5	0.8	0.5	0.8	0.9
Depression (self-reported)	0.3	0.3	1.3	0.2	0.4	0.5	0.5	0.4	1.1	0.7	0.5	0.8	0.4	0.3	0.5	0.6	0.4	0.8	0.4	0.6	0.3	0.5
Prospective memory result	0.3	0.3	1.5	0.6	0.5	0.5	0.8	0.4	0.1	0.4	0.1	0.1	0.6	0.7	0.6	0.4	0.6	0.3	0.8	1.2	0.6	0.2
Pulse wave reflection index	0.3	0.4	2.5	0.6	0.6	0.4	0.8	0.6	0.2	0.3	0.0	0.0	0.6	0.6	0.8	0.3	0.7	0.1	0.7	1.6	0.7	0.3
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.1	-0.5	-0.7	-0.7	-0.8	-0.8	-1.0	-0.8	-0.8	-0.9	-0.7	-0.7	-0.6	-0.9	-0.7	-1.0	-0.7	-0.6	-0.7	-0.7
Number of children fathered	0.3	0.3	0.6	-0.6	-0.6	-0.6	-0.5	-0.6	-0.1	-0.4	-0.8	-0.5	-0.6	-0.6	-0.5	-0.5	-0.7	-0.6	-0.7	-0.6	-0.7	-0.6
Ever had bowel cancer screening	0.3	0.3	1.3	-0.1	-0.6	-0.6	-0.5	-0.6	-0.4	-0.4	-0.7	-0.5	-0.5	-0.5	-0.6	-0.6	-0.6	-0.5	-0.6	-1.2	-0.7	-0.4
Osteoporosis (self-reported)	0.3	0.4	3.0	0.3	0.0	-0.1	-0.8	0.1	-1.7	-0.9	0.1	-0.9	0.1	-0.1	-0.3	-0.6	0.2	-0.9	-0.1	-0.7	0.2	-0.1
Illnesses of father: None of the above (group 1)	0.3	0.4	1.0	0.8	0.5	0.6	0.1	0.4	0.6	0.7	0.8	1.0	0.3	0.2	0.0	0.7	0.4	0.9	0.3	-0.9	0.5	0.6
Mother’s age at death	0.3	0.3	0.6	0.7	0.6	0.5	0.7	0.5	0.6	0.4	0.4	0.4	0.5	0.7	0.6	0.6	0.6	0.4	0.7	0.6	0.6	0.5
Unable to work because of sickness or disability	0.3	0.4	1.1	0.1	0.5	0.7	0.3	0.3	1.1	0.8	0.7	1.0	0.4	0.4	0.3	0.8	0.4	0.9	0.3	-0.7	0.4	0.7
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.3	-0.7	-0.4	-0.5	-0.6	-0.4	-0.7	-1.2	-0.1	-1.1	-0.3	-0.2	-0.2	-0.7	-0.3	-1.0	-0.4	-0.0	-0.4	-0.2
Waist Hip Ratio (WHR)	0.2	1.0	2.1	0.7	0.8	0.9	1.5	0.9	1.4	1.2	0.5	1.1	0.8	1.2	0.8	1.0	0.8	1.2	1.1	1.3	0.8	0.9
Respiratory disease	0.2	0.4	1.0	0.5	0.7	0.6	0.3	0.7	-0.2	0.3	0.8	0.4	0.7	0.7	0.5	0.5	0.7	0.3	0.5	1.0	0.7	0.6
Average weekly spirits intake	0.2	0.3	1.4	0.4	0.2	0.1	0.5	0.4	-0.8	-0.7	0.3	-0.8	0.3	0.4	0.2	-0.5	0.4	-0.4	0.7	1.2	0.4	0.3
Hearing difficulty/problems: Yes	0.2	0.3	0.6	-0.5	-0.4	-0.4	-0.7	-0.4	-0.8	-0.5	-0.6	-0.7	-0.3	-0.4	-0.2	-0.6	-0.3	-0.7	-0.5	-0.6	-0.4	-0.3
Medication: Co-codamol	0.2	0.2	0.5	-0.0	0.3	0.3	0.5	0.4	0.7	0.2	0.7	0.4	0.3	0.5	0.5	0.5	0.3	0.4	0.3	0.4	0.2	0.6
Maternal smoking around birth	0.2	0.3	1.2	0.4	0.3	0.4	0.9	0.4	0.6	0.5	0.2	0.4	0.4	0.7	0.6	0.5	0.3	0.4	0.5	1.1	0.3	0.4
Fed-up feelings	0.2	0.4	1.0	0.8	0.6	0.6	0.5	0.7	0.7	0.4	0.8	0.6	0.6	0.5	0.7	0.4	0.6	0.6	0.6	0.3	0.5	1.0
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	1.0	-1.0	-0.7	-0.7	-0.3	-0.7	-0.0	-0.8	-0.9	-0.9	-0.6	-0.6	-0.3	-0.4	-0.7	-0.8	-0.5	0.1	-0.6	-0.9
Sitting height	0.2	1.7	3.3	1.8	1.4	1.5	1.0	1.3	1.1	1.6	1.0	1.5	1.3	1.2	1.4	1.3	1.4	1.4	1.1	0.7	1.3	1.3
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	1.2	-0.8	-0.7	-0.7	-0.1	-0.7	-0.3	-0.5	-1.1	-0.7	-0.6	-0.5	-0.3	-0.5	-0.6	-0.7	-0.4	0.4	-0.6	-1.1
Illnesses of siblings	0.2	0.3	0.8	0.7	0.7	0.7	0.2	0.7	0.0	0.3	0.8	0.4	0.7	0.6	0.4	0.6	0.8	0.4	0.6	0.0	0.9	0.7
Lung cancer (father)	0.2	0.2	0.6	-0.4	-0.6	-0.5	-0.4	-0.5	-0.3	-0.2	-0.8	-0.3	-0.6	-0.5	-0.5	-0.5	-0.6	-0.3	-0.5	-0.2	-0.6	-0.6
Breastfed as a baby	0.2	0.3	0.8	0.9	0.5	0.3	-0.0	0.5	-0.8	-0.4	0.3	-0.7	0.7	0.5	0.6	-0.1	0.7	-0.5	0.5	0.1	0.6	0.6
Gout (self-reported)	0.2	0.3	1.1	-0.4	-0.4	-0.5	-0.7	-0.6	-1.1	-0.6	-0.3	-0.5	-0.5	-0.5	-0.8	-0.6	-0.4	-0.6	-0.5	-0.8	-0.4	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.5	-0.4	-0.6	-0.5	-0.3	-0.6	0.3	-0.4	-0.1	-0.0	-0.6	-0.5	-0.7	-0.2	-0.7	-0.1	-0.7	0.1	-0.7	-0.4
Age at first live birth	0.2	0.4	1.2	-0.7	-0.5	-0.3	-0.6	-0.7	0.4	0.6	-1.1	0.5	-0.7	-0.9	-0.7	-0.2	-0.7	0.3	-0.7	-0.7	-0.7	-0.9
Shortness of breath walking on level ground	0.2	0.3	1.5	-0.0	0.2	0.3	0.2	-0.0	1.0	1.1	-0.1	1.2	-0.0	-0.1	0.2	0.6	0.0	0.9	-0.1	-0.4	-0.1	0.1
Medication: Blood pressure	0.2	0.4	2.1	0.2	0.5	0.5	0.8	0.3	1.4	0.8	0.5	0.9	0.4	0.4	0.7	0.9	0.4	0.8	0.5	0.1	0.4	0.4
Illnesses of siblings: Diabetes	0.2	0.2	0.9	-0.0	0.4	0.3	1.0	0.3	0.3	0.3	0.0	0.1	0.4	0.6	0.6	0.4	0.5	0.3	0.8	0.6	0.5	0.1
Medication: Gliclazide	0.2	0.3	0.6	0.2	0.7	0.6	0.4	0.5	0.1	0.2	0.6	0.1	0.7	0.5	0.6	0.2	0.8	0.3	0.8	0.3	0.7	0.7
Guilty feelings	0.2	0.3	0.6	0.5	0.5	0.5	0.6	0.4	0.7	0.8	0.3	0.8	0.4	0.4	0.4	0.6	0.4	0.8	0.5	0.2	0.4	0.5
Ever taken oral contraceptive pill	0.2	0.3	1.5	-0.2	-0.4	-0.4	-0.5	-0.2	-1.2	-0.4	-0.5	-0.5	-0.4	-0.3	-0.7	-0.6	-0.4	-0.5	-0.3	-0.4	-0.3	-0.5
Medication: Blood pressure	0.2	0.4	0.9	-0.3	-0.4	-0.5	-0.9	-0.4	-0.7	-0.8	-0.3	-0.8	-0.5	-0.8	-0.4	-0.9	-0.3	-0.8	-0.5	-0.7	-0.4	-0.2
Number of operations (self-reported)	0.2	0.3	0.6	0.3	0.5	0.5	0.8	0.3	0.8	0.3	0.5	0.4	0.5	0.6	0.5	0.6	0.5	0.4	0.7	0.1	0.5	0.3
Average weekly beer plus cider intake	0.2	0.3	1.0	0.3	0.4	0.5	0.3	0.2	1.0	0.9	0.4	1.0	0.3	0.2	0.4	0.8	0.3	0.8	0.2	-0.2	0.3	0.4
Bipolar Disorder (2018)	0.1	0.2	0.7	-0.7	-0.3	-0.4	-0.4	-0.5	-0.1	-0.8	0.1	-0.6	-0.4	-0.6	-0.1	-0.2	-0.3	-0.7	-0.4	-0.5	-0.2	-0.5
Bipolar Disorder or Schizophrenia	0.1	0.3	1.2	0.1	0.5	0.4	0.6	0.3	1.1	-0.1	0.9	0.1	0.5	0.4	0.6	0.6	0.5	0.3	0.6	0.5	0.6	0.5
Alzheimer’s Disease (in mother)	0.1	0.2	0.5	0.4	0.3	0.4	0.5	0.3	0.3	0.4	0.6	0.6	0.3	0.3	0.3	0.4	0.3	0.6	0.3	0.7	0.2	0.3
Alzheimer’s Disease (in father)	0.1	0.1	0.5	-0.1	0.1	0.1	0.3	0.0	0.7	0.2	-0.2	0.0	0.2	0.2	0.4	0.4	0.1	0.1	0.1	0.2	0.1	-0.1
Coronary Artery Disease (CAD)	0.1	0.1	1.1	-0.1	0.0	0.1	0.6	-0.1	1.1	0.2	0.0	0.2	0.1	0.5	0.4	0.5	-0.0	0.3	0.2	0.6	-0.1	0.0
Ulcerative Colitis	0.1	0.1	0.3	-0.3	-0.3	-0.2	0.3	-0.3	0.6	-0.2	-0.5	-0.3	-0.3	0.0	-0.2	0.1	-0.3	-0.1	0.0	-0.4	-0.2	-0.3
Systolic Blood Pressure	0.1	0.5	1.2	1.1	0.7	0.8	0.5	0.8	0.4	0.6	0.9	0.7	0.7	0.5	0.5	0.5	0.7	0.8	0.7	0.3	0.8	0.8
Smoking Status	0.1	0.3	1.7	0.0	0.3	0.3	0.7	0.4	0.6	0.1	0.6	0.3	0.4	0.5	0.4	0.5	0.3	0.4	0.4	1.3	0.3	0.4
Allergy or Eczema	0.1	0.2	1.4	0.1	-0.0	-0.3	-0.6	-0.2	-1.2	-0.7	0.1	-0.8	0.0	-0.3	-0.1	-0.6	0.1	-0.8	-0.1	-0.7	0.2	-0.1
Lung FVC	0.1	0.5	2.1	-0.2	0.1	-0.2	-0.3	0.2	-1.4	-0.9	-0.4	-1.4	0.3	0.3	0.3	-0.7	0.3	-1.1	0.2	1.2	0.2	-0.1
Supplements: Zinc	0.1	0.1	0.5	0.3	0.3	0.4	0.3	0.2	-0.2	-0.0	0.7	0.2	0.3	0.3	0.1	0.2	0.3	0.2	0.4	-0.1	0.4	0.3
Pack years adult smoking proportion	0.1	0.2	1.1	-0.4	-0.2	-0.1	0.4	-0.2	1.0	0.6	0.0	0.8	-0.3	-0.0	-0.2	0.5	-0.4	0.6	-0.2	-0.2	-0.4	-0.2
Qualifications: CSEs or equivalent	0.1	0.1	0.5	0.3	0.4	0.4	0.1	0.3	0.5	0.7	-0.0	0.6	0.2	0.1	0.3	0.6	0.3	0.5	0.2	-0.2	0.4	0.1
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.8	-0.1	-0.2	-0.3	-0.6	-0.3	-0.9	-0.5	-0.3	-0.5	-0.2	-0.3	-0.3	-0.4	-0.2	-0.6	-0.3	-0.7	-0.2	-0.3
Stomach or abdominal pain in last month	0.1	0.1	0.5	-0.2	0.2	0.1	-0.2	0.2	-0.2	-0.2	0.6	-0.1	0.2	0.1	0.1	0.0	0.2	-0.1	0.0	-0.7	0.2	0.5
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	1.3	-0.3	-0.1	0.1	0.2	-0.3	1.1	0.7	0.2	1.0	-0.3	-0.3	-0.2	0.4	-0.3	0.8	-0.2	-0.3	-0.3	-0.0
Hearing difficulty/problems with background noise	0.1	0.1	0.4	-0.4	-0.3	-0.3	-0.4	-0.4	-0.4	-0.6	-0.1	-0.6	-0.2	-0.2	-0.1	-0.4	-0.2	-0.6	-0.3	-0.4	-0.3	-0.1
Ever unenthusiastic/disinterested for a whole week	0.1	0.2	0.7	0.3	0.4	0.4	0.4	0.4	0.4	0.4	0.3	0.4	0.3	0.3	0.3	0.3	0.3	0.4	0.4	0.8	0.4	0.3
Qualifications: None of the above	0.1	0.2	0.6	-0.4	-0.5	-0.5	0.1	-0.4	-0.0	-0.6	-0.5	-0.7	-0.3	-0.1	-0.1	-0.4	-0.4	-0.6	-0.1	0.0	-0.4	-0.3
Financial difficulties in last 2 years	0.1	0.1	0.6	0.3	0.2	0.3	0.2	0.3	-0.0	0.3	0.7	0.7	0.2	0.1	0.0	0.3	0.2	0.5	0.1	0.2	0.2	0.2
Mouth/teeth dental problems	0.1	0.2	0.7	0.1	-0.3	-0.3	-0.9	-0.2	-0.7	0.2	-0.8	0.0	-0.4	-0.5	-0.6	-0.3	-0.4	-0.2	-0.6	-0.5	-0.3	-0.5
Allergy	0.1	0.1	0.9	-0.2	-0.0	0.1	0.3	-0.0	0.9	0.5	0.0	0.7	-0.2	-0.1	0.0	0.4	-0.1	0.6	-0.0	-0.0	-0.1	-0.0
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.4	0.1	-0.1	0.1	0.3	-0.0	0.7	0.5	-0.3	0.4	-0.1	0.1	-0.0	0.3	-0.1	0.4	0.0	0.5	-0.1	-0.1
Medication: Lansoprazole	0.1	0.1	0.3	0.5	0.1	0.2	0.2	0.3	-0.5	-0.2	0.5	-0.2	0.3	0.4	0.1	-0.1	0.2	-0.1	0.2	-0.2	0.1	0.5
Length of working week for main job	0.1	0.1	0.2	-0.4	-0.2	-0.2	-0.5	-0.1	-0.2	-0.2	-0.1	-0.2	-0.1	-0.2	-0.1	-0.2	-0.2	-0.3	-0.4	-0.5	-0.3	0.1
Exposure to tobacco smoke at home	0.1	0.2	0.3	0.2	0.4	0.4	0.4	0.4	0.4	0.5	0.1	0.3	0.4	0.5	0.5	0.5	0.4	0.3	0.4	0.6	0.5	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.4	-0.6	-0.6	-0.5	-0.0	-0.5	0.5	-0.1	-0.4	-0.0	-0.6	-0.3	-0.5	-0.1	-0.6	-0.0	-0.4	-0.2	-0.6	-0.5
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	1.3	0.6	0.4	0.3	-0.2	0.4	-1.1	0.4	0.5	0.5	0.3	0.2	-0.2	0.0	0.4	0.4	0.1	0.2	0.4	0.3
Number of full brothers	0.1	0.1	0.9	-0.3	0.1	0.1	0.9	-0.1	1.0	0.1	-0.0	-0.0	0.1	0.4	0.3	0.4	0.1	0.2	0.5	0.5	0.1	-0.0
Wheeze or whistling in the chest in last year	0.1	0.1	0.5	-0.0	0.3	0.2	0.1	0.3	-0.1	-0.3	0.5	-0.3	0.4	0.3	0.7	0.2	0.4	-0.3	0.2	0.6	0.3	0.4
Leg pain on walking	0.1	0.1	0.3	-0.4	-0.4	-0.4	0.1	-0.5	0.5	-0.2	-0.4	-0.1	-0.4	-0.2	-0.2	-0.0	-0.4	-0.1	-0.2	0.3	-0.4	-0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.1	1.3	-0.3	-0.3	-0.2	-0.2	-0.5	0.5	-0.1	-0.3	-0.0	-0.4	-0.4	-0.2	-0.1	-0.3	-0.1	-0.3	-1.1	-0.4	-0.2
Diabetes diagnosed by doctor	0.1	0.2	0.6	0.1	0.6	0.4	0.5	0.4	0.2	-0.0	0.3	-0.2	0.6	0.4	0.7	0.1	0.7	0.0	0.8	0.7	0.6	0.5
Commuting to job workplace: Walk	0.1	0.1	0.6	0.1	0.1	0.2	0.1	0.1	0.1	0.8	-0.1	0.8	0.0	0.0	-0.1	0.4	-0.0	0.6	-0.0	-0.1	0.1	-0.2
Average weekly champagne plus white wine intake	0.1	0.1	0.4	-0.4	-0.3	-0.4	0.0	-0.3	-0.3	-0.2	-0.6	-0.3	-0.4	-0.3	-0.4	-0.4	-0.3	-0.2	-0.1	0.6	-0.3	-0.6
Medication: Atorvastatin	0.1	0.1	0.2	-0.3	-0.3	-0.2	0.0	-0.4	0.5	-0.0	-0.3	0.0	-0.3	-0.3	-0.1	-0.0	-0.4	-0.0	-0.3	0.1	-0.5	-0.3
Irritability	0.1	0.2	0.8	0.7	0.4	0.4	0.6	0.5	-0.3	-0.0	0.9	0.2	0.4	0.4	0.3	0.0	0.5	0.3	0.6	0.4	0.4	0.6
Fractured/broken bones in last 5 years	0.1	0.1	0.6	0.0	-0.1	0.0	0.1	-0.2	0.7	0.5	-0.2	0.5	-0.2	-0.1	-0.1	0.4	-0.2	0.4	-0.2	-0.4	-0.2	-0.2
Ever depressed for a whole week	0.1	0.1	0.6	0.1	0.3	0.3	0.2	0.2	0.8	0.4	-0.2	0.2	0.3	0.1	0.6	0.3	0.3	0.2	0.2	0.3	0.3	0.2
Heart disease (siblings)	0.1	0.2	0.6	-0.2	-0.3	-0.2	0.1	-0.5	0.7	0.4	-0.6	0.3	-0.4	-0.2	-0.1	0.0	-0.4	0.3	-0.3	-0.8	-0.5	-0.2
Alcohol drinker status: Previous	0.1	0.1	0.2	-0.4	-0.2	-0.1	0.3	-0.1	0.5	-0.5	0.2	-0.3	-0.1	-0.0	0.0	-0.0	-0.1	-0.2	0.1	0.4	-0.1	-0.0
Pack years of smoking	0.1	0.2	0.9	-0.5	-0.3	-0.2	0.3	-0.2	1.0	0.6	-0.2	0.8	-0.4	-0.1	-0.3	0.4	-0.5	0.6	-0.4	-0.3	-0.5	-0.3
Hair Pigment	0.0	0.7	1.1	0.7	0.8	0.8	0.8	1.0	0.6	0.9	0.4	0.6	0.8	1.0	0.9	0.9	0.8	0.7	0.8	1.0	0.9	0.7
Tanning	0.0	0.1	0.3	-0.0	0.3	0.4	-0.5	-0.2	-0.3	0.1	0.3	0.3	0.1	-0.6	-0.2	-0.2	0.3	0.2	0.0	0.2	0.2	-0.1
Other serious medical condition/disability diagnosed by doctor	0.0	0.0	0.0	-0.0	0.1	0.0	0.2	0.2	0.1	-0.2	0.2	-0.2	0.2	0.2	0.2	0.1	0.1	-0.1	0.2	0.1	0.2	0.1
Systolic blood pressure, automated reading	0.0	0.0	0.4	0.3	0.0	0.0	-0.0	0.2	-0.1	-0.1	-0.0	-0.2	0.1	0.0	0.2	-0.2	0.1	-0.1	0.1	0.6	0.1	0.1
Trunk fat percentage	0.0	0.2	0.5	0.0	-0.4	-0.5	-0.3	-0.4	-0.3	-0.7	-0.2	-0.7	-0.4	-0.3	-0.3	-0.7	-0.4	-0.6	-0.3	-0.2	-0.5	-0.0
Taking other prescription medications	0.0	0.0	0.1	-0.3	-0.0	0.0	0.2	-0.2	0.2	0.2	-0.1	0.2	-0.0	0.0	0.0	0.1	-0.1	0.1	-0.0	0.2	-0.2	-0.1
Medication: Simvastatin	0.0	0.0	0.2	-0.4	-0.0	-0.0	0.3	-0.1	0.1	0.3	-0.4	0.1	-0.1	0.0	-0.1	0.0	-0.1	0.2	0.2	-0.1	0.0	-0.2
Exposure to tobacco smoke outside home	0.0	0.1	0.2	-0.1	0.0	0.1	0.0	0.0	0.5	0.2	0.4	0.5	-0.1	-0.1	-0.0	0.4	-0.1	0.3	-0.1	0.2	0.0	-0.0
Long-standing illness, disability or infirmity	0.0	0.1	0.6	-0.5	-0.1	-0.1	-0.4	-0.2	-0.1	-0.1	-0.0	0.0	-0.2	-0.3	-0.3	-0.1	-0.1	-0.1	-0.2	-0.8	-0.1	-0.1
Back pain experienced in last month	0.0	0.1	0.5	-0.1	-0.0	0.1	0.0	0.3	0.2	0.4	-0.1	0.4	0.0	0.0	0.2	0.3	-0.1	0.3	-0.2	0.7	-0.1	-0.0
Number of self-reported non-cancer illnesses	0.0	0.0	0.2	-0.3	-0.0	-0.1	-0.1	-0.1	0.1	-0.4	0.2	-0.3	-0.0	-0.1	0.1	-0.1	-0.0	-0.3	-0.1	-0.3	-0.0	0.0
Supplements: Fish oil (including cod liver oil)	0.0	0.0	0.5	0.2	-0.1	-0.1	-0.2	-0.0	0.4	-0.0	-0.0	-0.0	-0.0	-0.1	0.0	0.2	-0.1	-0.1	-0.2	-0.7	-0.1	0.0
Ever had prostate specific antigen (PSA) test	0.0	0.1	0.3	-0.3	-0.1	-0.0	0.0	-0.2	0.3	0.4	-0.5	0.1	-0.0	0.1	0.1	0.1	-0.1	0.1	-0.1	-0.6	-0.2	-0.0

Hub : Genes

C16orf88

Models

Trait associations