Best TWAS P=2.4e-09 · Best GWAS P=4.3e-08 conditioned to 0.418
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Artery Aorta | CTC-435M10.6 | 0.16 | 0.14 | lasso | 3 | 0.13 | 1.3e-07 | 5.3 | 5.2 | 1.7e-07 | 0.99 | 0.02 | 0.98 | FALSE |
2 | GTEx | Brain Cerebellar Hemisphere | B3GNT8 | 0.38 | 0.30 | lasso | 5 | 0.23 | 1.1e-06 | 5.5 | 5.2 | 1.7e-07 | 0.97 | 0.01 | 0.98 | FALSE |
3 | GTEx | Brain Cerebellar Hemisphere | CTC-435M10.6 | 0.29 | 0.20 | lasso | 4 | 0.18 | 2.6e-05 | 5.5 | 5.5 | 3.7e-08 | 0.99 | 0.01 | 0.96 | FALSE |
4 | GTEx | Brain Cerebellum | B3GNT8 | 0.28 | 0.23 | lasso | 5 | 0.21 | 9.2e-07 | 5.5 | 5.3 | 9.9e-08 | 0.99 | 0.02 | 0.98 | FALSE |
5 | GTEx | Brain Cerebellum | CTC-435M10.6 | 0.18 | 0.01 | lasso | 4 | 0.03 | 5.1e-02 | 5.2 | 5.6 | 2.6e-08 | 0.88 | 0.02 | 0.86 | FALSE |
6 | GTEx | Nerve Tibial | CTC-435M10.6 | 0.18 | 0.15 | lasso | 6 | 0.14 | 5.5e-10 | 5.0 | 5.1 | 2.7e-07 | 0.98 | 0.02 | 0.98 | FALSE |
7 | GTEx | Testis | EXOSC5 | 0.31 | 0.33 | enet | 10 | 0.33 | 1.8e-15 | 5.1 | 5.2 | 2.5e-07 | 0.99 | 0.02 | 0.98 | FALSE |
8 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | BCKDHA | 0.02 | 0.02 | lasso | 2 | 0.02 | 1.5e-02 | 5.2 | -5.2 | 2.0e-07 | -0.99 | 0.01 | 0.80 | FALSE |
9 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ATP5SL | 0.02 | 0.03 | enet | 4 | 0.02 | 7.0e-04 | 5.2 | -5.2 | 2.1e-07 | -0.99 | 0.02 | 0.89 | FALSE |
10 | The Cancer Genome Atlas | Brain Lower Grade Glioma | EXOSC5 | 0.04 | 0.03 | lasso | 2 | 0.02 | 5.8e-03 | 5.5 | 5.4 | 7.4e-08 | 0.95 | 0.01 | 0.77 | FALSE |
11 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | ATP5SL | 0.23 | 0.05 | blup | 18 | 0.05 | 4.5e-03 | 5.5 | -5.9 | 2.9e-09 | -0.90 | 0.01 | 0.83 | FALSE |
12 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ATP5SL | 0.03 | 0.03 | blup | 18 | 0.03 | 4.1e-04 | 5.5 | -5.3 | 1.2e-07 | -0.99 | 0.01 | 0.92 | FALSE |
13 | The Cancer Genome Atlas | Rectum Adenocarcinoma | B3GNT8 | 0.39 | 0.08 | blup | 20 | 0.07 | 1.1e-02 | 5.2 | 6.0 | 2.4e-09 | 0.85 | 0.00 | 0.29 | TRUE |
14 | The Cancer Genome Atlas | Thyroid Carcinoma | ATP5SL | 0.02 | 0.02 | blup | 18 | 0.02 | 3.5e-03 | 5.5 | -5.2 | 2.5e-07 | -0.99 | 0.01 | 0.80 | FALSE |