TWAS hub - BCKDHA

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1150	0.0260	6.4e-11	0.080	0.105	0.096	0.104	0.105	5.6e-10	1.1e-12	9.7e-12	1.4e-12	8.9e-13
2	YFS	Blood	0.0766	0.0185	1.1e-13	0.050	0.053	0.058	0.056	0.056	4.7e-16	6.4e-17	1.9e-18	7.1e-18	7.3e-18
3	TCGA	Bladder Urothelial Carcinoma	0.0200	0.0130	9.7e-03	0.025	0.012	0.014	NA	0.016	3.2e-03	3.2e-02	2.3e-02	NA	1.5e-02
4	TCGA	Head and Neck Squamous Cell Carcinoma	0.0343	0.0213	2.0e-03	0.031	0.027	0.031	NA	0.029	1.9e-04	4.4e-04	1.8e-04	NA	3.2e-04
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.1034	0.0494	7.8e-03	0.004	0.024	0.013	NA	0.003	9.6e-02	9.2e-04	1.1e-02	NA	1.5e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Hair/balding pattern: Pattern 4	12.6	30.6	50.3	6.4	5.7	7.1	5.4	0.3
Height	7.6	146.6	262.4	-13.8	-14.2	-16.2	-8.5	2.4
Comparative height size at age 10	7.6	41.6	75.7	-7.4	-7.2	-8.7	-5.0	0.2
Standing height	7.4	73.4	132.2	-10.0	-9.8	-11.5	-6.2	1.3
Sitting height	6.0	42.8	74.0	-7.5	-7.4	-8.6	-5.4	0.8
Headache pain in last month	5.7	9.8	14.7	3.8	3.2	3.7	3.1	0.7
Alcohol drinker status: Never	5.6	6.7	11.2	-2.9	-3.3	-3.1	-1.8	0.9
Medication: Paracetamol	4.8	8.0	10.4	3.1	3.0	2.7	3.2	1.9
Medication: Paracetamol	4.8	7.4	10.4	3.2	2.9	2.7	3.0	1.4
Ever unenthusiastic/disinterested for a whole week	4.6	5.6	8.2	-2.8	-1.9	-2.7	-2.9	1.0
Heart disease (siblings)	4.6	5.6	9.1	-2.8	-3.0	-2.4	-2.2	-0.8
Supplements: Fish oil (including cod liver oil)	4.5	5.9	8.0	2.7	1.4	2.1	2.8	2.8
Hair/balding pattern: Pattern 3	3.8	5.7	10.8	2.7	1.7	3.3	2.4	-1.4
Medication: Ibuprofen	3.7	4.4	6.8	2.4	2.2	1.5	2.6	1.6
Medication: Ibuprofen (e.g. Nurofen)	3.6	4.5	6.1	2.2	2.0	1.4	2.5	2.4
Hearing difficulty/problems with background noise	3.5	5.6	8.6	2.5	2.9	2.5	2.1	1.5
Trunk fat-free mass	3.5	20.2	36.4	-5.2	-5.2	-6.0	-3.1	1.0
Trunk predicted mass	3.5	20.0	36.2	-5.1	-5.2	-6.0	-3.1	0.9
Whole body fat-free mass	3.2	18.2	33.1	-4.8	-4.9	-5.8	-2.9	1.5
Bilateral oophorectomy (both ovaries removed)	3.1	3.6	4.3	-2.0	-2.1	-2.0	-1.5	1.9
Eye problems/disorders: Glaucoma	3.1	3.7	5.4	1.9	2.1	2.1	2.3	1.0
Basal metabolic rate	3.1	17.1	30.7	-4.8	-4.7	-5.5	-2.9	1.4
Heel bone mineral density (BMD) T-score, automated (right)	3.0	6.8	11.2	2.6	2.6	2.9	3.3	-1.1
Glaucoma (self-reported)	3.0	3.5	5.8	1.9	1.6	1.7	2.4	1.5
Emphysema/chronic bronchitis	3.0	3.4	5.0	-2.2	-2.1	-2.1	-1.4	1.0
Whole body water mass	3.0	17.0	30.5	-4.7	-4.7	-5.5	-2.8	1.3
Average weekly beer plus cider intake	2.9	4.2	7.1	1.8	2.0	1.4	2.2	2.7
Medication: Atenolol	2.8	3.5	7.1	-1.6	-2.7	-1.7	-2.2	-0.5
Chronic bronchitis/emphysema (mother)	2.8	3.3	5.6	1.8	2.4	1.6	1.1	1.9
Pulse rate, automated reading	2.8	9.1	13.9	3.2	3.6	3.7	2.1	-2.0
Leg predicted mass (right)	2.8	14.8	26.4	-4.2	-4.5	-5.1	-2.3	2.2
Coronary Artery Disease (CAD)	2.7	3.3	8.2	-1.7	-2.9	-2.3	0.0	-0.4
Leg fat-free mass (left)	2.7	14.5	27.0	-4.2	-4.4	-5.2	-2.3	1.8
Leg predicted mass (left)	2.7	14.5	27.0	-4.2	-4.4	-5.2	-2.3	1.7
Qualifications: NVQ or HND or HNC or equivalent	2.7	3.2	5.4	1.9	1.9	1.8	2.3	0.5
Leg fat-free mass (right)	2.7	14.6	26.1	-4.2	-4.5	-5.1	-2.3	2.2
Qualifications: None of the above	2.6	5.5	8.2	-2.6	-2.9	-2.7	-2.4	0.1
Illnesses of siblings	2.6	3.7	5.6	2.1	2.4	2.3	1.6	0.2
Heart disease (mother)	2.6	3.2	6.2	-1.9	-1.3	-1.6	-2.5	-1.3
Leg pain on walking	2.6	3.2	5.4	-1.9	-1.4	-1.4	-1.9	-2.3
Arm fat-free mass (left)	2.6	13.0	21.8	-4.2	-4.2	-4.7	-2.8	0.7
Arm predicted mass (left)	2.6	13.1	21.0	-4.2	-4.2	-4.6	-3.0	0.6
Heart attack	2.5	3.2	6.7	-1.3	-2.6	-1.8	-2.1	0.5
Medication for pain relief, constipation, heartburn	2.4	4.1	5.4	-2.3	-1.9	-2.0	-2.1	-1.8
Weight	2.1	10.3	18.1	-3.6	-3.5	-4.3	-2.2	1.8
Arm fat-free mass (right)	2.1	10.7	18.2	-3.9	-3.7	-4.3	-2.4	0.9
Arm predicted mass (right)	2.1	10.8	17.8	-3.9	-3.8	-4.2	-2.5	0.7
Prostate Cancer	2.0	2.8	6.7	2.0	1.6	2.6	0.0	-1.0
HbA1C	2.0	2.2	3.4	1.8	1.4	1.3	1.6	1.2
Ever had hysterectomy (womb removed)	2.0	2.2	3.8	-1.7	-1.7	-1.3	-2.0	-0.1
Mineral and other dietary supplements	2.0	2.7	3.5	-1.9	-1.2	-1.8	-1.8	-1.5
Heart attack/myocardial infarction (self-reported)	2.0	2.6	6.1	-1.0	-2.5	-1.5	-1.9	0.5
Heel T-Score	1.9	15.4	28.8	2.5	3.2	4.6	3.2	-5.4
Age when periods started (menarche)	1.9	4.5	5.8	-1.9	-2.2	-1.6	-2.4	-2.4
Medication: Ventolin 100micrograms inhaler	1.9	2.5	9.0	1.1	0.6	0.5	1.3	3.0
Myopia	1.9	2.8	5.6	-1.6	-2.4	-2.1	-0.6	1.0
Worrier / anxious feelings	1.8	3.5	8.5	1.2	1.9	1.6	1.0	2.9
Pulse rate	1.8	3.0	5.4	1.6	1.9	1.9	0.4	-2.3
Osteoporosis (self-reported)	1.8	2.3	3.3	1.2	1.5	1.0	1.8	1.8
Forced vital capacity (FVC), Best measure	1.7	6.0	12.8	-3.0	-1.9	-3.6	-1.7	1.3
Eye problems/disorders: None of the above	1.7	2.0	2.7	-1.3	-1.6	-1.2	-1.3	-1.6
Mouth/teeth dental problems: Mouth ulcers	1.7	2.7	4.8	-1.9	-1.6	-2.2	-1.1	1.2
Osteoarthritis (self-reported)	1.7	2.2	3.2	-1.8	-0.5	-1.6	-1.5	-1.7
Systolic Blood Pressure	1.6	8.2	16.5	-2.4	-2.5	-1.9	-3.0	-4.1
Sensitivity / hurt feelings	1.6	2.7	11.2	-0.5	0.8	-0.7	0.9	3.3
Hearing difficulty/problems: Yes	1.6	2.4	3.7	1.7	1.5	1.4	1.9	1.1
Smoking status: Previous	1.6	2.5	4.5	-1.7	-1.4	-1.6	-2.1	-0.6
Breast cancer (self-reported)	1.6	1.9	4.4	-1.4	-2.1	-1.6	-0.4	-0.5
Diastolic blood pressure, automated reading	1.6	5.0	8.0	2.4	2.1	2.8	2.1	-1.5
Qualifications: A levels/AS levels or equivalent	1.5	3.4	5.7	2.4	1.8	2.0	1.7	1.0
Prospective memory result	1.5	1.8	3.2	1.8	1.4	1.3	1.3	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.5	1.9	9.4	-0.2	-0.4	-0.1	-0.3	3.1
Migraine (self-reported)	1.5	1.9	3.8	1.7	1.1	2.0	0.9	0.9
Bipolar Disorder or Schizophrenia	1.4	3.5	7.9	1.8	1.6	0.8	1.8	2.8
Type 2 Diabetes (T2D) (2012)	1.4	1.6	2.7	1.3	1.2	1.6	1.1	-0.9
Number of treatments/medications taken	1.4	2.4	3.5	1.9	1.4	1.7	1.1	1.6
Medication: Co-codamol	1.4	1.6	4.1	1.3	0.6	0.5	1.4	2.0
Heel bone mineral density (BMD) T-score, automated (left)	1.4	3.2	5.7	1.7	1.6	2.0	2.4	-1.1
Diverticular disease/diverticulitis (self-reported)	1.4	1.6	4.9	-1.1	-0.5	-0.3	-1.4	-2.2
Shortness of breath walking on level ground	1.4	1.7	3.2	-0.9	-1.8	-1.0	-1.6	-0.7
Medication: Allopurinol	1.4	1.9	3.3	1.1	1.5	1.5	1.8	0.3
Neuroticism (2016)	1.3	1.9	4.2	-1.0	-1.3	-1.2	-1.0	2.1
Schizophrenia (2014)	1.3	2.8	4.1	1.7	1.8	1.1	1.6	2.0
Respiratory disease	1.3	2.9	9.6	0.7	0.2	-0.2	2.1	3.1
Angina	1.3	1.7	2.9	-1.1	-1.7	-1.5	-1.4	0.3
Trunk fat mass	1.3	5.7	10.4	-2.8	-2.2	-3.2	-1.6	1.7
Had other major operations	1.3	1.6	2.8	-1.7	-1.5	-1.5	-0.9	-0.3
Forced vital capacity (FVC)	1.3	4.9	11.3	-2.7	-1.7	-3.4	-1.4	1.0
Hip circumference	1.3	5.7	10.4	-2.8	-2.2	-3.2	-1.5	1.9
Qualifications: College or University degree	1.3	4.1	7.9	2.5	1.7	2.8	1.3	1.3
Mean time to correctly identify matches	1.3	2.5	4.7	1.3	1.0	0.8	2.2	2.1
Age started oral contraceptive pill	1.3	1.6	3.3	-1.3	-1.1	-1.3	-1.8	-0.4
Systolic blood pressure, automated reading	1.2	3.6	8.1	-1.7	-1.6	-1.3	-1.7	-2.8
Impedance of leg (right)	1.2	5.7	8.0	-2.6	-1.2	-2.1	-2.8	-2.7
High blood pressure (mother)	1.2	1.7	2.5	1.5	1.1	1.4	1.6	0.6
Hair/balding pattern: Pattern 2	1.2	1.5	2.2	-1.2	-0.7	-1.5	-1.1	1.5
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.5	4.1	-1.9	-1.7	-2.0	-1.3	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.4	1.6	1.2	1.0	1.3	1.2	1.2
Ever taken oral contraceptive pill	1.2	1.4	2.4	-1.6	-0.4	-1.4	-1.5	-0.0
Commuting to job workplace: Cycle	1.2	1.5	2.3	-1.0	-1.5	-1.0	-1.3	-1.1
Schizophrenia (2018)	1.1	2.3	5.0	1.6	1.5	0.9	1.1	2.2
Crohns Disease (2017)	1.1	2.3	4.2	-1.5	-1.8	-1.2	-2.1	-0.6
Severe depression (siblings)	1.1	1.2	2.7	0.7	1.2	1.2	0.2	-1.6
Mouth/teeth dental problems	1.1	1.7	3.3	0.9	1.1	1.8	-0.6	-1.7
Vitamin and mineral supplements	1.0	1.4	2.0	-1.4	-0.7	-1.3	-1.0	-1.3
Medication: Metformin	1.0	1.5	2.8	0.8	0.7	1.7	-1.4	-1.2
Townsend deprivation index at recruitment	1.0	1.4	3.5	-0.9	-1.9	-1.0	-1.4	-0.3
Impedance of arm (right)	1.0	4.8	11.2	-2.5	-2.1	-3.3	-1.4	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.1	6.9	-2.2	-1.2	-2.6	-1.0	1.0
Birth weight of first child	1.0	1.8	6.8	0.2	0.4	-0.6	1.2	2.6
Average weekly champagne plus white wine intake	1.0	1.4	2.0	1.3	1.3	1.4	1.3	-0.4
Wears glasses or contact lenses	1.0	1.2	3.3	0.9	-0.0	0.3	1.3	1.8
Ever smoked	1.0	1.7	2.7	1.4	1.6	1.6	1.1	0.2
Risk taking	1.0	1.5	2.7	1.2	1.4	1.0	1.6	0.5
Mean Putamen Volume	0.9	1.0	2.3	-1.4	-0.6	-1.5	-0.6	0.3
Chronotype (morning person)	0.9	2.0	5.7	-1.2	-1.2	-1.1	-2.4	-0.5
Waist circumference	0.9	3.3	6.2	-1.6	-1.5	-2.2	-0.5	2.5
Allergy	0.9	2.1	3.6	1.6	1.6	1.9	1.1	0.6
Number of live births	0.9	1.2	4.1	-0.3	-0.8	-1.0	0.5	2.0
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.1	2.7	-0.6	-0.7	-0.9	-1.0	1.6
Medication: Lansoprazole	0.9	1.1	2.0	1.0	1.4	1.0	0.7	0.9
Qualifications: O levels/GCSEs or equivalent	0.9	1.5	2.8	1.2	1.4	1.0	1.7	0.3
Mouth/teeth dental problems: Bleeding gums	0.9	1.1	2.3	-0.7	-0.6	-1.5	0.5	1.5
Exposure to tobacco smoke outside home	0.9	1.3	2.4	1.3	1.2	1.5	0.8	0.1
Angina (self-reported)	0.9	1.1	2.2	-0.8	-1.5	-1.2	-1.2	0.1
Medication: Omeprazole	0.9	1.1	3.5	-0.5	-0.8	-1.1	-0.0	1.9
Qualifications: nursing, teaching	0.9	1.4	2.3	1.5	1.3	1.5	0.6	0.5
Illnesses of father: None of the above (group 1)	0.9	1.1	2.3	0.4	1.1	0.9	1.0	-1.5
Hearing aid user	0.9	1.0	1.9	1.4	1.0	1.2	0.8	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.9	1.1	3.0	-0.6	-0.5	-0.3	-1.4	-1.7
Bipolar Disorder (2018)	0.8	1.3	2.9	0.9	0.6	0.2	1.5	1.7
Lupus	0.8	1.3	2.7	0.9	1.1	1.1	0.7	-1.6
Supplements: Glucosamine	0.8	1.1	1.9	1.0	1.2	1.4	0.9	-0.5
Forced expiratory volume in 1-second (FEV1)	0.8	2.7	7.0	-2.0	-1.0	-2.6	-0.9	1.0
Pulse wave reflection index	0.8	1.0	2.9	1.0	0.2	1.0	0.5	1.7
Loud music exposure frequency	0.8	0.9	2.2	-1.3	-0.2	-1.5	-0.8	0.1
Medication: Amlodipine	0.8	1.1	2.1	1.4	0.8	1.5	0.9	0.1
Whole body fat mass	0.8	3.3	5.9	-2.1	-1.6	-2.4	-1.2	1.5
Mother’s age at death	0.8	1.0	2.0	0.9	1.4	1.0	1.1	0.3
Reaction Time	0.7	1.4	2.4	1.1	1.1	0.7	1.6	1.2
LDL Cholesterol	0.7	1.2	2.2	1.5	1.1	1.2	0.9	-0.1
Cardiovascular Disease	0.7	2.2	4.7	-1.5	-1.5	-0.6	-2.2	-1.2
Type 2 Diabetes (T2D) (2018)	0.7	1.3	2.7	0.6	0.6	1.4	-1.2	-1.6
Hair Pigment	0.7	19.2	34.5	-4.9	-3.7	-4.8	-5.9	-0.6
Relative age voice broke	0.7	1.0	1.6	1.2	1.3	1.2	0.4	-0.8
Impedance of leg (left)	0.7	3.3	5.3	-2.0	-0.8	-1.5	-2.3	-2.0
Blood clot in the leg (DVT)	0.7	0.9	2.4	-0.4	-0.3	-0.1	-1.4	-1.6
High blood pressure (siblings)	0.7	1.0	1.5	-1.2	-1.0	-1.2	-0.8	0.4
Long-standing illness, disability or infirmity	0.7	1.1	2.0	1.2	0.9	1.2	0.1	1.4
Commuting to job workplace: Walk	0.7	0.8	2.2	-0.3	-1.5	-0.5	-0.3	-1.2
Medication: Lisinopril	0.7	0.9	1.7	0.8	1.0	0.2	1.3	1.2
Fractured/broken bones in last 5 years	0.7	0.9	1.5	-1.0	-0.8	-1.2	-0.5	0.9
Ovarian Cancer	0.6	0.7	1.5	0.8	0.4	0.2	1.2	1.2
Neuroticism	0.6	1.4	6.7	-0.2	0.2	-0.3	-0.4	2.6
Trunk fat percentage	0.6	2.5	4.5	-1.8	-1.2	-2.1	-1.0	1.5
Hand grip strength (right)	0.6	1.6	6.8	-0.2	0.4	0.5	-0.8	-2.6
Current tobacco smoking	0.6	1.0	1.9	0.9	0.7	1.4	1.4	0.5
Alcohol usually taken with meals	0.6	1.0	2.4	-1.0	-0.6	-0.9	-1.6	-0.8
Pain all over the body in last month	0.6	0.7	1.3	-0.7	-0.7	-0.7	-1.1	0.7
Neuroticism score	0.6	1.2	5.1	-0.6	-0.0	-0.6	-0.4	2.2
Falls in the last year	0.6	0.8	1.4	1.2	0.6	1.2	0.7	0.8
Impedance of arm (left)	0.6	2.8	7.3	-2.0	-1.4	-2.7	-0.9	0.3
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	2.7	0.6	1.3	0.1	1.6	0.2
Number of full brothers	0.6	0.8	1.6	-0.7	-1.0	-0.6	-1.3	-0.7
Pulse wave peak to peak time	0.6	0.7	1.6	-1.3	-0.1	-1.1	-0.1	-0.8
Leg fat mass (right)	0.6	2.2	3.1	-1.8	-1.2	-1.8	-1.5	1.0
Number of full sisters	0.6	0.7	2.4	0.0	-0.6	-0.3	-0.7	1.6
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	1.5	1.0	0.5	0.8	1.2	-0.2
Medication: Aspirin	0.6	0.8	1.8	-0.2	-1.0	0.1	-1.1	-1.3
Miserableness	0.6	1.1	2.1	-1.3	-0.9	-0.8	-1.5	-0.3
Irritability	0.6	1.1	2.2	-1.0	-0.2	-1.5	-0.9	1.1
Medication: Omeprazole (e.g. Zanprol)	0.6	0.8	2.9	0.5	-0.0	0.2	0.8	1.7
Pain experienced in last month	0.6	0.9	1.5	-0.9	-1.1	-0.3	-1.0	-1.2
Supplements: Calcium	0.6	0.6	1.2	-0.9	-0.8	-0.8	-1.1	-0.2
Basal cell carcinoma (self-reported)	0.6	0.7	2.4	-0.7	-0.3	-0.4	-0.8	-1.6
Impedance of whole body	0.6	3.0	4.9	-2.2	-1.4	-2.2	-1.7	-0.9
Body Mass Index (BMI) (2010)	0.5	0.6	1.4	-0.5	-0.6	-0.5	-1.2	-1.0
Triglycerides	0.5	0.9	1.7	1.3	0.5	1.3	0.8	0.0
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.8	0.7	0.7	0.2	0.9	1.4
Ever used hormone-replacement therapy (HRT)	0.5	0.6	1.5	-0.7	-0.1	-1.1	0.2	1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.6	2.3	0.4	0.0	0.2	0.7	1.5
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.5	-0.5	-0.6	-0.7	-0.2	1.2
Financial difficulties in last 2 years	0.5	0.7	1.6	0.7	0.8	0.7	1.2	0.3
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	1.6	0.5	0.2	0.2	1.3	1.1
Happiness	0.5	0.6	2.6	0.3	-0.3	-0.3	0.4	1.6
Illnesses of mother	0.5	0.6	2.7	-0.4	-0.1	-0.0	-0.3	-1.7
Gout (self-reported)	0.5	0.7	1.8	0.5	0.8	0.9	1.3	0.0
Worry too long after embarrassment	0.5	0.9	3.9	0.2	0.6	0.1	-0.3	2.0
Age at first live birth	0.5	0.9	1.7	0.6	0.9	1.2	0.3	-1.3
Neck or shoulder pain in last month	0.5	0.7	3.1	-0.1	-0.0	-0.4	0.3	1.7
Supplements: Vitamin C	0.5	0.5	2.1	0.4	-0.6	-0.0	-0.0	1.5
Illnesses of father: Heart disease	0.5	0.8	1.7	-0.2	-1.0	-0.8	-0.7	1.3
Handedness (chirality/laterality): Left-handed	0.5	0.5	1.1	-0.5	-1.0	-1.0	-0.6	0.2
Ever had bowel cancer screening	0.5	0.6	1.7	-0.5	-1.3	-0.8	-0.1	0.6
Diabetes diagnosed by doctor	0.5	0.8	1.5	0.5	0.3	1.2	-1.2	-0.9
Alzheimer’s Disease (in mother)	0.4	0.5	0.9	-0.8	-0.9	-0.8	-0.1	-0.6
Crohns Disease (2012)	0.4	0.7	2.4	-0.3	-0.9	-0.0	-1.6	0.3
HDL Cholesterol	0.4	0.7	1.4	0.9	0.9	1.2	0.7	0.2
Blood White Count	0.4	3.3	8.0	-1.4	-0.4	-0.3	-2.5	-2.8
Relative age of first facial hair	0.4	0.9	1.6	0.8	1.1	1.0	0.2	-1.3
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	1.0	0.8	0.6	1.0	-0.6	0.1
Average weekly fortified wine intake	0.4	0.5	1.7	-0.2	0.6	0.2	0.3	-1.3
Maternal smoking around birth	0.4	0.6	1.6	0.8	0.5	0.2	1.3	0.4
Chronic bronchitis/emphysema (father)	0.4	0.4	0.7	0.6	0.3	0.6	0.7	0.8
Number of incorrect matches in round	0.4	0.6	1.1	-1.0	-0.8	-1.0	-0.8	0.0
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	2.7	-0.3	-0.2	-0.3	-0.5	1.6
Diabetes (self-reported)	0.4	0.6	1.4	0.7	0.3	1.2	-0.7	-0.5
Medication: Ramipril	0.4	0.5	1.3	0.4	-0.2	1.1	-0.2	-1.1
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.8	-0.8	-0.0	-0.2	-1.3	0.5
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	1.3	-0.9	-1.1	-0.8	0.1	-1.1
Birth weight	0.4	0.9	3.6	-0.0	-0.5	-0.9	0.3	1.9
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.4	1.4	0.6	0.3	0.3	1.2	0.5
Medication: Blood pressure	0.4	0.6	1.7	-0.4	-0.8	0.0	-1.3	-0.8
Medication: Seretide 50 evohaler	0.4	0.5	0.8	0.7	0.8	0.4	0.9	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.9	-0.5	-0.5	-0.1	-0.5	-1.4
Suffer from ‘nerves’	0.4	0.6	0.9	-0.8	-1.0	-0.6	-0.9	0.4
Overall health rating	0.4	0.8	3.8	0.2	-0.0	-0.0	0.5	2.0
Family relationship satisfaction	0.4	0.5	1.3	-0.4	-0.3	-0.9	-0.1	1.1
Loneliness, isolation	0.4	0.6	1.9	-0.3	-0.8	-0.7	0.1	1.4
Medication: Aspirin	0.4	0.5	0.9	0.2	-0.7	0.5	-0.8	-0.9
Smoking status: Current	0.4	0.6	1.2	0.7	0.5	1.1	1.0	0.4
Financial situation satisfaction	0.4	0.5	0.9	0.6	0.5	0.6	0.9	-0.9
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.0	-0.4	-1.0	-0.3	-0.5	0.9
Ever depressed for a whole week	0.4	0.6	0.9	-0.7	-0.4	-0.7	-1.0	0.9
Leg fat mass (left)	0.4	1.6	2.2	-1.5	-1.0	-1.4	-1.3	1.1
Schizophrenia vs Biploar Disorder	0.3	0.4	0.9	-0.6	0.0	-0.3	-0.6	-1.0
Irritable Bowel Disease (IBD)	0.3	0.8	2.0	-1.0	-0.9	-0.6	-1.4	-0.1
Breast Cancer	0.3	0.6	1.1	0.9	1.0	1.0	0.5	-0.0
Rheumatoid Arthritis	0.3	0.5	1.2	-0.5	-1.1	-0.9	-0.3	0.1
Allergy or Eczema	0.3	0.8	2.3	-0.8	-0.8	-1.5	0.3	0.4
Lung FVC	0.3	1.4	4.0	0.9	2.0	1.3	0.8	0.1
Hand grip strength (left)	0.3	0.7	2.8	0.4	0.4	0.6	-0.4	-1.7
Average weekly spirits intake	0.3	0.4	0.7	0.7	0.8	0.9	-0.1	-0.3
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.9	-0.4	-0.9	-0.4	-0.7	0.4
Fed-up feelings	0.3	0.5	0.9	-0.4	-0.9	-0.8	-0.1	1.0
Qualifications: CSEs or equivalent	0.3	0.4	0.9	-0.9	-0.5	-0.9	-0.4	-0.3
Hayfever, allergic rhinitis or eczema	0.3	0.8	1.5	-0.9	-0.8	-1.2	-0.5	-0.8
Multivitamins +/- minerals	0.3	0.4	0.6	0.6	0.5	0.4	0.8	0.8
Pulse wave Arterial Stiffness index	0.3	0.4	1.1	0.6	-0.5	0.3	-0.2	1.1
Arm fat mass (right)	0.3	1.4	2.7	-1.2	-0.7	-1.5	-0.5	1.6
Tense / ‘highly strung’	0.3	0.5	1.8	-0.2	0.3	-0.5	-0.2	1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.4	-0.8	-0.1	-0.4	-0.6	1.2
Number of children fathered	0.3	0.4	0.8	-0.9	0.3	-0.9	-0.0	-0.5
Alcohol intake frequency.	0.3	0.7	2.9	0.4	-0.6	0.2	0.1	1.7
Chest pain or discomfort	0.3	0.4	0.9	0.5	0.7	0.9	0.5	0.3
Age at last live birth	0.3	0.5	0.7	0.8	0.7	0.5	0.8	0.6
Commuting to job workplace: Car/motor vehicle	0.3	0.4	1.4	-0.5	0.0	-0.2	-0.3	-1.2
Knee pain experienced in last month	0.3	0.5	1.1	0.7	1.0	0.4	0.8	-0.0
Illnesses of siblings: Diabetes	0.3	0.4	0.9	-0.6	-0.2	-0.0	-0.9	-0.8
Mood swings	0.3	0.5	0.9	-0.8	-0.2	-0.9	-0.9	-0.1
Eye problems/disorders: Cataract	0.3	0.4	0.6	-0.8	-0.2	-0.5	-0.7	-0.7
Medication: Gliclazide	0.3	0.4	0.8	0.4	0.0	0.6	-0.8	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	2.0	0.7	1.4	0.8	0.1	-0.3
Arm fat mass (left)	0.3	1.3	2.7	-1.2	-0.7	-1.4	-0.6	1.6
Number of self-reported non-cancer illnesses	0.3	0.5	1.5	-0.3	-0.7	-0.2	-0.7	1.2
Guilty feelings	0.3	0.5	2.0	0.2	0.3	-0.0	0.7	1.4
Number of operations (self-reported)	0.3	0.4	0.8	-0.9	0.2	-0.7	-0.5	-0.7
Ever had prostate specific antigen (PSA) test	0.3	0.3	1.0	0.1	-0.3	0.2	1.0	-0.7
Pack years of smoking	0.3	0.5	1.6	0.2	-0.5	-0.3	0.5	1.3
Neuroticism (Nagel 2018)	0.2	0.4	1.5	-0.5	0.2	-0.7	-0.2	1.2
Major Depression (MDD)	0.2	0.3	0.9	-0.3	0.1	-0.9	0.0	0.6
Verbal and Numeric Reasoning (VNR)	0.2	0.4	0.8	0.5	0.9	0.8	0.3	0.4
Bipolar Disorder (2011)	0.2	0.1	0.7	0.0	0.0	0.8	0.0	0.3
Fasting Glucose	0.2	0.3	0.7	0.2	0.1	0.4	0.7	0.8
Waist Hip Ratio (WHR)	0.2	0.8	1.1	-0.8	-1.1	-1.1	0.4	1.0
Hypothyroidism (self reported)	0.2	0.4	1.2	-0.4	-0.5	-0.3	0.4	-1.1
Tanning	0.2	1.9	3.1	-1.1	-1.8	-1.4	-1.2	1.4
Medication for hormone replacement therapy	0.2	0.2	0.4	-0.5	-0.4	-0.5	-0.6	0.4
Supplements: Zinc	0.2	0.2	0.7	0.2	0.5	-0.5	0.1	0.8
Diabetes (father)	0.2	0.3	0.5	0.5	0.2	0.7	-0.0	0.7
Pack years adult smoking proportion	0.2	0.4	1.3	0.3	-0.2	-0.1	0.6	1.1
Taking other prescription medications	0.2	0.4	0.9	0.7	0.4	0.4	0.4	0.9
Serious illness, injury or assault to yourself	0.2	0.3	0.4	0.5	0.5	0.5	0.3	-0.6
Stomach or abdominal pain in last month	0.2	0.2	0.9	-0.0	-0.2	-0.1	-0.5	-1.0
Medication: Levothyroxine sodium	0.2	0.3	0.6	-0.4	-0.7	-0.5	0.8	-0.2
Body mass index (BMI)	0.2	0.9	1.8	0.8	1.0	0.8	0.6	1.3
Past tobacco smoking	0.2	0.4	1.3	0.6	0.3	0.5	1.1	0.2
Nervous feelings	0.2	0.3	1.1	-0.1	-0.2	0.3	-0.6	1.0
Had menopause	0.2	0.3	1.1	-0.1	0.3	0.0	0.2	1.1
Medication: Simvastatin	0.2	0.4	0.9	0.6	-0.0	0.7	-0.2	0.9
Fluid intelligence score	0.2	0.4	1.0	0.5	0.8	1.0	0.2	-0.0
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.6	-0.5	-0.6	-0.5	-0.8	0.2
Mouth/teeth dental problems: Dentures	0.2	0.4	0.6	-0.3	-0.6	-0.7	0.8	0.7
Asthma	0.2	0.3	0.8	0.1	0.1	-0.2	0.8	0.9
Medication: Cholesterol lowering	0.2	0.3	1.0	0.5	-0.2	1.0	-0.5	0.1
Depression (self-reported)	0.2	0.2	0.4	0.4	0.3	0.6	0.3	0.6
Lung cancer (father)	0.2	0.2	0.5	-0.2	-0.4	-0.7	0.1	0.5
Length of working week for main job	0.2	0.2	0.5	0.4	0.0	0.2	0.7	0.5
Exposure to tobacco smoke at home	0.2	0.3	0.8	0.5	0.3	0.3	0.9	-0.3
Body fat percentage	0.2	0.7	1.4	-0.9	-0.3	-1.0	-0.7	1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.5	0.7	0.6	0.4	0.1	0.2
Arm fat percentage (left)	0.2	0.8	3.0	0.4	0.9	0.2	0.5	1.7
Friendships satisfaction	0.2	0.3	0.6	-0.7	-0.3	-0.8	-0.5	0.3
Back pain experienced in last month	0.2	0.3	0.6	0.2	0.7	0.2	0.5	0.8
Commuting to job workplace: Public transport	0.2	0.2	0.5	0.4	0.3	0.2	0.7	0.6
Medication: Bendroflumethiazide	0.2	0.3	0.7	-0.5	-0.6	-0.4	-0.8	-0.5
Vascular/heart problems diagnosed by doctor	0.2	0.6	1.2	0.7	1.1	0.5	0.9	-0.4
Alcohol drinker status: Previous	0.2	0.2	0.5	0.6	0.2	0.7	-0.5	-0.3
Depressed Affect (Nagel 2018)	0.1	0.3	0.5	-0.6	-0.4	-0.7	-0.4	0.4
Intelligence (Savage-Jansen 2018)	0.1	0.4	0.7	0.6	0.5	0.8	0.2	0.9
Worry (Nagel 2018)	0.1	0.3	0.6	0.4	0.6	0.3	0.4	0.8
Alzheimer’s Disease (in father)	0.1	0.1	0.4	-0.3	-0.1	0.2	-0.2	-0.6
Alzheimer’s Disease (including proxy)	0.1	0.1	0.3	-0.4	-0.1	-0.1	0.6	-0.4
Ulcerative Colitis (UC)	0.1	0.3	0.7	0.3	0.9	0.7	0.3	-0.1
Age at First Birth	0.1	0.1	0.4	0.3	-0.1	0.2	0.6	0.2
Primary Biliary Cirrhosis	0.1	0.1	0.3	0.5	0.1	0.5	0.3	0.1
Ulcerative Colitis	0.1	0.2	0.6	0.2	0.8	0.5	-0.0	-0.1
Blood Eosinophil Count	0.1	0.8	1.6	-1.2	-0.7	-1.3	-0.4	-0.6
Blood Platelet Count	0.1	1.0	4.2	0.4	2.0	0.5	-0.7	0.3
Blood Red Count	0.1	1.0	2.0	0.3	0.8	0.6	-1.3	-1.4
Smoking Status	0.1	0.1	0.4	-0.3	-0.2	0.1	-0.0	0.7
Lung FEV1/FVC ratio	0.1	0.6	1.8	-0.3	-1.3	-0.5	-0.8	0.5
Diabetes (mother)	0.1	0.1	0.3	0.3	0.3	0.3	-0.1	0.6
High blood pressure	0.1	0.1	0.3	-0.4	-0.5	0.2	-0.5	-0.1
Arm fat percentage (right)	0.1	0.6	2.5	0.2	0.5	-0.1	0.2	1.6
Time employed in main current job	0.1	0.1	0.2	-0.5	0.2	-0.2	-0.0	-0.1
Alcohol intake versus 10 years previously	0.1	0.1	0.3	0.1	0.3	0.0	0.5	-0.5
Father’s age at death	0.1	0.1	0.3	-0.0	0.4	0.4	0.1	-0.5
Noisy workplace	0.1	0.2	0.7	-0.0	-0.0	-0.3	-0.1	0.8
Peak expiratory flow (PEF)	0.1	0.3	1.1	-0.2	0.2	-0.6	-0.1	1.0
Leg fat percentage (right)	0.1	0.3	1.3	-0.6	0.4	-0.1	-1.1	0.0
Wheeze or whistling in the chest in last year	0.1	0.2	0.3	-0.5	-0.5	-0.5	0.0	-0.5
Health satisfaction	0.1	0.1	0.2	0.1	-0.3	0.1	0.4	-0.5
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.4	0.2	-0.1	0.6	0.5	0.2
Had major operations	0.1	0.1	0.4	-0.2	-0.3	0.1	-0.2	-0.6
Hypertension (Self-reported)	0.1	0.2	0.4	-0.5	-0.6	-0.0	-0.6	-0.3
Medication for cholesterol	0.1	0.1	0.4	-0.1	0.2	0.2	0.3	-0.6
Asthma (self-reported)	0.1	0.2	0.5	-0.2	-0.1	-0.5	0.5	0.7
Medication: Blood pressure	0.1	0.1	0.3	-0.1	-0.6	-0.5	-0.2	-0.1
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.2	-0.3	0.2	-0.3	-0.1	-0.4
High cholesterol (Self-reported)	0.1	0.1	0.3	0.3	0.0	0.5	-0.4	0.2
Medication: Atorvastatin	0.1	0.2	0.3	0.4	-0.3	0.5	-0.6	-0.0
Illnesses of father: High blood pressure	0.1	0.1	0.5	-0.0	-0.3	-0.2	-0.2	-0.7
Leg fat percentage (left)	0.1	0.3	0.7	-0.3	0.5	0.2	-0.9	0.5
Cholesterol lowering medication	0.1	0.2	0.8	0.4	-0.0	0.0	-0.2	0.9
Depression (Nagel 2018)	0.0	0.1	0.1	0.3	-0.3	0.3	0.3	0.1
BMI	0.0	0.1	0.2	-0.1	-0.2	0.3	-0.4	0.2
Breastfed as a baby	0.0	0.1	0.1	0.2	0.4	0.2	0.2	0.2
Comparative body size at age 10	0.0	0.1	0.2	0.2	-0.2	0.3	0.5	-0.5
Average weekly red wine intake	0.0	0.0	0.1	-0.0	0.0	0.0	0.4	0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.0	0.0	0.1	-0.1	0.0	-0.3	0.1	0.0
Unable to work because of sickness or disability	0.0	0.1	0.1	0.3	0.1	0.3	-0.1	-0.3

Hub : Genes

BCKDHA

Models

Trait associations