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chr14:102,544,860-105,211,221

Best TWAS P=3.68e-11 · Best GWAS P=1.44e-11 conditioned to 0.000139

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
51	The Cancer Genome Atlas	Lung Adenocarcinoma	C14orf153	0.06	0.02	blup	38	0.04	2.4e-05	-5.1	-6.6	3.7e-11	0.03	0.02	0.92	TRUE
44	METSIM	Adipose	TRAF3	0.04	0.02	enet	7	0.04	4.5e-06	5.5	5.9	4.0e-09	0.79	0.04	0.96	TRUE
52	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	CKB	0.03	0.00	blup	34	0.02	1.4e-03	5.2	-6.5	6.4e-11	0.03	0.02	0.68	FALSE
54	The Cancer Genome Atlas	Prostate Adenocarcinoma	C14orf153	0.09	0.08	blup	38	0.09	6.2e-10	-5.4	-6.4	1.2e-10	0.04	0.01	0.99	FALSE
50	The Cancer Genome Atlas	Brain Lower Grade Glioma	C14orf153	0.04	0.01	blup	38	0.03	6.2e-04	4.8	-6.4	1.5e-10	0.03	0.02	0.76	FALSE
55	The Cancer Genome Atlas	Prostate Adenocarcinoma	CKB	0.07	0.09	blup	32	0.10	1.1e-10	5.5	-6.3	3.9e-10	0.02	0.01	0.99	FALSE
35	GTEx	Spleen	KLC1	0.15	0.05	lasso	3	0.03	6.4e-02	5.5	6.2	4.7e-10	-0.03	0.04	0.62	FALSE
5	GTEx	Adrenal Gland	KLC1	0.15	0.03	lasso	3	0.06	4.6e-03	5.3	6.2	5.1e-10	-0.03	0.06	0.63	FALSE
13	GTEx	Brain Frontal Cortex BA9	APOPT1	0.17	0.07	lasso	3	0.08	4.6e-03	5.5	-6.2	5.9e-10	0.02	0.04	0.80	FALSE
14	GTEx	Breast Mammary Tissue	KLC1	0.12	0.02	enet	26	0.07	2.9e-04	4.4	6.2	7.0e-10	0.00	0.23	0.74	FALSE
1	GTEx	Adipose Subcutaneous	KLC1	0.05	0.03	lasso	3	0.03	1.8e-03	4.8	6.2	7.5e-10	-0.02	0.07	0.75	FALSE
42	METSIM	Adipose	MARK3	0.03	0.02	lasso	6	0.03	6.3e-05	5.2	-6.1	9.7e-10	0.04	0.08	0.91	FALSE
47	The Cancer Genome Atlas	Glioblastoma Multiforme	C14orf153	0.14	0.01	blup	40	0.03	3.5e-02	-5.1	-6.0	1.4e-09	0.02	0.01	0.38	FALSE
26	GTEx	Muscle Skeletal	APOPT1	0.14	0.21	enet	10	0.22	6.7e-21	-5.1	5.9	2.9e-09	-0.02	0.06	0.94	FALSE
57	The Cancer Genome Atlas	Thyroid Carcinoma	KLC1	0.04	0.01	blup	82	0.03	5.4e-04	4.9	5.9	3.6e-09	-0.03	0.03	0.81	FALSE
53	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	C14orf153	0.11	0.11	lasso	3	0.10	1.1e-04	-5.4	-5.9	4.6e-09	0.03	0.01	0.95	FALSE
25	GTEx	Muscle Skeletal	KLC1	0.11	0.07	lasso	7	0.08	3.3e-08	-5.1	5.8	5.0e-09	-0.02	0.09	0.90	FALSE
3	GTEx	Adipose Subcutaneous	APOPT1	0.06	0.02	lasso	5	0.02	8.2e-03	5.5	-5.8	5.2e-09	0.03	0.08	0.82	FALSE
33	GTEx	Skin Sun Exposed Lower leg	MARK3	0.10	0.09	enet	13	0.08	7.5e-07	-5.2	-5.8	6.2e-09	0.02	0.27	0.73	FALSE
6	GTEx	Artery Aorta	KLC1	0.10	0.14	lasso	3	0.14	6.1e-08	-5.1	5.8	8.5e-09	0.00	0.09	0.90	FALSE
17	GTEx	Cells Transformed fibroblasts	APOPT1	0.14	0.12	lasso	3	0.10	6.4e-08	-5.2	-5.7	1.0e-08	0.00	0.08	0.91	FALSE
16	GTEx	Cells Transformed fibroblasts	KLC1	0.16	0.11	enet	17	0.10	3.1e-08	5.5	5.7	1.4e-08	-0.03	0.03	0.97	FALSE
23	GTEx	Lung	CKB	0.07	0.01	lasso	2	0.01	3.4e-02	-5.2	-5.7	1.5e-08	0.01	0.09	0.75	FALSE
56	The Cancer Genome Atlas	Stomach Adenocarcinoma	C14orf153	0.20	0.05	lasso	2	0.04	8.8e-04	5.5	-5.6	1.9e-08	0.02	0.01	0.86	FALSE
12	GTEx	Artery Tibial	RP11-73M18.6	0.05	0.03	lasso	2	0.02	4.7e-03	5.5	5.6	2.2e-08	-0.04	0.05	0.80	FALSE
4	GTEx	Adipose Visceral Omentum	KLC1	0.06	0.02	lasso	2	0.00	2.2e-01	-5.2	5.6	2.3e-08	0.00	0.08	0.49	FALSE
46	The Cancer Genome Atlas	Breast Invasive Carcinoma	C14orf153	0.05	0.02	lasso	4	0.02	8.0e-05	-5.1	-5.6	2.3e-08	0.03	0.02	0.98	FALSE
18	GTEx	Colon Transverse	KLC1	0.16	0.01	lasso	7	0.00	1.9e-01	4.9	5.5	3.1e-08	-0.02	0.07	0.56	FALSE
24	GTEx	Muscle Skeletal	ZFYVE21	0.10	0.05	lasso	2	0.03	3.3e-04	-5.2	5.5	4.5e-08	-0.02	0.09	0.86	FALSE
2	GTEx	Adipose Subcutaneous	XRCC3	0.09	0.08	lasso	5	0.07	3.8e-06	5.2	5.5	5.0e-08	-0.03	0.08	0.92	FALSE
34	GTEx	Skin Sun Exposed Lower leg	KLC1	0.06	0.09	enet	19	0.08	2.2e-07	5.5	5.5	5.0e-08	-0.02	0.04	0.96	FALSE
21	GTEx	Esophagus Muscularis	KLC1	0.07	0.01	enet	10	0.02	2.6e-02	-5.2	5.4	5.5e-08	-0.04	0.07	0.67	FALSE
19	GTEx	Colon Transverse	BAG5	0.14	0.05	lasso	10	0.02	4.8e-02	5.4	5.4	6.8e-08	-0.06	0.08	0.76	FALSE
28	GTEx	Pituitary	MARK3	0.21	0.27	enet	8	0.25	4.9e-07	-5.1	-5.4	7.4e-08	0.02	0.22	0.64	FALSE
48	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MARK3	0.07	0.03	blup	64	0.06	5.5e-07	-3.8	-5.3	8.8e-08	0.03	0.04	0.95	FALSE
20	GTEx	Esophagus Mucosa	XRCC3	0.12	0.15	lasso	2	0.13	4.4e-09	5.3	5.3	9.3e-08	-0.02	0.04	0.96	FALSE
31	GTEx	Prostate	RP11-73M18.8	0.15	0.29	lasso	1	0.25	5.2e-07	5.3	5.3	9.5e-08	-0.02	0.05	0.88	FALSE
30	GTEx	Prostate	MARK3	0.18	0.22	enet	11	0.20	8.0e-06	-5.1	-5.3	1.0e-07	0.03	0.20	0.61	FALSE
7	GTEx	Artery Coronary	APOPT1	0.19	0.02	lasso	5	0.05	1.2e-02	3.5	-5.3	1.1e-07	0.07	0.07	0.33	FALSE
27	GTEx	Nerve Tibial	XRCC3	0.08	0.06	lasso	3	0.05	3.5e-04	5.5	5.3	1.1e-07	-0.05	0.07	0.93	FALSE
29	GTEx	Pituitary	RP11-73M18.8	0.23	0.17	lasso	2	0.13	3.6e-04	5.5	5.3	1.2e-07	-0.04	0.05	0.68	FALSE
49	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	XRCC3	0.03	0.04	enet	3	0.04	6.1e-05	5.3	5.3	1.2e-07	-0.02	0.01	0.99	FALSE
40	GTEx	Whole Blood	KLC1	0.16	0.13	lasso	3	0.11	3.6e-10	5.3	5.3	1.3e-07	-0.03	0.04	0.96	FALSE
22	GTEx	Lung	MARK3	0.06	0.02	lasso	3	0.01	6.6e-02	-5.1	-5.2	1.6e-07	0.02	0.18	0.61	FALSE
9	GTEx	Artery Tibial	KLC1	0.11	0.08	lasso	3	0.08	1.1e-06	-5.2	5.2	1.7e-07	-0.01	0.09	0.90	FALSE
32	GTEx	Skin Not Sun Exposed Suprapubic	XRCC3	0.14	0.03	lasso	14	0.03	1.3e-02	5.3	5.2	1.7e-07	-0.02	0.08	0.89	FALSE
37	GTEx	Testis	ZFYVE21	0.11	0.14	lasso	2	0.11	1.4e-05	-5.2	5.2	1.8e-07	0.00	0.09	0.86	FALSE
8	GTEx	Artery Tibial	ZFYVE21	0.11	0.09	lasso	1	0.08	8.0e-07	-5.2	5.2	2.2e-07	0.00	0.08	0.91	FALSE
36	GTEx	Stomach	MARK3	0.10	0.09	lasso	2	0.04	4.5e-03	-5.1	-5.2	2.2e-07	0.02	0.16	0.54	FALSE
39	GTEx	Thyroid	APOPT1	0.11	0.12	lasso	1	0.10	1.9e-08	5.2	-5.2	2.2e-07	0.02	0.13	0.87	FALSE
43	METSIM	Adipose	TDRD9	0.08	0.04	lasso	10	0.06	1.9e-09	4.9	-5.2	2.2e-07	0.03	0.14	0.86	FALSE
38	GTEx	Testis	KLC1	0.17	0.17	lasso	2	0.15	4.4e-07	5.3	5.2	2.3e-07	-0.02	0.08	0.91	FALSE
10	GTEx	Artery Tibial	TRMT61A	0.07	0.07	lasso	3	0.06	2.4e-05	-5.2	-5.2	2.7e-07	0.03	0.11	0.87	FALSE
41	GTEx	Whole Blood	XRCC3	0.08	0.12	lasso	3	0.10	1.3e-09	5.3	5.1	2.7e-07	-0.02	0.04	0.96	FALSE
45	YFS	Blood	KLC1	0.01	0.01	blup	389	0.01	1.0e-03	-5.2	5.1	2.8e-07	-0.03	0.08	0.79	FALSE
11	GTEx	Artery Tibial	RP11-73M18.8	0.09	0.06	lasso	4	0.09	7.4e-08	5.5	5.1	2.9e-07	-0.04	0.04	0.96	FALSE
15	GTEx	Breast Mammary Tissue (Female)	KLC1	0.09	0.00	lasso	2	0.00	2.4e-01	4.8	5.1	3.0e-07	-0.01	0.07	0.29	FALSE