Best TWAS P=9.49e-10 · Best GWAS P=4.55e-10 conditioned to 0.0089
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | EFCAB5 | 0.11 | 0.18 | blup | 392 | 0.17 | 1.7e-20 | -5.41 | -5.9 | 3.0e-09 | -0.58 | 0.10 | 0.90 | FALSE |
2 | GTEx | Brain Nucleus accumbens basal ganglia | CORO6 | 0.11 | 0.10 | lasso | 2 | 0.05 | 2.2e-02 | -5.11 | 5.2 | 2.5e-07 | 0.57 | 0.06 | 0.76 | FALSE |
3 | GTEx | Esophagus Muscularis | SSH2 | 0.04 | 0.01 | enet | 10 | 0.00 | 3.3e-01 | -4.80 | -5.5 | 4.9e-08 | -0.45 | 0.31 | 0.46 | FALSE |
4 | GTEx | Lung | SSH2 | 0.08 | 0.05 | lasso | 6 | 0.06 | 2.7e-05 | -4.57 | -5.1 | 2.7e-07 | -0.64 | 0.47 | 0.53 | FALSE |
5 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | EFCAB5 | 0.06 | 0.08 | lasso | 2 | 0.07 | 1.4e-06 | -4.90 | -5.4 | 5.9e-08 | -0.68 | 0.06 | 0.93 | FALSE |
6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | EFCAB5 | 0.02 | 0.04 | lasso | 4 | 0.04 | 1.9e-08 | -5.41 | -5.2 | 1.7e-07 | -0.54 | 0.07 | 0.93 | FALSE |
7 | The Cancer Genome Atlas | Colon Adenocarcinoma | CCDC55 | 0.15 | 0.01 | blup | 64 | 0.04 | 1.9e-03 | -5.69 | 6.1 | 9.5e-10 | 0.72 | 0.02 | 0.58 | TRUE |
8 | The Cancer Genome Atlas | Colon Adenocarcinoma | EFCAB5 | 0.06 | 0.05 | blup | 79 | 0.03 | 5.7e-03 | -5.41 | -5.4 | 5.9e-08 | -0.56 | 0.04 | 0.93 | FALSE |
9 | The Cancer Genome Atlas | Esophageal Carcinoma | CCDC55 | 0.27 | 0.00 | blup | 64 | 0.00 | 3.5e-01 | -0.78 | 5.5 | 3.4e-08 | 0.89 | 0.01 | 0.37 | FALSE |
10 | The Cancer Genome Atlas | Prostate Adenocarcinoma | EFCAB5 | 0.04 | 0.03 | enet | 10 | 0.02 | 6.0e-03 | -5.39 | -5.9 | 3.1e-09 | -0.68 | 0.04 | 0.93 | FALSE |
11 | The Cancer Genome Atlas | Soft Tissue Sarcoma | EFCAB5 | 0.06 | 0.07 | lasso | 2 | 0.05 | 8.2e-04 | -5.41 | -5.4 | 8.4e-08 | -0.56 | 0.04 | 0.94 | FALSE |
12 | The Cancer Genome Atlas | Thyroid Carcinoma | EFCAB5 | 0.11 | 0.18 | enet | 13 | 0.20 | 5.8e-19 | -5.41 | -5.4 | 7.7e-08 | -0.58 | 0.11 | 0.89 | FALSE |