Best TWAS P=8.87e-11 · Best GWAS P=7.85e-10 conditioned to 0.00396
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | CHRNB1 | 0.29 | 0.14 | lasso | 5 | 0.14 | 1.0e-07 | -5.3 | -5.1 | 2.8e-07 | -0.02 | 0.14 | 0.85 | FALSE |
| 2 | GTEx | Esophagus Mucosa | CHRNB1 | 0.19 | 0.11 | lasso | 2 | 0.13 | 7.3e-09 | -5.3 | -5.1 | 2.7e-07 | -0.01 | 0.25 | 0.75 | FALSE |
| 3 | GTEx | Skin Not Sun Exposed Suprapubic | CHRNB1 | 0.17 | 0.15 | lasso | 3 | 0.16 | 7.4e-09 | -5.3 | -5.3 | 1.0e-07 | -0.02 | 0.09 | 0.91 | FALSE |
| 4 | NTR | Blood | TNFSF12 | 0.06 | 0.07 | bslmm | 462 | 0.07 | 9.4e-23 | 4.7 | 5.3 | 1.4e-07 | 0.00 | 0.83 | 0.16 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | CHRNB1 | 0.11 | 0.08 | lasso | 6 | 0.08 | 7.8e-11 | -5.3 | -5.3 | 1.4e-07 | -0.02 | 0.11 | 0.89 | FALSE |
| 6 | YFS | Blood | CHRNB1 | 0.04 | 0.02 | lasso | 5 | 0.04 | 8.5e-12 | -5.3 | -5.1 | 3.0e-07 | -0.01 | 0.09 | 0.90 | FALSE |
| 7 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | CHRNB1 | 0.07 | 0.04 | blup | 57 | 0.05 | 1.6e-03 | -5.3 | -6.0 | 2.1e-09 | -0.02 | 0.01 | 0.72 | FALSE |
| 8 | The Cancer Genome Atlas | Glioblastoma Multiforme | AMAC1L3 | 0.14 | 0.12 | lasso | 3 | 0.12 | 1.8e-04 | -5.9 | 5.7 | 9.9e-09 | 0.02 | 0.00 | 0.92 | FALSE |
| 9 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | CHRNB1 | 0.06 | 0.07 | lasso | 6 | 0.07 | 1.8e-08 | -4.6 | -5.5 | 3.7e-08 | -0.08 | 0.16 | 0.84 | FALSE |
| 10 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CHRNB1 | 0.04 | 0.03 | blup | 57 | 0.02 | 1.5e-03 | 5.1 | -5.6 | 2.4e-08 | -0.05 | 0.04 | 0.48 | FALSE |
| 11 | The Cancer Genome Atlas | Brain Lower Grade Glioma | C17orf81 | 0.04 | 0.05 | enet | 8 | 0.04 | 1.2e-05 | -4.1 | -5.5 | 3.6e-08 | -0.67 | 0.04 | 0.78 | TRUE |
| 12 | The Cancer Genome Atlas | Lung Adenocarcinoma | CHRNB1 | 0.03 | 0.02 | blup | 57 | 0.02 | 7.8e-04 | -5.3 | -6.5 | 8.9e-11 | -0.05 | 0.01 | 0.98 | TRUE |
| 13 | The Cancer Genome Atlas | Prostate Adenocarcinoma | TNFSF12-TNFSF13 | 0.03 | 0.00 | lasso | 4 | 0.01 | 2.9e-02 | 4.7 | 5.1 | 2.7e-07 | 0.01 | 0.02 | 0.43 | FALSE |
| 14 | The Cancer Genome Atlas | Stomach Adenocarcinoma | CHRNB1 | 0.06 | 0.00 | blup | 57 | 0.03 | 4.5e-03 | -1.8 | -6.0 | 1.7e-09 | -0.03 | 0.00 | 0.78 | FALSE |
| 15 | The Cancer Genome Atlas | Thyroid Carcinoma | CHRNB1 | 0.09 | 0.02 | blup | 57 | 0.05 | 2.6e-05 | 4.2 | -5.2 | 1.7e-07 | -0.04 | 0.12 | 0.74 | FALSE |