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chr17:6,652,789-8,161,149

Best TWAS P=8.87e-11 · Best GWAS P=7.85e-10 conditioned to 0.00396

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
12	The Cancer Genome Atlas	Lung Adenocarcinoma	CHRNB1	0.03	0.02	blup	57	0.02	7.8e-04	-5.3	-6.5	8.9e-11	-0.05	0.01	0.98	TRUE
11	The Cancer Genome Atlas	Brain Lower Grade Glioma	C17orf81	0.04	0.05	enet	8	0.04	1.2e-05	-4.1	-5.5	3.6e-08	-0.67	0.04	0.78	TRUE
14	The Cancer Genome Atlas	Stomach Adenocarcinoma	CHRNB1	0.06	0.00	blup	57	0.03	4.5e-03	-1.8	-6.0	1.7e-09	-0.03	0.00	0.78	FALSE
7	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	CHRNB1	0.07	0.04	blup	57	0.05	1.6e-03	-5.3	-6.0	2.1e-09	-0.02	0.01	0.72	FALSE
8	The Cancer Genome Atlas	Glioblastoma Multiforme	AMAC1L3	0.14	0.12	lasso	3	0.12	1.8e-04	-5.9	5.7	9.9e-09	0.02	0.00	0.92	FALSE
10	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CHRNB1	0.04	0.03	blup	57	0.02	1.5e-03	5.1	-5.6	2.4e-08	-0.05	0.04	0.48	FALSE
9	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CHRNB1	0.06	0.07	lasso	6	0.07	1.8e-08	-4.6	-5.5	3.7e-08	-0.08	0.16	0.84	FALSE
3	GTEx	Skin Not Sun Exposed Suprapubic	CHRNB1	0.17	0.15	lasso	3	0.16	7.4e-09	-5.3	-5.3	1.0e-07	-0.02	0.09	0.91	FALSE
4	NTR	Blood	TNFSF12	0.06	0.07	bslmm	462	0.07	9.4e-23	4.7	5.3	1.4e-07	0.00	0.83	0.16	FALSE
5	ROSMAP	Brain Pre-frontal Cortex	CHRNB1	0.11	0.08	lasso	6	0.08	7.8e-11	-5.3	-5.3	1.4e-07	-0.02	0.11	0.89	FALSE
15	The Cancer Genome Atlas	Thyroid Carcinoma	CHRNB1	0.09	0.02	blup	57	0.05	2.6e-05	4.2	-5.2	1.7e-07	-0.04	0.12	0.74	FALSE
2	GTEx	Esophagus Mucosa	CHRNB1	0.19	0.11	lasso	2	0.13	7.3e-09	-5.3	-5.1	2.7e-07	-0.01	0.25	0.75	FALSE
13	The Cancer Genome Atlas	Prostate Adenocarcinoma	TNFSF12-TNFSF13	0.03	0.00	lasso	4	0.01	2.9e-02	4.7	5.1	2.7e-07	0.01	0.02	0.43	FALSE
1	GTEx	Adipose Visceral Omentum	CHRNB1	0.29	0.14	lasso	5	0.14	1.0e-07	-5.3	-5.1	2.8e-07	-0.02	0.14	0.85	FALSE
6	YFS	Blood	CHRNB1	0.04	0.02	lasso	5	0.04	8.5e-12	-5.3	-5.1	3.0e-07	-0.01	0.09	0.90	FALSE