Hub : Genes

CORO6

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Nucleus accumbens basal ganglia	0.1050	0.0580	0.00440	0.096	NA	0.029	NA	0.047	1.6e-03	NA	5.6e-02	NA	2.2e-02
2	GTEx	Thyroid	0.2330	0.0640	0.00000	0.357	NA	0.363	NA	0.370	2.1e-28	NA	6.2e-29	NA	1.2e-29
3	METSIM	Adipose	0.0159	0.0100	0.00820	0.017	0.006	0.006	0.008	0.005	1.3e-03	3.2e-02	4.2e-02	0.017	4.4e-02
4	TCGA	Breast Invasive Carcinoma	0.0294	0.0168	0.00023	0.006	0.010	0.011	NA	0.005	1.7e-02	3.6e-03	1.7e-03	NA	3.1e-02
5	TCGA	Thyroid Carcinoma	0.2800	0.0680	0.00000	0.396	0.339	0.371	NA	0.388	5.0e-41	5.9e-34	8.0e-38	NA	6.2e-40

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	1.0	1.5	1.7	-1.2	1.3	-1.3	-1.2	1.2
Bipolar Disorder or Schizophrenia	0.9	2.3	2.8	-1.7	1.6	-1.6	-1.3	1.4
Depressed Affect (Nagel 2018)	0.3	0.7	1.0	1.0	-1.0	0.7	-0.6	-0.8
Depression (Nagel 2018)	0.1	0.1	0.2	0.0	-0.5	-0.1	-0.4	-0.4
Intelligence (Savage-Jansen 2018)	6.4	19.6	21.8	4.2	-4.7	4.3	4.2	-4.7
Neuroticism (Nagel 2018)	0.1	0.2	0.5	0.5	-0.7	-0.1	-0.4	-0.4
Schizophrenia (2018)	0.4	0.8	1.4	-1.2	1.0	-1.0	0.0	0.8
Schizophrenia vs Biploar Disorder	1.3	1.7	3.5	1.0	-1.4	0.6	1.9	-1.4
Worry (Nagel 2018)	0.2	0.3	1.4	-0.3	0.3	-1.2	0.1	0.4
Alzheimer’s Disease (in mother)	2.7	3.2	3.9	-2.0	2.0	-1.8	-1.3	1.8
Alzheimer’s Disease (in father)	1.6	1.7	3.5	-1.3	1.7	-0.5	-0.4	1.9
Alzheimer’s Disease (including proxy)	6.3	9.1	11.4	-3.3	3.4	-2.6	-2.3	3.4
Crohns Disease (2017)	0.5	1.1	1.7	-0.7	1.3	-0.6	-1.1	1.3
Irritable Bowel Disease (IBD)	0.2	0.5	1.1	1.1	-0.7	0.5	0.5	-0.7
Ulcerative Colitis (UC)	1.9	3.5	4.6	2.1	-2.1	1.3	1.7	-2.2
Major Depression (MDD)	0.5	0.7	2.4	-0.8	0.5	-1.5	0.0	0.0
Reaction Time	0.2	0.3	0.5	0.5	-0.4	0.7	-0.3	-0.6
Verbal and Numeric Reasoning (VNR)	3.9	9.3	11.2	3.1	-3.0	3.3	2.7	-3.1
Breast Cancer	1.4	3.5	6.0	2.1	-1.8	0.5	2.4	-1.9
Ovarian Cancer	0.0	0.0	0.1	0.2	0.0	-0.4	0.1	0.1
Prostate Cancer	0.2	0.2	0.8	0.5	0.0	-0.9	0.4	-0.1
Age at First Birth	0.2	0.3	0.7	0.5	-0.9	0.2	0.0	-0.7
Bipolar Disorder (2011)	4.3	4.1	8.3	-2.7	2.2	-2.9	0.0	0.0
Body Mass Index (BMI) (2010)	0.3	0.4	0.8	0.5	-0.6	0.9	0.8	0.0
Coronary Artery Disease (CAD)	1.4	1.7	4.3	1.8	-2.1	1.0	0.0	0.0
Crohns Disease (2012)	0.9	1.4	2.8	-1.1	1.6	-0.6	0.0	1.7
Mean Putamen Volume	1.6	1.8	2.9	1.7	-1.6	0.8	0.9	-1.5
Fasting Glucose	3.2	3.8	6.7	-2.2	1.9	-2.6	-0.6	1.9
HbA1C	0.2	0.3	0.6	-0.4	0.4	-0.8	-0.4	0.6
HDL Cholesterol	1.8	3.1	4.9	-1.5	2.2	-2.0	-2.1	0.0
LDL Cholesterol	0.6	0.9	1.5	1.1	-1.2	1.1	0.9	0.0
Lupus	0.2	0.3	0.6	-0.7	-0.6	-0.3	0.3	-0.7
Neuroticism (2016)	0.4	0.6	1.6	-0.5	0.2	-1.0	-1.3	0.3
Primary Biliary Cirrhosis	0.7	1.1	1.3	-1.0	1.1	-1.0	-0.8	1.1
Rheumatoid Arthritis	0.4	0.6	0.8	0.7	-0.9	0.8	-0.3	-0.8
Schizophrenia (2014)	0.1	0.2	0.4	-0.6	0.3	-0.6	-0.1	0.2
Triglycerides	0.2	0.4	1.0	-1.0	0.0	-0.7	0.6	0.0
Type 2 Diabetes (T2D) (2012)	2.1	2.5	5.2	1.6	-2.3	2.1	0.0	0.0
Ulcerative Colitis	1.1	1.7	2.9	1.6	-1.6	0.6	0.0	-1.7
Blood Eosinophil Count	0.2	1.3	2.3	0.1	-1.5	0.6	1.4	-1.4
Blood Platelet Count	3.3	38.4	136.9	2.1	-4.2	-3.8	11.7	-4.3
Blood Red Count	4.3	41.8	47.9	6.8	-6.9	6.6	5.0	-6.8
Blood White Count	8.4	62.6	72.2	-8.5	8.1	-8.5	-5.9	8.3
Heel T-Score	16.5	131.6	185.0	-12.6	11.6	-13.6	-6.9	11.5
BMI	4.6	26.5	31.5	5.6	-5.3	5.0	4.7	-5.1
Height	2.3	44.9	56.7	-6.9	7.5	-6.4	-5.1	7.3
Waist Hip Ratio (WHR)	0.1	0.6	1.4	-0.8	-0.0	-0.8	1.2	-0.1
Systolic Blood Pressure	0.4	2.0	2.8	1.7	-1.3	1.1	1.6	-1.4
Smoking Status	0.9	2.3	3.8	-1.6	1.1	-1.4	-1.9	1.3
Allergy or Eczema	1.5	3.8	6.8	1.6	-2.1	1.2	2.6	-2.0
Cardiovascular Disease	5.9	19.6	22.7	4.4	-4.8	4.7	3.7	-4.5
Hypothyroidism (self reported)	6.4	14.8	19.4	3.8	-4.4	3.3	3.2	-4.4
Respiratory disease	0.3	0.6	1.4	-0.8	0.3	-1.0	-1.2	0.3
Type 2 Diabetes (T2D) (2018)	1.0	1.9	2.8	1.5	-1.7	0.4	1.5	-1.5
Lung FEV1/FVC ratio	32.3	163.6	187.7	13.7	-13.6	13.3	9.4	-13.4
Lung FVC	2.3	11.5	13.3	-3.4	3.6	-3.5	-2.7	3.6
Neuroticism	0.6	1.3	2.9	-0.7	0.8	-1.2	-1.7	1.0
Chronotype (morning person)	0.2	0.4	0.9	0.5	-0.7	0.7	0.3	-0.9
Hair Pigment	0.4	10.6	18.0	-4.2	3.2	-2.3	-3.0	3.2
Tanning	0.1	0.6	1.3	-0.8	1.1	-0.2	-0.7	0.8
Hand grip strength (left)	0.4	1.1	2.1	-1.2	1.4	-0.4	-0.4	1.3
Number of treatments/medications taken	2.8	5.0	7.3	2.4	-2.7	1.9	1.1	-2.7
Average weekly spirits intake	1.5	1.9	3.1	-1.1	1.4	-1.2	-1.8	1.4
Sensitivity / hurt feelings	1.3	2.2	2.7	-1.4	1.5	-1.6	-1.4	1.5
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.3	0.0	-0.6	0.4	-0.1	-0.6
Hearing difficulty/problems: Yes	0.8	1.3	2.1	1.4	-1.1	1.5	-0.1	-1.0
Relative age of first facial hair	0.0	0.0	0.1	-0.3	-0.1	0.2	-0.2	-0.1
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.9	0.7	-0.7	1.4	0.4	-0.6
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.3	-0.4	0.6	-1.1	-0.0	0.7
Ever had hysterectomy (womb removed)	1.0	1.1	2.0	1.1	-1.2	0.2	0.9	-1.4
Systolic blood pressure, automated reading	0.7	1.9	4.9	1.1	-1.1	1.0	2.2	-1.1
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.3	-0.2	-0.2	-0.6	0.5	-0.1
Angina	7.8	10.2	14.4	3.5	-3.8	2.7	1.9	-3.6
Medication for hormone replacement therapy	0.9	1.0	1.3	-1.1	1.0	-1.1	-0.8	1.0
Vitamin and mineral supplements	0.4	0.5	1.2	-0.7	0.5	-1.1	-0.2	0.7
Supplements: Zinc	3.8	4.1	5.7	2.4	-2.2	2.0	1.1	-2.2
Medication: Co-codamol	0.3	0.4	1.1	-1.0	0.2	-0.6	0.6	0.2
Medication: Metformin	3.5	5.0	6.7	2.4	-2.6	1.3	2.1	-2.5
Diabetes (father)	0.4	0.4	0.7	0.7	-0.4	0.7	0.8	-0.6
Diabetes (mother)	2.2	2.8	4.2	1.5	-1.8	1.2	2.0	-1.7
Severe depression (siblings)	0.4	0.4	1.4	-0.3	0.1	-0.7	1.2	0.0
Pack years adult smoking proportion	0.5	0.7	1.8	0.1	-0.2	1.2	-1.4	-0.3
Impedance of leg (right)	0.1	0.5	0.9	0.9	-0.8	0.7	0.2	-0.6
Leg fat-free mass (left)	0.1	0.5	1.1	-0.5	1.0	-0.5	0.4	1.0
Trunk fat percentage	3.4	13.7	20.1	4.5	-3.6	3.8	3.3	-3.2
Hand grip strength (right)	0.8	2.3	4.4	-1.4	2.1	-0.8	-0.9	1.9
Townsend deprivation index at recruitment	2.4	3.4	5.5	-2.0	1.9	-0.6	-2.3	2.0
Current tobacco smoking	0.6	0.9	2.8	-0.7	0.7	0.5	-1.7	0.8
Average weekly fortified wine intake	1.9	2.2	3.5	-1.4	1.5	-1.9	-1.1	1.5
Maternal smoking around birth	0.3	0.5	1.7	-0.5	0.4	0.1	-1.3	0.3
Fed-up feelings	0.1	0.2	0.9	-0.1	-0.3	-0.0	-1.0	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.6	1.1	-0.9	0.5	-1.1	-0.7	0.6
Relative age voice broke	0.9	1.4	1.6	-1.3	1.2	-1.3	-1.0	1.2
Taking other prescription medications	4.0	6.2	7.3	2.6	-2.7	2.7	1.6	-2.6
Age when periods started (menarche)	0.8	1.9	2.8	-1.7	1.3	-1.0	-1.6	1.1
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.1	0.1	-0.9	0.6	-0.2	-1.0
Heel bone mineral density (BMD) T-score, automated (left)	10.6	24.0	31.0	-5.6	4.8	-5.6	-3.3	4.9
Tinnitus: Yes, but not now, but have in the past	0.8	0.8	1.3	1.0	-1.0	1.1	0.1	-0.8
Qualifications: CSEs or equivalent	1.7	2.2	4.2	-1.2	2.0	-1.2	-0.1	2.0
Serious illness, injury or assault to yourself	1.0	1.2	3.1	0.8	-0.9	0.7	1.8	-0.9
High blood pressure	4.1	11.3	13.9	3.1	-3.5	3.7	3.3	-3.2
Hayfever, allergic rhinitis or eczema	2.2	4.7	6.9	2.0	-2.2	1.8	2.6	-2.2
Multivitamins +/- minerals	1.9	2.4	2.7	1.6	-1.5	1.7	1.5	-1.5
Stomach or abdominal pain in last month	5.1	6.4	8.2	2.9	-2.6	2.7	1.9	-2.5
Supplements: Glucosamine	0.1	0.1	0.1	0.1	-0.2	-0.4	0.3	-0.3
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	0.7	0.9	-0.5	0.5	0.8	-0.7
Medication: Atenolol	1.1	1.4	2.3	1.2	-1.5	1.0	0.6	-1.4
Medication: Levothyroxine sodium	0.6	1.1	2.1	0.8	-1.3	0.8	0.6	-1.5
Sitting height	1.0	6.8	10.7	-2.9	2.5	-3.3	-1.3	2.6
Chronic bronchitis/emphysema (father)	0.3	0.4	0.8	-0.2	0.7	-0.2	-0.9	0.8
High blood pressure (mother)	2.3	3.2	3.5	1.6	-1.9	1.9	1.7	-1.9
Body mass index (BMI)	3.8	16.1	20.6	4.5	-3.9	4.3	3.7	-3.6
Impedance of leg (left)	0.1	0.3	0.5	-0.4	0.4	-0.6	-0.7	0.5
Leg predicted mass (left)	0.1	0.7	1.3	-0.6	1.1	-0.6	0.4	1.1
Trunk fat mass	2.0	8.7	13.1	3.6	-2.6	3.1	2.9	-2.3
Waist circumference	3.0	11.1	13.3	3.5	-3.2	3.4	3.6	-3.0
Number of incorrect matches in round	7.8	12.9	18.5	-3.3	3.8	-4.3	-2.5	3.7
Past tobacco smoking	0.3	0.5	1.1	0.9	-0.3	1.0	0.5	-0.6
Alcohol usually taken with meals	1.0	1.7	3.1	-1.4	1.2	-1.8	-0.7	1.1
Nervous feelings	0.5	1.0	2.1	-0.8	0.9	-1.5	-0.6	1.0
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.7	0.2	-0.4	-0.1	0.8	-0.4
Hearing difficulty/problems with background noise	0.3	0.5	0.6	0.7	-0.7	0.8	-0.8	-0.7
Hair/balding pattern: Pattern 2	0.2	0.3	0.8	-0.1	0.7	-0.1	0.5	0.9
Had menopause	2.7	3.4	5.0	2.2	-1.8	1.8	1.5	-1.8
Had other major operations	0.7	0.9	1.8	1.0	-0.8	1.4	0.8	-0.7
Forced vital capacity (FVC)	7.5	29.0	34.2	-5.6	5.7	-5.8	-4.0	5.5
Heel bone mineral density (BMD) T-score, automated (right)	7.8	17.9	22.9	-4.8	4.2	-4.7	-3.0	4.2
Ever unenthusiastic/disinterested for a whole week	0.8	0.9	1.4	1.0	-1.2	0.8	-0.3	-1.2
Qualifications: None of the above	0.8	1.7	3.8	-1.4	0.9	-0.9	-2.0	1.1
Financial difficulties in last 2 years	0.2	0.2	0.5	-0.7	0.5	0.0	-0.0	0.7
Mouth/teeth dental problems	0.2	0.4	1.5	-0.3	0.4	-1.2	0.1	0.3
Heart attack	7.5	9.6	12.4	2.9	-3.4	2.5	3.1	-3.5
Allergy	0.8	1.9	2.7	-1.2	1.6	-0.9	-1.3	1.6
Pain all over the body in last month	0.2	0.3	0.7	-0.5	-0.4	-0.9	0.2	-0.4
Diabetes (self-reported)	3.0	4.6	6.6	2.4	-2.6	1.1	1.9	-2.5
Hayfever/allergic rhinitis (self-reported)	0.4	0.6	0.8	0.7	-0.9	0.7	0.4	-0.9
Medication: Ramipril	0.4	0.5	0.8	0.7	-0.7	0.9	0.2	-0.7
Medication: Simvastatin	2.8	4.1	5.5	2.1	-2.3	2.1	1.4	-2.1
Fluid intelligence score	4.7	9.8	10.3	3.2	-3.2	3.1	3.0	-3.1
Illnesses of siblings	14.2	19.9	24.2	-4.3	4.9	-4.4	-3.9	4.8
Neuroticism score	0.7	1.5	1.9	-1.2	1.1	-1.4	-1.3	1.2
Weight	0.3	1.6	2.6	1.6	-0.8	1.4	1.6	-0.6
Impedance of arm (right)	0.3	1.5	2.8	-0.6	0.9	-1.5	-1.7	1.0
Arm fat percentage (right)	4.7	18.4	26.6	5.2	-4.2	4.5	3.5	-3.9
Trunk fat-free mass	0.6	3.7	5.3	-2.1	2.3	-1.8	-0.4	2.3
Hip circumference	0.6	2.6	4.1	2.0	-1.2	1.6	1.9	-1.0
Time employed in main current job	0.1	0.1	0.2	0.1	0.2	0.5	0.2	0.3
Alcohol intake versus 10 years previously	1.1	1.6	4.6	0.9	-1.3	2.1	0.2	-1.0
Father’s age at death	0.6	0.8	1.5	-0.7	1.2	-0.4	-0.9	1.1
Worrier / anxious feelings	0.0	0.1	0.2	-0.0	-0.1	-0.5	0.4	0.1
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.4	0.7	-0.6	0.3	0.4	-0.4
Falls in the last year	0.9	1.3	2.2	-0.4	1.3	-0.8	-1.5	1.3
Hair/balding pattern: Pattern 3	0.3	0.5	1.2	-0.2	-0.6	-0.3	1.1	-0.8
Number of live births	0.0	0.0	0.1	0.1	0.1	-0.3	0.1	0.1
Forced expiratory volume in 1-second (FEV1)	0.6	1.9	3.1	-1.3	1.5	-1.8	-0.8	1.4
Pulse rate	0.0	0.1	0.2	0.5	-0.1	-0.3	0.0	-0.1
Happiness	0.2	0.3	0.8	-0.4	-0.4	0.2	-0.9	-0.3
Noisy workplace	3.6	4.4	8.7	-1.7	2.0	-1.4	-3.0	2.1
Qualifications: A levels/AS levels or equivalent	0.0	0.1	0.3	0.5	-0.0	-0.1	-0.3	0.1
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.2	2.6	1.6	-1.1	1.0	0.5	-0.9
Mouth/teeth dental problems: Dentures	0.1	0.2	0.5	-0.7	0.2	0.2	0.6	0.2
Asthma	0.5	1.0	1.7	-1.2	0.7	-1.3	-1.0	0.6
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	2.2	-0.2	0.8	-0.4	-1.5	0.7
Medication: Cholesterol lowering	2.0	3.2	5.4	1.6	-2.3	1.1	1.3	-2.2
Depression (self-reported)	0.7	0.8	2.6	0.7	-0.7	0.3	1.6	-0.6
Medication: Lansoprazole	0.8	0.9	2.9	0.6	-0.7	0.5	1.7	-0.6
Prospective memory result	5.0	6.1	7.1	-2.4	2.7	-2.1	-2.6	2.6
Lung cancer (father)	0.2	0.3	0.7	-0.2	0.7	-0.2	0.3	0.8
Illnesses of mother	7.4	9.1	10.4	-3.1	3.2	-2.5	-2.9	3.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	1.0	-0.7	0.9	-1.0	-0.7	0.8
Pulse wave Arterial Stiffness index	0.1	0.1	0.3	-0.6	0.2	-0.2	0.3	0.3
Impedance of arm (left)	0.4	1.9	3.5	-0.8	1.1	-1.6	-1.9	1.1
Arm fat mass (right)	3.0	12.2	17.3	4.2	-3.3	3.6	3.3	-3.0
Trunk predicted mass	0.6	3.4	5.0	-1.9	2.2	-1.7	-0.4	2.2
Standing height	3.5	34.8	42.1	-6.0	6.5	-6.1	-4.1	6.4
Length of working week for main job	0.9	1.0	1.6	-1.3	1.0	-1.2	0.4	1.0
Exposure to tobacco smoke at home	1.6	1.8	3.2	-1.2	1.6	-1.0	-0.7	1.8
Breastfed as a baby	0.9	1.1	1.7	1.3	-0.9	1.3	0.6	-0.9
Tense / ‘highly strung’	0.2	0.3	0.8	-0.6	0.2	-0.6	0.9	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	1.6	2.4	4.0	1.6	-1.5	1.0	2.0	-1.4
Hair/balding pattern: Pattern 4	0.4	0.9	2.9	0.1	0.6	-1.1	-1.7	0.6
Birth weight of first child	3.7	6.7	9.0	-2.5	2.6	-3.0	-2.1	2.6
Peak expiratory flow (PEF)	4.1	9.4	13.1	3.6	-3.2	2.7	2.4	-3.2
Pulse wave reflection index	0.2	0.2	1.1	0.1	-0.2	1.1	-0.1	-0.0
Ever highly irritable/argumentative for 2 days	0.3	0.3	1.5	-0.4	-0.0	-0.2	-1.2	0.0
Loud music exposure frequency	0.5	0.6	1.2	-1.1	0.6	-0.9	0.0	0.5
Qualifications: O levels/GCSEs or equivalent	0.2	0.2	0.9	0.9	-0.0	0.2	0.6	0.0
Mouth/teeth dental problems: Bleeding gums	1.3	1.7	2.2	-1.3	1.4	-0.6	-1.5	1.5
Blood clot in the leg (DVT)	4.0	5.1	6.1	2.2	-2.2	2.2	2.5	-2.2
Medication: Paracetamol	0.1	0.2	0.3	0.6	-0.5	-0.4	-0.5	-0.5
Headache pain in last month	0.3	0.5	2.2	-0.3	-0.1	0.3	-1.5	-0.2
Medication for cholesterol, blood pressure or diabetes	5.8	9.6	12.8	-3.4	3.6	-3.1	-1.8	3.3
Glaucoma (self-reported)	0.5	0.6	1.2	0.3	-1.1	0.6	0.5	-1.0
Gout (self-reported)	0.7	0.9	1.5	1.0	-1.2	0.9	0.3	-1.1
Hypothyroidism/myxoedema (self-reported)	3.6	7.1	10.1	2.5	-3.1	2.3	2.0	-3.2
Medication: Amlodipine	3.1	4.3	6.9	2.4	-2.2	2.6	0.4	-1.9
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.5	-0.9	0.4	-1.2	-0.1	0.2
Birth weight	1.8	3.9	9.9	-1.4	2.0	-0.7	-3.1	1.9
Chronic bronchitis/emphysema (mother)	2.2	2.5	3.4	1.5	-1.5	1.8	1.7	-1.3
High blood pressure (siblings)	12.3	17.7	20.3	4.2	-4.5	4.2	3.8	-4.4
Forced vital capacity (FVC), Best measure	6.2	22.6	26.0	-5.0	5.0	-5.1	-3.6	4.8
Body fat percentage	4.8	18.9	26.8	5.2	-4.2	4.5	3.9	-3.8
Leg fat percentage (right)	8.1	29.4	39.6	6.3	-5.2	5.9	4.7	-4.8
Arm fat-free mass (right)	0.2	0.8	1.4	-0.8	1.2	-0.4	0.5	1.2
Exposure to tobacco smoke outside home	0.1	0.1	0.4	0.4	-0.0	0.7	0.3	0.0
Comparative body size at age 10	1.2	3.3	4.3	1.6	-1.6	1.9	2.1	-1.9
Number of full brothers	0.5	0.6	1.8	-0.7	0.5	0.3	-1.3	0.7
Worry too long after embarrassment	1.9	3.2	5.3	-1.6	1.8	-2.3	-0.8	2.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.7	-0.6	0.2	-0.8	0.3	0.2
Wheeze or whistling in the chest in last year	1.0	1.7	2.5	1.3	-1.5	1.4	-0.1	-1.6
Number of children fathered	0.8	1.0	1.4	1.0	-0.7	1.1	1.2	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.2	0.4	0.4	-0.3	0.1	-0.7	-0.3
Age at first live birth	0.9	1.6	2.7	1.6	-1.5	0.6	0.6	-1.5
Pulse wave peak to peak time	0.1	0.1	0.3	0.2	0.2	-0.1	-0.5	0.1
Health satisfaction	1.7	2.2	3.2	1.2	-1.8	1.3	1.4	-1.6
Shortness of breath walking on level ground	0.1	0.1	0.3	-0.4	-0.2	-0.1	-0.6	-0.1
Qualifications: College or University degree	0.1	0.2	0.6	-0.4	0.1	-0.8	0.2	0.1
Eye problems/disorders: None of the above	0.2	0.2	0.5	0.7	-0.1	0.7	-0.2	-0.4
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.6	0.0	0.6	0.2	-1.3	0.8
Emphysema/chronic bronchitis	0.1	0.1	0.2	0.2	0.0	-0.3	-0.4	0.0
Medication for pain relief, constipation, heartburn	1.3	2.3	3.6	-1.9	1.8	-1.1	-0.4	1.8
Neck or shoulder pain in last month	1.8	2.6	3.6	1.2	-1.9	1.9	1.1	-1.8
Medication: Blood pressure	6.3	11.1	14.5	3.7	-3.5	3.8	2.0	-3.3
Angina (self-reported)	7.4	9.7	13.6	3.4	-3.7	2.6	2.0	-3.5
Migraine (self-reported)	3.5	4.3	6.7	-1.7	2.0	-1.9	-2.6	2.1
Medication: Ibuprofen	0.3	0.3	0.7	-0.2	0.7	-0.4	-0.9	0.5
Medication: Allopurinol	1.6	2.1	2.8	1.1	-1.5	1.7	1.6	-1.3
Medication: Omeprazole	0.2	0.3	0.5	0.2	-0.6	0.7	0.0	-0.6
Medication: Seretide 50 evohaler	0.1	0.1	0.2	-0.5	-0.0	0.3	-0.4	-0.2
Mean time to correctly identify matches	0.7	1.4	1.9	1.4	-1.2	1.3	0.2	-1.4
Heart disease (mother)	3.5	4.2	5.5	2.3	-2.3	1.5	2.0	-2.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	0.8	-0.7	-0.0	-0.9	0.4	-0.1
Whole body fat mass	2.9	11.9	17.2	4.2	-3.2	3.6	3.3	-2.9
Leg fat mass (right)	5.0	19.4	27.1	5.2	-4.1	4.7	4.1	-3.8
Arm predicted mass (right)	0.2	1.0	1.7	-1.0	1.3	-0.6	0.4	1.3
Pulse rate, automated reading	0.2	0.6	1.3	-0.4	0.7	-0.7	-1.2	0.7
Alcohol intake frequency.	0.7	1.6	2.9	-1.3	1.4	-0.0	-1.7	1.3
Comparative height size at age 10	2.6	14.6	18.1	-3.7	4.3	-3.8	-3.0	4.2
Number of full sisters	0.3	0.4	0.9	0.3	-0.3	0.7	-1.0	-0.3
Suffer from ‘nerves’	0.3	0.5	0.9	-0.4	0.8	-0.8	-0.4	0.9
Overall health rating	0.9	1.9	3.1	1.1	-1.6	1.8	0.7	-1.3
Chest pain or discomfort	6.8	9.8	14.5	3.2	-3.8	3.1	1.6	-3.5
Had major operations	0.1	0.1	0.4	0.0	0.1	0.3	-0.7	0.2
Age at last live birth	0.2	0.3	0.8	-0.2	0.1	-0.7	-0.9	0.2
Family relationship satisfaction	1.0	1.3	2.0	0.9	-1.3	1.4	0.4	-1.3
Leg pain on walking	0.1	0.1	0.2	0.5	-0.3	0.1	0.3	-0.2
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.2	-0.2	0.3	0.4	0.3	0.2
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.6	-0.8	0.6	-0.3	0.3	0.6
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	1.0	-1.0	1.0	-0.9	-0.6	0.9
Medication: Aspirin	8.9	11.7	16.4	3.9	-4.0	2.9	1.6	-3.9
Supplements: Vitamin C	0.9	1.0	1.8	1.1	-0.9	1.4	-0.3	-1.0
Knee pain experienced in last month	3.4	5.2	8.0	2.2	-2.1	2.8	2.4	-1.9
Hypertension (Self-reported)	4.5	12.4	15.7	3.3	-3.6	4.0	3.4	-3.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.5	5.4	0.9	-0.6	0.8	2.3	-0.5
Illnesses of father: Heart disease	2.9	4.0	4.9	2.1	-2.2	1.0	2.2	-2.2
Illnesses of siblings: Diabetes	0.1	0.1	0.2	-0.4	0.3	0.2	-0.1	0.4
Smoking status: Previous	0.2	0.3	1.1	-0.7	0.1	-1.0	-0.3	0.3
Forced expiratory volume in 1-second (FEV1), predicted	3.5	7.2	10.1	-2.7	3.2	-2.4	-1.7	3.1
Whole body fat-free mass	0.4	2.2	3.5	-1.5	1.9	-1.3	-0.1	1.9
Leg fat-free mass (right)	0.5	2.8	4.2	-1.7	2.0	-1.6	-0.5	2.1
Arm fat percentage (left)	4.8	19.0	26.8	5.2	-4.3	4.6	3.6	-4.0
Average weekly red wine intake	0.4	0.7	2.8	-0.4	0.2	-1.7	-0.6	0.2
Handedness (chirality/laterality): Left-handed	0.4	0.4	1.3	-1.1	0.2	-0.9	-0.2	0.1
Mood swings	1.1	2.0	3.3	1.7	-1.4	1.8	-0.8	-1.1
Loneliness, isolation	0.1	0.2	0.7	-0.1	-0.3	-0.2	0.9	-0.3
Long-standing illness, disability or infirmity	0.2	0.4	1.3	0.5	-0.5	0.2	1.1	-0.2
Ever had bowel cancer screening	2.3	2.7	4.1	2.0	-2.0	0.8	1.3	-1.8
Diabetes diagnosed by doctor	2.4	4.0	5.9	2.1	-2.4	0.9	1.9	-2.3
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	1.7	-1.0	0.6	-0.4	-1.3	0.5
Friendships satisfaction	0.4	0.5	1.1	0.6	-1.0	0.4	-0.5	-1.0
Qualifications: nursing, teaching	0.9	1.5	3.1	1.5	-0.8	1.8	0.7	-0.9
Commuting to job workplace: Walk	1.2	1.3	4.2	0.7	-0.9	0.7	2.0	-0.8
Eye problems/disorders: Cataract	1.0	1.1	1.9	1.4	-1.0	1.2	0.9	-0.8
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	1.5	0.7	-1.2	1.1	0.1	-1.2
Medication for cholesterol	1.9	2.8	3.6	-1.3	1.9	-1.8	-1.4	1.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.1	2.5	3.8	1.4	-1.2	1.9	1.9	-1.3
Back pain experienced in last month	6.2	9.1	10.7	2.6	-3.2	3.3	2.7	-3.3
Mineral and other dietary supplements	0.5	0.7	1.1	-1.0	0.9	-0.6	-0.3	1.1
Breast cancer (self-reported)	0.8	1.0	2.1	-0.9	0.9	-0.6	-1.4	0.9
Asthma (self-reported)	0.3	0.6	1.3	-1.0	0.3	-1.1	-0.7	0.2
Osteoporosis (self-reported)	0.1	0.2	0.5	0.7	0.1	-0.2	0.4	0.2
Osteoarthritis (self-reported)	1.9	2.5	4.8	-1.7	1.4	-2.2	0.6	1.5
Medication: Aspirin	7.9	10.2	14.7	3.7	-3.8	2.6	1.7	-3.7
Medication: Gliclazide	1.8	2.0	2.8	1.7	-1.5	0.5	1.7	-1.4
Illnesses of father: None of the above (group 1)	3.2	3.9	4.8	-2.0	2.2	-1.6	-1.9	2.2
Smoking status: Current	0.7	1.1	2.6	-1.0	0.9	0.1	-1.6	1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.2	1.5	1.2	-1.0	0.8	1.2	-1.1
Whole body water mass	0.4	2.2	3.6	-1.5	1.9	-1.3	-0.2	1.9
Leg predicted mass (right)	0.5	2.9	4.4	-1.7	2.1	-1.6	-0.4	2.1
Arm fat mass (left)	2.9	12.0	17.3	4.2	-3.3	3.6	3.2	-3.0
Number of self-reported non-cancer illnesses	8.3	14.4	18.0	4.2	-4.0	3.8	3.1	-3.8
Average weekly champagne plus white wine intake	0.9	1.2	2.9	1.2	-1.0	1.7	-0.0	-0.8
Miserableness	0.0	0.0	0.1	-0.0	-0.2	-0.2	-0.4	0.0
Guilty feelings	0.2	0.3	0.7	-0.6	0.4	-0.8	-0.4	0.5
Wears glasses or contact lenses	1.8	2.0	3.0	1.7	-1.4	0.8	1.7	-1.4
Ever taken oral contraceptive pill	0.7	0.7	1.2	-1.1	1.0	-0.3	-0.5	1.1
Hearing aid user	0.8	0.9	1.4	-1.2	0.8	-1.1	-0.7	0.8
Mother’s age at death	0.3	0.4	1.8	1.4	-0.4	0.2	-0.2	-0.2
Financial situation satisfaction	0.3	0.3	0.5	-0.7	0.3	-0.7	-0.6	0.4
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.4	-0.2	-0.2	0.6	-0.7	-0.1
Commuting to job workplace: Public transport	0.6	0.7	3.7	0.1	0.1	0.2	-1.9	0.1
Eye problems/disorders: Glaucoma	0.2	0.2	0.6	-0.8	0.0	-0.2	-0.6	0.1
Medication: Blood pressure	1.0	1.9	2.9	1.1	-1.7	1.5	1.1	-1.4
Pain type(s) experienced in last month: Hip pain	5.0	6.3	8.4	2.3	-2.3	2.9	2.8	-2.2
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.8	0.5	-0.3	0.2	0.9	-0.4
High cholesterol (Self-reported)	3.0	5.3	6.7	2.1	-2.6	2.6	1.6	-2.5
Medication: Bendroflumethiazide	0.1	0.2	0.5	0.5	-0.5	0.7	0.1	-0.2
Medication: Paracetamol	0.1	0.2	0.8	0.2	-0.1	-0.9	-0.1	-0.2
Medication: Lisinopril	3.3	4.3	5.9	2.4	-2.0	2.4	1.4	-2.0
Medication: Atorvastatin	2.0	2.5	4.3	1.5	-1.9	1.2	1.0	-2.1
Illnesses of father: High blood pressure	2.4	3.0	4.1	1.6	-1.7	1.6	2.0	-1.6
Alcohol drinker status: Never	0.4	0.5	2.2	-0.3	0.2	0.1	-1.5	0.1
Ever smoked	0.1	0.1	0.2	-0.3	0.1	-0.3	-0.3	0.4
Basal metabolic rate	0.2	0.9	1.8	-0.8	1.3	-0.7	0.3	1.3
Leg fat percentage (left)	5.7	20.6	27.9	5.3	-4.3	5.0	4.0	-3.9
Arm fat-free mass (left)	0.1	0.5	0.7	-0.5	0.8	-0.3	0.8	0.9
Number of operations (self-reported)	2.1	3.1	5.3	2.2	-1.7	2.3	0.6	-1.5
Average weekly beer plus cider intake	0.2	0.3	1.3	0.0	-0.2	1.1	-0.3	-0.1
Irritability	1.9	3.2	4.6	2.1	-2.0	2.0	0.2	-1.8
Risk taking	0.4	0.5	1.1	0.6	-0.8	1.0	0.0	-0.8
Ever had prostate specific antigen (PSA) test	1.3	1.5	2.5	1.2	-1.1	1.1	1.6	-1.1
Fractured/broken bones in last 5 years	3.6	4.7	5.8	2.4	-2.1	2.3	1.7	-2.2
Age started oral contraceptive pill	0.9	1.1	1.5	1.1	-0.9	1.0	1.2	-0.9
Diastolic blood pressure, automated reading	1.7	5.4	7.5	1.8	-2.1	2.6	2.7	-2.2
Ever depressed for a whole week	0.2	0.3	0.7	-0.1	-0.6	0.0	-0.8	-0.6
Unable to work because of sickness or disability	0.8	1.0	1.5	-1.2	0.9	-1.0	-0.6	1.1
Commuting to job workplace: Cycle	0.7	0.9	2.3	0.8	-0.8	0.6	-1.5	-0.7
Myopia	0.2	0.2	0.3	0.6	-0.4	0.4	-0.6	-0.4
Vascular/heart problems diagnosed by doctor	4.8	13.1	15.3	-3.5	3.9	-3.9	-3.2	3.6
Cholesterol lowering medication	16.5	24.2	27.7	4.8	-5.2	5.0	4.2	-5.3
Medication: Omeprazole (e.g. Zanprol)	0.0	0.0	0.1	-0.3	-0.0	-0.2	0.3	0.0
Pain experienced in last month	5.8	9.7	14.0	-2.8	3.2	-3.7	-2.5	3.2
Supplements: Calcium	0.8	0.9	3.1	1.0	-0.5	1.8	-0.0	-0.5
Basal cell carcinoma (self-reported)	0.5	0.6	0.8	-0.8	0.8	-0.8	-0.9	0.5
Heart attack/myocardial infarction (self-reported)	6.6	8.5	10.8	2.8	-3.1	2.4	2.9	-3.3
Deep venous thrombosis (DVT) (self-reported)	3.7	4.7	5.9	2.1	-2.1	2.1	2.4	-2.1
Heart disease (siblings)	6.8	8.3	9.9	3.1	-3.0	3.1	2.4	-2.8
Alcohol drinker status: Previous	0.9	1.0	2.1	-0.2	1.1	0.3	-1.4	1.2
Pack years of smoking	0.6	0.8	1.9	0.5	-0.6	1.4	-1.1	-0.7
Impedance of whole body	0.1	0.6	1.1	-0.4	0.6	-0.9	-1.1	0.6
Leg fat mass (left)	3.7	14.6	20.5	4.5	-3.5	4.1	3.7	-3.2
Arm predicted mass (left)	0.1	0.4	1.0	-0.3	0.6	-0.2	1.0	0.7