Best TWAS P=2.9e-11 · Best GWAS P=1.14e-11 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | TUBG2 | 0.21 | 0.18 | enet | 17 | 0.26 | 2.1e-21 | -4.0 | -5.4 | 6.6e-08 | -0.75 | 0.92 | 0.08 | FALSE |
2 | GTEx | Artery Tibial | HSD17B1 | 0.12 | 0.07 | lasso | 9 | 0.07 | 4.4e-06 | -5.0 | -5.2 | 1.7e-07 | -0.60 | 0.30 | 0.69 | FALSE |
3 | GTEx | Artery Tibial | RP11-400F19.6 | 0.07 | 0.01 | lasso | 5 | 0.01 | 3.0e-02 | 6.8 | -6.6 | 3.0e-11 | -0.97 | 0.00 | 0.99 | FALSE |
4 | GTEx | Brain Caudate basal ganglia | TUBG2 | 0.39 | 0.24 | enet | 45 | 0.25 | 7.7e-08 | -5.0 | -6.0 | 1.9e-09 | -0.67 | 0.12 | 0.87 | FALSE |
5 | GTEx | Cells Transformed fibroblasts | TUBG2 | 0.16 | 0.18 | lasso | 4 | 0.17 | 6.5e-13 | -5.0 | -5.2 | 2.0e-07 | -0.66 | 0.99 | 0.01 | FALSE |
6 | GTEx | Cells Transformed fibroblasts | CNTNAP1 | 0.07 | 0.08 | lasso | 5 | 0.06 | 1.9e-05 | 5.0 | 5.3 | 1.4e-07 | 0.73 | 0.12 | 0.73 | FALSE |
7 | GTEx | Cells Transformed fibroblasts | CTD-3193K9.3 | 0.07 | 0.08 | lasso | 3 | 0.07 | 1.2e-05 | 5.0 | 5.1 | 2.8e-07 | 0.71 | 0.18 | 0.74 | FALSE |
8 | GTEx | Esophagus Mucosa | TUBG2 | 0.09 | 0.09 | lasso | 4 | 0.11 | 5.5e-08 | -5.0 | -6.4 | 1.6e-10 | -0.84 | 0.02 | 0.98 | FALSE |
9 | GTEx | Esophagus Muscularis | TUBG2 | 0.14 | 0.16 | enet | 17 | 0.06 | 2.1e-04 | -5.0 | -5.2 | 1.8e-07 | -0.66 | 0.96 | 0.04 | FALSE |
10 | GTEx | Esophagus Muscularis | NAGLU | 0.29 | 0.09 | lasso | 5 | 0.07 | 6.2e-05 | 5.5 | -5.5 | 4.1e-08 | -0.82 | 0.28 | 0.62 | FALSE |
11 | GTEx | Esophagus Muscularis | RP11-400F19.8 | 0.17 | 0.05 | lasso | 4 | 0.02 | 3.9e-02 | 5.5 | -5.8 | 8.6e-09 | -0.70 | 0.04 | 0.43 | FALSE |
12 | GTEx | Lung | TUBG2 | 0.08 | 0.02 | enet | 8 | 0.04 | 7.8e-04 | -5.0 | -5.3 | 9.5e-08 | -0.74 | 0.08 | 0.76 | FALSE |
13 | GTEx | Muscle Skeletal | TUBG2 | 0.12 | 0.09 | lasso | 8 | 0.10 | 1.1e-09 | 5.7 | -5.4 | 8.2e-08 | -0.91 | 0.00 | 1.00 | FALSE |
14 | GTEx | Nerve Tibial | RP11-400F19.8 | 0.10 | 0.03 | lasso | 3 | 0.02 | 8.2e-03 | 5.5 | -5.3 | 1.4e-07 | -0.83 | 0.14 | 0.25 | FALSE |
15 | GTEx | Pancreas | CNTNAP1 | 0.13 | 0.09 | lasso | 7 | 0.09 | 9.1e-05 | 5.3 | 5.7 | 9.4e-09 | 0.82 | 0.16 | 0.60 | FALSE |
16 | GTEx | Pancreas | FAM134C | 0.08 | 0.04 | enet | 9 | 0.03 | 2.0e-02 | 4.1 | 5.2 | 2.3e-07 | 0.80 | 0.10 | 0.62 | FALSE |
17 | GTEx | Pancreas | CTD-3193K9.3 | 0.12 | 0.07 | lasso | 5 | 0.07 | 5.7e-04 | 5.3 | 5.7 | 1.1e-08 | 0.83 | 0.13 | 0.50 | FALSE |
18 | GTEx | Skin Not Sun Exposed Suprapubic | TUBG2 | 0.15 | 0.13 | lasso | 5 | 0.12 | 4.0e-07 | 6.8 | -6.7 | 2.9e-11 | -0.99 | 0.00 | 1.00 | TRUE |
19 | GTEx | Skin Sun Exposed Lower leg | TUBG2 | 0.14 | 0.10 | enet | 25 | 0.12 | 4.9e-10 | -4.9 | -5.9 | 4.3e-09 | -0.83 | 0.01 | 0.99 | FALSE |
20 | GTEx | Stomach | HSD17B1P1 | 0.10 | 0.04 | lasso | 3 | 0.04 | 6.9e-03 | 5.0 | -5.9 | 2.8e-09 | -0.76 | 0.09 | 0.38 | FALSE |
21 | GTEx | Thyroid | HSD17B1P1 | 0.04 | 0.00 | enet | 9 | 0.00 | 2.2e-01 | -5.0 | -6.0 | 1.8e-09 | -0.74 | 0.06 | 0.75 | FALSE |
22 | METSIM | Adipose | TUBG2 | 0.08 | 0.09 | lasso | 6 | 0.09 | 5.2e-13 | 4.1 | -5.2 | 2.0e-07 | -0.79 | 0.97 | 0.03 | FALSE |
23 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TUBG2 | 0.02 | 0.01 | lasso | 2 | 0.01 | 1.7e-02 | 5.7 | -5.7 | 1.3e-08 | -0.86 | 0.00 | 0.80 | FALSE |
24 | The Cancer Genome Atlas | Brain Lower Grade Glioma | HSD17B1 | 0.30 | 0.05 | enet | 14 | 0.06 | 2.8e-07 | -4.2 | -5.6 | 2.4e-08 | -0.71 | 0.44 | 0.53 | FALSE |
25 | The Cancer Genome Atlas | Lung Adenocarcinoma | TUBG2 | 0.07 | 0.01 | enet | 7 | 0.02 | 2.2e-03 | 5.7 | -5.6 | 1.7e-08 | -0.80 | 0.00 | 0.89 | FALSE |
26 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | PSMC3IP | 0.02 | 0.02 | blup | 33 | 0.02 | 9.8e-04 | -5.0 | -6.0 | 1.9e-09 | -0.78 | 0.03 | 0.76 | FALSE |
27 | The Cancer Genome Atlas | Prostate Adenocarcinoma | TUBG2 | 0.04 | 0.02 | blup | 29 | 0.02 | 1.5e-03 | -4.9 | -5.6 | 2.4e-08 | -0.70 | 0.02 | 0.69 | FALSE |
28 | The Cancer Genome Atlas | Thyroid Carcinoma | HSD17B1 | 0.05 | 0.07 | blup | 29 | 0.07 | 2.3e-07 | -4.0 | -5.5 | 3.7e-08 | -0.76 | 0.66 | 0.33 | FALSE |
29 | The Cancer Genome Atlas | Thyroid Carcinoma | TUBG2 | 0.20 | 0.13 | blup | 29 | 0.17 | 1.7e-16 | 5.7 | -5.7 | 1.3e-08 | -0.84 | 0.00 | 1.00 | FALSE |