TWAS hub - PSMC3IP

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Head and Neck Squamous Cell Carcinoma	0.0399	0.0316	0.0034	0.003	0.013	0.011	NA	0.007	0.1400	0.01200	0.0210	NA	0.0450
2	TCGA	Brain Lower Grade Glioma	0.0178	0.0134	0.0065	0.015	0.016	0.014	NA	0.013	0.0061	0.00540	0.0097	NA	0.0100
3	TCGA	Lung Squamous Cell Carcinoma	0.0224	0.0163	0.0015	0.016	0.023	0.010	NA	0.018	0.0050	0.00098	0.0230	NA	0.0034

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Medication: Metformin	8.4	11.8	18.6	-2.8	-3.0	-4.3
Migraine (self-reported)	7.7	9.5	10.7	3.2	2.8	3.3
Arm fat mass (left)	6.9	28.1	41.2	-4.2	-5.1	-6.4
Trunk fat mass	6.5	28.0	37.6	-4.5	-5.1	-6.1
Arm fat mass (right)	6.4	26.3	39.2	-4.0	-4.9	-6.3
Mouth/teeth dental problems: Loose teeth	6.1	7.2	11.5	-2.1	-2.4	-3.4
Ovarian Cancer	5.8	7.6	9.9	-2.3	-2.7	-3.1
Weight	5.7	27.8	35.3	-4.3	-5.5	-5.9
Whole body fat mass	5.6	23.4	33.0	-4.0	-4.6	-5.7
Alcohol intake frequency.	5.6	13.0	21.3	-2.4	-3.5	-4.6
Blood White Count	5.5	40.6	61.6	-5.3	-5.6	-7.8
Trunk fat percentage	5.5	22.0	30.8	-4.2	-4.2	-5.6
Arm fat percentage (right)	5.5	21.8	36.1	-3.7	-4.0	-6.0
Illnesses of father: Heart disease	5.5	7.6	9.9	-2.4	-2.7	-3.1
Arm fat percentage (left)	5.4	21.6	34.9	-3.6	-4.1	-5.9
Exposure to tobacco smoke outside home	5.2	6.9	8.7	-2.3	-2.5	-3.0
Age at First Birth	5.1	7.4	8.2	2.5	2.8	2.9
HDL Cholesterol	5.1	8.5	10.5	2.8	2.7	3.2
Worry too long after embarrassment	5.0	8.4	10.4	2.4	3.0	3.2
Diabetes diagnosed by doctor	5.0	8.2	15.8	-1.8	-2.4	-4.0
Mouth/teeth dental problems: Dentures	4.9	8.3	11.6	-1.6	-3.4	-3.3
Illnesses of father: None of the above (group 1)	4.9	6.1	6.8	2.6	2.5	2.3
Hayfever, allergic rhinitis or eczema	4.8	10.4	20.2	1.8	2.8	4.5
Birth weight of first child	4.5	8.2	11.0	3.3	2.5	2.7
Body fat percentage	4.5	17.6	27.1	-3.5	-3.7	-5.2
Hayfever/allergic rhinitis (self-reported)	4.4	5.8	10.2	1.4	2.3	3.2
Qualifications: O levels/GCSEs or equivalent	4.4	7.0	7.7	2.8	2.8	2.4
Hip circumference	4.2	18.1	21.3	-3.7	-4.6	-4.4
Number of treatments/medications taken	4.0	7.2	9.5	2.3	3.1	2.6
Body mass index (BMI)	4.0	17.2	28.4	-2.9	-3.8	-5.3
Leg fat mass (right)	4.0	15.6	23.4	-3.1	-3.7	-4.8
Leg fat mass (left)	4.0	15.5	23.7	-3.0	-3.7	-4.9
Leg predicted mass (left)	3.9	20.6	25.6	-3.3	-5.1	-5.0
Maternal smoking around birth	3.8	5.6	8.8	-1.9	-2.1	-3.0
Leg fat-free mass (left)	3.7	19.8	24.6	-3.2	-5.0	-4.9
Basal metabolic rate	3.6	20.2	25.7	-3.4	-5.1	-4.8
Average weekly champagne plus white wine intake	3.5	4.8	5.8	1.9	2.4	2.2
Medication for hormone replacement therapy	3.4	3.8	5.5	-1.9	-1.5	-2.4
Qualifications: A levels/AS levels or equivalent	3.4	7.5	8.8	2.7	2.6	3.0
Arm fat-free mass (left)	3.4	17.1	22.3	-3.1	-4.7	-4.4
Allergy or Eczema	3.3	8.7	19.0	1.1	2.4	4.4
Hand grip strength (left)	3.3	8.6	11.0	-3.3	-2.9	-2.5
Alzheimer’s Disease (in father)	3.2	3.5	6.0	-2.4	-1.6	-1.4
Leg fat-free mass (right)	3.2	17.1	21.6	-2.9	-4.7	-4.6
Leg predicted mass (right)	3.2	17.1	21.5	-2.9	-4.6	-4.6
Ulcerative Colitis (UC)	3.1	5.9	14.1	-3.8	-1.9	-0.2
Hearing difficulty/problems: Yes	3.1	4.7	6.8	2.0	1.9	2.6
Waist circumference	3.1	11.3	21.6	-2.0	-2.9	-4.7
Illnesses of siblings	3.1	4.4	8.6	1.4	1.7	2.9
Medication: Gliclazide	3.1	3.5	4.3	-1.7	-1.9	-2.1
Whole body water mass	3.1	17.6	23.9	-3.1	-4.9	-4.3
Hand grip strength (right)	3.0	8.1	10.2	-2.9	-3.2	-2.4
Had menopause	3.0	3.7	5.7	-2.4	-2.1	-0.9
Allergy	3.0	6.8	14.7	-1.5	-1.8	-3.8
Whole body fat-free mass	3.0	17.1	23.5	-3.1	-4.8	-4.3
Arm predicted mass (left)	3.0	15.2	20.1	-2.9	-4.5	-4.2
Schizophrenia vs Biploar Disorder	2.9	3.8	5.6	-2.4	-1.9	-1.5
Diabetes (self-reported)	2.9	4.5	10.0	-0.8	-1.7	-3.2
Knee pain experienced in last month	2.9	4.5	8.0	-1.5	-1.8	-2.8
Medication: Allopurinol	2.8	3.8	4.9	1.5	2.0	2.2
Type 2 Diabetes (T2D) (2018)	2.7	5.1	11.0	-1.3	-1.6	-3.3
Tense / ‘highly strung’	2.7	4.5	4.9	-2.2	-2.0	-2.2
BMI	2.6	15.1	23.4	-3.0	-3.6	-4.8
Medication: Co-codamol	2.6	3.0	3.4	-1.8	-1.7	-1.7
Breastfed as a baby	2.6	3.2	3.9	1.9	1.5	2.0
Arm fat-free mass (right)	2.6	13.3	18.9	-2.7	-4.3	-3.7
Mother’s age at death	2.6	3.3	6.8	0.8	1.6	2.6
Blood Eosinophil Count	2.5	19.4	26.1	-5.1	-4.7	-3.2
Arm predicted mass (right)	2.5	12.8	18.5	-2.5	-4.3	-3.7
Height	2.4	46.4	65.6	-6.8	-8.1	-5.3
Trunk fat-free mass	2.4	14.0	20.5	-2.9	-4.5	-3.6
Trunk predicted mass	2.4	14.0	20.3	-2.9	-4.5	-3.6
Birth weight	2.4	5.3	6.9	2.3	1.9	2.6
Commuting to job workplace: Public transport	2.4	2.8	3.9	1.6	1.4	2.0
Age started oral contraceptive pill	2.4	3.0	4.2	1.3	2.0	1.8
Heart disease (siblings)	2.4	3.0	3.3	-1.6	-1.8	-1.8
Cardiovascular Disease	2.3	7.7	11.0	-2.9	-1.9	-3.3
Medication: Lansoprazole	2.3	2.6	3.5	1.6	1.9	1.3
Gout (self-reported)	2.3	3.1	3.4	1.8	1.6	1.9
Commuting to job workplace: Cycle	2.3	2.8	3.2	1.4	1.7	1.8
Intelligence (Savage-Jansen 2018)	2.2	6.7	7.6	2.4	2.7	2.6
Diabetes (father)	2.2	2.7	6.0	-1.1	-1.0	-2.5
Qualifications: None of the above	2.2	4.7	6.5	-1.7	-2.6	-2.2
Mouth/teeth dental problems	2.2	3.4	6.1	1.5	2.5	1.4
Frequency of tiredness / lethargy in last 2 weeks	2.2	3.5	5.4	2.3	1.7	1.6
Leg fat percentage (right)	2.2	7.8	13.5	-2.2	-2.3	-3.7
Osteoporosis (self-reported)	2.2	2.7	4.9	1.0	1.5	2.2
Alzheimer’s Disease (including proxy)	2.1	3.1	3.8	-1.6	-1.7	-2.0
Mean Putamen Volume	2.1	2.4	3.7	-0.9	-1.6	-1.9
Hearing difficulty/problems with background noise	2.1	3.3	7.6	1.0	1.2	2.8
Lung cancer (father)	2.1	2.4	2.9	-1.5	-1.4	-1.7
Headache pain in last month	2.1	3.5	5.2	2.3	1.4	1.9
Number of full brothers	2.1	2.6	3.5	-0.9	-1.9	-1.9
Medication for cholesterol	2.1	3.2	6.2	1.5	1.0	2.5
Impedance of leg (left)	2.0	9.8	14.3	1.6	3.5	3.8
Leg fat percentage (left)	2.0	7.3	13.3	-2.0	-2.1	-3.6
Worry (Nagel 2018)	1.9	4.0	6.4	-2.5	-1.7	-1.6
Severe depression (siblings)	1.9	2.2	3.4	1.3	1.2	1.9
Chronic bronchitis/emphysema (mother)	1.9	2.2	2.4	-1.5	-1.5	-1.3
Pulse rate, automated reading	1.9	6.2	8.4	-2.2	-2.4	-2.9
Illnesses of siblings: Diabetes	1.9	2.3	5.5	-0.5	-1.1	-2.3
Asthma (self-reported)	1.9	3.7	9.7	0.4	1.1	3.1
Eye problems/disorders: Diabetes related eye disease	1.8	2.0	3.3	-0.7	-1.4	-1.8
Hypothyroidism/myxoedema (self-reported)	1.8	3.5	6.2	-1.9	-2.5	-0.8
Mineral and other dietary supplements	1.8	2.4	2.9	-1.2	-1.7	-1.7
Alcohol drinker status: Previous	1.8	2.1	3.1	-1.4	-1.2	-1.8
Body Mass Index (BMI) (2010)	1.7	2.3	2.5	-1.4	-1.5	-1.6
LDL Cholesterol	1.7	2.6	4.5	2.1	1.8	0.4
Forced expiratory volume in 1-second (FEV1)	1.7	5.7	7.6	-2.5	-2.8	-1.8
Supplements: Vitamin C	1.7	2.1	3.4	0.9	1.4	1.8
Wears glasses or contact lenses	1.7	1.9	2.9	1.4	1.0	1.7
Glaucoma (self-reported)	1.6	1.9	3.0	1.1	1.7	1.2
High cholesterol (Self-reported)	1.6	2.8	4.9	-1.6	-1.0	-2.2
Breast Cancer	1.5	3.5	9.8	-3.1	-0.6	0.6
Impedance of leg (right)	1.5	7.1	11.6	1.1	2.9	3.4
Medication: Levothyroxine sodium	1.5	2.5	5.0	-1.5	-2.2	-0.6
High blood pressure (mother)	1.5	2.2	3.6	-0.1	1.9	1.7
Forced vital capacity (FVC)	1.5	5.9	8.5	-2.9	-2.8	-1.3
Standing height	1.5	15.3	22.6	-4.1	-4.8	-2.6
Eye problems/disorders: None of the above	1.5	1.8	2.6	-0.7	-1.5	-1.6
Ever taken oral contraceptive pill	1.5	1.7	2.1	1.2	1.5	1.2
Supplements: Fish oil (including cod liver oil)	1.5	2.0	2.2	1.3	1.5	1.4
Number of operations (self-reported)	1.5	2.2	2.7	1.6	1.6	1.2
Irritable Bowel Disease (IBD)	1.4	3.3	7.3	-2.7	-0.8	1.4
Waist Hip Ratio (WHR)	1.4	6.3	9.8	3.1	2.9	-0.6
Ever used hormone-replacement therapy (HRT)	1.4	1.7	1.9	-1.4	-1.2	-1.4
Pack years adult smoking proportion	1.4	2.1	4.9	-0.1	-1.1	-2.2
Qualifications: CSEs or equivalent	1.4	1.9	3.8	-0.2	-1.4	-1.9
Father’s age at death	1.4	1.8	4.5	0.4	0.9	2.1
Prospective memory result	1.4	1.8	4.1	0.2	1.0	2.0
Medication: Amlodipine	1.4	2.0	2.8	-1.4	-1.1	-1.7
Age at first live birth	1.4	2.5	3.5	1.0	1.9	1.7
Comparative height size at age 10	1.4	7.6	9.2	-3.0	-3.0	-2.1
Irritability	1.4	2.3	3.6	1.9	1.8	0.6
Pack years of smoking	1.4	2.1	4.7	-0.3	-1.2	-2.2
Prostate Cancer	1.3	1.8	2.2	-1.5	-1.4	-1.2
Systolic blood pressure, automated reading	1.3	3.7	7.7	-2.8	-1.6	-0.8
Asthma	1.3	2.5	7.0	0.3	0.7	2.6
Illnesses of mother	1.3	1.6	3.4	1.9	0.7	1.0
Osteoarthritis (self-reported)	1.3	1.7	2.4	1.6	1.1	1.3
Supplements: Calcium	1.3	1.4	2.2	0.8	1.2	1.5
Basal cell carcinoma (self-reported)	1.3	1.6	2.3	0.8	1.5	1.3
Crohns Disease (2012)	1.2	1.9	4.6	-0.3	1.0	2.1
Angina	1.2	1.6	2.6	-1.0	-1.1	-1.6
Hair/balding pattern: Pattern 2	1.2	1.5	2.0	1.0	1.3	1.4
Medication: Ramipril	1.2	1.6	2.3	-1.5	-0.8	-1.3
Angina (self-reported)	1.2	1.5	2.7	-0.9	-1.1	-1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.5	2.0	1.1	1.1	1.4
Medication: Aspirin	1.2	1.5	2.8	-1.7	-0.4	-1.3
Loneliness, isolation	1.2	1.6	3.7	1.9	0.9	0.6
Ever had bowel cancer screening	1.2	1.4	2.2	0.6	1.3	1.5
Medication: Aspirin	1.2	1.6	3.0	-1.7	-0.4	-1.3
Cholesterol lowering medication	1.2	1.7	2.9	-1.2	-0.8	-1.7
Lupus	1.1	1.6	2.7	1.6	0.8	1.2
Tinnitus: Yes, but not now, but have in the past	1.1	1.1	1.4	-1.2	-1.1	-0.9
Heel bone mineral density (BMD) T-score, automated (right)	1.1	2.5	5.6	-1.3	-0.5	-2.4
Happiness	1.1	1.4	2.0	1.1	1.4	1.0
Forced expiratory volume in 1-second (FEV1), Best measure	1.1	3.4	4.1	-1.9	-2.0	-1.5
Age at last live birth	1.1	1.5	2.7	1.2	1.6	0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	1.8	1.0	1.0	1.3
Verbal and Numeric Reasoning (VNR)	1.0	2.5	3.2	1.7	1.8	1.2
Heel T-Score	1.0	7.7	17.6	-2.3	-0.4	-4.2
Pulse wave reflection index	1.0	1.2	1.8	1.0	0.9	1.3
Qualifications: College or University degree	1.0	3.0	5.8	0.4	1.8	2.4
Suffer from ‘nerves’	1.0	1.6	1.9	-1.1	-1.2	-1.4
Average weekly red wine intake	1.0	1.5	3.8	0.1	0.9	2.0
Commuting to job workplace: Walk	1.0	1.1	2.2	0.5	1.0	1.5
Eye problems/disorders: Glaucoma	1.0	1.2	1.8	1.0	1.3	0.8
Medication: Lisinopril	1.0	1.3	2.3	-1.5	-0.6	-1.1
Myopia	1.0	1.4	1.8	1.4	1.2	1.0
Crohns Disease (2017)	0.9	2.1	5.0	-1.1	0.3	2.2
Falls in the last year	0.9	1.2	1.4	-1.1	-1.0	-1.2
Medication: Cholesterol lowering	0.9	1.4	3.3	-0.8	-0.1	-1.8
Medication: Seretide 50 evohaler	0.9	1.1	2.1	-0.8	-1.5	-0.6
Chest pain or discomfort	0.9	1.3	1.6	-1.0	-1.3	-1.1
Mouth/teeth dental problems: Mouth ulcers	0.9	1.5	4.3	0.3	0.2	2.1
Number of self-reported non-cancer illnesses	0.9	1.6	3.0	0.7	1.1	1.7
Hearing aid user	0.9	1.0	1.6	0.9	0.7	1.3
Unable to work because of sickness or disability	0.9	1.1	1.7	-0.4	-1.2	-1.3
Reaction Time	0.8	1.6	3.1	-0.7	-1.1	-1.8
Neuroticism (2016)	0.8	1.2	2.8	-0.2	-1.7	-0.8
Ever had hysterectomy (womb removed)	0.8	0.9	1.0	-1.0	-0.9	-0.9
Supplements: Zinc	0.8	0.9	1.4	0.7	1.2	1.0
Townsend deprivation index at recruitment	0.8	1.2	2.2	1.5	0.8	0.8
Current tobacco smoking	0.8	1.4	1.8	-0.8	-1.4	-1.2
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.8	4.2	-1.0	-0.3	-2.1
Multivitamins +/- minerals	0.8	1.0	1.1	1.1	1.0	1.0
Nervous feelings	0.8	1.4	1.7	-1.3	-1.3	-1.0
Ever unenthusiastic/disinterested for a whole week	0.8	0.9	1.4	-0.8	-1.2	-0.9
Pulse wave peak to peak time	0.8	1.0	1.6	-0.6	-0.9	-1.2
Shortness of breath walking on level ground	0.8	1.0	1.3	0.8	1.0	1.1
Mean time to correctly identify matches	0.8	1.5	2.4	-0.9	-1.1	-1.6
Overall health rating	0.8	1.8	1.8	-1.4	-1.3	-1.4
Mood swings	0.8	1.5	3.2	1.8	1.1	-0.1
Diastolic blood pressure, automated reading	0.8	2.5	4.1	-1.3	-1.3	-2.0
Alzheimer’s Disease (in mother)	0.7	0.8	1.1	-0.6	-1.0	-1.1
Ulcerative Colitis	0.7	1.0	1.8	-1.1	0.4	1.3
Taking other prescription medications	0.7	1.1	2.3	0.6	0.7	1.5
Sitting height	0.7	5.3	8.6	-2.6	-2.9	-0.7
Financial difficulties in last 2 years	0.7	0.9	1.5	1.2	0.1	-1.1
Alcohol intake versus 10 years previously	0.7	1.1	1.8	-0.2	-1.3	-1.2
Length of working week for main job	0.7	0.8	1.0	0.4	-1.0	-1.0
Peak expiratory flow (PEF)	0.7	1.7	2.4	-1.3	-1.5	-1.0
Forced vital capacity (FVC), Best measure	0.7	2.7	4.0	-2.0	-1.9	-0.8
Qualifications: nursing, teaching	0.7	1.1	1.7	0.7	1.1	1.3
Guilty feelings	0.7	1.1	1.4	0.9	1.2	1.0
Vascular/heart problems diagnosed by doctor	0.7	1.9	2.7	1.6	0.7	1.6
Triglycerides	0.6	1.0	2.2	-0.9	-0.1	-1.5
Systolic Blood Pressure	0.6	3.2	8.2	-2.9	-1.2	-0.3
Respiratory disease	0.6	1.4	3.8	-0.4	0.4	1.9
Stomach or abdominal pain in last month	0.6	0.8	1.1	0.3	1.0	1.1
Fluid intelligence score	0.6	1.2	1.5	1.1	1.2	0.9
Hair/balding pattern: Pattern 4	0.6	1.3	2.7	-1.6	-1.0	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	0.9	-0.7	-0.9	-1.0
Pain type(s) experienced in last month: Hip pain	0.6	0.7	1.3	-1.1	-0.8	-0.3
Medication: Atorvastatin	0.6	0.7	1.6	-0.2	-0.7	-1.3
Risk taking	0.6	0.9	1.1	1.1	1.0	0.8
Vitamin and mineral supplements	0.5	0.6	0.9	-0.6	-0.8	-1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.6	0.6	-0.8	-0.8	-0.8
High blood pressure	0.5	1.3	1.9	-1.4	-0.4	-1.3
Medication: Simvastatin	0.5	0.8	1.6	-0.9	0.2	-1.3
Neuroticism score	0.5	1.0	1.6	1.3	0.9	0.7
Time employed in main current job	0.5	0.5	1.1	0.7	1.0	0.2
Pulse wave Arterial Stiffness index	0.5	0.6	1.3	0.4	0.6	1.1
Blood clot in the leg (DVT)	0.5	0.6	1.0	0.3	-1.0	-0.9
Number of children fathered	0.5	0.5	1.3	-0.2	-1.1	-0.5
Medication: Ibuprofen	0.5	0.5	0.8	0.8	0.9	0.4
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.6	-0.5	-0.3	-1.2
Eye problems/disorders: Cataract	0.5	0.6	1.1	-0.3	1.0	0.9
Smoking status: Current	0.5	0.8	1.1	-0.5	-1.1	-1.1
Medication: Paracetamol	0.5	0.7	1.3	0.3	1.1	0.9
Impedance of whole body	0.5	2.5	4.6	-0.0	1.7	2.1
Schizophrenia (2018)	0.4	0.9	2.5	-1.6	-0.3	-0.1
HbA1C	0.4	0.5	1.1	-0.2	-0.6	-1.0
Schizophrenia (2014)	0.4	0.8	2.5	-1.6	-0.1	0.0
Type 2 Diabetes (T2D) (2012)	0.4	0.5	0.7	-0.6	-0.8	-0.6
Lung FVC	0.4	2.0	4.2	-2.1	-1.3	-0.1
Tanning	0.4	5.3	6.9	2.6	2.1	2.2
Number of incorrect matches in round	0.4	0.7	1.5	-0.7	0.3	1.2
Hair/balding pattern: Pattern 3	0.4	0.6	1.5	-0.3	-0.6	-1.2
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	0.6	0.7	0.6	0.8
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	1.3	0.8	-0.1	1.1
Medication: Ventolin 100micrograms inhaler	0.4	0.6	1.6	0.1	0.3	1.3
Leg pain on walking	0.4	0.5	0.9	0.9	-0.3	0.6
Miserableness	0.4	0.7	1.6	1.3	0.6	0.2
Average weekly beer plus cider intake	0.4	0.6	1.8	0.1	-0.3	-1.3
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.1	0.3	0.6	1.0
Ever depressed for a whole week	0.4	0.5	1.3	-0.5	-1.1	-0.3
Depressed Affect (Nagel 2018)	0.3	0.6	1.4	1.2	0.7	-0.2
Blood Red Count	0.3	2.6	4.7	-2.2	-0.9	-1.5
Hypothyroidism (self reported)	0.3	0.8	1.8	-0.8	-1.3	0.1
Frequency of depressed mood in last 2 weeks	0.3	0.4	0.7	0.6	0.8	0.3
Diabetes (mother)	0.3	0.4	1.2	-0.1	0.0	-1.1
Fed-up feelings	0.3	0.6	1.2	1.1	0.2	-0.6
Medication: Atenolol	0.3	0.4	1.0	0.1	0.2	-1.0
Alcohol usually taken with meals	0.3	0.5	1.2	0.5	0.4	1.1
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	0.9	-0.8	-0.9	-0.3
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.3	0.6	0.7	0.8	0.0
Neck or shoulder pain in last month	0.3	0.4	0.9	0.9	0.2	0.6
Heart disease (mother)	0.3	0.3	0.6	-0.6	-0.2	-0.8
Hypertension (Self-reported)	0.3	0.7	1.2	-1.0	-0.1	-1.1
Smoking status: Previous	0.3	0.5	1.0	0.0	0.7	1.0
Friendships satisfaction	0.3	0.3	0.5	-0.4	-0.7	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.5	0.7	0.5	0.4
Back pain experienced in last month	0.3	0.4	0.4	-0.6	-0.6	-0.6
Financial situation satisfaction	0.3	0.3	0.9	0.9	0.2	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.6	0.6	-0.8	-0.6
Bipolar Disorder (2018)	0.2	0.3	0.8	0.1	0.9	0.4
Bipolar Disorder or Schizophrenia	0.2	0.5	1.3	-1.1	0.3	0.2
Major Depression (MDD)	0.2	0.2	0.3	-0.5	-0.5	-0.1
Bipolar Disorder (2011)	0.2	0.2	0.4	-0.6	-0.1	0.4
Fasting Glucose	0.2	0.2	0.3	-0.5	-0.4	-0.5
Rheumatoid Arthritis	0.2	0.2	0.6	0.0	0.8	0.1
Sensitivity / hurt feelings	0.2	0.4	0.8	0.9	0.6	-0.1
Relative age of first facial hair	0.2	0.3	0.8	-0.5	-0.9	0.1
Average weekly fortified wine intake	0.2	0.3	0.7	-0.4	0.1	0.8
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	0.5	0.7	0.4	-0.5
Supplements: Glucosamine	0.2	0.3	0.5	-0.0	0.7	0.6
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.4	0.2	0.7	0.3
Noisy workplace	0.2	0.3	0.8	-0.1	-0.9	0.2
Exposure to tobacco smoke at home	0.2	0.2	0.5	0.3	-0.1	-0.7
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.5	0.7	-0.3	-0.4
Medication: Paracetamol	0.2	0.3	0.8	-0.1	0.9	0.4
High blood pressure (siblings)	0.2	0.2	0.5	-0.4	0.3	-0.7
Comparative body size at age 10	0.2	0.6	0.8	-0.5	-0.9	-0.9
Wheeze or whistling in the chest in last year	0.2	0.4	0.8	-0.4	-0.9	0.5
Health satisfaction	0.2	0.3	0.3	-0.5	-0.5	-0.5
Medication for pain relief, constipation, heartburn	0.2	0.3	0.8	0.4	-0.9	0.0
Medication: Omeprazole	0.2	0.3	0.6	-0.8	-0.4	-0.2
Number of full sisters	0.2	0.2	0.4	-0.6	0.0	-0.6
Had major operations	0.2	0.2	0.6	0.8	0.3	0.2
Family relationship satisfaction	0.2	0.2	0.6	-0.1	-0.2	-0.8
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.4	-0.7	-0.4	0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	0.5	-0.7	-0.7	-0.6
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.5	-0.1	0.1	0.7
Long-standing illness, disability or infirmity	0.2	0.3	0.4	0.6	0.5	0.4
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.4	-0.6	-0.2	0.4
Medication: Blood pressure	0.2	0.3	0.5	-0.7	0.4	-0.6
Illnesses of father: High blood pressure	0.2	0.2	0.3	-0.6	0.5	0.3
Ever smoked	0.2	0.3	0.6	-0.6	-0.0	0.8
Fractured/broken bones in last 5 years	0.2	0.2	0.5	0.4	0.1	0.7
Depression (Nagel 2018)	0.1	0.2	0.3	-0.5	-0.1	-0.6
Coronary Artery Disease (CAD)	0.1	0.1	0.2	0.1	0.3	-0.5
Primary Biliary Cirrhosis	0.1	0.1	0.2	0.5	0.4	0.1
Smoking Status	0.1	0.2	0.4	0.3	-0.6	-0.0
Lung FEV1/FVC ratio	0.1	0.7	1.8	1.3	0.5	-0.1
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.3	-0.5	0.0	-0.1
Relative age voice broke	0.1	0.1	0.2	0.4	-0.3	0.4
Serious illness, injury or assault to yourself	0.1	0.1	0.3	0.3	-0.1	-0.6
Chronic bronchitis/emphysema (father)	0.1	0.1	0.2	0.2	-0.5	0.4
Past tobacco smoking	0.1	0.2	0.3	0.4	-0.2	-0.5
Heart attack	0.1	0.2	0.4	0.6	0.4	-0.1
Impedance of arm (right)	0.1	0.6	0.9	-0.9	0.7	0.7
Worrier / anxious feelings	0.1	0.3	0.5	0.3	0.7	0.5
Number of live births	0.1	0.2	0.3	-0.1	-0.3	-0.6
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.3	-0.5	0.1	0.2
Depression (self-reported)	0.1	0.1	0.2	0.5	0.4	-0.1
Impedance of arm (left)	0.1	0.6	1.3	-1.1	0.3	0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.5	0.7	-0.1	-0.3
Loud music exposure frequency	0.1	0.1	0.3	0.3	-0.5	-0.0
Emphysema/chronic bronchitis	0.1	0.1	0.2	-0.0	-0.4	-0.5
Medication: Blood pressure	0.1	0.2	0.3	-0.4	0.2	-0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.2	-0.4	-0.3	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.3	0.4	-0.5	-0.4	-0.6
Medication: Bendroflumethiazide	0.1	0.2	0.4	-0.1	0.2	-0.6
Alcohol drinker status: Never	0.1	0.1	0.2	0.5	0.2	0.1
Medication: Omeprazole (e.g. Zanprol)	0.1	0.2	0.3	-0.6	-0.2	-0.4
Pain experienced in last month	0.1	0.1	0.3	-0.6	0.3	0.2
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.3	0.6	0.4	-0.1
Neuroticism (Nagel 2018)	0.0	0.0	0.1	0.2	0.3	-0.1
Blood Platelet Count	0.0	0.5	0.8	0.8	0.9	0.5
Neuroticism	0.0	0.1	0.1	0.3	0.3	0.2
Chronotype (morning person)	0.0	0.1	0.1	0.1	0.3	-0.3
Hair Pigment	0.0	0.2	0.4	-0.5	-0.1	0.7
Average weekly spirits intake	0.0	0.0	0.1	0.3	-0.1	-0.1
Age when periods started (menarche)	0.0	0.1	0.2	0.0	-0.4	0.1
Had other major operations	0.0	0.0	0.1	-0.1	0.3	0.2
Pain all over the body in last month	0.0	0.0	0.0	-0.1	0.2	-0.1
Pulse rate	0.0	0.1	0.1	-0.3	-0.3	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.0	0.0	0.1	0.0	0.3	-0.1
Qualifications: NVQ or HND or HNC or equivalent	0.0	0.0	0.0	0.1	0.0	-0.1
Breast cancer (self-reported)	0.0	0.0	0.1	0.3	-0.2	0.2

Hub : Genes

PSMC3IP

Models

Trait associations