Hub : Genes

FAM134C

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Pancreas 0.0840 0.0400 0.00930 0.036 NA 0.030 NA 0.028 0.0120 NA 2.0e-02 NA 2.3e-02
2 NTR Blood 0.0131 0.0081 0.01500 0.000 0.005 0.004 0.005 0.001 0.2600 0.0095 1.3e-02 0.0082 1.6e-01
3 YFS Blood 0.0289 0.0123 0.00057 0.005 0.004 0.014 0.007 0.012 0.0051 0.0120 1.2e-05 0.0022 5.8e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 1.2 1.9 3.4 -0.6 1.8 1.4
Bipolar Disorder or Schizophrenia 1.5 3.6 5.6 -1.0 2.1 2.4
Depressed Affect (Nagel 2018) 0.9 1.9 3.1 0.6 -1.8 -1.5
Depression (Nagel 2018) 4.1 6.1 11.9 0.6 -3.4 -2.5
Intelligence (Savage-Jansen 2018) 0.7 2.1 3.7 -1.6 1.9 -0.4
Neuroticism (Nagel 2018) 0.2 0.4 1.0 -0.4 -1.0 -0.4
Schizophrenia (2018) 0.8 1.7 3.3 -0.7 1.2 1.8
Schizophrenia vs Biploar Disorder 0.2 0.3 0.7 0.8 -0.1 0.4
Worry (Nagel 2018) 0.4 0.9 2.2 -0.1 0.6 1.5
Alzheimer’s Disease (in mother) 2.5 2.9 5.1 1.6 -2.3 -0.9
Alzheimer’s Disease (in father) 0.6 0.7 1.5 0.5 0.5 1.2
Alzheimer’s Disease (including proxy) 2.1 3.0 5.4 2.3 -1.9 -0.2
Crohns Disease (2017) 14.3 31.5 36.1 -4.9 5.9 6.0
Irritable Bowel Disease (IBD) 17.4 41.5 53.6 -4.3 7.2 7.3
Ulcerative Colitis (UC) 10.7 20.1 29.6 -2.0 5.2 5.4
Major Depression (MDD) 0.5 0.6 0.9 -0.2 0.9 0.9
Reaction Time 0.7 1.4 2.5 1.6 -1.0 -0.8
Verbal and Numeric Reasoning (VNR) 0.3 0.7 1.1 0.4 1.1 -0.9
Breast Cancer 3.2 7.7 12.8 -3.0 0.9 3.6
Ovarian Cancer 2.9 3.9 7.3 2.7 -1.6 -1.4
Prostate Cancer 1.0 1.4 3.8 0.2 -1.9 -0.7
Age at First Birth 2.7 3.9 5.1 -2.2 2.0 1.6
Bipolar Disorder (2011) 5.3 5.1 6.9 -1.6 2.6 2.4
Body Mass Index (BMI) (2010) 1.0 1.3 2.8 1.7 -0.6 0.8
Coronary Artery Disease (CAD) 4.2 5.0 10.4 0.9 -1.9 -3.2
Crohns Disease (2012) 11.5 18.4 19.2 -4.2 4.3 4.4
Mean Putamen Volume 1.8 2.0 4.5 2.1 -1.2 -0.3
Fasting Glucose 0.4 0.4 0.6 0.0 0.8 0.8
HbA1C 1.0 1.1 2.0 1.0 -0.6 -1.4
HDL Cholesterol 2.0 3.3 5.0 -2.2 1.3 1.8
LDL Cholesterol 1.0 1.5 3.8 0.6 -0.7 -1.9
Lupus 0.3 0.5 1.1 -0.5 0.4 -1.0
Neuroticism (2016) 0.5 0.7 0.9 1.0 -0.9 -0.7
Primary Biliary Cirrhosis 0.5 0.7 1.1 -0.7 -0.7 -1.1
Rheumatoid Arthritis 1.3 1.8 3.2 -0.4 -1.4 -1.8
Schizophrenia (2014) 1.7 3.7 5.4 -0.9 2.2 2.3
Triglycerides 0.8 1.3 2.8 1.7 -0.2 -1.0
Type 2 Diabetes (T2D) (2012) 0.2 0.2 0.6 -0.1 0.8 -0.1
Ulcerative Colitis 9.7 14.1 21.1 -2.3 4.6 4.0
Blood Eosinophil Count 0.5 3.5 7.3 0.3 -1.8 2.7
Blood Platelet Count 0.1 0.7 2.0 0.3 1.4 0.3
Blood Red Count 0.1 0.9 1.7 0.2 0.9 1.3
Blood White Count 4.9 36.6 51.7 7.0 -7.2 -3.0
Heel T-Score 1.3 10.5 20.5 4.5 -1.6 -2.9
BMI 1.8 10.6 16.3 4.0 -3.6 -1.5
Height 0.4 8.0 11.8 2.8 -3.4 2.1
Waist Hip Ratio (WHR) 2.4 10.9 19.4 2.6 -2.6 -4.4
Systolic Blood Pressure 3.1 15.3 20.7 -2.1 4.5 4.5
Smoking Status 0.3 0.6 0.8 0.6 0.8 0.9
Allergy or Eczema 5.6 14.8 39.1 -6.2 0.7 2.2
Cardiovascular Disease 1.5 5.0 6.9 2.0 -2.6 -2.0
Hypothyroidism (self reported) 0.8 1.9 3.3 -1.5 -1.8 0.6
Respiratory disease 1.9 4.2 11.2 -3.4 -0.6 1.0
Type 2 Diabetes (T2D) (2018) 3.5 6.5 8.6 2.9 -2.3 -2.4
Lung FEV1/FVC ratio 0.4 2.2 3.2 1.8 -1.7 -0.9
Lung FVC 1.1 5.6 10.4 -0.6 2.5 3.2
Neuroticism 0.1 0.2 0.5 -0.7 -0.5 0.2
Chronotype (morning person) 0.7 1.5 2.3 0.0 -1.5 -1.5
Hair Pigment 0.0 0.6 1.0 -1.0 -0.7 -0.5
Tanning 0.1 1.8 4.9 -0.3 2.2 0.5
Hand grip strength (left) 0.2 0.6 0.8 0.9 0.7 0.6
Number of treatments/medications taken 1.9 3.4 5.5 -2.3 -0.4 -2.1
Average weekly spirits intake 0.4 0.5 1.2 0.4 -0.3 -1.1
Sensitivity / hurt feelings 1.4 2.3 4.4 0.1 -1.6 -2.1
Frequency of depressed mood in last 2 weeks 2.0 2.8 6.5 -0.0 -2.5 -1.4
Hearing difficulty/problems: Yes 2.1 3.1 4.1 -2.0 1.8 1.5
Relative age of first facial hair 0.1 0.1 0.3 -0.5 0.1 -0.3
Other serious medical condition/disability diagnosed by doctor 0.6 0.7 1.6 -0.6 -1.3 -0.5
Ever used hormone-replacement therapy (HRT) 0.3 0.4 1.2 1.1 -0.0 -0.1
Ever had hysterectomy (womb removed) 0.6 0.7 1.0 1.0 0.7 0.8
Systolic blood pressure, automated reading 2.5 7.1 14.1 -0.8 2.6 3.8
Eye problems/disorders: Diabetes related eye disease 2.1 2.3 3.9 2.0 -1.0 -1.5
Angina 0.8 1.0 2.2 1.5 -0.9 -0.2
Medication for hormone replacement therapy 1.4 1.6 3.5 1.9 -0.8 -0.8
Vitamin and mineral supplements 0.9 1.3 2.2 1.5 -1.2 0.5
Supplements: Zinc 0.8 0.9 1.5 -1.2 1.0 -0.4
Medication: Co-codamol 1.4 1.6 4.6 0.4 -2.1 -0.4
Medication: Metformin 4.5 6.4 11.4 3.4 -2.6 -1.0
Diabetes (father) 3.2 3.9 4.4 1.7 -2.1 -2.1
Diabetes (mother) 2.7 3.4 6.9 1.2 -2.6 -1.4
Severe depression (siblings) 1.0 1.1 1.9 -1.2 1.4 -0.3
Pack years adult smoking proportion 1.6 2.5 6.7 2.6 -0.1 -0.9
Impedance of leg (right) 2.7 13.0 22.2 -4.7 3.8 1.5
Leg fat-free mass (left) 2.9 15.4 23.8 4.9 -4.6 -1.0
Trunk fat percentage 2.8 11.3 16.2 3.9 -4.0 -1.7
Hand grip strength (right) 0.2 0.7 0.8 0.9 0.9 0.5
Townsend deprivation index at recruitment 0.2 0.3 0.4 -0.6 0.6 0.3
Current tobacco smoking 0.6 1.0 1.6 1.2 0.4 1.2
Average weekly fortified wine intake 1.3 1.5 2.8 -1.7 1.1 0.7
Maternal smoking around birth 1.9 2.8 7.2 2.7 -1.0 -0.1
Fed-up feelings 1.1 1.9 3.8 1.0 -2.0 -1.0
Frequency of unenthusiasm / disinterest in last 2 weeks 3.2 4.3 11.0 0.2 -3.3 -1.3
Relative age voice broke 0.4 0.5 1.4 -0.4 -0.0 -1.2
Taking other prescription medications 2.1 3.2 7.3 -2.7 -1.3 -0.8
Age when periods started (menarche) 0.1 0.2 0.3 -0.4 0.6 0.1
Bilateral oophorectomy (both ovaries removed) 0.7 0.8 1.4 0.8 -0.6 -1.2
Heel bone mineral density (BMD) T-score, automated (left) 1.0 2.2 5.7 2.4 -0.9 -0.1
Tinnitus: Yes, but not now, but have in the past 0.7 0.7 1.6 0.2 1.3 0.7
Qualifications: CSEs or equivalent 3.5 4.6 7.0 2.0 -1.7 -2.6
Serious illness, injury or assault to yourself 3.0 3.6 6.9 1.1 -2.6 -1.7
High blood pressure 0.1 0.3 0.7 0.9 -0.0 -0.1
Hayfever, allergic rhinitis or eczema 5.8 12.5 34.2 -5.8 0.7 1.7
Multivitamins +/- minerals 0.9 1.1 2.3 -0.9 1.5 -0.2
Stomach or abdominal pain in last month 0.5 0.6 1.5 -1.2 -0.4 0.0
Supplements: Glucosamine 0.6 0.8 1.5 -0.6 0.7 1.2
Diverticular disease/diverticulitis (self-reported) 0.5 0.6 1.3 -0.5 -0.3 -1.1
Medication: Atenolol 2.0 2.5 3.0 1.5 -1.7 -1.5
Medication: Levothyroxine sodium 0.8 1.4 3.9 -0.5 -2.0 -0.1
Sitting height 0.7 5.0 14.4 -0.6 0.2 3.8
Chronic bronchitis/emphysema (father) 0.8 0.9 1.7 -1.0 0.3 1.3
High blood pressure (mother) 4.3 6.0 8.9 -3.0 2.2 2.1
Body mass index (BMI) 3.8 16.3 28.8 5.4 -4.2 -1.6
Impedance of leg (left) 2.7 13.2 24.5 -5.0 3.8 0.9
Leg predicted mass (left) 2.9 15.4 23.8 4.9 -4.6 -1.0
Trunk fat mass 3.5 15.2 22.7 4.8 -4.6 -1.4
Waist circumference 4.3 15.6 24.4 4.9 -4.4 -1.9
Number of incorrect matches in round 3.1 5.1 6.4 -2.3 1.9 2.5
Past tobacco smoking 0.1 0.1 0.1 0.4 0.3 -0.3
Alcohol usually taken with meals 0.6 1.0 2.1 -0.9 1.5 0.5
Nervous feelings 0.0 0.1 0.1 -0.0 0.4 0.3
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.4 0.6 -0.2 -0.6 0.8
Hearing difficulty/problems with background noise 4.7 7.4 13.7 -3.7 1.5 2.5
Hair/balding pattern: Pattern 2 1.1 1.4 3.8 -1.9 0.2 -0.6
Had menopause 2.6 3.3 8.9 -0.2 1.0 3.0
Had other major operations 0.0 0.0 0.1 -0.0 0.3 -0.0
Forced vital capacity (FVC) 0.4 1.5 4.4 -0.2 0.3 2.1
Heel bone mineral density (BMD) T-score, automated (right) 1.4 3.1 9.1 3.0 -0.2 0.5
Ever unenthusiastic/disinterested for a whole week 0.4 0.5 0.7 0.5 -0.8 -0.8
Qualifications: None of the above 0.5 1.0 1.5 1.2 -1.2 0.2
Financial difficulties in last 2 years 2.8 3.8 5.2 2.3 -1.6 -1.9
Mouth/teeth dental problems 1.4 2.2 4.1 -0.4 1.5 -2.0
Heart attack 1.1 1.4 2.9 0.6 -1.7 -0.9
Allergy 3.9 9.0 24.5 5.0 0.1 -1.5
Pain all over the body in last month 1.5 1.6 3.8 -0.4 -0.8 -1.9
Diabetes (self-reported) 4.7 7.2 11.6 3.4 -2.0 -2.5
Hayfever/allergic rhinitis (self-reported) 5.2 6.9 18.1 -4.3 1.4 0.9
Medication: Ramipril 0.8 1.0 2.2 0.7 -1.5 0.6
Medication: Simvastatin 0.9 1.3 2.3 0.9 -1.5 -0.9
Fluid intelligence score 0.0 0.1 0.1 0.4 0.1 -0.2
Illnesses of siblings 4.5 6.3 9.6 -3.1 2.2 2.1
Neuroticism score 0.4 0.8 1.4 -0.7 -1.2 -0.8
Weight 3.4 16.8 29.5 5.4 -4.5 -0.7
Impedance of arm (right) 0.7 3.1 8.6 -2.9 0.7 -0.6
Arm fat percentage (right) 4.8 18.9 26.8 5.2 -4.8 -2.6
Trunk fat-free mass 1.4 8.0 16.2 4.0 -2.7 0.8
Hip circumference 1.4 6.1 10.8 2.7 -3.3 -0.1
Time employed in main current job 0.3 0.4 1.0 0.3 1.0 -0.2
Alcohol intake versus 10 years previously 0.5 0.7 1.9 1.4 -0.4 -0.3
Father’s age at death 6.1 8.2 10.6 -2.0 3.2 3.2
Worrier / anxious feelings 0.2 0.5 1.2 -1.1 0.4 0.0
Frequency of tiredness / lethargy in last 2 weeks 1.5 2.4 4.1 -1.0 -1.4 -2.0
Falls in the last year 0.9 1.2 1.9 1.0 -1.4 -0.8
Hair/balding pattern: Pattern 3 1.0 1.4 4.0 2.0 -0.6 0.1
Number of live births 0.7 0.9 2.0 1.4 -0.9 -0.2
Forced expiratory volume in 1-second (FEV1) 0.2 0.8 1.2 1.1 -0.8 0.7
Pulse rate 0.1 0.3 0.5 0.7 -0.4 0.2
Happiness 1.3 1.6 3.0 -0.5 -1.7 -1.2
Noisy workplace 1.5 1.9 2.6 -1.2 1.2 1.6
Qualifications: A levels/AS levels or equivalent 0.8 1.7 3.4 -1.8 1.2 -0.4
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.1 0.3 0.3 0.3 0.5
Mouth/teeth dental problems: Dentures 4.7 8.0 13.0 3.6 -3.2 -1.0
Asthma 3.7 7.3 19.1 -4.4 -0.4 1.6
Medication: Ibuprofen (e.g. Nurofen) 0.7 0.9 1.6 0.9 -0.4 -1.3
Medication: Cholesterol lowering 1.4 2.2 2.9 1.6 -1.7 -1.1
Depression (self-reported) 1.9 2.3 3.6 0.1 -1.8 -1.9
Medication: Lansoprazole 3.7 4.2 8.2 -0.6 -2.0 -2.9
Prospective memory result 3.8 4.7 9.4 -3.1 0.9 2.0
Lung cancer (father) 0.6 0.7 1.5 1.2 -0.7 -0.4
Illnesses of mother 0.1 0.1 0.3 -0.0 0.6 -0.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.6 0.9 0.9 -0.8 0.5
Pulse wave Arterial Stiffness index 0.3 0.4 1.1 -1.0 0.0 0.1
Impedance of arm (left) 0.8 3.5 9.2 -3.0 1.1 0.2
Arm fat mass (right) 4.7 19.5 32.3 5.7 -4.8 -1.8
Trunk predicted mass 1.4 7.8 15.8 4.0 -2.7 0.7
Standing height 0.2 1.9 3.1 0.9 -1.3 1.8
Length of working week for main job 2.6 2.8 7.5 2.7 -0.7 -0.7
Exposure to tobacco smoke at home 0.5 0.5 1.1 1.1 -0.5 -0.5
Breastfed as a baby 2.2 2.7 4.4 -0.4 1.9 2.1
Tense / ‘highly strung’ 0.6 1.0 2.1 1.4 -0.8 0.5
Seen doctor (GP) for nerves, anxiety, tension or depression 0.7 1.1 1.7 1.3 -0.1 -1.2
Hair/balding pattern: Pattern 4 0.6 1.6 4.1 0.0 0.8 2.0
Birth weight of first child 0.8 1.5 2.4 -1.3 0.6 -1.6
Peak expiratory flow (PEF) 0.6 1.4 2.5 1.0 -1.6 -0.7
Pulse wave reflection index 0.4 0.5 0.9 -0.9 0.8 0.1
Ever highly irritable/argumentative for 2 days 1.3 1.6 3.2 0.7 -1.0 -1.8
Loud music exposure frequency 0.3 0.4 0.6 -0.5 0.5 0.8
Qualifications: O levels/GCSEs or equivalent 0.4 0.6 0.9 -0.4 0.9 -1.0
Mouth/teeth dental problems: Bleeding gums 0.7 0.8 1.5 -1.2 -0.7 0.7
Blood clot in the leg (DVT) 2.6 3.4 4.5 2.1 -2.1 -1.1
Medication: Paracetamol 1.2 2.0 4.9 -1.0 -0.2 -2.2
Headache pain in last month 1.1 1.9 3.9 -1.3 -0.2 -2.0
Medication for cholesterol, blood pressure or diabetes 0.9 1.6 3.0 -0.8 1.7 1.0
Glaucoma (self-reported) 1.0 1.1 2.0 -1.4 0.7 0.9
Gout (self-reported) 0.6 0.8 2.0 -1.4 -0.5 -0.5
Hypothyroidism/myxoedema (self-reported) 0.7 1.3 2.6 -0.7 -1.6 0.9
Medication: Amlodipine 0.5 0.7 1.7 1.3 -0.4 0.3
Medication: Ventolin 100micrograms inhaler 1.7 2.2 4.8 -2.2 -1.1 0.7
Birth weight 0.5 1.1 2.4 -1.6 0.9 0.4
Chronic bronchitis/emphysema (mother) 0.5 0.6 1.1 1.0 0.5 0.7
High blood pressure (siblings) 0.1 0.1 0.3 0.1 0.0 -0.5
Forced vital capacity (FVC), Best measure 0.3 1.0 2.6 -0.4 0.2 1.6
Body fat percentage 2.9 11.4 16.2 4.0 -3.9 -1.7
Leg fat percentage (right) 1.6 5.8 10.2 3.2 -2.6 -0.7
Arm fat-free mass (right) 1.4 7.1 15.4 3.9 -2.4 0.7
Exposure to tobacco smoke outside home 2.5 3.4 6.6 2.6 -1.9 0.2
Comparative body size at age 10 0.6 1.7 2.5 1.6 -1.4 -0.8
Number of full brothers 1.1 1.3 2.8 1.7 -1.0 -0.5
Worry too long after embarrassment 2.0 3.4 8.3 -2.9 1.2 0.8
Seen a psychiatrist for nerves, anxiety, tension or depression 1.4 1.8 4.8 0.3 -2.2 -0.7
Wheeze or whistling in the chest in last year 0.6 1.0 2.0 -1.4 -1.0 0.1
Number of children fathered 1.4 1.6 3.6 0.9 -1.9 -0.6
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.4 0.7 0.5 0.9 -0.3
Age at first live birth 0.6 1.1 2.5 -1.6 -0.1 -0.8
Pulse wave peak to peak time 0.3 0.4 1.0 1.0 -0.4 0.0
Health satisfaction 0.4 0.6 1.4 -0.4 -1.2 0.2
Shortness of breath walking on level ground 1.1 1.4 3.1 -1.8 -0.5 -0.8
Qualifications: College or University degree 1.4 4.3 5.5 -2.3 2.3 1.6
Eye problems/disorders: None of the above 1.9 2.2 4.2 2.1 0.5 1.4
Mouth/teeth dental problems: Loose teeth 4.6 5.4 9.4 3.1 -2.6 -0.5
Emphysema/chronic bronchitis 1.3 1.5 2.4 1.1 -1.5 -0.9
Medication for pain relief, constipation, heartburn 0.5 0.8 1.1 0.9 0.6 1.1
Neck or shoulder pain in last month 0.3 0.4 0.7 -0.0 -0.8 -0.7
Medication: Blood pressure 0.5 1.0 1.5 0.7 -1.2 -0.9
Angina (self-reported) 1.0 1.3 2.8 1.7 -0.9 -0.5
Migraine (self-reported) 2.5 3.1 8.5 -2.9 0.2 -0.9
Medication: Ibuprofen 0.3 0.4 0.8 0.9 -0.1 -0.6
Medication: Allopurinol 1.9 2.5 7.0 -2.6 -0.4 -0.5
Medication: Omeprazole 0.2 0.2 0.4 -0.6 0.4 0.4
Medication: Seretide 50 evohaler 0.6 0.7 1.7 0.3 -1.3 0.5
Mean time to correctly identify matches 0.5 0.9 2.2 1.5 -0.6 -0.2
Heart disease (mother) 3.5 4.3 7.3 0.7 -2.7 -2.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.6 0.7 1.6 -1.3 0.6 0.5
Whole body fat mass 3.5 14.7 22.3 4.7 -4.4 -1.4
Leg fat mass (right) 2.9 11.1 18.4 4.3 -3.7 -1.1
Arm predicted mass (right) 1.6 8.0 17.4 4.2 -2.5 0.4
Pulse rate, automated reading 1.5 5.0 9.9 3.1 -2.2 -0.4
Alcohol intake frequency. 4.6 10.8 13.6 3.7 -3.5 -2.5
Comparative height size at age 10 0.2 1.2 1.8 0.9 -1.3 1.1
Number of full sisters 0.4 0.5 1.1 0.6 -0.4 -1.1
Suffer from ‘nerves’ 0.3 0.5 0.8 0.9 -0.8 -0.1
Overall health rating 0.8 1.7 4.7 0.5 -2.2 0.4
Chest pain or discomfort 0.1 0.1 0.3 0.5 -0.1 -0.0
Had major operations 0.3 0.3 0.8 0.3 -0.3 -0.9
Age at last live birth 1.3 1.9 3.8 0.4 -1.3 -2.0
Family relationship satisfaction 2.6 3.2 5.2 1.0 -2.3 -1.9
Leg pain on walking 0.3 0.3 0.7 -0.8 0.5 -0.1
Qualifications: NVQ or HND or HNC or equivalent 0.1 0.1 0.2 0.1 -0.0 -0.5
Commuting to job workplace: Car/motor vehicle 0.8 0.9 2.7 1.7 0.1 0.2
Illness, injury, bereavement, stress in last 2 years 1.4 1.7 2.0 -1.3 1.2 1.4
Medication: Aspirin 0.6 0.7 2.1 0.2 -1.5 0.2
Supplements: Vitamin C 2.2 2.6 6.8 -2.6 0.9 0.5
Knee pain experienced in last month 6.0 9.3 12.6 3.1 -3.5 -2.4
Hypertension (Self-reported) 0.1 0.2 0.6 0.8 -0.1 -0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.8 0.9 2.0 -1.4 -0.6 -0.6
Illnesses of father: Heart disease 2.5 3.4 5.6 2.4 -1.9 -1.1
Illnesses of siblings: Diabetes 5.6 6.9 8.0 2.8 -2.1 -2.8
Smoking status: Previous 0.2 0.3 0.6 -0.8 -0.6 -0.0
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.2 0.2 0.5 -0.4 -0.4
Whole body fat-free mass 1.9 10.8 20.3 4.5 -3.5 0.0
Leg fat-free mass (right) 2.7 14.3 22.1 4.7 -4.4 -1.1
Arm fat percentage (left) 4.3 17.2 24.8 5.0 -4.7 -2.3
Average weekly red wine intake 2.3 3.4 6.5 -2.6 1.7 0.9
Handedness (chirality/laterality): Left-handed 0.5 0.6 1.3 -1.1 0.5 0.4
Mood swings 0.8 1.4 2.2 0.1 -1.5 -1.5
Loneliness, isolation 0.7 0.9 1.7 0.0 -1.3 -1.0
Long-standing illness, disability or infirmity 1.0 1.5 3.5 -0.6 -1.9 -0.8
Ever had bowel cancer screening 1.4 1.7 2.4 -1.6 1.4 0.7
Diabetes diagnosed by doctor 5.1 8.3 12.3 3.5 -2.5 -2.5
Ever had stillbirth, spontaneous miscarriage or termination 1.0 1.1 1.9 0.3 -1.4 -1.1
Friendships satisfaction 0.4 0.5 1.1 0.7 -1.0 -0.2
Qualifications: nursing, teaching 0.6 0.9 1.0 -1.0 1.0 -0.8
Commuting to job workplace: Walk 2.7 2.9 6.5 -2.5 1.0 1.1
Eye problems/disorders: Cataract 0.8 0.9 2.8 -1.7 0.2 -0.0
Mouth/teeth dental problems: Mouth ulcers 4.3 6.9 8.9 -3.0 2.3 2.5
Medication for cholesterol 1.8 2.8 4.9 -2.2 1.3 1.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.3 1.0 0.0 0.3 -1.0
Back pain experienced in last month 1.0 1.5 3.8 0.6 0.5 1.9
Mineral and other dietary supplements 0.6 0.8 1.9 1.4 -0.5 0.6
Breast cancer (self-reported) 0.0 0.0 0.0 0.1 -0.1 0.0
Asthma (self-reported) 4.9 9.7 24.3 -4.9 0.1 2.2
Osteoporosis (self-reported) 2.4 2.9 8.1 -2.9 0.8 0.1
Osteoarthritis (self-reported) 0.7 0.9 1.8 -0.9 -0.1 -1.4
Medication: Aspirin 0.5 0.7 2.1 0.2 -1.4 0.0
Medication: Gliclazide 1.2 1.3 2.6 1.0 -1.6 -0.6
Illnesses of father: None of the above (group 1) 0.3 0.3 0.7 -0.4 0.8 -0.4
Smoking status: Current 0.6 1.0 1.5 1.2 0.6 1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.5 0.6 0.7 -0.6 -0.7
Whole body water mass 1.9 10.9 20.5 4.5 -3.5 0.0
Leg predicted mass (right) 2.8 14.8 22.6 4.8 -4.5 -1.2
Arm fat mass (left) 4.8 19.5 33.2 5.8 -4.8 -1.7
Number of self-reported non-cancer illnesses 1.6 2.8 8.4 -2.9 -0.2 0.4
Average weekly champagne plus white wine intake 1.2 1.6 2.7 -1.7 1.2 -0.8
Miserableness 0.3 0.5 0.8 0.4 -0.9 -0.8
Guilty feelings 0.6 0.9 1.2 -1.0 -0.7 -1.1
Wears glasses or contact lenses 1.0 1.1 1.5 -1.2 1.2 0.6
Ever taken oral contraceptive pill 1.6 1.8 3.3 -0.9 1.8 1.1
Hearing aid user 0.3 0.4 0.9 -0.9 0.2 0.5
Mother’s age at death 2.4 3.0 7.7 -2.8 -0.2 1.2
Financial situation satisfaction 2.0 2.4 4.5 1.1 -2.1 -1.2
Tinnitus: Yes, now most or all of the time 0.9 1.0 1.3 -1.1 1.1 0.8
Commuting to job workplace: Public transport 1.4 1.6 3.1 -1.8 1.4 0.1
Eye problems/disorders: Glaucoma 0.3 0.3 0.9 -1.0 -0.1 -0.2
Medication: Blood pressure 0.2 0.4 0.7 0.6 0.8 0.3
Pain type(s) experienced in last month: Hip pain 0.2 0.2 0.6 -0.1 -0.8 -0.2
Supplements: Fish oil (including cod liver oil) 0.6 0.8 1.6 -0.9 0.2 -1.3
High cholesterol (Self-reported) 0.9 1.6 3.1 1.8 -1.2 -0.6
Medication: Bendroflumethiazide 0.5 0.7 1.2 1.1 -0.3 -0.9
Medication: Paracetamol 0.8 1.2 2.6 -1.0 0.0 -1.6
Medication: Lisinopril 0.0 0.1 0.1 0.3 0.2 -0.2
Medication: Atorvastatin 1.6 2.0 3.5 1.2 -1.9 -1.1
Illnesses of father: High blood pressure 0.7 0.8 1.5 -1.2 0.8 0.6
Alcohol drinker status: Never 0.2 0.3 0.8 0.3 -0.9 0.2
Ever smoked 0.8 1.4 2.6 -0.5 1.1 1.6
Basal metabolic rate 2.4 13.0 23.7 4.9 -3.9 -0.2
Leg fat percentage (left) 1.7 6.1 10.2 3.2 -2.7 -1.0
Arm fat-free mass (left) 2.0 10.4 22.2 4.7 -3.0 0.2
Number of operations (self-reported) 1.1 1.6 4.1 -0.8 -0.4 -2.0
Average weekly beer plus cider intake 1.9 2.7 4.8 2.2 -1.3 -1.3
Irritability 2.0 3.4 5.6 -0.2 -2.1 -2.4
Risk taking 0.5 0.8 1.2 -0.0 1.1 -1.1
Ever had prostate specific antigen (PSA) test 1.7 2.0 3.1 -1.8 1.6 0.4
Fractured/broken bones in last 5 years 0.7 0.8 2.4 -1.6 -0.3 0.2
Age started oral contraceptive pill 1.4 1.8 3.1 -1.2 1.8 0.9
Diastolic blood pressure, automated reading 1.7 5.4 6.4 2.5 -2.2 -2.2
Ever depressed for a whole week 1.0 1.2 2.4 0.2 1.6 1.1
Unable to work because of sickness or disability 2.8 3.6 5.3 1.6 -2.3 -1.8
Commuting to job workplace: Cycle 0.6 0.8 1.4 -1.0 0.1 -1.2
Myopia 0.1 0.1 0.3 -0.3 0.2 -0.5
Vascular/heart problems diagnosed by doctor 0.3 0.7 1.0 -1.0 1.0 0.5
Cholesterol lowering medication 1.5 2.2 3.9 1.5 -2.0 -0.6
Medication: Omeprazole (e.g. Zanprol) 0.1 0.1 0.3 -0.4 0.5 0.0
Pain experienced in last month 0.7 1.2 1.5 -0.9 1.2 1.2
Supplements: Calcium 1.4 1.6 3.7 -1.9 0.7 -0.7
Basal cell carcinoma (self-reported) 0.9 1.1 1.8 -1.3 1.1 0.4
Heart attack/myocardial infarction (self-reported) 1.0 1.3 2.7 0.5 -1.6 -0.9
Deep venous thrombosis (DVT) (self-reported) 2.4 3.1 4.4 2.0 -2.1 -1.1
Heart disease (siblings) 3.0 3.7 7.2 1.5 -2.7 -1.2
Alcohol drinker status: Previous 0.5 0.6 1.2 0.8 -1.1 -0.1
Pack years of smoking 1.5 2.3 6.0 2.5 -0.1 -0.8
Impedance of whole body 1.5 7.5 17.1 -4.1 2.2 0.6
Leg fat mass (left) 2.9 11.4 18.6 4.3 -3.7 -1.2
Arm predicted mass (left) 1.9 9.7 20.5 4.5 -2.9 0.3