TWAS hub - FAM134C

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Pancreas	0.0840	0.0400	0.00930	0.036	NA	0.030	NA	0.028	0.0120	NA	2.0e-02	NA	2.3e-02
2	NTR	Blood	0.0131	0.0081	0.01500	0.000	0.005	0.004	0.005	0.001	0.2600	0.0095	1.3e-02	0.0082	1.6e-01
3	YFS	Blood	0.0289	0.0123	0.00057	0.005	0.004	0.014	0.007	0.012	0.0051	0.0120	1.2e-05	0.0022	5.8e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Irritable Bowel Disease (IBD)	17.4	41.5	53.6	-4.3	7.2	7.3
Crohns Disease (2017)	14.3	31.5	36.1	-4.9	5.9	6.0
Crohns Disease (2012)	11.5	18.4	19.2	-4.2	4.3	4.4
Ulcerative Colitis (UC)	10.7	20.1	29.6	-2.0	5.2	5.4
Ulcerative Colitis	9.7	14.1	21.1	-2.3	4.6	4.0
Father’s age at death	6.1	8.2	10.6	-2.0	3.2	3.2
Knee pain experienced in last month	6.0	9.3	12.6	3.1	-3.5	-2.4
Hayfever, allergic rhinitis or eczema	5.8	12.5	34.2	-5.8	0.7	1.7
Allergy or Eczema	5.6	14.8	39.1	-6.2	0.7	2.2
Illnesses of siblings: Diabetes	5.6	6.9	8.0	2.8	-2.1	-2.8
Bipolar Disorder (2011)	5.3	5.1	6.9	-1.6	2.6	2.4
Hayfever/allergic rhinitis (self-reported)	5.2	6.9	18.1	-4.3	1.4	0.9
Diabetes diagnosed by doctor	5.1	8.3	12.3	3.5	-2.5	-2.5
Blood White Count	4.9	36.6	51.7	7.0	-7.2	-3.0
Asthma (self-reported)	4.9	9.7	24.3	-4.9	0.1	2.2
Arm fat percentage (right)	4.8	18.9	26.8	5.2	-4.8	-2.6
Arm fat mass (left)	4.8	19.5	33.2	5.8	-4.8	-1.7
Hearing difficulty/problems with background noise	4.7	7.4	13.7	-3.7	1.5	2.5
Diabetes (self-reported)	4.7	7.2	11.6	3.4	-2.0	-2.5
Mouth/teeth dental problems: Dentures	4.7	8.0	13.0	3.6	-3.2	-1.0
Arm fat mass (right)	4.7	19.5	32.3	5.7	-4.8	-1.8
Mouth/teeth dental problems: Loose teeth	4.6	5.4	9.4	3.1	-2.6	-0.5
Alcohol intake frequency.	4.6	10.8	13.6	3.7	-3.5	-2.5
Medication: Metformin	4.5	6.4	11.4	3.4	-2.6	-1.0
Illnesses of siblings	4.5	6.3	9.6	-3.1	2.2	2.1
High blood pressure (mother)	4.3	6.0	8.9	-3.0	2.2	2.1
Waist circumference	4.3	15.6	24.4	4.9	-4.4	-1.9
Arm fat percentage (left)	4.3	17.2	24.8	5.0	-4.7	-2.3
Mouth/teeth dental problems: Mouth ulcers	4.3	6.9	8.9	-3.0	2.3	2.5
Coronary Artery Disease (CAD)	4.2	5.0	10.4	0.9	-1.9	-3.2
Depression (Nagel 2018)	4.1	6.1	11.9	0.6	-3.4	-2.5
Allergy	3.9	9.0	24.5	5.0	0.1	-1.5
Body mass index (BMI)	3.8	16.3	28.8	5.4	-4.2	-1.6
Prospective memory result	3.8	4.7	9.4	-3.1	0.9	2.0
Asthma	3.7	7.3	19.1	-4.4	-0.4	1.6
Medication: Lansoprazole	3.7	4.2	8.2	-0.6	-2.0	-2.9
Type 2 Diabetes (T2D) (2018)	3.5	6.5	8.6	2.9	-2.3	-2.4
Qualifications: CSEs or equivalent	3.5	4.6	7.0	2.0	-1.7	-2.6
Trunk fat mass	3.5	15.2	22.7	4.8	-4.6	-1.4
Heart disease (mother)	3.5	4.3	7.3	0.7	-2.7	-2.3
Whole body fat mass	3.5	14.7	22.3	4.7	-4.4	-1.4
Weight	3.4	16.8	29.5	5.4	-4.5	-0.7
Breast Cancer	3.2	7.7	12.8	-3.0	0.9	3.6
Diabetes (father)	3.2	3.9	4.4	1.7	-2.1	-2.1
Frequency of unenthusiasm / disinterest in last 2 weeks	3.2	4.3	11.0	0.2	-3.3	-1.3
Systolic Blood Pressure	3.1	15.3	20.7	-2.1	4.5	4.5
Number of incorrect matches in round	3.1	5.1	6.4	-2.3	1.9	2.5
Serious illness, injury or assault to yourself	3.0	3.6	6.9	1.1	-2.6	-1.7
Heart disease (siblings)	3.0	3.7	7.2	1.5	-2.7	-1.2
Ovarian Cancer	2.9	3.9	7.3	2.7	-1.6	-1.4
Leg fat-free mass (left)	2.9	15.4	23.8	4.9	-4.6	-1.0
Leg predicted mass (left)	2.9	15.4	23.8	4.9	-4.6	-1.0
Body fat percentage	2.9	11.4	16.2	4.0	-3.9	-1.7
Leg fat mass (right)	2.9	11.1	18.4	4.3	-3.7	-1.1
Leg fat mass (left)	2.9	11.4	18.6	4.3	-3.7	-1.2
Trunk fat percentage	2.8	11.3	16.2	3.9	-4.0	-1.7
Financial difficulties in last 2 years	2.8	3.8	5.2	2.3	-1.6	-1.9
Leg predicted mass (right)	2.8	14.8	22.6	4.8	-4.5	-1.2
Unable to work because of sickness or disability	2.8	3.6	5.3	1.6	-2.3	-1.8
Age at First Birth	2.7	3.9	5.1	-2.2	2.0	1.6
Diabetes (mother)	2.7	3.4	6.9	1.2	-2.6	-1.4
Impedance of leg (right)	2.7	13.0	22.2	-4.7	3.8	1.5
Impedance of leg (left)	2.7	13.2	24.5	-5.0	3.8	0.9
Leg fat-free mass (right)	2.7	14.3	22.1	4.7	-4.4	-1.1
Commuting to job workplace: Walk	2.7	2.9	6.5	-2.5	1.0	1.1
Had menopause	2.6	3.3	8.9	-0.2	1.0	3.0
Length of working week for main job	2.6	2.8	7.5	2.7	-0.7	-0.7
Blood clot in the leg (DVT)	2.6	3.4	4.5	2.1	-2.1	-1.1
Family relationship satisfaction	2.6	3.2	5.2	1.0	-2.3	-1.9
Alzheimer’s Disease (in mother)	2.5	2.9	5.1	1.6	-2.3	-0.9
Systolic blood pressure, automated reading	2.5	7.1	14.1	-0.8	2.6	3.8
Exposure to tobacco smoke outside home	2.5	3.4	6.6	2.6	-1.9	0.2
Migraine (self-reported)	2.5	3.1	8.5	-2.9	0.2	-0.9
Illnesses of father: Heart disease	2.5	3.4	5.6	2.4	-1.9	-1.1
Waist Hip Ratio (WHR)	2.4	10.9	19.4	2.6	-2.6	-4.4
Osteoporosis (self-reported)	2.4	2.9	8.1	-2.9	0.8	0.1
Mother’s age at death	2.4	3.0	7.7	-2.8	-0.2	1.2
Basal metabolic rate	2.4	13.0	23.7	4.9	-3.9	-0.2
Deep venous thrombosis (DVT) (self-reported)	2.4	3.1	4.4	2.0	-2.1	-1.1
Average weekly red wine intake	2.3	3.4	6.5	-2.6	1.7	0.9
Breastfed as a baby	2.2	2.7	4.4	-0.4	1.9	2.1
Supplements: Vitamin C	2.2	2.6	6.8	-2.6	0.9	0.5
Alzheimer’s Disease (including proxy)	2.1	3.0	5.4	2.3	-1.9	-0.2
Hearing difficulty/problems: Yes	2.1	3.1	4.1	-2.0	1.8	1.5
Eye problems/disorders: Diabetes related eye disease	2.1	2.3	3.9	2.0	-1.0	-1.5
Taking other prescription medications	2.1	3.2	7.3	-2.7	-1.3	-0.8
HDL Cholesterol	2.0	3.3	5.0	-2.2	1.3	1.8
Frequency of depressed mood in last 2 weeks	2.0	2.8	6.5	-0.0	-2.5	-1.4
Medication: Atenolol	2.0	2.5	3.0	1.5	-1.7	-1.5
Worry too long after embarrassment	2.0	3.4	8.3	-2.9	1.2	0.8
Financial situation satisfaction	2.0	2.4	4.5	1.1	-2.1	-1.2
Arm fat-free mass (left)	2.0	10.4	22.2	4.7	-3.0	0.2
Irritability	2.0	3.4	5.6	-0.2	-2.1	-2.4
Respiratory disease	1.9	4.2	11.2	-3.4	-0.6	1.0
Number of treatments/medications taken	1.9	3.4	5.5	-2.3	-0.4	-2.1
Maternal smoking around birth	1.9	2.8	7.2	2.7	-1.0	-0.1
Depression (self-reported)	1.9	2.3	3.6	0.1	-1.8	-1.9
Eye problems/disorders: None of the above	1.9	2.2	4.2	2.1	0.5	1.4
Medication: Allopurinol	1.9	2.5	7.0	-2.6	-0.4	-0.5
Whole body fat-free mass	1.9	10.8	20.3	4.5	-3.5	0.0
Whole body water mass	1.9	10.9	20.5	4.5	-3.5	0.0
Average weekly beer plus cider intake	1.9	2.7	4.8	2.2	-1.3	-1.3
Arm predicted mass (left)	1.9	9.7	20.5	4.5	-2.9	0.3
Mean Putamen Volume	1.8	2.0	4.5	2.1	-1.2	-0.3
BMI	1.8	10.6	16.3	4.0	-3.6	-1.5
Medication for cholesterol	1.8	2.8	4.9	-2.2	1.3	1.3
Schizophrenia (2014)	1.7	3.7	5.4	-0.9	2.2	2.3
Medication: Ventolin 100micrograms inhaler	1.7	2.2	4.8	-2.2	-1.1	0.7
Leg fat percentage (left)	1.7	6.1	10.2	3.2	-2.7	-1.0
Ever had prostate specific antigen (PSA) test	1.7	2.0	3.1	-1.8	1.6	0.4
Diastolic blood pressure, automated reading	1.7	5.4	6.4	2.5	-2.2	-2.2
Pack years adult smoking proportion	1.6	2.5	6.7	2.6	-0.1	-0.9
Leg fat percentage (right)	1.6	5.8	10.2	3.2	-2.6	-0.7
Arm predicted mass (right)	1.6	8.0	17.4	4.2	-2.5	0.4
Number of self-reported non-cancer illnesses	1.6	2.8	8.4	-2.9	-0.2	0.4
Ever taken oral contraceptive pill	1.6	1.8	3.3	-0.9	1.8	1.1
Medication: Atorvastatin	1.6	2.0	3.5	1.2	-1.9	-1.1
Bipolar Disorder or Schizophrenia	1.5	3.6	5.6	-1.0	2.1	2.4
Cardiovascular Disease	1.5	5.0	6.9	2.0	-2.6	-2.0
Pain all over the body in last month	1.5	1.6	3.8	-0.4	-0.8	-1.9
Frequency of tiredness / lethargy in last 2 weeks	1.5	2.4	4.1	-1.0	-1.4	-2.0
Noisy workplace	1.5	1.9	2.6	-1.2	1.2	1.6
Pulse rate, automated reading	1.5	5.0	9.9	3.1	-2.2	-0.4
Cholesterol lowering medication	1.5	2.2	3.9	1.5	-2.0	-0.6
Pack years of smoking	1.5	2.3	6.0	2.5	-0.1	-0.8
Impedance of whole body	1.5	7.5	17.1	-4.1	2.2	0.6
Sensitivity / hurt feelings	1.4	2.3	4.4	0.1	-1.6	-2.1
Medication for hormone replacement therapy	1.4	1.6	3.5	1.9	-0.8	-0.8
Medication: Co-codamol	1.4	1.6	4.6	0.4	-2.1	-0.4
Heel bone mineral density (BMD) T-score, automated (right)	1.4	3.1	9.1	3.0	-0.2	0.5
Mouth/teeth dental problems	1.4	2.2	4.1	-0.4	1.5	-2.0
Trunk fat-free mass	1.4	8.0	16.2	4.0	-2.7	0.8
Hip circumference	1.4	6.1	10.8	2.7	-3.3	-0.1
Medication: Cholesterol lowering	1.4	2.2	2.9	1.6	-1.7	-1.1
Trunk predicted mass	1.4	7.8	15.8	4.0	-2.7	0.7
Arm fat-free mass (right)	1.4	7.1	15.4	3.9	-2.4	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.4	1.8	4.8	0.3	-2.2	-0.7
Number of children fathered	1.4	1.6	3.6	0.9	-1.9	-0.6
Qualifications: College or University degree	1.4	4.3	5.5	-2.3	2.3	1.6
Illness, injury, bereavement, stress in last 2 years	1.4	1.7	2.0	-1.3	1.2	1.4
Ever had bowel cancer screening	1.4	1.7	2.4	-1.6	1.4	0.7
Commuting to job workplace: Public transport	1.4	1.6	3.1	-1.8	1.4	0.1
Age started oral contraceptive pill	1.4	1.8	3.1	-1.2	1.8	0.9
Supplements: Calcium	1.4	1.6	3.7	-1.9	0.7	-0.7
Rheumatoid Arthritis	1.3	1.8	3.2	-0.4	-1.4	-1.8
Heel T-Score	1.3	10.5	20.5	4.5	-1.6	-2.9
Average weekly fortified wine intake	1.3	1.5	2.8	-1.7	1.1	0.7
Happiness	1.3	1.6	3.0	-0.5	-1.7	-1.2
Ever highly irritable/argumentative for 2 days	1.3	1.6	3.2	0.7	-1.0	-1.8
Emphysema/chronic bronchitis	1.3	1.5	2.4	1.1	-1.5	-0.9
Age at last live birth	1.3	1.9	3.8	0.4	-1.3	-2.0
Bipolar Disorder (2018)	1.2	1.9	3.4	-0.6	1.8	1.4
Medication: Paracetamol	1.2	2.0	4.9	-1.0	-0.2	-2.2
Medication: Gliclazide	1.2	1.3	2.6	1.0	-1.6	-0.6
Average weekly champagne plus white wine intake	1.2	1.6	2.7	-1.7	1.2	-0.8
Lung FVC	1.1	5.6	10.4	-0.6	2.5	3.2
Fed-up feelings	1.1	1.9	3.8	1.0	-2.0	-1.0
Hair/balding pattern: Pattern 2	1.1	1.4	3.8	-1.9	0.2	-0.6
Heart attack	1.1	1.4	2.9	0.6	-1.7	-0.9
Headache pain in last month	1.1	1.9	3.9	-1.3	-0.2	-2.0
Number of full brothers	1.1	1.3	2.8	1.7	-1.0	-0.5
Shortness of breath walking on level ground	1.1	1.4	3.1	-1.8	-0.5	-0.8
Number of operations (self-reported)	1.1	1.6	4.1	-0.8	-0.4	-2.0
Prostate Cancer	1.0	1.4	3.8	0.2	-1.9	-0.7
Body Mass Index (BMI) (2010)	1.0	1.3	2.8	1.7	-0.6	0.8
HbA1C	1.0	1.1	2.0	1.0	-0.6	-1.4
LDL Cholesterol	1.0	1.5	3.8	0.6	-0.7	-1.9
Severe depression (siblings)	1.0	1.1	1.9	-1.2	1.4	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.2	5.7	2.4	-0.9	-0.1
Hair/balding pattern: Pattern 3	1.0	1.4	4.0	2.0	-0.6	0.1
Glaucoma (self-reported)	1.0	1.1	2.0	-1.4	0.7	0.9
Angina (self-reported)	1.0	1.3	2.8	1.7	-0.9	-0.5
Long-standing illness, disability or infirmity	1.0	1.5	3.5	-0.6	-1.9	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.1	1.9	0.3	-1.4	-1.1
Back pain experienced in last month	1.0	1.5	3.8	0.6	0.5	1.9
Wears glasses or contact lenses	1.0	1.1	1.5	-1.2	1.2	0.6
Ever depressed for a whole week	1.0	1.2	2.4	0.2	1.6	1.1
Heart attack/myocardial infarction (self-reported)	1.0	1.3	2.7	0.5	-1.6	-0.9
Depressed Affect (Nagel 2018)	0.9	1.9	3.1	0.6	-1.8	-1.5
Vitamin and mineral supplements	0.9	1.3	2.2	1.5	-1.2	0.5
Multivitamins +/- minerals	0.9	1.1	2.3	-0.9	1.5	-0.2
Medication: Simvastatin	0.9	1.3	2.3	0.9	-1.5	-0.9
Falls in the last year	0.9	1.2	1.9	1.0	-1.4	-0.8
Medication for cholesterol, blood pressure or diabetes	0.9	1.6	3.0	-0.8	1.7	1.0
Tinnitus: Yes, now most or all of the time	0.9	1.0	1.3	-1.1	1.1	0.8
High cholesterol (Self-reported)	0.9	1.6	3.1	1.8	-1.2	-0.6
Basal cell carcinoma (self-reported)	0.9	1.1	1.8	-1.3	1.1	0.4
Schizophrenia (2018)	0.8	1.7	3.3	-0.7	1.2	1.8
Triglycerides	0.8	1.3	2.8	1.7	-0.2	-1.0
Hypothyroidism (self reported)	0.8	1.9	3.3	-1.5	-1.8	0.6
Angina	0.8	1.0	2.2	1.5	-0.9	-0.2
Supplements: Zinc	0.8	0.9	1.5	-1.2	1.0	-0.4
Medication: Levothyroxine sodium	0.8	1.4	3.9	-0.5	-2.0	-0.1
Chronic bronchitis/emphysema (father)	0.8	0.9	1.7	-1.0	0.3	1.3
Medication: Ramipril	0.8	1.0	2.2	0.7	-1.5	0.6
Qualifications: A levels/AS levels or equivalent	0.8	1.7	3.4	-1.8	1.2	-0.4
Impedance of arm (left)	0.8	3.5	9.2	-3.0	1.1	0.2
Birth weight of first child	0.8	1.5	2.4	-1.3	0.6	-1.6
Overall health rating	0.8	1.7	4.7	0.5	-2.2	0.4
Commuting to job workplace: Car/motor vehicle	0.8	0.9	2.7	1.7	0.1	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	2.0	-1.4	-0.6	-0.6
Mood swings	0.8	1.4	2.2	0.1	-1.5	-1.5
Eye problems/disorders: Cataract	0.8	0.9	2.8	-1.7	0.2	-0.0
Medication: Paracetamol	0.8	1.2	2.6	-1.0	0.0	-1.6
Ever smoked	0.8	1.4	2.6	-0.5	1.1	1.6
Intelligence (Savage-Jansen 2018)	0.7	2.1	3.7	-1.6	1.9	-0.4
Reaction Time	0.7	1.4	2.5	1.6	-1.0	-0.8
Chronotype (morning person)	0.7	1.5	2.3	0.0	-1.5	-1.5
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	1.4	0.8	-0.6	-1.2
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	1.6	0.2	1.3	0.7
Sitting height	0.7	5.0	14.4	-0.6	0.2	3.8
Impedance of arm (right)	0.7	3.1	8.6	-2.9	0.7	-0.6
Number of live births	0.7	0.9	2.0	1.4	-0.9	-0.2
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	1.6	0.9	-0.4	-1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	1.7	1.3	-0.1	-1.2
Mouth/teeth dental problems: Bleeding gums	0.7	0.8	1.5	-1.2	-0.7	0.7
Hypothyroidism/myxoedema (self-reported)	0.7	1.3	2.6	-0.7	-1.6	0.9
Loneliness, isolation	0.7	0.9	1.7	0.0	-1.3	-1.0
Osteoarthritis (self-reported)	0.7	0.9	1.8	-0.9	-0.1	-1.4
Illnesses of father: High blood pressure	0.7	0.8	1.5	-1.2	0.8	0.6
Fractured/broken bones in last 5 years	0.7	0.8	2.4	-1.6	-0.3	0.2
Pain experienced in last month	0.7	1.2	1.5	-0.9	1.2	1.2
Alzheimer’s Disease (in father)	0.6	0.7	1.5	0.5	0.5	1.2
Other serious medical condition/disability diagnosed by doctor	0.6	0.7	1.6	-0.6	-1.3	-0.5
Ever had hysterectomy (womb removed)	0.6	0.7	1.0	1.0	0.7	0.8
Current tobacco smoking	0.6	1.0	1.6	1.2	0.4	1.2
Supplements: Glucosamine	0.6	0.8	1.5	-0.6	0.7	1.2
Alcohol usually taken with meals	0.6	1.0	2.1	-0.9	1.5	0.5
Lung cancer (father)	0.6	0.7	1.5	1.2	-0.7	-0.4
Tense / ‘highly strung’	0.6	1.0	2.1	1.4	-0.8	0.5
Hair/balding pattern: Pattern 4	0.6	1.6	4.1	0.0	0.8	2.0
Peak expiratory flow (PEF)	0.6	1.4	2.5	1.0	-1.6	-0.7
Gout (self-reported)	0.6	0.8	2.0	-1.4	-0.5	-0.5
Comparative body size at age 10	0.6	1.7	2.5	1.6	-1.4	-0.8
Wheeze or whistling in the chest in last year	0.6	1.0	2.0	-1.4	-1.0	0.1
Age at first live birth	0.6	1.1	2.5	-1.6	-0.1	-0.8
Medication: Seretide 50 evohaler	0.6	0.7	1.7	0.3	-1.3	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.6	-1.3	0.6	0.5
Medication: Aspirin	0.6	0.7	2.1	0.2	-1.5	0.2
Qualifications: nursing, teaching	0.6	0.9	1.0	-1.0	1.0	-0.8
Mineral and other dietary supplements	0.6	0.8	1.9	1.4	-0.5	0.6
Smoking status: Current	0.6	1.0	1.5	1.2	0.6	1.1
Guilty feelings	0.6	0.9	1.2	-1.0	-0.7	-1.1
Supplements: Fish oil (including cod liver oil)	0.6	0.8	1.6	-0.9	0.2	-1.3
Commuting to job workplace: Cycle	0.6	0.8	1.4	-1.0	0.1	-1.2
Major Depression (MDD)	0.5	0.6	0.9	-0.2	0.9	0.9
Neuroticism (2016)	0.5	0.7	0.9	1.0	-0.9	-0.7
Primary Biliary Cirrhosis	0.5	0.7	1.1	-0.7	-0.7	-1.1
Blood Eosinophil Count	0.5	3.5	7.3	0.3	-1.8	2.7
Stomach or abdominal pain in last month	0.5	0.6	1.5	-1.2	-0.4	0.0
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.3	-0.5	-0.3	-1.1
Qualifications: None of the above	0.5	1.0	1.5	1.2	-1.2	0.2
Alcohol intake versus 10 years previously	0.5	0.7	1.9	1.4	-0.4	-0.3
Exposure to tobacco smoke at home	0.5	0.5	1.1	1.1	-0.5	-0.5
Medication: Amlodipine	0.5	0.7	1.7	1.3	-0.4	0.3
Birth weight	0.5	1.1	2.4	-1.6	0.9	0.4
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.1	1.0	0.5	0.7
Medication for pain relief, constipation, heartburn	0.5	0.8	1.1	0.9	0.6	1.1
Medication: Blood pressure	0.5	1.0	1.5	0.7	-1.2	-0.9
Mean time to correctly identify matches	0.5	0.9	2.2	1.5	-0.6	-0.2
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.3	-1.1	0.5	0.4
Medication: Aspirin	0.5	0.7	2.1	0.2	-1.4	0.0
Medication: Bendroflumethiazide	0.5	0.7	1.2	1.1	-0.3	-0.9
Risk taking	0.5	0.8	1.2	-0.0	1.1	-1.1
Alcohol drinker status: Previous	0.5	0.6	1.2	0.8	-1.1	-0.1
Worry (Nagel 2018)	0.4	0.9	2.2	-0.1	0.6	1.5
Fasting Glucose	0.4	0.4	0.6	0.0	0.8	0.8
Height	0.4	8.0	11.8	2.8	-3.4	2.1
Lung FEV1/FVC ratio	0.4	2.2	3.2	1.8	-1.7	-0.9
Average weekly spirits intake	0.4	0.5	1.2	0.4	-0.3	-1.1
Relative age voice broke	0.4	0.5	1.4	-0.4	-0.0	-1.2
Forced vital capacity (FVC)	0.4	1.5	4.4	-0.2	0.3	2.1
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	0.7	0.5	-0.8	-0.8
Neuroticism score	0.4	0.8	1.4	-0.7	-1.2	-0.8
Pulse wave reflection index	0.4	0.5	0.9	-0.9	0.8	0.1
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	0.9	-0.4	0.9	-1.0
Health satisfaction	0.4	0.6	1.4	-0.4	-1.2	0.2
Number of full sisters	0.4	0.5	1.1	0.6	-0.4	-1.1
Friendships satisfaction	0.4	0.5	1.1	0.7	-1.0	-0.2
Verbal and Numeric Reasoning (VNR)	0.3	0.7	1.1	0.4	1.1	-0.9
Lupus	0.3	0.5	1.1	-0.5	0.4	-1.0
Smoking Status	0.3	0.6	0.8	0.6	0.8	0.9
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.2	1.1	-0.0	-0.1
Time employed in main current job	0.3	0.4	1.0	0.3	1.0	-0.2
Pulse wave Arterial Stiffness index	0.3	0.4	1.1	-1.0	0.0	0.1
Loud music exposure frequency	0.3	0.4	0.6	-0.5	0.5	0.8
Forced vital capacity (FVC), Best measure	0.3	1.0	2.6	-0.4	0.2	1.6
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	0.7	0.5	0.9	-0.3
Pulse wave peak to peak time	0.3	0.4	1.0	1.0	-0.4	0.0
Neck or shoulder pain in last month	0.3	0.4	0.7	-0.0	-0.8	-0.7
Medication: Ibuprofen	0.3	0.4	0.8	0.9	-0.1	-0.6
Suffer from ‘nerves’	0.3	0.5	0.8	0.9	-0.8	-0.1
Had major operations	0.3	0.3	0.8	0.3	-0.3	-0.9
Leg pain on walking	0.3	0.3	0.7	-0.8	0.5	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	1.0	0.0	0.3	-1.0
Illnesses of father: None of the above (group 1)	0.3	0.3	0.7	-0.4	0.8	-0.4
Miserableness	0.3	0.5	0.8	0.4	-0.9	-0.8
Hearing aid user	0.3	0.4	0.9	-0.9	0.2	0.5
Eye problems/disorders: Glaucoma	0.3	0.3	0.9	-1.0	-0.1	-0.2
Vascular/heart problems diagnosed by doctor	0.3	0.7	1.0	-1.0	1.0	0.5
Neuroticism (Nagel 2018)	0.2	0.4	1.0	-0.4	-1.0	-0.4
Schizophrenia vs Biploar Disorder	0.2	0.3	0.7	0.8	-0.1	0.4
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.6	-0.1	0.8	-0.1
Hand grip strength (left)	0.2	0.6	0.8	0.9	0.7	0.6
Hand grip strength (right)	0.2	0.7	0.8	0.9	0.9	0.5
Townsend deprivation index at recruitment	0.2	0.3	0.4	-0.6	0.6	0.3
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.4	0.6	-0.2	-0.6	0.8
Worrier / anxious feelings	0.2	0.5	1.2	-1.1	0.4	0.0
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	1.2	1.1	-0.8	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	0.9	0.9	-0.8	0.5
Standing height	0.2	1.9	3.1	0.9	-1.3	1.8
Medication: Omeprazole	0.2	0.2	0.4	-0.6	0.4	0.4
Comparative height size at age 10	0.2	1.2	1.8	0.9	-1.3	1.1
Smoking status: Previous	0.2	0.3	0.6	-0.8	-0.6	-0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	0.6	0.7	-0.6	-0.7
Medication: Blood pressure	0.2	0.4	0.7	0.6	0.8	0.3
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.6	-0.1	-0.8	-0.2
Alcohol drinker status: Never	0.2	0.3	0.8	0.3	-0.9	0.2
Blood Platelet Count	0.1	0.7	2.0	0.3	1.4	0.3
Blood Red Count	0.1	0.9	1.7	0.2	0.9	1.3
Neuroticism	0.1	0.2	0.5	-0.7	-0.5	0.2
Tanning	0.1	1.8	4.9	-0.3	2.2	0.5
Relative age of first facial hair	0.1	0.1	0.3	-0.5	0.1	-0.3
Age when periods started (menarche)	0.1	0.2	0.3	-0.4	0.6	0.1
High blood pressure	0.1	0.3	0.7	0.9	-0.0	-0.1
Past tobacco smoking	0.1	0.1	0.1	0.4	0.3	-0.3
Pulse rate	0.1	0.3	0.5	0.7	-0.4	0.2
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.3	0.3	0.3	0.5
Illnesses of mother	0.1	0.1	0.3	-0.0	0.6	-0.2
High blood pressure (siblings)	0.1	0.1	0.3	0.1	0.0	-0.5
Chest pain or discomfort	0.1	0.1	0.3	0.5	-0.1	-0.0
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.2	0.1	-0.0	-0.5
Hypertension (Self-reported)	0.1	0.2	0.6	0.8	-0.1	-0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.2	0.5	-0.4	-0.4
Myopia	0.1	0.1	0.3	-0.3	0.2	-0.5
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.3	-0.4	0.5	0.0
Hair Pigment	0.0	0.6	1.0	-1.0	-0.7	-0.5
Nervous feelings	0.0	0.1	0.1	-0.0	0.4	0.3
Had other major operations	0.0	0.0	0.1	-0.0	0.3	-0.0
Fluid intelligence score	0.0	0.1	0.1	0.4	0.1	-0.2
Breast cancer (self-reported)	0.0	0.0	0.0	0.1	-0.1	0.0
Medication: Lisinopril	0.0	0.1	0.1	0.3	0.2	-0.2

Hub : Genes

FAM134C

Models

Trait associations