Best TWAS P=3.18e-12 · Best GWAS P=2.48e-07 conditioned to 0.0113
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | MAP3K3 | 0.10 | 0.04 | enet | 12 | 0.05 | 9.0e-04 | -5.1 | -5.4 | 8.6e-08 | 0.83 | 0.03 | 0.89 | FALSE |
| 2 | GTEx | Breast Mammary Tissue | MAP3K3 | 0.10 | 0.11 | lasso | 8 | 0.08 | 8.9e-05 | -5.1 | -5.1 | 2.9e-07 | 1.00 | 0.03 | 0.97 | FALSE |
| 3 | GTEx | Breast Mammary Tissue (Female) | CD79B | 0.04 | 0.07 | lasso | 2 | 0.03 | 4.2e-02 | 4.9 | -5.1 | 2.7e-07 | 0.38 | 0.04 | 0.26 | FALSE |
| 4 | GTEx | Cells EBV-transformed lymphocytes | DDX42 | 0.11 | 0.14 | lasso | 2 | 0.12 | 1.3e-04 | -5.1 | 5.1 | 3.1e-07 | -0.98 | 0.03 | 0.90 | FALSE |
| 5 | GTEx | Esophagus Muscularis | DCAF7 | 0.08 | 0.06 | lasso | 7 | 0.05 | 6.7e-04 | -5.1 | -5.1 | 3.1e-07 | 0.98 | 0.03 | 0.95 | FALSE |
| 6 | GTEx | Lung | MAP3K3 | 0.07 | 0.07 | lasso | 2 | 0.06 | 2.8e-05 | -5.2 | -5.1 | 2.7e-07 | 1.00 | 0.03 | 0.97 | FALSE |
| 7 | GTEx | Nerve Tibial | MAP3K3 | 0.07 | 0.10 | lasso | 2 | 0.08 | 4.1e-06 | -5.1 | -5.1 | 3.0e-07 | 0.99 | 0.03 | 0.97 | FALSE |
| 8 | GTEx | Skin Not Sun Exposed Suprapubic | MAP3K3 | 0.12 | 0.13 | enet | 10 | 0.15 | 1.8e-08 | -5.1 | -5.1 | 2.9e-07 | 0.99 | 0.03 | 0.97 | FALSE |
| 9 | GTEx | Stomach | DCAF7 | 0.24 | 0.00 | enet | 33 | 0.08 | 1.2e-04 | -1.8 | -7.0 | 3.2e-12 | 0.41 | 0.04 | 0.44 | TRUE |