Best TWAS P=8.36e-13 · Best GWAS P=2.04e-16 conditioned to 0.000199
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | ATP5G1 | 0.07 | 0.05 | lasso | 3 | 0.06 | 4.7e-08 | -6.20 | 6.3 | 2.4e-10 | -0.62 | 0.94 | 0.06 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | CDK5RAP3 | 0.15 | 0.12 | bslmm | 392 | 0.14 | 3.6e-16 | 5.10 | -5.2 | 1.7e-07 | 0.09 | 0.46 | 0.54 | FALSE |
3 | CommonMind | Brain Pre-frontal Cortex | SNF8 | 0.08 | 0.07 | lasso | 5 | 0.08 | 9.3e-10 | -5.58 | 7.2 | 8.4e-13 | -0.84 | 0.08 | 0.92 | TRUE |
4 | GTEx | Adipose Subcutaneous | KANSL1 | 0.35 | 0.09 | enet | 13 | 0.12 | 1.1e-09 | 4.55 | -5.2 | 2.1e-07 | 0.03 | 0.00 | 0.97 | FALSE |
5 | GTEx | Adrenal Gland | ARL17A | 0.52 | 0.01 | lasso | 7 | 0.19 | 2.2e-07 | 5.18 | 5.1 | 2.7e-07 | 0.02 | 0.00 | 0.99 | FALSE |
6 | GTEx | Artery Aorta | CDK5RAP3 | 0.26 | 0.22 | lasso | 11 | 0.25 | 5.8e-14 | -4.94 | -5.5 | 4.9e-08 | 0.12 | 0.91 | 0.09 | FALSE |
7 | GTEx | Artery Aorta | SNF8 | 0.12 | 0.12 | lasso | 6 | 0.10 | 2.3e-06 | -5.45 | 5.5 | 4.0e-08 | -0.63 | 0.68 | 0.23 | FALSE |
8 | GTEx | Artery Aorta | AC091133.1 | 0.10 | 0.07 | lasso | 5 | 0.07 | 1.2e-04 | -5.45 | 5.8 | 7.9e-09 | -0.65 | 0.30 | 0.47 | FALSE |
9 | GTEx | Artery Aorta | NSFP1 | 0.40 | 0.19 | lasso | 5 | 0.24 | 3.3e-13 | 5.18 | 5.3 | 1.2e-07 | 0.02 | 0.00 | 1.00 | FALSE |
10 | GTEx | Artery Aorta | RP11-6N17.9 | 0.23 | 0.12 | enet | 19 | 0.19 | 9.5e-11 | -4.94 | -5.5 | 2.9e-08 | 0.09 | 0.93 | 0.07 | FALSE |
11 | GTEx | Artery Aorta | RP11-6N17.10 | 0.20 | 0.07 | enet | 24 | 0.14 | 3.5e-08 | -4.94 | -5.7 | 9.0e-09 | 0.11 | 0.44 | 0.22 | FALSE |
12 | GTEx | Artery Tibial | ARL17A | 0.69 | 0.37 | lasso | 9 | 0.44 | 5.4e-38 | 5.18 | 5.3 | 1.1e-07 | 0.02 | 0.00 | 1.00 | FALSE |
13 | GTEx | Artery Tibial | RP11-6N17.9 | 0.16 | 0.14 | lasso | 4 | 0.12 | 6.2e-10 | -4.94 | -5.2 | 1.6e-07 | 0.12 | 0.90 | 0.10 | FALSE |
14 | GTEx | Brain Caudate basal ganglia | RP11-6N17.9 | 0.45 | -0.01 | enet | 28 | 0.16 | 3.3e-05 | -0.53 | -5.6 | 2.4e-08 | 0.09 | 0.06 | 0.15 | FALSE |
15 | GTEx | Brain Cerebellar Hemisphere | CDK5RAP3 | 0.22 | 0.10 | lasso | 6 | 0.09 | 2.6e-03 | 4.67 | -5.7 | 1.2e-08 | 0.09 | 0.08 | 0.42 | FALSE |
16 | GTEx | Brain Cerebellar Hemisphere | RP11-6N17.10 | 0.21 | 0.16 | lasso | 5 | 0.13 | 3.8e-04 | 4.67 | -5.4 | 7.1e-08 | 0.09 | 0.09 | 0.45 | FALSE |
17 | GTEx | Brain Cerebellum | ATP5G1 | 0.22 | 0.26 | lasso | 3 | 0.24 | 8.2e-08 | -5.21 | 5.2 | 2.0e-07 | -0.59 | 0.81 | 0.11 | FALSE |
18 | GTEx | Brain Cortex | ATP5G1 | 0.16 | 0.15 | lasso | 2 | 0.14 | 1.3e-04 | -5.30 | 5.3 | 1.1e-07 | -0.60 | 0.15 | 0.25 | FALSE |
19 | GTEx | Brain Cortex | ARL17A | 0.35 | 0.20 | lasso | 6 | 0.25 | 1.7e-07 | 5.18 | 6.2 | 5.4e-10 | 0.01 | 0.00 | 0.97 | FALSE |
20 | GTEx | Brain Nucleus accumbens basal ganglia | CDK5RAP3 | 0.21 | 0.04 | lasso | 4 | 0.02 | 7.2e-02 | 5.54 | -5.4 | 8.1e-08 | 0.08 | 0.08 | 0.41 | FALSE |
21 | GTEx | Brain Putamen basal ganglia | CDK5RAP3 | 0.26 | 0.10 | lasso | 3 | 0.13 | 5.1e-04 | -4.94 | -5.2 | 1.5e-07 | 0.07 | 0.05 | 0.15 | FALSE |
22 | GTEx | Cells Transformed fibroblasts | SNF8 | 0.12 | 0.10 | lasso | 3 | 0.12 | 5.1e-09 | -5.44 | 6.0 | 2.3e-09 | -0.66 | 0.99 | 0.01 | FALSE |
23 | GTEx | Cells Transformed fibroblasts | AC091133.1 | 0.14 | 0.07 | enet | 22 | 0.09 | 1.9e-07 | -5.30 | 5.4 | 6.4e-08 | -0.60 | 0.88 | 0.08 | FALSE |
24 | GTEx | Colon Sigmoid | ARL17A | 0.66 | 0.47 | lasso | 10 | 0.50 | 4.2e-20 | 5.18 | 5.3 | 1.0e-07 | 0.02 | 0.00 | 1.00 | FALSE |
25 | GTEx | Colon Sigmoid | NSFP1 | 0.51 | 0.28 | enet | 11 | 0.33 | 2.3e-12 | 5.18 | 5.5 | 3.0e-08 | 0.03 | 0.00 | 1.00 | FALSE |
26 | GTEx | Esophagus Gastroesophageal Junction | CDK5RAP3 | 0.21 | 0.09 | lasso | 6 | 0.07 | 1.2e-03 | -4.94 | -5.7 | 1.2e-08 | 0.10 | 0.09 | 0.50 | FALSE |
27 | GTEx | Esophagus Gastroesophageal Junction | ARL17A | 0.53 | 0.26 | enet | 9 | 0.37 | 2.0e-14 | 3.34 | 5.1 | 2.7e-07 | 0.01 | 0.00 | 1.00 | FALSE |
28 | GTEx | Esophagus Gastroesophageal Junction | RP11-6N17.9 | 0.18 | 0.14 | lasso | 3 | 0.09 | 4.9e-04 | -4.94 | -6.1 | 1.3e-09 | 0.12 | 0.03 | 0.73 | FALSE |
29 | GTEx | Esophagus Muscularis | COPZ2 | 0.14 | 0.04 | lasso | 5 | 0.06 | 1.3e-04 | 3.69 | 5.3 | 1.5e-07 | -0.05 | 0.18 | 0.04 | FALSE |
30 | GTEx | Esophagus Muscularis | ATP5G1 | 0.09 | 0.06 | lasso | 5 | 0.05 | 4.5e-04 | -5.30 | 5.3 | 9.7e-08 | -0.60 | 0.17 | 0.51 | FALSE |
31 | GTEx | Esophagus Muscularis | SNF8 | 0.08 | 0.03 | lasso | 3 | 0.01 | 5.7e-02 | -6.50 | 6.4 | 1.7e-10 | -0.71 | 0.03 | 0.77 | FALSE |
32 | GTEx | Esophagus Muscularis | NSFP1 | 0.42 | 0.22 | enet | 16 | 0.24 | 5.0e-15 | 5.18 | 5.2 | 2.0e-07 | 0.03 | 0.00 | 1.00 | FALSE |
33 | GTEx | Heart Atrial Appendage | CDK5RAP3 | 0.13 | 0.00 | enet | 18 | 0.04 | 5.1e-03 | 1.07 | -5.6 | 2.1e-08 | 0.10 | 0.09 | 0.05 | FALSE |
34 | GTEx | Heart Atrial Appendage | ATP5G1 | 0.22 | 0.10 | enet | 6 | 0.13 | 1.3e-06 | -5.44 | 5.5 | 4.3e-08 | -0.62 | 0.95 | 0.01 | FALSE |
35 | GTEx | Heart Atrial Appendage | ARL17A | 0.39 | 0.20 | lasso | 4 | 0.22 | 5.3e-10 | 5.18 | 5.3 | 1.1e-07 | 0.02 | 0.00 | 1.00 | FALSE |
36 | GTEx | Heart Atrial Appendage | NSFP1 | 0.47 | 0.25 | lasso | 4 | 0.29 | 2.4e-13 | 5.18 | 5.3 | 9.6e-08 | 0.02 | 0.00 | 1.00 | FALSE |
37 | GTEx | Heart Left Ventricle | ATP5G1 | 0.24 | 0.22 | lasso | 4 | 0.22 | 9.3e-12 | -6.04 | 6.6 | 5.0e-11 | -0.64 | 1.00 | 0.00 | FALSE |
38 | GTEx | Liver | ARL17A | 0.34 | 0.18 | lasso | 9 | 0.18 | 9.8e-06 | 5.18 | 6.3 | 3.7e-10 | 0.04 | 0.00 | 0.94 | TRUE |
39 | GTEx | Liver | NSFP1 | 0.27 | 0.24 | lasso | 2 | 0.22 | 6.3e-07 | 5.18 | 5.2 | 2.1e-07 | 0.04 | 0.00 | 0.99 | FALSE |
40 | GTEx | Lung | KANSL1 | 0.34 | 0.07 | enet | 30 | 0.11 | 1.7e-08 | 4.55 | -5.6 | 2.0e-08 | 0.06 | 0.00 | 0.91 | FALSE |
41 | GTEx | Muscle Skeletal | ATP5G1 | 0.13 | 0.08 | enet | 18 | 0.07 | 5.1e-07 | -5.31 | 5.4 | 6.1e-08 | -0.67 | 0.92 | 0.08 | FALSE |
42 | GTEx | Muscle Skeletal | UBE2Z | 0.06 | 0.02 | lasso | 8 | 0.03 | 9.8e-04 | -6.04 | 6.1 | 9.8e-10 | -0.66 | 0.41 | 0.47 | FALSE |
43 | GTEx | Muscle Skeletal | AC003665.1 | 0.05 | 0.03 | enet | 8 | 0.03 | 1.4e-03 | 4.81 | 6.1 | 1.3e-09 | -0.11 | 0.12 | 0.73 | FALSE |
44 | GTEx | Nerve Tibial | CDK5RAP3 | 0.41 | 0.35 | enet | 23 | 0.36 | 6.1e-27 | -4.94 | -5.7 | 1.2e-08 | 0.12 | 0.90 | 0.10 | FALSE |
45 | GTEx | Nerve Tibial | UBE2Z | 0.12 | 0.04 | enet | 16 | 0.05 | 1.5e-04 | -5.45 | 5.6 | 2.1e-08 | -0.60 | 0.89 | 0.01 | FALSE |
46 | GTEx | Nerve Tibial | RP11-6N17.9 | 0.29 | 0.27 | lasso | 4 | 0.27 | 2.1e-19 | -4.94 | -5.2 | 1.5e-07 | 0.12 | 0.90 | 0.10 | FALSE |
47 | GTEx | Nerve Tibial | RP11-6N17.10 | 0.28 | 0.19 | lasso | 8 | 0.19 | 1.6e-13 | -4.94 | -5.7 | 1.4e-08 | 0.12 | 0.90 | 0.10 | FALSE |
48 | GTEx | Ovary | ATP5G1 | 0.15 | 0.08 | enet | 13 | 0.09 | 2.8e-03 | -5.17 | 6.4 | 1.5e-10 | -0.66 | 0.06 | 0.72 | FALSE |
49 | GTEx | Pancreas | CDK5RAP3 | 0.11 | -0.01 | lasso | 4 | 0.02 | 5.1e-02 | 4.67 | -6.1 | 1.1e-09 | 0.04 | 0.09 | 0.18 | FALSE |
50 | GTEx | Pancreas | RP11-6N17.9 | 0.15 | 0.04 | lasso | 5 | 0.04 | 9.3e-03 | -2.25 | -5.7 | 9.2e-09 | 0.07 | 0.13 | 0.17 | FALSE |
51 | GTEx | Pituitary | ARL17A | 0.63 | 0.43 | lasso | 6 | 0.42 | 8.6e-12 | 5.18 | 5.2 | 1.6e-07 | 0.03 | 0.00 | 1.00 | FALSE |
52 | GTEx | Pituitary | ARL17B | 0.27 | 0.22 | enet | 6 | 0.21 | 4.7e-06 | 5.18 | 5.3 | 1.5e-07 | 0.03 | 0.00 | 0.95 | FALSE |
53 | GTEx | Pituitary | NSFP1 | 0.52 | 0.36 | lasso | 5 | 0.36 | 5.6e-10 | 5.18 | 5.5 | 4.2e-08 | 0.03 | 0.00 | 1.00 | FALSE |
54 | GTEx | Skin Not Sun Exposed Suprapubic | UBE2Z | 0.11 | 0.07 | lasso | 6 | 0.04 | 1.8e-03 | -6.50 | 6.6 | 4.5e-11 | -0.68 | 0.10 | 0.12 | FALSE |
55 | GTEx | Skin Sun Exposed Lower leg | KANSL1 | 0.39 | 0.11 | enet | 20 | 0.16 | 6.8e-13 | 4.55 | -5.2 | 1.9e-07 | -0.01 | 0.00 | 0.97 | FALSE |
56 | GTEx | Skin Sun Exposed Lower leg | UBE2Z | 0.14 | 0.11 | lasso | 9 | 0.14 | 6.3e-12 | -5.21 | 6.0 | 2.6e-09 | -0.64 | 1.00 | 0.00 | FALSE |
57 | GTEx | Stomach | RP11-6N17.9 | 0.13 | 0.02 | lasso | 6 | 0.04 | 8.0e-03 | 4.99 | -5.6 | 2.6e-08 | 0.06 | 0.11 | 0.70 | FALSE |
58 | GTEx | Testis | SNF8 | 0.23 | 0.11 | lasso | 5 | 0.08 | 1.6e-04 | -5.45 | 5.4 | 5.2e-08 | -0.62 | 0.68 | 0.08 | FALSE |
59 | GTEx | Testis | LRRC37A | 0.71 | 0.46 | enet | 10 | 0.55 | 5.7e-29 | 5.18 | 5.2 | 2.4e-07 | 0.01 | 0.00 | 1.00 | FALSE |
60 | GTEx | Testis | RP11-6N17.4 | 0.14 | 0.02 | lasso | 10 | 0.02 | 4.8e-02 | 5.57 | 5.6 | 1.8e-08 | -0.07 | 0.14 | 0.72 | FALSE |
61 | GTEx | Thyroid | CDK5RAP3 | 0.21 | 0.14 | lasso | 5 | 0.18 | 1.6e-13 | -4.94 | -6.1 | 1.4e-09 | 0.13 | 0.90 | 0.10 | FALSE |
62 | GTEx | Thyroid | ATP5G1 | 0.09 | 0.04 | enet | 19 | 0.10 | 6.9e-08 | -5.30 | 5.2 | 2.0e-07 | -0.66 | 0.19 | 0.78 | FALSE |
63 | GTEx | Thyroid | SNF8 | 0.11 | 0.08 | lasso | 3 | 0.07 | 2.5e-06 | -5.31 | 5.7 | 9.5e-09 | -0.61 | 0.89 | 0.08 | FALSE |
64 | GTEx | Thyroid | RP11-6N17.9 | 0.22 | 0.14 | lasso | 5 | 0.14 | 5.2e-11 | -4.94 | -5.9 | 2.9e-09 | 0.12 | 0.90 | 0.10 | FALSE |
65 | GTEx | Thyroid | RP11-6N17.10 | 0.19 | 0.12 | lasso | 5 | 0.13 | 3.0e-10 | -4.94 | -6.3 | 3.8e-10 | 0.13 | 0.90 | 0.10 | FALSE |
66 | GTEx | Uterus | CDK5RAP3 | 0.41 | 0.28 | lasso | 5 | 0.26 | 4.5e-06 | -4.94 | -5.4 | 6.5e-08 | 0.11 | 0.11 | 0.06 | FALSE |
67 | GTEx | Uterus | RP11-6N17.10 | 0.43 | 0.26 | lasso | 6 | 0.24 | 1.3e-05 | -4.94 | -5.4 | 6.9e-08 | 0.12 | 0.09 | 0.08 | FALSE |
68 | METSIM | Adipose | LRRC37A | 0.56 | 0.25 | lasso | 5 | 0.32 | 5.5e-49 | 5.18 | 5.4 | 5.7e-08 | 0.01 | 0.00 | 1.00 | FALSE |
69 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SNF8 | 0.01 | 0.01 | blup | 47 | 0.01 | 9.1e-03 | -3.72 | 5.2 | 1.6e-07 | -0.60 | 0.06 | 0.23 | FALSE |
70 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | CBX1 | 0.03 | 0.01 | lasso | 3 | 0.01 | 8.7e-03 | 5.54 | -5.2 | 2.5e-07 | 0.09 | 0.01 | 0.82 | FALSE |
71 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ATP5G1 | 0.08 | 0.02 | enet | 7 | 0.02 | 3.1e-03 | -5.84 | 5.2 | 1.5e-07 | -0.59 | 0.02 | 0.77 | FALSE |
72 | The Cancer Genome Atlas | Brain Lower Grade Glioma | SNF8 | 0.11 | 0.12 | lasso | 4 | 0.12 | 1.4e-13 | -5.60 | 5.8 | 6.3e-09 | -0.65 | 0.51 | 0.49 | FALSE |
73 | The Cancer Genome Atlas | Brain Lower Grade Glioma | TTLL6 | 0.03 | 0.00 | blup | 59 | 0.02 | 2.7e-03 | -4.50 | -5.3 | 1.1e-07 | 0.54 | 0.02 | 0.83 | FALSE |
74 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CBX1 | 0.03 | 0.04 | lasso | 4 | 0.04 | 3.7e-05 | 5.62 | -5.4 | 5.6e-08 | 0.07 | 0.01 | 0.99 | FALSE |
75 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CDK5RAP3 | 0.06 | 0.00 | blup | 62 | 0.03 | 1.0e-03 | -3.64 | -6.8 | 1.3e-11 | 0.07 | 0.01 | 0.52 | TRUE |
76 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SNF8 | 0.05 | 0.06 | blup | 47 | 0.06 | 1.0e-06 | -6.50 | 5.7 | 1.4e-08 | -0.64 | 0.04 | 0.96 | FALSE |
77 | The Cancer Genome Atlas | Thyroid Carcinoma | SNF8 | 0.16 | 0.18 | lasso | 7 | 0.18 | 5.9e-17 | -5.45 | 5.5 | 3.8e-08 | -0.64 | 0.45 | 0.55 | FALSE |
78 | The Cancer Genome Atlas | Thyroid Carcinoma | UBE2Z | 0.13 | 0.09 | lasso | 4 | 0.12 | 2.7e-11 | -5.44 | 6.0 | 2.0e-09 | -0.64 | 0.05 | 0.95 | FALSE |