Best TWAS P=3.86e-10 · Best GWAS P=3.77e-09 conditioned to 0.0795
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | BMP8A | 0.05 | 0.03 | lasso | 3 | 0.02 | 8.8e-04 | 5.4 | 5.5 | 3.7e-08 | 0.70 | 0.06 | 0.88 | FALSE |
| 2 | GTEx | Adrenal Gland | PABPC4 | 0.20 | 0.09 | lasso | 8 | 0.06 | 3.0e-03 | 5.2 | -6.3 | 3.9e-10 | -0.76 | 0.03 | 0.87 | TRUE |
| 3 | GTEx | Breast Mammary Tissue | PABPC4 | 0.13 | 0.02 | enet | 14 | 0.04 | 3.4e-03 | 5.4 | -5.2 | 1.6e-07 | -0.68 | 0.07 | 0.82 | FALSE |
| 4 | GTEx | Breast Mammary Tissue (Female) | PABPC4 | 0.10 | 0.00 | enet | 9 | 0.01 | 1.5e-01 | 5.3 | -5.7 | 1.2e-08 | -0.77 | 0.04 | 0.31 | FALSE |
| 5 | GTEx | Cells Transformed fibroblasts | PABPC4 | 0.07 | 0.09 | lasso | 1 | 0.06 | 2.7e-05 | 5.2 | -5.2 | 1.6e-07 | -0.66 | 0.05 | 0.93 | FALSE |
| 6 | GTEx | Esophagus Mucosa | PABPC4 | 0.06 | 0.06 | lasso | 3 | 0.08 | 7.3e-06 | 5.4 | -5.2 | 1.6e-07 | -0.71 | 0.07 | 0.92 | FALSE |
| 7 | GTEx | Nerve Tibial | RP11-69E11.8 | 0.05 | 0.00 | lasso | 3 | 0.01 | 6.9e-02 | 5.2 | -5.4 | 6.7e-08 | -0.71 | 0.04 | 0.82 | FALSE |
| 8 | GTEx | Skin Not Sun Exposed Suprapubic | PABPC4 | 0.12 | 0.10 | lasso | 3 | 0.05 | 1.0e-03 | 5.4 | -5.4 | 7.5e-08 | -0.69 | 0.06 | 0.87 | FALSE |
| 9 | The Cancer Genome Atlas | Brain Lower Grade Glioma | BMP8A | 0.05 | 0.01 | blup | 48 | 0.04 | 6.8e-05 | 5.1 | 5.9 | 2.7e-09 | 0.66 | 0.00 | 0.97 | FALSE |
| 10 | The Cancer Genome Atlas | Lung Adenocarcinoma | PABPC4 | 0.04 | 0.03 | enet | 8 | 0.04 | 4.5e-05 | 5.4 | -5.3 | 1.5e-07 | -0.61 | 0.00 | 1.00 | FALSE |
| 11 | The Cancer Genome Atlas | Thyroid Carcinoma | PABPC4 | 0.09 | 0.07 | enet | 5 | 0.08 | 4.1e-08 | 5.2 | -6.0 | 1.6e-09 | -0.51 | 0.00 | 1.00 | FALSE |