Best TWAS P=8.74e-11 · Best GWAS P=9.33e-14 conditioned to 3.33e-05
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | KLC1 | 0.05 | 0.03 | lasso | 3 | 0.03 | 1.8e-03 | 3.7 | 5.2 | 2.3e-07 | -0.02 | 0.06 | 0.80 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | KLC1 | 0.06 | 0.02 | lasso | 2 | 0.00 | 2.2e-01 | -5.1 | 5.4 | 5.5e-08 | 0.00 | 0.04 | 0.72 | FALSE |
| 3 | GTEx | Adrenal Gland | KLC1 | 0.15 | 0.03 | lasso | 3 | 0.06 | 4.6e-03 | 4.8 | 5.7 | 1.0e-08 | -0.03 | 0.08 | 0.50 | FALSE |
| 4 | GTEx | Artery Aorta | KLC1 | 0.10 | 0.14 | lasso | 3 | 0.14 | 6.1e-08 | -5.0 | 5.5 | 3.6e-08 | 0.00 | 0.03 | 0.97 | FALSE |
| 5 | GTEx | Artery Tibial | TRMT61A | 0.07 | 0.07 | lasso | 3 | 0.06 | 2.4e-05 | -4.9 | -5.2 | 1.9e-07 | 0.03 | 0.07 | 0.92 | FALSE |
| 6 | GTEx | Breast Mammary Tissue | KLC1 | 0.12 | 0.02 | enet | 26 | 0.07 | 2.9e-04 | 4.2 | 5.4 | 8.3e-08 | 0.00 | 0.39 | 0.52 | FALSE |
| 7 | GTEx | Cells Transformed fibroblasts | KLC1 | 0.16 | 0.11 | enet | 17 | 0.10 | 3.1e-08 | 4.9 | 5.2 | 1.7e-07 | -0.03 | 0.07 | 0.93 | FALSE |
| 8 | GTEx | Cells Transformed fibroblasts | APOPT1 | 0.14 | 0.12 | lasso | 3 | 0.10 | 6.4e-08 | -5.0 | -5.5 | 4.4e-08 | 0.00 | 0.03 | 0.97 | FALSE |
| 9 | GTEx | Esophagus Muscularis | KLC1 | 0.07 | 0.01 | enet | 10 | 0.02 | 2.6e-02 | -5.1 | 5.4 | 5.1e-08 | -0.04 | 0.04 | 0.78 | FALSE |
| 10 | GTEx | Lung | MARK3 | 0.06 | 0.02 | lasso | 3 | 0.01 | 6.6e-02 | -4.8 | -5.2 | 2.3e-07 | 0.02 | 0.38 | 0.18 | FALSE |
| 11 | GTEx | Lung | CKB | 0.07 | 0.01 | lasso | 2 | 0.01 | 3.4e-02 | -5.1 | -5.4 | 6.0e-08 | 0.01 | 0.04 | 0.88 | FALSE |
| 12 | GTEx | Muscle Skeletal | ZFYVE21 | 0.10 | 0.05 | lasso | 2 | 0.03 | 3.3e-04 | -5.0 | 5.2 | 2.2e-07 | -0.02 | 0.03 | 0.95 | FALSE |
| 13 | GTEx | Muscle Skeletal | KLC1 | 0.11 | 0.07 | lasso | 7 | 0.08 | 3.3e-08 | -5.0 | 5.4 | 7.7e-08 | -0.02 | 0.03 | 0.96 | FALSE |
| 14 | GTEx | Muscle Skeletal | APOPT1 | 0.14 | 0.21 | enet | 10 | 0.22 | 6.7e-21 | -5.1 | 5.6 | 2.2e-08 | -0.02 | 0.01 | 0.99 | FALSE |
| 15 | GTEx | Skin Sun Exposed Lower leg | MARK3 | 0.10 | 0.09 | enet | 13 | 0.08 | 7.5e-07 | -4.9 | -5.3 | 1.2e-07 | 0.02 | 0.90 | 0.10 | FALSE |
| 16 | METSIM | Adipose | MARK3 | 0.03 | 0.02 | lasso | 6 | 0.03 | 6.3e-05 | 4.0 | -5.1 | 3.1e-07 | 0.04 | 0.95 | 0.01 | FALSE |
| 17 | METSIM | Adipose | TRAF3 | 0.04 | 0.02 | enet | 7 | 0.04 | 4.5e-06 | 6.2 | 6.5 | 8.7e-11 | 0.79 | 0.04 | 0.95 | TRUE |
| 18 | YFS | Blood | KLC1 | 0.01 | 0.01 | blup | 389 | 0.01 | 1.0e-03 | -5.0 | 5.2 | 1.9e-07 | -0.03 | 0.02 | 0.93 | FALSE |
| 19 | The Cancer Genome Atlas | Breast Invasive Carcinoma | C14orf153 | 0.05 | 0.02 | lasso | 4 | 0.02 | 8.0e-05 | -5.1 | -5.4 | 8.5e-08 | 0.03 | 0.00 | 0.99 | FALSE |
| 20 | The Cancer Genome Atlas | Glioblastoma Multiforme | C14orf153 | 0.14 | 0.01 | blup | 40 | 0.03 | 3.5e-02 | -5.1 | -5.6 | 1.8e-08 | 0.02 | 0.01 | 0.48 | FALSE |
| 21 | The Cancer Genome Atlas | Brain Lower Grade Glioma | C14orf153 | 0.04 | 0.01 | blup | 38 | 0.03 | 6.2e-04 | 3.7 | -5.3 | 1.3e-07 | 0.03 | 0.02 | 0.76 | FALSE |
| 22 | The Cancer Genome Atlas | Lung Adenocarcinoma | C14orf153 | 0.06 | 0.02 | blup | 38 | 0.04 | 2.4e-05 | -5.1 | -5.8 | 6.5e-09 | 0.03 | 0.02 | 0.91 | FALSE |
| 23 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | CKB | 0.03 | 0.00 | blup | 34 | 0.02 | 1.4e-03 | 4.0 | -5.6 | 1.9e-08 | 0.03 | 0.01 | 0.70 | FALSE |
| 24 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | C14orf153 | 0.11 | 0.11 | lasso | 3 | 0.10 | 1.1e-04 | -5.3 | -5.6 | 2.9e-08 | 0.03 | 0.00 | 0.98 | FALSE |
| 25 | The Cancer Genome Atlas | Prostate Adenocarcinoma | C14orf153 | 0.09 | 0.08 | blup | 38 | 0.09 | 6.2e-10 | -5.3 | -5.9 | 3.2e-09 | 0.04 | 0.00 | 1.00 | TRUE |
| 26 | The Cancer Genome Atlas | Prostate Adenocarcinoma | MARK3 | 0.07 | 0.06 | enet | 7 | 0.08 | 1.0e-08 | -4.7 | -5.1 | 2.9e-07 | 0.03 | 0.02 | 0.97 | FALSE |