Best TWAS P=8.95e-20 · Best GWAS P=3.52e-27 conditioned to 1.8e-09
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Artery Aorta | UBN1 | 0.18 | 0.15 | lasso | 4 | 0.14 | 6.8e-08 | 5.9 | -5.3 | 1.0e-07 | -0.04 | 0.11 | 0.88 | FALSE |
2 | GTEx | Brain Cerebellum | SLX4 | 0.33 | 0.14 | lasso | 3 | 0.10 | 6.8e-04 | 4.9 | -5.2 | 1.9e-07 | -0.01 | 0.16 | 0.05 | FALSE |
3 | GTEx | Brain Frontal Cortex BA9 | NLRC3 | 0.50 | 0.18 | enet | 30 | 0.33 | 1.6e-09 | 3.0 | -5.9 | 4.0e-09 | 0.03 | 0.44 | 0.06 | TRUE |
4 | GTEx | Brain Hippocampus | CLUAP1 | 0.37 | 0.10 | lasso | 5 | 0.09 | 4.9e-03 | 4.5 | 5.4 | 6.8e-08 | 0.02 | 0.17 | 0.06 | FALSE |
5 | GTEx | Esophagus Mucosa | UBN1 | 0.12 | 0.06 | lasso | 3 | 0.08 | 5.1e-06 | 5.4 | -5.7 | 1.0e-08 | -0.05 | 0.11 | 0.88 | FALSE |
6 | GTEx | Esophagus Muscularis | UBN1 | 0.18 | 0.19 | lasso | 4 | 0.19 | 9.1e-12 | 5.9 | -5.8 | 9.0e-09 | -0.04 | 0.20 | 0.80 | FALSE |
7 | GTEx | Nerve Tibial | UBN1 | 0.14 | 0.12 | lasso | 4 | 0.11 | 5.6e-08 | 5.9 | -5.9 | 3.8e-09 | -0.04 | 0.20 | 0.79 | TRUE |
8 | GTEx | Skin Sun Exposed Lower leg | CLUAP1 | 0.34 | 0.25 | lasso | 6 | 0.27 | 1.1e-22 | 4.9 | 5.2 | 1.8e-07 | 0.04 | 1.00 | 0.00 | FALSE |
9 | GTEx | Skin Sun Exposed Lower leg | PPL | 0.10 | 0.04 | lasso | 6 | 0.02 | 5.7e-03 | 5.4 | 5.3 | 1.2e-07 | 0.05 | 0.08 | 0.71 | FALSE |
10 | GTEx | Skin Sun Exposed Lower leg | UBN1 | 0.16 | 0.15 | lasso | 5 | 0.17 | 9.5e-14 | 5.9 | -5.5 | 4.5e-08 | -0.05 | 0.22 | 0.78 | FALSE |
11 | ROSMAP | Brain Pre-frontal Cortex | RP11-462G12.1 | 0.11 | 0.07 | enet | 18 | 0.06 | 1.1e-08 | -10.5 | -9.1 | 8.9e-20 | 0.86 | 0.00 | 1.00 | TRUE |
12 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | NLRC3 | 0.05 | 0.01 | blup | 39 | 0.02 | 9.8e-03 | 5.1 | -5.2 | 2.2e-07 | -0.09 | 0.00 | 0.84 | FALSE |
13 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ROGDI | 0.03 | 0.04 | lasso | 3 | 0.03 | 1.6e-04 | 5.4 | -5.3 | 1.3e-07 | 0.01 | 0.01 | 0.96 | FALSE |