TWAS hub - PPL

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Frontal Cortex BA9	0.346	0.1215	6.2e-03	0.008	NA	-0.011	NA	-0.009	1.9e-01	NA	8.1e-01	NA	6.3e-01
2	GTEx	Skin Sun Exposed Lower leg	0.098	0.0400	2.1e-03	0.040	NA	0.008	NA	0.022	2.7e-04	NA	6.3e-02	NA	5.7e-03
3	ROSMAP	Brain Pre-frontal Cortex	0.147	0.0373	7.5e-09	0.099	0.099	0.126	0.127	0.111	1.0e-12	1.2e-12	6.2e-16	5.5e-16	3.8e-14

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Reason for reducing amount of alcohol drunk: Health precaution	5.0	5.8	13.0	0.8	-3.6	1.9
Body Mass Index (BMI) (2010)	4.7	6.5	15.1	-1.6	3.9	-1.3
Leg fat mass (right)	4.6	17.8	34.8	-2.9	5.9	-3.2
Trunk fat mass	4.5	19.4	37.6	-2.7	6.1	-3.6
Weight	4.5	22.0	39.7	-2.9	6.3	-4.2
Loud music exposure frequency	4.5	4.9	9.9	0.6	-2.1	3.1
Whole body fat mass	4.5	18.9	36.1	-2.8	6.0	-3.6
Waist circumference	4.4	16.2	31.9	-2.3	5.7	-3.4
Leg fat mass (left)	4.3	16.6	30.9	-2.8	5.6	-3.3
Medication: Amlodipine	4.1	5.7	7.7	2.4	-1.9	2.8
Arm fat mass (left)	3.9	16.1	28.9	-2.7	5.4	-3.4
Arm fat mass (right)	3.7	15.3	28.0	-2.7	5.3	-3.2
Guilty feelings	3.7	5.5	7.7	1.7	-2.8	2.5
Verbal and Numeric Reasoning (VNR)	3.6	8.6	15.6	-2.7	3.9	-1.8
BMI	3.6	21.0	38.9	-2.4	6.2	-4.3
Leg fat-free mass (left)	3.6	18.9	30.4	-3.0	5.5	-4.2
Leg predicted mass (left)	3.5	18.5	29.2	-3.0	5.4	-4.2
Ever taken oral contraceptive pill	3.5	3.9	9.7	1.1	-3.1	-0.7
Trunk fat percentage	3.3	13.3	28.2	-2.0	5.3	-2.8
Pulse wave peak to peak time	3.3	3.9	8.2	-0.0	1.9	-2.9
Basal metabolic rate	3.3	18.4	28.6	-2.9	5.3	-4.2
Hip circumference	3.1	13.3	28.9	-1.2	5.4	-3.1
Body mass index (BMI)	3.0	12.9	21.5	-2.8	4.6	-3.1
Body fat percentage	3.0	12.0	26.1	-1.8	5.1	-2.6
Leg fat-free mass (right)	3.0	16.2	22.9	-2.9	4.8	-4.1
Leg predicted mass (right)	3.0	16.1	23.3	-2.8	4.8	-4.1
Neuroticism score	2.9	6.1	9.6	1.1	-2.8	3.1
Leg fat percentage (right)	2.9	10.6	23.6	-2.1	4.9	-2.0
Pulse wave Arterial Stiffness index	2.8	3.3	7.8	-0.1	-1.4	2.8
Arm fat percentage (left)	2.8	11.0	21.3	-2.3	4.6	-2.6
Arm predicted mass (left)	2.8	14.2	22.9	-2.5	4.8	-3.7
Intelligence (Savage-Jansen 2018)	2.7	8.2	17.3	-2.0	4.2	-1.9
Neuroticism (Nagel 2018)	2.7	6.3	13.1	0.3	-2.4	3.6
Fed-up feelings	2.7	4.8	12.4	0.7	-1.2	3.5
Arm fat percentage (right)	2.7	10.8	21.5	-2.2	4.6	-2.5
Whole body fat-free mass	2.7	15.2	23.3	-2.7	4.8	-3.9
Whole body water mass	2.7	15.2	23.0	-2.6	4.8	-4.0
HDL Cholesterol	2.6	4.4	6.9	2.1	-2.6	1.3
Neuroticism	2.6	6.2	10.6	0.8	-2.7	3.3
Medication: Metformin	2.6	3.6	4.7	-1.3	2.1	-2.2
Arm fat-free mass (right)	2.6	13.5	20.5	-2.7	4.5	-3.5
Arm predicted mass (right)	2.6	13.2	20.8	-2.6	4.6	-3.4
Leg fat percentage (left)	2.6	9.5	19.5	-2.1	4.4	-2.2
Arm fat-free mass (left)	2.6	13.0	22.3	-2.3	4.7	-3.4
Serious illness, injury or assault of a close relative in last 2 years	2.5	2.9	5.3	2.3	1.8	-0.2
Exposure to tobacco smoke at home	2.4	2.7	5.5	-2.4	0.9	-1.4
Mineral and other dietary supplements	2.4	3.3	6.1	-1.3	2.5	-1.4
Prostate Cancer	2.3	3.3	8.7	-0.3	-3.0	1.1
Relative age voice broke	2.3	3.5	9.1	3.0	-1.0	0.6
Chronic bronchitis/emphysema (father)	2.3	2.7	7.6	-0.3	2.8	-0.7
Commuting to job workplace: Car/motor vehicle	2.2	2.5	5.7	-0.6	1.2	-2.4
Miserableness	2.2	3.9	6.9	0.6	-2.1	2.6
Current tobacco smoking	2.1	3.5	6.8	-2.6	1.3	-1.3
Trunk fat-free mass	2.1	11.8	18.3	-2.3	4.3	-3.4
Irritability	2.1	3.5	7.7	1.5	-2.8	0.8
Systolic Blood Pressure	2.0	10.2	19.4	2.3	-4.4	2.5
Nervous feelings	2.0	3.7	6.6	1.8	-1.2	2.6
Trunk predicted mass	2.0	11.6	17.9	-2.3	4.2	-3.4
Worry too long after embarrassment	2.0	3.3	3.9	1.7	-1.7	2.0
Mouth/teeth dental problems: Loose teeth	2.0	2.3	6.0	-1.0	2.5	-0.2
Medication: Seretide 50 evohaler	2.0	2.3	4.0	-1.6	0.5	-2.0
Depressed Affect (Nagel 2018)	1.9	3.9	8.0	0.1	-1.9	2.8
Number of full sisters	1.9	2.3	3.2	-1.8	1.1	-1.6
Medication: Gliclazide	1.9	2.1	2.3	-1.5	1.4	1.5
Triglycerides	1.8	2.9	3.9	-1.7	2.0	1.3
Tinnitus: Yes, but not now, but have in the past	1.8	1.9	3.4	-1.8	-0.3	-1.5
Qualifications: A levels/AS levels or equivalent	1.8	4.0	6.3	-0.3	2.4	-2.5
Seen doctor (GP) for nerves, anxiety, tension or depression	1.8	2.7	7.0	1.1	0.1	2.6
Medication: Aspirin	1.8	2.4	3.3	1.8	-1.6	1.1
Financial situation satisfaction	1.8	2.2	6.4	-2.5	-0.4	0.1
LDL Cholesterol	1.7	2.7	7.8	-0.6	2.8	-0.0
Medication for hormone replacement therapy	1.7	1.9	4.9	0.2	-0.9	2.2
Had menopause	1.7	2.1	5.4	0.6	-0.8	2.3
Tense / ‘highly strung’	1.7	2.8	6.4	0.5	-1.3	2.5
Hair/balding pattern: Pattern 4	1.7	4.0	10.3	-1.2	3.2	-0.6
Health satisfaction	1.7	2.2	4.7	-2.2	0.4	-1.3
Supplements: Fish oil (including cod liver oil)	1.7	2.3	4.9	0.8	-2.2	1.1
Worry (Nagel 2018)	1.6	3.3	8.4	-0.0	-1.3	2.9
Crohns Disease (2017)	1.6	3.6	5.8	-0.3	2.2	-2.4
Major Depression (MDD)	1.6	1.9	4.4	0.0	1.2	-2.1
Relative age of first facial hair	1.6	3.3	5.2	2.0	-2.3	-0.8
Qualifications: None of the above	1.6	3.5	5.9	2.4	-1.7	1.3
Fluid intelligence score	1.6	3.3	7.0	-1.5	2.6	-0.8
Qualifications: O levels/GCSEs or equivalent	1.6	2.6	4.8	-0.3	1.7	-2.2
Hypertension (Self-reported)	1.6	4.4	8.3	1.6	-2.9	1.5
Mood swings	1.6	2.8	4.0	1.2	-1.7	2.0
Alcohol drinker status: Never	1.6	1.9	3.7	-0.9	1.1	-1.9
Crohns Disease (2012)	1.5	2.5	6.0	-0.5	1.1	-2.5
Heel bone mineral density (BMD) T-score, automated (left)	1.5	3.4	7.1	1.8	0.2	-2.7
Gout (self-reported)	1.5	2.1	2.6	-1.1	1.6	-1.5
Comparative height size at age 10	1.5	8.1	16.8	-1.6	4.1	-2.2
Medication for cholesterol	1.5	2.2	4.1	0.4	1.6	-2.0
Qualifications: CSEs or equivalent	1.4	1.9	2.9	1.7	-1.4	0.9
High blood pressure	1.4	4.0	7.3	1.5	-2.7	1.5
Average weekly red wine intake	1.4	2.0	4.0	-2.0	0.0	-1.4
Eye problems/disorders: Cataract	1.4	1.6	4.1	2.0	-0.2	0.8
Smoking status: Current	1.4	2.2	5.4	-2.3	1.0	-0.6
Commuting to job workplace: Public transport	1.4	1.6	4.6	-0.5	-0.3	2.1
Ever had prostate specific antigen (PSA) test	1.4	1.6	2.5	0.5	1.4	-1.6
Other serious medical condition/disability diagnosed by doctor	1.3	1.7	4.9	-0.4	2.2	-0.2
Systolic blood pressure, automated reading	1.3	3.8	6.1	1.3	-2.0	2.5
Noisy workplace	1.3	1.6	2.5	-1.0	-1.6	1.1
Illnesses of siblings: Diabetes	1.3	1.5	4.2	2.0	-0.6	-0.2
Irritable Bowel Disease (IBD)	1.2	2.8	4.8	-0.6	1.8	-2.2
Pain all over the body in last month	1.2	1.3	1.9	-1.4	1.3	-0.7
Prospective memory result	1.2	1.5	4.0	-0.5	-0.4	2.0
Birth weight of first child	1.2	2.2	3.5	0.5	1.9	-1.7
Pulse wave reflection index	1.2	1.5	2.4	0.1	-1.4	1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.6	1.8	1.2	-1.2	1.4
Qualifications: College or University degree	1.2	3.9	7.7	-0.9	1.8	-2.8
Eye problems/disorders: None of the above	1.2	1.3	2.9	-1.7	0.1	-1.1
Vascular/heart problems diagnosed by doctor	1.2	3.3	5.9	-1.0	2.4	-1.7
Bipolar Disorder (2018)	1.1	1.8	3.2	0.6	-1.3	1.8
Reaction Time	1.1	2.0	4.5	-2.1	-0.7	-1.1
Breast Cancer	1.1	2.6	6.1	-2.5	1.2	-0.5
Height	1.1	20.4	39.3	-2.5	6.3	-4.0
Hearing difficulty/problems with background noise	1.1	1.8	4.2	1.1	-2.0	0.2
Hair/balding pattern: Pattern 2	1.1	1.4	2.9	1.7	1.0	-0.4
Worrier / anxious feelings	1.1	2.1	5.1	-0.1	-1.0	2.3
High blood pressure (siblings)	1.1	1.6	2.5	0.8	-1.6	1.3
Osteoporosis (self-reported)	1.1	1.3	2.8	-1.7	0.6	-0.9
Osteoarthritis (self-reported)	1.1	1.4	2.2	1.5	-0.2	1.4
Medication: Aspirin	1.1	1.5	2.2	1.5	-1.1	1.0
Cardiovascular Disease	1.0	3.3	9.8	-0.0	-3.1	0.2
Chronotype (morning person)	1.0	2.3	3.5	1.9	-1.7	-0.7
Sensitivity / hurt feelings	1.0	1.7	4.3	-0.1	-1.0	2.1
Vitamin and mineral supplements	1.0	1.3	3.0	1.7	1.0	-0.2
Impedance of leg (left)	1.0	5.0	6.1	2.5	-2.2	2.0
Migraine (self-reported)	1.0	1.3	3.0	-1.7	0.2	-0.9
Ever had bowel cancer screening	1.0	1.2	1.9	1.4	0.3	1.2
Tinnitus: Yes, now most or all of the time	1.0	1.1	1.5	1.2	-0.9	1.0
Average weekly beer plus cider intake	1.0	1.4	4.0	0.0	-0.6	2.0
Mean Putamen Volume	0.9	1.0	1.8	-1.4	1.0	0.4
Impedance of leg (right)	0.9	4.2	6.1	2.5	-1.6	2.1
Sitting height	0.9	6.3	14.9	-0.6	3.9	-1.9
Standing height	0.9	9.1	18.9	-0.7	4.3	-2.8
Medication: Ventolin 100micrograms inhaler	0.9	1.2	3.5	-0.1	1.9	-0.0
Number of children fathered	0.9	1.1	1.9	0.2	1.1	-1.4
Emphysema/chronic bronchitis	0.9	1.0	2.7	-0.0	1.6	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	2.2	-0.4	-1.0	-1.5
Alcohol intake frequency.	0.9	2.2	2.3	-1.5	1.5	-1.5
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	2.0	-1.4	1.1	0.3
Handedness (chirality/laterality): Left-handed	0.9	1.0	2.8	-1.7	-0.5	-0.1
Qualifications: nursing, teaching	0.9	1.4	2.7	-0.3	1.3	-1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.8	3.0	1.5	-0.5	1.7
Fractured/broken bones in last 5 years	0.9	1.2	2.2	-1.5	1.1	0.4
Diastolic blood pressure, automated reading	0.9	2.7	4.7	1.2	-1.4	2.2
Pack years of smoking	0.9	1.3	3.2	-0.5	1.8	-0.8
Age at First Birth	0.8	1.1	1.8	1.3	-0.8	1.0
Medication: Co-codamol	0.8	1.0	2.4	-0.7	1.5	0.3
Illnesses of siblings	0.8	1.1	1.4	-1.0	0.9	-1.2
Hair/balding pattern: Pattern 3	0.8	1.2	2.1	-1.0	-1.4	-0.6
Mouth/teeth dental problems: Dentures	0.8	1.3	2.1	0.3	1.3	-1.4
Chronic bronchitis/emphysema (mother)	0.8	0.9	1.8	0.5	-0.8	1.3
Mean time to correctly identify matches	0.8	1.5	4.1	-2.0	-0.7	-0.0
Mouth/teeth dental problems: Mouth ulcers	0.8	1.2	3.4	1.8	0.2	-0.4
Mother’s age at death	0.8	1.0	1.4	0.5	1.1	-1.2
Risk taking	0.8	1.1	1.6	0.5	-1.3	1.3
Myopia	0.8	1.2	2.4	1.0	-0.2	-1.6
Impedance of whole body	0.8	4.1	6.0	2.4	-1.4	2.1
Schizophrenia vs Biploar Disorder	0.7	0.9	1.4	-1.2	1.1	-0.4
Ovarian Cancer	0.7	0.9	1.1	-0.9	-1.0	0.9
Waist Hip Ratio (WHR)	0.7	3.4	4.6	-2.2	2.0	-1.3
Number of treatments/medications taken	0.7	1.2	2.6	1.0	-1.6	0.1
Medication: Atenolol	0.7	0.9	1.9	-0.5	-1.4	-0.8
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.2	1.9	-1.2	-1.4	0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.5	2.1	1.4	-1.3	-0.9
Ever unenthusiastic/disinterested for a whole week	0.7	0.8	2.4	0.0	-1.5	-0.1
Number of live births	0.7	1.0	2.6	0.1	0.7	-1.6
Medication: Cholesterol lowering	0.7	1.1	3.0	-0.4	0.3	-1.7
Depression (self-reported)	0.7	0.8	2.3	-1.5	0.3	0.4
Medication: Ibuprofen	0.7	0.8	2.1	-0.0	-1.4	-0.6
Loneliness, isolation	0.7	1.0	1.6	0.6	-1.0	1.3
Medication: Lisinopril	0.7	1.0	1.6	1.1	-1.2	-0.4
Unable to work because of sickness or disability	0.7	0.9	2.1	-1.4	0.6	-0.6
Alzheimer’s Disease (including proxy)	0.6	0.9	2.0	-0.3	-1.4	0.7
Lupus	0.6	0.9	1.8	0.8	-0.6	-1.4
Primary Biliary Cirrhosis	0.6	0.9	1.3	0.9	-1.1	0.8
Pack years adult smoking proportion	0.6	0.9	1.6	-0.8	1.2	-0.7
Average weekly fortified wine intake	0.6	0.7	1.5	-0.4	1.2	0.7
Maternal smoking around birth	0.6	0.9	2.4	-0.2	-1.6	0.4
Stomach or abdominal pain in last month	0.6	0.7	1.3	1.1	-0.9	-0.3
Impedance of arm (right)	0.6	3.0	4.0	2.0	-1.1	1.9
Illnesses of mother	0.6	0.7	1.8	-0.1	1.3	-0.5
Impedance of arm (left)	0.6	2.6	4.0	2.0	-0.9	1.7
Number of full brothers	0.6	0.7	1.6	-0.4	-1.2	-0.6
Medication for pain relief, constipation, heartburn	0.6	1.0	1.9	0.0	1.4	-1.0
Illness, injury, bereavement, stress in last 2 years	0.6	0.8	2.3	-1.5	-0.3	0.1
Back pain experienced in last month	0.6	0.9	1.6	0.8	1.3	0.8
Alcohol drinker status: Previous	0.6	0.6	1.3	-1.2	0.3	-0.7
Alzheimer’s Disease (in mother)	0.5	0.6	1.3	-0.7	-1.1	0.4
HbA1C	0.5	0.5	0.8	-0.7	0.5	-0.9
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.7	-0.3	-0.4	1.3
Ever had hysterectomy (womb removed)	0.5	0.6	1.5	-0.2	1.2	-0.5
Diabetes (mother)	0.5	0.6	1.6	-0.3	0.2	-1.3
Hand grip strength (right)	0.5	1.3	3.6	0.0	0.5	-1.9
Number of incorrect matches in round	0.5	0.9	2.2	0.5	-0.4	1.5
Mouth/teeth dental problems	0.5	0.8	0.9	-0.9	-0.7	0.9
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	1.0	-0.9	-1.0	-0.6
Father’s age at death	0.5	0.7	1.6	-0.3	-0.7	1.3
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	1.2	0.7	-1.1	-0.5
Lung cancer (father)	0.5	0.5	0.6	-0.7	0.7	0.8
Peak expiratory flow (PEF)	0.5	1.1	2.5	0.3	-0.8	-1.6
Exposure to tobacco smoke outside home	0.5	0.6	1.0	-0.8	1.0	-0.5
Neck or shoulder pain in last month	0.5	0.7	1.3	1.1	-0.1	0.9
Suffer from ‘nerves’	0.5	0.7	1.0	1.0	-0.6	0.9
Overall health rating	0.5	1.1	1.5	-0.8	1.2	1.0
Chest pain or discomfort	0.5	0.7	1.1	-1.0	0.0	1.0
Supplements: Vitamin C	0.5	0.6	1.0	-1.0	-0.7	-0.5
Knee pain experienced in last month	0.5	0.8	2.2	0.3	0.1	1.5
Breast cancer (self-reported)	0.5	0.6	1.2	0.0	-0.7	1.1
Average weekly champagne plus white wine intake	0.5	0.7	1.9	-0.3	-1.4	-0.2
Medication: Atorvastatin	0.5	0.7	1.7	-1.3	0.6	0.0
Age started oral contraceptive pill	0.5	0.6	1.7	0.1	-0.3	1.3
Pain experienced in last month	0.5	0.8	1.2	-0.7	1.1	-0.9
Neuroticism (2016)	0.4	0.6	1.5	0.4	0.0	-1.2
Type 2 Diabetes (T2D) (2012)	0.4	0.4	0.8	-0.9	0.3	-0.6
Blood Platelet Count	0.4	4.4	12.3	-0.8	-3.5	-0.6
Smoking Status	0.4	1.0	2.1	-1.5	-0.4	0.7
Type 2 Diabetes (T2D) (2018)	0.4	0.8	1.3	0.6	0.8	-1.2
Hand grip strength (left)	0.4	1.0	2.8	-0.0	0.5	-1.7
Had other major operations	0.4	0.4	1.2	-0.3	1.1	-0.2
Alcohol intake versus 10 years previously	0.4	0.6	1.3	1.1	-0.7	0.0
Falls in the last year	0.4	0.5	1.2	0.4	-0.5	1.1
Medication: Lansoprazole	0.4	0.5	0.7	0.3	0.7	-0.9
Headache pain in last month	0.4	0.7	1.0	0.5	1.0	-1.0
Birth weight	0.4	0.9	1.8	-0.0	1.0	-1.3
Medication: Blood pressure	0.4	0.7	1.6	0.6	-1.3	0.0
Medication: Allopurinol	0.4	0.6	1.4	-0.4	0.4	-1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	0.9	-0.7	0.9	0.2
Commuting to job workplace: Walk	0.4	0.4	0.6	0.7	0.8	-0.3
Medication: Blood pressure	0.4	0.7	1.3	-0.0	-1.1	0.9
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.6	-0.2	1.2	-0.0
Medication: Omeprazole (e.g. Zanprol)	0.4	0.4	1.2	0.3	-0.1	-1.1
Supplements: Calcium	0.4	0.4	0.8	-0.2	0.9	-0.7
Bipolar Disorder or Schizophrenia	0.3	0.6	1.4	0.2	-0.7	1.2
Depression (Nagel 2018)	0.3	0.5	0.8	-0.9	0.4	0.7
Heel T-Score	0.3	2.2	5.9	0.7	-0.1	-2.4
Lung FVC	0.3	1.5	1.7	-1.2	1.3	-1.1
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.9	1.0	-0.2	-0.1
Supplements: Zinc	0.3	0.3	0.7	0.8	-0.1	-0.5
Diabetes (father)	0.3	0.4	0.8	0.9	-0.6	0.1
Severe depression (siblings)	0.3	0.3	0.5	-0.2	0.6	-0.7
Age when periods started (menarche)	0.3	0.8	1.2	0.9	-0.6	1.1
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	0.8	0.5	0.9	0.1
Alcohol usually taken with meals	0.3	0.5	1.5	0.4	1.2	-0.1
Forced vital capacity (FVC)	0.3	1.2	1.9	-0.2	1.3	-1.4
Heart attack	0.3	0.3	1.0	-1.0	0.2	-0.2
Allergy	0.3	0.7	0.9	-0.9	0.9	-0.5
Medication: Simvastatin	0.3	0.5	1.1	1.1	-0.5	-0.2
Pulse rate	0.3	0.5	1.2	-0.1	0.5	1.1
Length of working week for main job	0.3	0.4	0.5	0.7	-0.1	0.7
Ever highly irritable/argumentative for 2 days	0.3	0.4	0.9	-0.9	-0.6	0.1
Medication for cholesterol, blood pressure or diabetes	0.3	0.6	0.9	-1.0	0.8	0.4
Comparative body size at age 10	0.3	0.8	1.6	-0.7	1.3	-0.5
Medication: Omeprazole	0.3	0.3	0.6	-0.1	-0.5	-0.8
Pulse rate, automated reading	0.3	1.1	3.0	0.5	-0.0	1.7
Smoking status: Previous	0.3	0.4	0.6	0.8	-0.6	0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	1.6	0.4	-0.1	-1.3
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.4	0.6	-0.8	0.6	0.2
Medication: Bendroflumethiazide	0.3	0.5	0.5	-0.7	-0.7	-0.7
Commuting to job workplace: Cycle	0.3	0.3	0.6	-0.1	0.6	0.8
Basal cell carcinoma (self-reported)	0.3	0.4	0.8	0.4	-0.9	-0.4
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.1	-1.0	0.3	0.2
Alzheimer’s Disease (in father)	0.2	0.2	0.4	-0.2	0.7	-0.2
Ulcerative Colitis (UC)	0.2	0.3	0.7	-0.5	-0.1	-0.8
Fasting Glucose	0.2	0.2	0.5	-0.4	0.2	0.7
Ulcerative Colitis	0.2	0.3	0.5	0.7	0.1	-0.6
Blood Eosinophil Count	0.2	1.6	2.9	1.2	-1.7	0.8
Hypothyroidism (self reported)	0.2	0.4	0.6	-0.7	-0.8	0.3
Lung FEV1/FVC ratio	0.2	1.1	2.2	0.8	1.5	-0.7
Average weekly spirits intake	0.2	0.3	0.7	-0.8	-0.3	0.2
Hearing difficulty/problems: Yes	0.2	0.4	0.7	-0.5	-0.4	-0.8
Angina	0.2	0.3	0.7	-0.4	0.9	0.2
Serious illness, injury or assault to yourself	0.2	0.2	0.5	0.7	-0.0	-0.3
Hayfever, allergic rhinitis or eczema	0.2	0.4	0.9	-0.2	-0.6	1.0
Multivitamins +/- minerals	0.2	0.2	0.4	-0.6	-0.6	-0.0
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.3	0.4	0.5	-0.6
High blood pressure (mother)	0.2	0.3	1.0	-0.1	-1.0	-0.0
Past tobacco smoking	0.2	0.4	0.8	-0.7	0.0	-0.9
Time employed in main current job	0.2	0.2	0.7	-0.8	0.1	0.0
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	1.0	-0.4	1.0	0.1
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	1.2	0.1	0.8	-1.1
Breastfed as a baby	0.2	0.3	0.4	-0.6	0.6	-0.3
Glaucoma (self-reported)	0.2	0.3	0.7	-0.1	0.1	0.9
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	0.9	-0.1	-1.0	-0.4
Forced vital capacity (FVC), Best measure	0.2	0.9	1.2	-0.7	0.9	-1.1
Age at first live birth	0.2	0.4	0.6	0.8	0.8	0.2
Diabetes diagnosed by doctor	0.2	0.3	0.9	-0.1	0.2	-1.0
Eye problems/disorders: Glaucoma	0.2	0.2	0.5	-0.7	0.1	0.3
Illnesses of father: High blood pressure	0.2	0.2	0.3	-0.4	-0.6	-0.2
Ever smoked	0.2	0.3	0.7	0.3	0.5	0.8
Number of operations (self-reported)	0.2	0.2	0.4	-0.2	-0.5	0.6
Heart disease (siblings)	0.2	0.3	0.7	0.2	-0.1	0.9
Rheumatoid Arthritis	0.1	0.2	0.3	0.1	0.4	0.5
Schizophrenia (2014)	0.1	0.3	0.6	-0.4	0.1	0.8
Allergy or Eczema	0.1	0.3	0.5	-0.4	-0.6	0.7
Hair Pigment	0.1	1.6	3.0	1.3	-1.7	-0.4
Tanning	0.1	1.4	2.7	-0.7	1.1	-1.6
Ever used hormone-replacement therapy (HRT)	0.1	0.2	0.5	-0.0	0.1	0.7
Townsend deprivation index at recruitment	0.1	0.2	0.3	0.6	0.2	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	0.5	-0.2	-0.7	0.2
Supplements: Glucosamine	0.1	0.1	0.2	0.5	-0.1	0.4
Financial difficulties in last 2 years	0.1	0.1	0.1	-0.3	0.3	-0.1
Happiness	0.1	0.1	0.3	-0.5	-0.3	0.2
Asthma	0.1	0.3	0.8	-0.0	-0.1	-0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	0.8	-0.4	0.9	-0.5
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.3	-0.5	-0.2	-0.3
Blood clot in the leg (DVT)	0.1	0.1	0.2	0.2	-0.5	0.3
Medication: Paracetamol	0.1	0.1	0.3	-0.1	0.1	0.6
Wheeze or whistling in the chest in last year	0.1	0.2	0.5	-0.7	-0.0	0.2
Angina (self-reported)	0.1	0.2	0.5	-0.1	0.7	0.2
Heart disease (mother)	0.1	0.1	0.4	0.1	0.1	0.6
Age at last live birth	0.1	0.2	0.4	0.3	-0.6	0.2
Family relationship satisfaction	0.1	0.1	0.2	0.4	-0.3	0.4
Leg pain on walking	0.1	0.1	0.2	0.4	0.1	0.1
Long-standing illness, disability or infirmity	0.1	0.2	0.4	-0.2	0.7	0.3
Friendships satisfaction	0.1	0.2	0.3	-0.1	-0.4	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.2	-0.1	-0.1	0.4
Asthma (self-reported)	0.1	0.2	0.6	0.0	-0.2	-0.8
Illnesses of father: None of the above (group 1)	0.1	0.1	0.2	0.4	-0.3	0.4
Number of self-reported non-cancer illnesses	0.1	0.2	0.3	0.1	0.5	0.5
Hearing aid user	0.1	0.1	0.2	-0.3	0.1	0.4
High cholesterol (Self-reported)	0.1	0.2	0.5	-0.3	-0.1	-0.7
Medication: Paracetamol	0.1	0.1	0.2	-0.4	0.4	-0.1
Ever depressed for a whole week	0.1	0.2	0.3	-0.5	-0.1	0.5
Cholesterol lowering medication	0.1	0.2	0.4	0.3	0.1	0.7
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.2	-0.3	-0.1	0.5
Schizophrenia (2018)	0.0	0.0	0.1	-0.4	-0.1	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	-0.2	0.0	-0.0
Blood Red Count	0.0	0.4	0.8	0.9	0.6	0.1
Blood White Count	0.0	0.0	0.1	0.1	-0.3	0.2
Respiratory disease	0.0	0.1	0.1	-0.2	0.3	-0.2
Taking other prescription medications	0.0	0.1	0.2	0.2	0.0	-0.4
Medication: Levothyroxine sodium	0.0	0.0	0.1	0.1	-0.3	-0.2
Diabetes (self-reported)	0.0	0.0	0.1	-0.0	-0.1	-0.3
Medication: Ramipril	0.0	0.0	0.1	-0.2	-0.1	-0.2
Shortness of breath walking on level ground	0.0	0.0	0.0	-0.0	0.2	0.2
Had major operations	0.0	0.0	0.1	-0.3	0.1	-0.1
Illnesses of father: Heart disease	0.0	0.0	0.1	-0.0	-0.2	0.0
Wears glasses or contact lenses	0.0	0.1	0.1	0.3	-0.2	-0.1

Hub : Genes

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Trait associations