Hub : Genes

PPL

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Frontal Cortex BA9 0.346 0.1215 6.2e-03 0.008 NA -0.011 NA -0.009 1.9e-01 NA 8.1e-01 NA 6.3e-01
2 GTEx Skin Sun Exposed Lower leg 0.098 0.0400 2.1e-03 0.040 NA 0.008 NA 0.022 2.7e-04 NA 6.3e-02 NA 5.7e-03
3 ROSMAP Brain Pre-frontal Cortex 0.147 0.0373 7.5e-09 0.099 0.099 0.126 0.127 0.111 1.0e-12 1.2e-12 6.2e-16 5.5e-16 3.8e-14

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 1.1 1.8 3.2 0.6 -1.3 1.8
Bipolar Disorder or Schizophrenia 0.3 0.6 1.4 0.2 -0.7 1.2
Depressed Affect (Nagel 2018) 1.9 3.9 8.0 0.1 -1.9 2.8
Depression (Nagel 2018) 0.3 0.5 0.8 -0.9 0.4 0.7
Intelligence (Savage-Jansen 2018) 2.7 8.2 17.3 -2.0 4.2 -1.9
Neuroticism (Nagel 2018) 2.7 6.3 13.1 0.3 -2.4 3.6
Schizophrenia (2018) 0.0 0.0 0.1 -0.4 -0.1 0.0
Schizophrenia vs Biploar Disorder 0.7 0.9 1.4 -1.2 1.1 -0.4
Worry (Nagel 2018) 1.6 3.3 8.4 -0.0 -1.3 2.9
Alzheimer’s Disease (in mother) 0.5 0.6 1.3 -0.7 -1.1 0.4
Alzheimer’s Disease (in father) 0.2 0.2 0.4 -0.2 0.7 -0.2
Alzheimer’s Disease (including proxy) 0.6 0.9 2.0 -0.3 -1.4 0.7
Crohns Disease (2017) 1.6 3.6 5.8 -0.3 2.2 -2.4
Irritable Bowel Disease (IBD) 1.2 2.8 4.8 -0.6 1.8 -2.2
Ulcerative Colitis (UC) 0.2 0.3 0.7 -0.5 -0.1 -0.8
Major Depression (MDD) 1.6 1.9 4.4 0.0 1.2 -2.1
Reaction Time 1.1 2.0 4.5 -2.1 -0.7 -1.1
Verbal and Numeric Reasoning (VNR) 3.6 8.6 15.6 -2.7 3.9 -1.8
Breast Cancer 1.1 2.6 6.1 -2.5 1.2 -0.5
Ovarian Cancer 0.7 0.9 1.1 -0.9 -1.0 0.9
Prostate Cancer 2.3 3.3 8.7 -0.3 -3.0 1.1
Age at First Birth 0.8 1.1 1.8 1.3 -0.8 1.0
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 4.7 6.5 15.1 -1.6 3.9 -1.3
Coronary Artery Disease (CAD) 0.0 0.0 0.0 -0.2 0.0 -0.0
Crohns Disease (2012) 1.5 2.5 6.0 -0.5 1.1 -2.5
Mean Putamen Volume 0.9 1.0 1.8 -1.4 1.0 0.4
Fasting Glucose 0.2 0.2 0.5 -0.4 0.2 0.7
HbA1C 0.5 0.5 0.8 -0.7 0.5 -0.9
HDL Cholesterol 2.6 4.4 6.9 2.1 -2.6 1.3
LDL Cholesterol 1.7 2.7 7.8 -0.6 2.8 -0.0
Lupus 0.6 0.9 1.8 0.8 -0.6 -1.4
Neuroticism (2016) 0.4 0.6 1.5 0.4 0.0 -1.2
Primary Biliary Cirrhosis 0.6 0.9 1.3 0.9 -1.1 0.8
Rheumatoid Arthritis 0.1 0.2 0.3 0.1 0.4 0.5
Schizophrenia (2014) 0.1 0.3 0.6 -0.4 0.1 0.8
Triglycerides 1.8 2.9 3.9 -1.7 2.0 1.3
Type 2 Diabetes (T2D) (2012) 0.4 0.4 0.8 -0.9 0.3 -0.6
Ulcerative Colitis 0.2 0.3 0.5 0.7 0.1 -0.6
Blood Eosinophil Count 0.2 1.6 2.9 1.2 -1.7 0.8
Blood Platelet Count 0.4 4.4 12.3 -0.8 -3.5 -0.6
Blood Red Count 0.0 0.4 0.8 0.9 0.6 0.1
Blood White Count 0.0 0.0 0.1 0.1 -0.3 0.2
Heel T-Score 0.3 2.2 5.9 0.7 -0.1 -2.4
BMI 3.6 21.0 38.9 -2.4 6.2 -4.3
Height 1.1 20.4 39.3 -2.5 6.3 -4.0
Waist Hip Ratio (WHR) 0.7 3.4 4.6 -2.2 2.0 -1.3
Systolic Blood Pressure 2.0 10.2 19.4 2.3 -4.4 2.5
Smoking Status 0.4 1.0 2.1 -1.5 -0.4 0.7
Allergy or Eczema 0.1 0.3 0.5 -0.4 -0.6 0.7
Cardiovascular Disease 1.0 3.3 9.8 -0.0 -3.1 0.2
Hypothyroidism (self reported) 0.2 0.4 0.6 -0.7 -0.8 0.3
Respiratory disease 0.0 0.1 0.1 -0.2 0.3 -0.2
Type 2 Diabetes (T2D) (2018) 0.4 0.8 1.3 0.6 0.8 -1.2
Lung FEV1/FVC ratio 0.2 1.1 2.2 0.8 1.5 -0.7
Lung FVC 0.3 1.5 1.7 -1.2 1.3 -1.1
Neuroticism 2.6 6.2 10.6 0.8 -2.7 3.3
Chronotype (morning person) 1.0 2.3 3.5 1.9 -1.7 -0.7
Hair Pigment 0.1 1.6 3.0 1.3 -1.7 -0.4
Tanning 0.1 1.4 2.7 -0.7 1.1 -1.6
Hand grip strength (left) 0.4 1.0 2.8 -0.0 0.5 -1.7
Number of treatments/medications taken 0.7 1.2 2.6 1.0 -1.6 0.1
Average weekly spirits intake 0.2 0.3 0.7 -0.8 -0.3 0.2
Sensitivity / hurt feelings 1.0 1.7 4.3 -0.1 -1.0 2.1
Frequency of depressed mood in last 2 weeks 0.5 0.7 1.7 -0.3 -0.4 1.3
Hearing difficulty/problems: Yes 0.2 0.4 0.7 -0.5 -0.4 -0.8
Relative age of first facial hair 1.6 3.3 5.2 2.0 -2.3 -0.8
Other serious medical condition/disability diagnosed by doctor 1.3 1.7 4.9 -0.4 2.2 -0.2
Ever used hormone-replacement therapy (HRT) 0.1 0.2 0.5 -0.0 0.1 0.7
Ever had hysterectomy (womb removed) 0.5 0.6 1.5 -0.2 1.2 -0.5
Systolic blood pressure, automated reading 1.3 3.8 6.1 1.3 -2.0 2.5
Eye problems/disorders: Diabetes related eye disease 0.3 0.3 0.9 1.0 -0.2 -0.1
Angina 0.2 0.3 0.7 -0.4 0.9 0.2
Medication for hormone replacement therapy 1.7 1.9 4.9 0.2 -0.9 2.2
Vitamin and mineral supplements 1.0 1.3 3.0 1.7 1.0 -0.2
Supplements: Zinc 0.3 0.3 0.7 0.8 -0.1 -0.5
Medication: Co-codamol 0.8 1.0 2.4 -0.7 1.5 0.3
Medication: Metformin 2.6 3.6 4.7 -1.3 2.1 -2.2
Diabetes (father) 0.3 0.4 0.8 0.9 -0.6 0.1
Diabetes (mother) 0.5 0.6 1.6 -0.3 0.2 -1.3
Severe depression (siblings) 0.3 0.3 0.5 -0.2 0.6 -0.7
Pack years adult smoking proportion 0.6 0.9 1.6 -0.8 1.2 -0.7
Impedance of leg (right) 0.9 4.2 6.1 2.5 -1.6 2.1
Leg fat-free mass (left) 3.6 18.9 30.4 -3.0 5.5 -4.2
Trunk fat percentage 3.3 13.3 28.2 -2.0 5.3 -2.8
Hand grip strength (right) 0.5 1.3 3.6 0.0 0.5 -1.9
Townsend deprivation index at recruitment 0.1 0.2 0.3 0.6 0.2 -0.5
Current tobacco smoking 2.1 3.5 6.8 -2.6 1.3 -1.3
Average weekly fortified wine intake 0.6 0.7 1.5 -0.4 1.2 0.7
Maternal smoking around birth 0.6 0.9 2.4 -0.2 -1.6 0.4
Fed-up feelings 2.7 4.8 12.4 0.7 -1.2 3.5
Frequency of unenthusiasm / disinterest in last 2 weeks 0.1 0.2 0.5 -0.2 -0.7 0.2
Relative age voice broke 2.3 3.5 9.1 3.0 -1.0 0.6
Taking other prescription medications 0.0 0.1 0.2 0.2 0.0 -0.4
Age when periods started (menarche) 0.3 0.8 1.2 0.9 -0.6 1.1
Bilateral oophorectomy (both ovaries removed) 0.3 0.4 0.8 0.5 0.9 0.1
Heel bone mineral density (BMD) T-score, automated (left) 1.5 3.4 7.1 1.8 0.2 -2.7
Tinnitus: Yes, but not now, but have in the past 1.8 1.9 3.4 -1.8 -0.3 -1.5
Qualifications: CSEs or equivalent 1.4 1.9 2.9 1.7 -1.4 0.9
Serious illness, injury or assault to yourself 0.2 0.2 0.5 0.7 -0.0 -0.3
High blood pressure 1.4 4.0 7.3 1.5 -2.7 1.5
Hayfever, allergic rhinitis or eczema 0.2 0.4 0.9 -0.2 -0.6 1.0
Multivitamins +/- minerals 0.2 0.2 0.4 -0.6 -0.6 -0.0
Stomach or abdominal pain in last month 0.6 0.7 1.3 1.1 -0.9 -0.3
Supplements: Glucosamine 0.1 0.1 0.2 0.5 -0.1 0.4
Diverticular disease/diverticulitis (self-reported) 0.2 0.2 0.3 0.4 0.5 -0.6
Medication: Atenolol 0.7 0.9 1.9 -0.5 -1.4 -0.8
Medication: Levothyroxine sodium 0.0 0.0 0.1 0.1 -0.3 -0.2
Sitting height 0.9 6.3 14.9 -0.6 3.9 -1.9
Chronic bronchitis/emphysema (father) 2.3 2.7 7.6 -0.3 2.8 -0.7
High blood pressure (mother) 0.2 0.3 1.0 -0.1 -1.0 -0.0
Body mass index (BMI) 3.0 12.9 21.5 -2.8 4.6 -3.1
Impedance of leg (left) 1.0 5.0 6.1 2.5 -2.2 2.0
Leg predicted mass (left) 3.5 18.5 29.2 -3.0 5.4 -4.2
Trunk fat mass 4.5 19.4 37.6 -2.7 6.1 -3.6
Waist circumference 4.4 16.2 31.9 -2.3 5.7 -3.4
Number of incorrect matches in round 0.5 0.9 2.2 0.5 -0.4 1.5
Past tobacco smoking 0.2 0.4 0.8 -0.7 0.0 -0.9
Alcohol usually taken with meals 0.3 0.5 1.5 0.4 1.2 -0.1
Nervous feelings 2.0 3.7 6.6 1.8 -1.2 2.6
Frequency of tenseness / restlessness in last 2 weeks 0.7 1.2 1.9 -1.2 -1.4 0.2
Hearing difficulty/problems with background noise 1.1 1.8 4.2 1.1 -2.0 0.2
Hair/balding pattern: Pattern 2 1.1 1.4 2.9 1.7 1.0 -0.4
Had menopause 1.7 2.1 5.4 0.6 -0.8 2.3
Had other major operations 0.4 0.4 1.2 -0.3 1.1 -0.2
Forced vital capacity (FVC) 0.3 1.2 1.9 -0.2 1.3 -1.4
Heel bone mineral density (BMD) T-score, automated (right) 0.7 1.5 2.1 1.4 -1.3 -0.9
Ever unenthusiastic/disinterested for a whole week 0.7 0.8 2.4 0.0 -1.5 -0.1
Qualifications: None of the above 1.6 3.5 5.9 2.4 -1.7 1.3
Financial difficulties in last 2 years 0.1 0.1 0.1 -0.3 0.3 -0.1
Mouth/teeth dental problems 0.5 0.8 0.9 -0.9 -0.7 0.9
Heart attack 0.3 0.3 1.0 -1.0 0.2 -0.2
Allergy 0.3 0.7 0.9 -0.9 0.9 -0.5
Pain all over the body in last month 1.2 1.3 1.9 -1.4 1.3 -0.7
Diabetes (self-reported) 0.0 0.0 0.1 -0.0 -0.1 -0.3
Hayfever/allergic rhinitis (self-reported) 0.5 0.7 1.0 -0.9 -1.0 -0.6
Medication: Ramipril 0.0 0.0 0.1 -0.2 -0.1 -0.2
Medication: Simvastatin 0.3 0.5 1.1 1.1 -0.5 -0.2
Fluid intelligence score 1.6 3.3 7.0 -1.5 2.6 -0.8
Illnesses of siblings 0.8 1.1 1.4 -1.0 0.9 -1.2
Neuroticism score 2.9 6.1 9.6 1.1 -2.8 3.1
Weight 4.5 22.0 39.7 -2.9 6.3 -4.2
Impedance of arm (right) 0.6 3.0 4.0 2.0 -1.1 1.9
Arm fat percentage (right) 2.7 10.8 21.5 -2.2 4.6 -2.5
Trunk fat-free mass 2.1 11.8 18.3 -2.3 4.3 -3.4
Hip circumference 3.1 13.3 28.9 -1.2 5.4 -3.1
Time employed in main current job 0.2 0.2 0.7 -0.8 0.1 0.0
Alcohol intake versus 10 years previously 0.4 0.6 1.3 1.1 -0.7 0.0
Father’s age at death 0.5 0.7 1.6 -0.3 -0.7 1.3
Worrier / anxious feelings 1.1 2.1 5.1 -0.1 -1.0 2.3
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.4 1.0 -0.4 1.0 0.1
Falls in the last year 0.4 0.5 1.2 0.4 -0.5 1.1
Hair/balding pattern: Pattern 3 0.8 1.2 2.1 -1.0 -1.4 -0.6
Number of live births 0.7 1.0 2.6 0.1 0.7 -1.6
Forced expiratory volume in 1-second (FEV1) 0.2 0.6 1.2 0.1 0.8 -1.1
Pulse rate 0.3 0.5 1.2 -0.1 0.5 1.1
Happiness 0.1 0.1 0.3 -0.5 -0.3 0.2
Noisy workplace 1.3 1.6 2.5 -1.0 -1.6 1.1
Qualifications: A levels/AS levels or equivalent 1.8 4.0 6.3 -0.3 2.4 -2.5
Serious illness, injury or assault of a close relative in last 2 years 2.5 2.9 5.3 2.3 1.8 -0.2
Mouth/teeth dental problems: Dentures 0.8 1.3 2.1 0.3 1.3 -1.4
Asthma 0.1 0.3 0.8 -0.0 -0.1 -0.9
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.7 1.2 0.7 -1.1 -0.5
Medication: Cholesterol lowering 0.7 1.1 3.0 -0.4 0.3 -1.7
Depression (self-reported) 0.7 0.8 2.3 -1.5 0.3 0.4
Medication: Lansoprazole 0.4 0.5 0.7 0.3 0.7 -0.9
Prospective memory result 1.2 1.5 4.0 -0.5 -0.4 2.0
Lung cancer (father) 0.5 0.5 0.6 -0.7 0.7 0.8
Illnesses of mother 0.6 0.7 1.8 -0.1 1.3 -0.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.4 0.8 -0.4 0.9 -0.5
Pulse wave Arterial Stiffness index 2.8 3.3 7.8 -0.1 -1.4 2.8
Impedance of arm (left) 0.6 2.6 4.0 2.0 -0.9 1.7
Arm fat mass (right) 3.7 15.3 28.0 -2.7 5.3 -3.2
Trunk predicted mass 2.0 11.6 17.9 -2.3 4.2 -3.4
Standing height 0.9 9.1 18.9 -0.7 4.3 -2.8
Length of working week for main job 0.3 0.4 0.5 0.7 -0.1 0.7
Exposure to tobacco smoke at home 2.4 2.7 5.5 -2.4 0.9 -1.4
Breastfed as a baby 0.2 0.3 0.4 -0.6 0.6 -0.3
Tense / ‘highly strung’ 1.7 2.8 6.4 0.5 -1.3 2.5
Seen doctor (GP) for nerves, anxiety, tension or depression 1.8 2.7 7.0 1.1 0.1 2.6
Hair/balding pattern: Pattern 4 1.7 4.0 10.3 -1.2 3.2 -0.6
Birth weight of first child 1.2 2.2 3.5 0.5 1.9 -1.7
Peak expiratory flow (PEF) 0.5 1.1 2.5 0.3 -0.8 -1.6
Pulse wave reflection index 1.2 1.5 2.4 0.1 -1.4 1.6
Ever highly irritable/argumentative for 2 days 0.3 0.4 0.9 -0.9 -0.6 0.1
Loud music exposure frequency 4.5 4.9 9.9 0.6 -2.1 3.1
Qualifications: O levels/GCSEs or equivalent 1.6 2.6 4.8 -0.3 1.7 -2.2
Mouth/teeth dental problems: Bleeding gums 0.1 0.1 0.3 -0.5 -0.2 -0.3
Blood clot in the leg (DVT) 0.1 0.1 0.2 0.2 -0.5 0.3
Medication: Paracetamol 0.1 0.1 0.3 -0.1 0.1 0.6
Headache pain in last month 0.4 0.7 1.0 0.5 1.0 -1.0
Medication for cholesterol, blood pressure or diabetes 0.3 0.6 0.9 -1.0 0.8 0.4
Glaucoma (self-reported) 0.2 0.3 0.7 -0.1 0.1 0.9
Gout (self-reported) 1.5 2.1 2.6 -1.1 1.6 -1.5
Hypothyroidism/myxoedema (self-reported) 0.2 0.4 0.9 -0.1 -1.0 -0.4
Medication: Amlodipine 4.1 5.7 7.7 2.4 -1.9 2.8
Medication: Ventolin 100micrograms inhaler 0.9 1.2 3.5 -0.1 1.9 -0.0
Birth weight 0.4 0.9 1.8 -0.0 1.0 -1.3
Chronic bronchitis/emphysema (mother) 0.8 0.9 1.8 0.5 -0.8 1.3
High blood pressure (siblings) 1.1 1.6 2.5 0.8 -1.6 1.3
Forced vital capacity (FVC), Best measure 0.2 0.9 1.2 -0.7 0.9 -1.1
Body fat percentage 3.0 12.0 26.1 -1.8 5.1 -2.6
Leg fat percentage (right) 2.9 10.6 23.6 -2.1 4.9 -2.0
Arm fat-free mass (right) 2.6 13.5 20.5 -2.7 4.5 -3.5
Exposure to tobacco smoke outside home 0.5 0.6 1.0 -0.8 1.0 -0.5
Comparative body size at age 10 0.3 0.8 1.6 -0.7 1.3 -0.5
Number of full brothers 0.6 0.7 1.6 -0.4 -1.2 -0.6
Worry too long after embarrassment 2.0 3.3 3.9 1.7 -1.7 2.0
Seen a psychiatrist for nerves, anxiety, tension or depression 1.2 1.6 1.8 1.2 -1.2 1.4
Wheeze or whistling in the chest in last year 0.1 0.2 0.5 -0.7 -0.0 0.2
Number of children fathered 0.9 1.1 1.9 0.2 1.1 -1.4
Reason for reducing amount of alcohol drunk: Health precaution 5.0 5.8 13.0 0.8 -3.6 1.9
Age at first live birth 0.2 0.4 0.6 0.8 0.8 0.2
Pulse wave peak to peak time 3.3 3.9 8.2 -0.0 1.9 -2.9
Health satisfaction 1.7 2.2 4.7 -2.2 0.4 -1.3
Shortness of breath walking on level ground 0.0 0.0 0.0 -0.0 0.2 0.2
Qualifications: College or University degree 1.2 3.9 7.7 -0.9 1.8 -2.8
Eye problems/disorders: None of the above 1.2 1.3 2.9 -1.7 0.1 -1.1
Mouth/teeth dental problems: Loose teeth 2.0 2.3 6.0 -1.0 2.5 -0.2
Emphysema/chronic bronchitis 0.9 1.0 2.7 -0.0 1.6 -0.5
Medication for pain relief, constipation, heartburn 0.6 1.0 1.9 0.0 1.4 -1.0
Neck or shoulder pain in last month 0.5 0.7 1.3 1.1 -0.1 0.9
Medication: Blood pressure 0.4 0.7 1.6 0.6 -1.3 0.0
Angina (self-reported) 0.1 0.2 0.5 -0.1 0.7 0.2
Migraine (self-reported) 1.0 1.3 3.0 -1.7 0.2 -0.9
Medication: Ibuprofen 0.7 0.8 2.1 -0.0 -1.4 -0.6
Medication: Allopurinol 0.4 0.6 1.4 -0.4 0.4 -1.2
Medication: Omeprazole 0.3 0.3 0.6 -0.1 -0.5 -0.8
Medication: Seretide 50 evohaler 2.0 2.3 4.0 -1.6 0.5 -2.0
Mean time to correctly identify matches 0.8 1.5 4.1 -2.0 -0.7 -0.0
Heart disease (mother) 0.1 0.1 0.4 0.1 0.1 0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.9 1.1 2.2 -0.4 -1.0 -1.5
Whole body fat mass 4.5 18.9 36.1 -2.8 6.0 -3.6
Leg fat mass (right) 4.6 17.8 34.8 -2.9 5.9 -3.2
Arm predicted mass (right) 2.6 13.2 20.8 -2.6 4.6 -3.4
Pulse rate, automated reading 0.3 1.1 3.0 0.5 -0.0 1.7
Alcohol intake frequency. 0.9 2.2 2.3 -1.5 1.5 -1.5
Comparative height size at age 10 1.5 8.1 16.8 -1.6 4.1 -2.2
Number of full sisters 1.9 2.3 3.2 -1.8 1.1 -1.6
Suffer from ‘nerves’ 0.5 0.7 1.0 1.0 -0.6 0.9
Overall health rating 0.5 1.1 1.5 -0.8 1.2 1.0
Chest pain or discomfort 0.5 0.7 1.1 -1.0 0.0 1.0
Had major operations 0.0 0.0 0.1 -0.3 0.1 -0.1
Age at last live birth 0.1 0.2 0.4 0.3 -0.6 0.2
Family relationship satisfaction 0.1 0.1 0.2 0.4 -0.3 0.4
Leg pain on walking 0.1 0.1 0.2 0.4 0.1 0.1
Qualifications: NVQ or HND or HNC or equivalent 0.9 1.1 2.0 -1.4 1.1 0.3
Commuting to job workplace: Car/motor vehicle 2.2 2.5 5.7 -0.6 1.2 -2.4
Illness, injury, bereavement, stress in last 2 years 0.6 0.8 2.3 -1.5 -0.3 0.1
Medication: Aspirin 1.8 2.4 3.3 1.8 -1.6 1.1
Supplements: Vitamin C 0.5 0.6 1.0 -1.0 -0.7 -0.5
Knee pain experienced in last month 0.5 0.8 2.2 0.3 0.1 1.5
Hypertension (Self-reported) 1.6 4.4 8.3 1.6 -2.9 1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.5 0.9 -0.7 0.9 0.2
Illnesses of father: Heart disease 0.0 0.0 0.1 -0.0 -0.2 0.0
Illnesses of siblings: Diabetes 1.3 1.5 4.2 2.0 -0.6 -0.2
Smoking status: Previous 0.3 0.4 0.6 0.8 -0.6 0.6
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.6 1.6 0.4 -0.1 -1.3
Whole body fat-free mass 2.7 15.2 23.3 -2.7 4.8 -3.9
Leg fat-free mass (right) 3.0 16.2 22.9 -2.9 4.8 -4.1
Arm fat percentage (left) 2.8 11.0 21.3 -2.3 4.6 -2.6
Average weekly red wine intake 1.4 2.0 4.0 -2.0 0.0 -1.4
Handedness (chirality/laterality): Left-handed 0.9 1.0 2.8 -1.7 -0.5 -0.1
Mood swings 1.6 2.8 4.0 1.2 -1.7 2.0
Loneliness, isolation 0.7 1.0 1.6 0.6 -1.0 1.3
Long-standing illness, disability or infirmity 0.1 0.2 0.4 -0.2 0.7 0.3
Ever had bowel cancer screening 1.0 1.2 1.9 1.4 0.3 1.2
Diabetes diagnosed by doctor 0.2 0.3 0.9 -0.1 0.2 -1.0
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.4 0.6 -0.8 0.6 0.2
Friendships satisfaction 0.1 0.2 0.3 -0.1 -0.4 0.6
Qualifications: nursing, teaching 0.9 1.4 2.7 -0.3 1.3 -1.6
Commuting to job workplace: Walk 0.4 0.4 0.6 0.7 0.8 -0.3
Eye problems/disorders: Cataract 1.4 1.6 4.1 2.0 -0.2 0.8
Mouth/teeth dental problems: Mouth ulcers 0.8 1.2 3.4 1.8 0.2 -0.4
Medication for cholesterol 1.5 2.2 4.1 0.4 1.6 -2.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.1 0.1 0.2 -0.1 -0.1 0.4
Back pain experienced in last month 0.6 0.9 1.6 0.8 1.3 0.8
Mineral and other dietary supplements 2.4 3.3 6.1 -1.3 2.5 -1.4
Breast cancer (self-reported) 0.5 0.6 1.2 0.0 -0.7 1.1
Asthma (self-reported) 0.1 0.2 0.6 0.0 -0.2 -0.8
Osteoporosis (self-reported) 1.1 1.3 2.8 -1.7 0.6 -0.9
Osteoarthritis (self-reported) 1.1 1.4 2.2 1.5 -0.2 1.4
Medication: Aspirin 1.1 1.5 2.2 1.5 -1.1 1.0
Medication: Gliclazide 1.9 2.1 2.3 -1.5 1.4 1.5
Illnesses of father: None of the above (group 1) 0.1 0.1 0.2 0.4 -0.3 0.4
Smoking status: Current 1.4 2.2 5.4 -2.3 1.0 -0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.9 1.8 3.0 1.5 -0.5 1.7
Whole body water mass 2.7 15.2 23.0 -2.6 4.8 -4.0
Leg predicted mass (right) 3.0 16.1 23.3 -2.8 4.8 -4.1
Arm fat mass (left) 3.9 16.1 28.9 -2.7 5.4 -3.4
Number of self-reported non-cancer illnesses 0.1 0.2 0.3 0.1 0.5 0.5
Average weekly champagne plus white wine intake 0.5 0.7 1.9 -0.3 -1.4 -0.2
Miserableness 2.2 3.9 6.9 0.6 -2.1 2.6
Guilty feelings 3.7 5.5 7.7 1.7 -2.8 2.5
Wears glasses or contact lenses 0.0 0.1 0.1 0.3 -0.2 -0.1
Ever taken oral contraceptive pill 3.5 3.9 9.7 1.1 -3.1 -0.7
Hearing aid user 0.1 0.1 0.2 -0.3 0.1 0.4
Mother’s age at death 0.8 1.0 1.4 0.5 1.1 -1.2
Financial situation satisfaction 1.8 2.2 6.4 -2.5 -0.4 0.1
Tinnitus: Yes, now most or all of the time 1.0 1.1 1.5 1.2 -0.9 1.0
Commuting to job workplace: Public transport 1.4 1.6 4.6 -0.5 -0.3 2.1
Eye problems/disorders: Glaucoma 0.2 0.2 0.5 -0.7 0.1 0.3
Medication: Blood pressure 0.4 0.7 1.3 -0.0 -1.1 0.9
Pain type(s) experienced in last month: Hip pain 0.4 0.5 1.6 -0.2 1.2 -0.0
Supplements: Fish oil (including cod liver oil) 1.7 2.3 4.9 0.8 -2.2 1.1
High cholesterol (Self-reported) 0.1 0.2 0.5 -0.3 -0.1 -0.7
Medication: Bendroflumethiazide 0.3 0.5 0.5 -0.7 -0.7 -0.7
Medication: Paracetamol 0.1 0.1 0.2 -0.4 0.4 -0.1
Medication: Lisinopril 0.7 1.0 1.6 1.1 -1.2 -0.4
Medication: Atorvastatin 0.5 0.7 1.7 -1.3 0.6 0.0
Illnesses of father: High blood pressure 0.2 0.2 0.3 -0.4 -0.6 -0.2
Alcohol drinker status: Never 1.6 1.9 3.7 -0.9 1.1 -1.9
Ever smoked 0.2 0.3 0.7 0.3 0.5 0.8
Basal metabolic rate 3.3 18.4 28.6 -2.9 5.3 -4.2
Leg fat percentage (left) 2.6 9.5 19.5 -2.1 4.4 -2.2
Arm fat-free mass (left) 2.6 13.0 22.3 -2.3 4.7 -3.4
Number of operations (self-reported) 0.2 0.2 0.4 -0.2 -0.5 0.6
Average weekly beer plus cider intake 1.0 1.4 4.0 0.0 -0.6 2.0
Irritability 2.1 3.5 7.7 1.5 -2.8 0.8
Risk taking 0.8 1.1 1.6 0.5 -1.3 1.3
Ever had prostate specific antigen (PSA) test 1.4 1.6 2.5 0.5 1.4 -1.6
Fractured/broken bones in last 5 years 0.9 1.2 2.2 -1.5 1.1 0.4
Age started oral contraceptive pill 0.5 0.6 1.7 0.1 -0.3 1.3
Diastolic blood pressure, automated reading 0.9 2.7 4.7 1.2 -1.4 2.2
Ever depressed for a whole week 0.1 0.2 0.3 -0.5 -0.1 0.5
Unable to work because of sickness or disability 0.7 0.9 2.1 -1.4 0.6 -0.6
Commuting to job workplace: Cycle 0.3 0.3 0.6 -0.1 0.6 0.8
Myopia 0.8 1.2 2.4 1.0 -0.2 -1.6
Vascular/heart problems diagnosed by doctor 1.2 3.3 5.9 -1.0 2.4 -1.7
Cholesterol lowering medication 0.1 0.2 0.4 0.3 0.1 0.7
Medication: Omeprazole (e.g. Zanprol) 0.4 0.4 1.2 0.3 -0.1 -1.1
Pain experienced in last month 0.5 0.8 1.2 -0.7 1.1 -0.9
Supplements: Calcium 0.4 0.4 0.8 -0.2 0.9 -0.7
Basal cell carcinoma (self-reported) 0.3 0.4 0.8 0.4 -0.9 -0.4
Heart attack/myocardial infarction (self-reported) 0.3 0.4 1.1 -1.0 0.3 0.2
Deep venous thrombosis (DVT) (self-reported) 0.1 0.1 0.2 -0.3 -0.1 0.5
Heart disease (siblings) 0.2 0.3 0.7 0.2 -0.1 0.9
Alcohol drinker status: Previous 0.6 0.6 1.3 -1.2 0.3 -0.7
Pack years of smoking 0.9 1.3 3.2 -0.5 1.8 -0.8
Impedance of whole body 0.8 4.1 6.0 2.4 -1.4 2.1
Leg fat mass (left) 4.3 16.6 30.9 -2.8 5.6 -3.3
Arm predicted mass (left) 2.8 14.2 22.9 -2.5 4.8 -3.7