Best TWAS P=6.27e-12 · Best GWAS P=5.31e-11 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | GPRC5B | 0.07 | 0.04 | lasso | 4 | 0.03 | 1.3e-03 | -6.6 | 6.9 | 6.3e-12 | -0.97 | 0.00 | 0.98 | TRUE |
| 2 | GTEx | Skin Sun Exposed Lower leg | ACSM5 | 0.21 | 0.04 | lasso | 9 | 0.07 | 3.6e-06 | 1.0 | -5.1 | 3.0e-07 | 0.16 | 0.29 | 0.30 | TRUE |
| 3 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | IQCK | 0.03 | 0.03 | lasso | 3 | 0.02 | 7.2e-04 | -5.2 | -5.3 | 1.2e-07 | 0.93 | 0.01 | 0.98 | FALSE |