Best TWAS P=9.07e-10 · Best GWAS P=3.46e-09 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | PABPC1L | 0.17 | 0.16 | lasso | 1 | 0.15 | 8.0e-18 | 5.7 | -5.7 | 1.0e-08 | -0.99 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | YWHAB | 0.13 | 0.17 | lasso | 2 | 0.15 | 2.8e-12 | 5.9 | -5.9 | 3.8e-09 | -1.00 | 0.00 | 1.00 | FALSE |
| 3 | GTEx | Adipose Visceral Omentum | YWHAB | 0.19 | 0.07 | lasso | 4 | 0.05 | 1.1e-03 | 5.7 | -5.9 | 3.8e-09 | -0.99 | 0.01 | 0.98 | FALSE |
| 4 | GTEx | Adrenal Gland | PABPC1L | 0.32 | 0.07 | lasso | 8 | 0.07 | 1.9e-03 | 5.7 | -5.2 | 2.6e-07 | -0.88 | 0.01 | 0.94 | FALSE |
| 5 | GTEx | Adrenal Gland | YWHAB | 0.23 | 0.15 | lasso | 3 | 0.10 | 1.4e-04 | 5.9 | -5.8 | 7.7e-09 | -1.00 | 0.01 | 0.99 | FALSE |
| 6 | GTEx | Artery Aorta | YWHAB | 0.29 | 0.17 | lasso | 5 | 0.15 | 1.3e-08 | 5.9 | -6.0 | 1.8e-09 | -0.99 | 0.01 | 0.99 | FALSE |
| 7 | GTEx | Artery Tibial | YWHAB | 0.17 | 0.15 | lasso | 3 | 0.16 | 3.5e-12 | 5.9 | -5.9 | 4.2e-09 | -1.00 | 0.00 | 1.00 | FALSE |
| 8 | GTEx | Brain Cerebellar Hemisphere | YWHAB | 0.42 | 0.22 | lasso | 4 | 0.18 | 2.3e-05 | 5.7 | -5.8 | 5.0e-09 | -0.99 | 0.01 | 0.98 | FALSE |
| 9 | GTEx | Brain Cerebellum | YWHAB | 0.43 | 0.19 | lasso | 7 | 0.16 | 1.7e-05 | 5.7 | -6.1 | 1.1e-09 | -0.97 | 0.01 | 0.98 | FALSE |
| 10 | GTEx | Brain Nucleus accumbens basal ganglia | YWHAB | 0.22 | 0.11 | lasso | 3 | 0.07 | 6.5e-03 | 5.7 | -6.0 | 1.7e-09 | -0.97 | 0.01 | 0.95 | FALSE |
| 11 | GTEx | Breast Mammary Tissue | YWHAB | 0.18 | 0.09 | lasso | 6 | 0.08 | 5.2e-05 | 5.9 | -5.6 | 1.6e-08 | -0.97 | 0.01 | 0.99 | FALSE |
| 12 | GTEx | Cells EBV-transformed lymphocytes | YWHAB | 0.27 | 0.12 | enet | 13 | 0.18 | 1.2e-06 | 5.4 | -5.9 | 4.8e-09 | -0.95 | 0.01 | 0.99 | FALSE |
| 13 | GTEx | Cells Transformed fibroblasts | PABPC1L | 0.12 | 0.03 | enet | 22 | 0.08 | 2.0e-06 | 3.5 | 5.3 | 1.5e-07 | 0.72 | 0.04 | 0.96 | FALSE |
| 14 | GTEx | Cells Transformed fibroblasts | YWHAB | 0.29 | 0.20 | enet | 21 | 0.26 | 1.5e-19 | 5.7 | -5.7 | 1.5e-08 | -0.84 | 0.01 | 0.99 | FALSE |
| 15 | GTEx | Colon Sigmoid | YWHAB | 0.27 | 0.14 | lasso | 4 | 0.10 | 1.7e-04 | 5.7 | -5.3 | 1.3e-07 | -0.94 | 0.01 | 0.98 | FALSE |
| 16 | GTEx | Esophagus Mucosa | YWHAB | 0.25 | 0.27 | enet | 7 | 0.27 | 4.2e-18 | 5.9 | -5.8 | 5.2e-09 | -0.99 | 0.01 | 0.99 | FALSE |
| 17 | GTEx | Esophagus Muscularis | YWHAB | 0.16 | 0.11 | lasso | 3 | 0.14 | 1.5e-08 | 4.8 | -5.3 | 9.0e-08 | -0.92 | 0.01 | 0.99 | FALSE |
| 18 | GTEx | Lung | YWHAB | 0.10 | 0.04 | lasso | 4 | 0.04 | 6.5e-04 | 5.9 | -5.9 | 3.5e-09 | -0.99 | 0.01 | 0.99 | FALSE |
| 19 | GTEx | Muscle Skeletal | YWHAB | 0.09 | 0.07 | lasso | 5 | 0.07 | 4.5e-07 | 5.7 | -5.3 | 9.0e-08 | -0.98 | 0.01 | 0.99 | FALSE |
| 20 | GTEx | Skin Not Sun Exposed Suprapubic | YWHAB | 0.33 | 0.24 | lasso | 4 | 0.26 | 1.6e-14 | 5.7 | -5.7 | 9.1e-09 | -0.96 | 0.01 | 0.99 | FALSE |
| 21 | GTEx | Skin Sun Exposed Lower leg | YWHAB | 0.17 | 0.18 | lasso | 2 | 0.17 | 4.7e-14 | 5.9 | -5.9 | 3.7e-09 | -1.00 | 0.00 | 1.00 | FALSE |
| 22 | GTEx | Testis | YWHAB | 0.23 | 0.23 | enet | 14 | 0.23 | 1.8e-10 | 5.9 | -5.5 | 3.9e-08 | -0.97 | 0.00 | 1.00 | FALSE |
| 23 | GTEx | Thyroid | YWHAB | 0.22 | 0.18 | lasso | 2 | 0.17 | 5.3e-13 | 5.9 | -5.9 | 3.5e-09 | -1.00 | 0.00 | 1.00 | FALSE |
| 24 | GTEx | Whole Blood | YWHAB | 0.20 | 0.10 | lasso | 9 | 0.10 | 1.6e-09 | 5.9 | -5.4 | 8.4e-08 | -0.98 | 0.01 | 0.99 | FALSE |
| 25 | NTR | Blood | YWHAB | 0.16 | 0.19 | lasso | 5 | 0.19 | 2.2e-58 | 5.7 | -5.7 | 1.0e-08 | -0.99 | 0.01 | 0.99 | FALSE |
| 26 | ROSMAP | Brain Pre-frontal Cortex | PABPC1L | 0.24 | 0.21 | lasso | 3 | 0.21 | 8.1e-27 | 5.7 | -5.4 | 5.3e-08 | -0.98 | 0.01 | 0.99 | FALSE |
| 27 | ROSMAP | Brain Pre-frontal Cortex | YWHAB | 0.56 | 0.58 | bslmm | 418 | 0.59 | 7.7e-94 | 5.9 | -5.9 | 4.4e-09 | -1.00 | 0.00 | 1.00 | FALSE |
| 28 | YFS | Blood | PABPC1L | 0.17 | 0.13 | enet | 41 | 0.14 | 1.8e-43 | 4.8 | 5.1 | 3.0e-07 | 0.79 | 0.66 | 0.34 | FALSE |
| 29 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PABPC1L | 0.02 | 0.02 | lasso | 4 | 0.02 | 2.2e-04 | 5.7 | -5.7 | 1.1e-08 | -0.99 | 0.01 | 0.99 | FALSE |
| 30 | The Cancer Genome Atlas | Colon Adenocarcinoma | PABPC1L | 0.08 | 0.01 | enet | 8 | 0.02 | 3.6e-02 | 5.7 | -5.7 | 1.1e-08 | -0.78 | 0.01 | 0.86 | FALSE |
| 31 | The Cancer Genome Atlas | Esophageal Carcinoma | YWHAB | 0.15 | 0.14 | lasso | 5 | 0.10 | 4.6e-04 | 5.4 | -5.2 | 2.2e-07 | -0.85 | 0.02 | 0.88 | FALSE |
| 32 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PABPC1L | 0.20 | 0.21 | lasso | 3 | 0.21 | 5.5e-23 | 5.7 | -5.7 | 1.0e-08 | -0.99 | 0.01 | 0.99 | FALSE |
| 33 | The Cancer Genome Atlas | Brain Lower Grade Glioma | YWHAB | 0.06 | 0.07 | enet | 6 | 0.09 | 7.4e-11 | 4.8 | -5.7 | 1.1e-08 | -0.94 | 0.01 | 0.99 | FALSE |
| 34 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | YWHAB | 0.07 | 0.06 | lasso | 2 | 0.06 | 1.3e-04 | 5.7 | -6.1 | 9.1e-10 | -0.99 | 0.01 | 0.97 | TRUE |
| 35 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PABPC1L | 0.08 | 0.14 | lasso | 4 | 0.14 | 4.2e-14 | 5.7 | -5.7 | 1.0e-08 | -0.99 | 0.01 | 0.99 | FALSE |
| 36 | The Cancer Genome Atlas | Prostate Adenocarcinoma | YWHAB | 0.07 | 0.06 | lasso | 6 | 0.06 | 3.1e-07 | 5.7 | -5.5 | 3.0e-08 | -0.96 | 0.01 | 0.99 | FALSE |
| 37 | The Cancer Genome Atlas | Stomach Adenocarcinoma | YWHAB | 0.04 | 0.05 | enet | 10 | 0.03 | 2.3e-03 | 5.4 | -5.2 | 1.6e-07 | -0.88 | 0.01 | 0.92 | FALSE |
| 38 | The Cancer Genome Atlas | Thyroid Carcinoma | YWHAB | 0.12 | 0.13 | lasso | 5 | 0.12 | 4.3e-12 | 5.7 | -5.8 | 7.0e-09 | -0.99 | 0.01 | 0.99 | FALSE |