Best TWAS P=2.93e-10 · Best GWAS P=7.67e-11 conditioned to 0.0134
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | UQCC | 0.07 | 0.04 | lasso | 2 | 0.05 | 1.4e-06 | 4.5 | -5.1 | 3.1e-07 | -0.53 | 0.99 | 0.01 | FALSE |
2 | GTEx | Artery Aorta | GGT7 | 0.06 | 0.00 | enet | 7 | 0.02 | 1.9e-02 | -5.0 | 6.3 | 2.9e-10 | 0.42 | 0.20 | 0.14 | TRUE |
3 | GTEx | Brain Nucleus accumbens basal ganglia | EDEM2 | 0.17 | 0.00 | lasso | 4 | 0.00 | 2.7e-01 | 5.4 | -5.5 | 3.8e-08 | -0.52 | 0.08 | 0.33 | FALSE |
4 | GTEx | Breast Mammary Tissue | ITCH | 0.09 | 0.04 | enet | 28 | 0.09 | 2.5e-05 | 3.9 | -5.3 | 9.1e-08 | -0.42 | 0.22 | 0.75 | FALSE |
5 | GTEx | Breast Mammary Tissue (Female) | ITCH | 0.09 | 0.02 | enet | 16 | 0.06 | 8.2e-03 | -5.9 | -5.4 | 5.7e-08 | -0.32 | 0.06 | 0.70 | FALSE |
6 | GTEx | Cells EBV-transformed lymphocytes | NCOA6 | 0.11 | 0.06 | enet | 15 | 0.06 | 3.9e-03 | 5.2 | -6.1 | 1.3e-09 | -0.70 | 0.11 | 0.58 | FALSE |
7 | GTEx | Colon Transverse | UQCC1 | 0.11 | 0.01 | lasso | 4 | 0.01 | 1.0e-01 | 6.5 | -5.4 | 6.0e-08 | -0.86 | 0.01 | 0.84 | FALSE |
8 | GTEx | Esophagus Mucosa | EPB41L1 | 0.26 | 0.16 | enet | 26 | 0.22 | 1.9e-14 | 3.5 | -5.1 | 2.8e-07 | -0.26 | 0.14 | 0.69 | TRUE |
9 | GTEx | Stomach | MAP1LC3A | 0.10 | 0.04 | enet | 10 | 0.05 | 1.3e-03 | -4.1 | 5.2 | 2.6e-07 | 0.40 | 0.26 | 0.27 | FALSE |
10 | GTEx | Thyroid | MYH7B | 0.06 | 0.03 | enet | 15 | 0.06 | 3.6e-05 | 5.2 | 5.8 | 5.2e-09 | 0.74 | 0.06 | 0.94 | FALSE |
11 | YFS | Blood | EIF2S2 | 0.07 | 0.07 | enet | 25 | 0.06 | 4.3e-20 | -5.7 | 6.2 | 4.7e-10 | 0.22 | 0.02 | 0.98 | TRUE |
12 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | UQCC | 0.08 | 0.01 | lasso | 3 | 0.01 | 9.0e-02 | 4.6 | -5.4 | 6.4e-08 | -0.52 | 0.18 | 0.33 | FALSE |
13 | The Cancer Genome Atlas | Brain Lower Grade Glioma | NCOA6 | 0.04 | 0.02 | blup | 65 | 0.04 | 6.1e-05 | -4.0 | -5.4 | 5.3e-08 | -0.25 | 0.19 | 0.48 | FALSE |
14 | The Cancer Genome Atlas | Prostate Adenocarcinoma | GGT7 | 0.05 | 0.02 | enet | 6 | 0.03 | 3.3e-04 | 5.5 | -5.6 | 2.4e-08 | -0.46 | 0.01 | 0.96 | FALSE |