Best TWAS P=2.27e-08 · Best GWAS P=1.61e-12 conditioned to 0.0287
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ADARB1 | 0.12 | 0.03 | blup | 656 | 0.03 | 3.6e-04 | -4.0 | -5.2 | 1.8e-07 | 0.51 | 0.30 | 0.66 | TRUE |
| 2 | GTEx | Muscle Skeletal | PTTG1IP | 0.07 | 0.01 | enet | 6 | 0.00 | 9.7e-02 | -6.5 | 5.6 | 2.3e-08 | -0.71 | 0.01 | 0.89 | TRUE |
| 3 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | ADARB1 | 0.07 | 0.01 | blup | 139 | 0.04 | 4.5e-03 | 4.9 | -5.4 | 6.6e-08 | 0.83 | 0.01 | 0.90 | FALSE |
| 4 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | C21orf122 | 0.05 | 0.04 | lasso | 3 | 0.04 | 6.5e-05 | 5.5 | -5.5 | 4.5e-08 | 0.60 | 0.00 | 0.99 | TRUE |
| 5 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | C21orf122 | 0.20 | 0.04 | lasso | 6 | 0.08 | 2.6e-04 | 5.5 | -5.3 | 8.9e-08 | 0.57 | 0.00 | 0.97 | FALSE |