Best TWAS P=3.47e-12 · Best GWAS P=4.39e-12 conditioned to 0.0145
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | BMP8A | 0.05 | 0.03 | lasso | 3 | 0.02 | 8.8e-04 | 5.9 | 6.1 | 1.4e-09 | 0.71 | 0.08 | 0.84 | FALSE |
| 2 | GTEx | Adrenal Gland | PABPC4 | 0.20 | 0.09 | lasso | 8 | 0.06 | 3.0e-03 | 5.7 | -7.0 | 3.5e-12 | -0.77 | 0.04 | 0.85 | TRUE |
| 3 | GTEx | Adrenal Gland | RP11-69E11.4 | 0.11 | 0.05 | lasso | 3 | 0.00 | 2.4e-01 | 4.7 | 5.6 | 2.4e-08 | 0.52 | 0.07 | 0.45 | FALSE |
| 4 | GTEx | Artery Tibial | PABPC4 | 0.10 | 0.10 | lasso | 4 | 0.10 | 3.4e-08 | 5.7 | -5.5 | 3.0e-08 | -0.72 | 0.53 | 0.46 | FALSE |
| 5 | GTEx | Breast Mammary Tissue | PABPC4 | 0.13 | 0.02 | enet | 14 | 0.04 | 3.4e-03 | 5.9 | -5.8 | 6.8e-09 | -0.70 | 0.10 | 0.77 | FALSE |
| 6 | GTEx | Breast Mammary Tissue (Female) | PABPC4 | 0.10 | 0.00 | enet | 9 | 0.01 | 1.5e-01 | 6.4 | -6.8 | 9.6e-12 | -0.83 | 0.04 | 0.36 | FALSE |
| 7 | GTEx | Cells Transformed fibroblasts | PABPC4 | 0.07 | 0.09 | lasso | 1 | 0.06 | 2.7e-05 | 5.7 | -5.7 | 1.0e-08 | -0.68 | 0.10 | 0.87 | FALSE |
| 8 | GTEx | Esophagus Mucosa | PABPC4 | 0.06 | 0.06 | lasso | 3 | 0.08 | 7.3e-06 | 5.9 | -5.8 | 6.8e-09 | -0.73 | 0.32 | 0.63 | FALSE |
| 9 | GTEx | Lung | PABPC4 | 0.05 | 0.03 | lasso | 3 | 0.02 | 1.3e-02 | 5.7 | -5.1 | 2.9e-07 | -0.64 | 0.14 | 0.67 | FALSE |
| 10 | GTEx | Nerve Tibial | PABPC4 | 0.17 | 0.08 | enet | 12 | 0.05 | 2.7e-04 | 5.7 | -5.4 | 8.8e-08 | -0.73 | 0.12 | 0.88 | FALSE |
| 11 | GTEx | Nerve Tibial | RP11-69E11.8 | 0.05 | 0.00 | lasso | 3 | 0.01 | 6.9e-02 | 5.7 | -6.0 | 2.2e-09 | -0.75 | 0.04 | 0.83 | FALSE |
| 12 | GTEx | Skin Not Sun Exposed Suprapubic | PABPC4 | 0.12 | 0.10 | lasso | 3 | 0.05 | 1.0e-03 | 5.9 | -5.9 | 2.8e-09 | -0.71 | 0.19 | 0.60 | FALSE |
| 13 | GTEx | Skin Sun Exposed Lower leg | PABPC4 | 0.11 | 0.09 | lasso | 7 | 0.08 | 2.7e-07 | 5.9 | -5.6 | 1.9e-08 | -0.71 | 0.10 | 0.90 | FALSE |
| 14 | GTEx | Skin Sun Exposed Lower leg | RP11-69E11.4 | 0.13 | 0.12 | lasso | 6 | 0.15 | 1.3e-12 | 5.2 | 5.2 | 2.3e-07 | 0.72 | 0.98 | 0.02 | FALSE |
| 15 | METSIM | Adipose | PABPC4 | 0.05 | 0.02 | lasso | 6 | 0.03 | 6.0e-05 | 5.9 | -5.4 | 5.8e-08 | -0.71 | 0.08 | 0.91 | FALSE |
| 16 | NTR | Blood | PABPC4 | 0.01 | 0.00 | blup | 383 | 0.00 | 2.8e-02 | 5.7 | -6.2 | 7.7e-10 | -0.68 | 0.02 | 0.75 | FALSE |
| 17 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PABPC4 | 0.03 | 0.03 | lasso | 2 | 0.04 | 1.3e-08 | 5.7 | -5.6 | 2.8e-08 | -0.62 | 0.00 | 1.00 | FALSE |
| 18 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | BMP8A | 0.04 | 0.03 | blup | 48 | 0.04 | 3.5e-05 | 4.2 | 5.9 | 3.6e-09 | 0.68 | 0.02 | 0.97 | FALSE |
| 19 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | PABPC4 | 0.03 | 0.01 | enet | 4 | 0.02 | 4.3e-03 | 5.7 | -5.5 | 4.2e-08 | -0.68 | 0.00 | 0.99 | FALSE |
| 20 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PABPC4 | 0.04 | 0.05 | blup | 31 | 0.04 | 1.2e-05 | 4.7 | -5.2 | 2.0e-07 | -0.57 | 0.03 | 0.96 | FALSE |
| 21 | The Cancer Genome Atlas | Brain Lower Grade Glioma | BMP8A | 0.05 | 0.01 | blup | 48 | 0.04 | 6.8e-05 | 6.1 | 6.5 | 9.9e-11 | 0.68 | 0.00 | 0.98 | FALSE |
| 22 | The Cancer Genome Atlas | Lung Adenocarcinoma | PABPC4 | 0.04 | 0.03 | enet | 8 | 0.04 | 4.5e-05 | 5.9 | -5.7 | 1.2e-08 | -0.62 | 0.00 | 1.00 | FALSE |
| 23 | The Cancer Genome Atlas | Thyroid Carcinoma | PABPC4 | 0.09 | 0.07 | enet | 5 | 0.08 | 4.1e-08 | 5.7 | -6.5 | 7.1e-11 | -0.62 | 0.00 | 1.00 | FALSE |