TWAS
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Traits
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Traits
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Arm fat-free mass (right)
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chr6:141,924,760-143,456,607
Best TWAS P=2.33e-18 · Best GWAS P=1.38e-19 conditioned to 1
142M
142.2M
142.4M
142.6M
142.8M
143M
143.2M
143.4M
0
5
10
15
20
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Adipose Subcutaneous
GPR126
0.06
0.04
lasso
4
0.04
0.00061
-8.5
8.7
2.3e-18
-0.97
0.02
0.96
TRUE
4
The Cancer Genome Atlas
Uterine Corpus Endometrial Carcinoma
NMBR
0.09
0.01
blup
46
0.04
0.03380
3.9
-5.5
4.2e-08
0.12
0.02
0.65
TRUE
2
METSIM
Adipose
GPR126
0.05
0.01
blup
429
0.02
0.00019
-4.3
6.4
2.0e-10
-0.74
0.11
0.89
FALSE
3
The Cancer Genome Atlas
Kidney Renal Clear Cell Carcinoma
VTA1
0.03
0.02
blup
66
0.02
0.00170
5.2
-5.1
3.0e-07
0.09
0.13
0.46
FALSE